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Journal Articles

River-81: A Multicenter, Open-Label, Dose-Finding Clinical Trial to Assess Safety, PK, PD, Clinical Efficacy of RVU120 in Combination with Venetoclax in Patients with AML Failing Prior Venetoclax Plus Hypomethylating Agent Therapy

Maria Benedetta Giannini, Adolfo De la Fuente Burguera, Adriano Venditti, Witold Prejzner, Sara García, Noemi Angelosanto, Hendrik Nogai, Renata Dudziak, Vakul Mohanty, Natalia Baran, Marta Obacz, Urszula Pakulska, Jerzy Woźnicki, Katarzyna Wiklik, Marta Micek, Tomasz Rzymski, Milena Mazan, Agnieszka Sroka-Porada, Gary Wilkinson, Aleksandra Butrym, Erika Borlenghi, Krzysztof Mądry, Jan Kulis, Diego Coelho, Daniel Grzywczak
Journal: Blood
Blood (2024) 144 (Supplement 1): 5999.
https://doi.org/10.1182/blood-2024-200055
Published: 2024
Journal Articles

Preliminary Safety and Efficacy of Emavusertib (CA-4948) in Combination with Ibrutinib in Relapsed/Refractory Primary Central Nervous System Lymphoma Patients with Prior Exposure to BTK Inhibitor

Grzegorz S. Nowakowski, Anna Paulina Dabrowska-Iwanicka, Christian Grommes, Han W. Tun, Christopher D' Angelo, Adolfo De la Fuente Burguera, Etai Levi, Radhakrishnan Ramchandren, Andrés José María Ferreri, Gaurav S Choudhary, Wanying Zhao, Dora Ferrari, Meaghan Fowle, Maureen Lane, Catherine Wang, Michal Taszner
Journal: Blood
Blood (2024) 144 (Supplement 1): 6020.
https://doi.org/10.1182/blood-2024-208359
Published: 2024
Journal Articles

Preliminary Safety, Efficacy, and Molecular Characterization of Emavusertib (CA-4948) in Relapsed/Refractory Acute Myeloid Leukemia Patients

Eric S. Winer, David Sallman, Adolfo De la Fuente Burguera, Amit Verma, Katharina Goetze, Yasmin Abaza, James P. Dugan, Thomas Cluzeau, Eduardo Rodriguez Arboli, Alice Mims, Stefanie Groepper, Itay Zilbershatz, Jane L. Liesveld, Walter Fiedler, Stefano R Tarantolo, Lionel Ades, Nikolaos Papadantonakis, Christoph Schliemann, Gaurav S Choudhary, Maureen Lane, Wanying Zhao, Ashish Jain, Cole Gallagher, Guillermo Garcia-Manero
Journal: Blood
Blood (2024) 144 (Supplement 1): 737.
https://doi.org/10.1182/blood-2024-207953
Published: 2024
Journal Articles

Real-World Outcomes Using Front-Line Midostaurine in Combination with Intensive Chemotherapy for Patients Aged ≥ 60 Years Old with FLT3 Mutated Acute Myeloid Leukemia

Gaspar Aspas Requena, Pierre Yves Dumas, Rebeca Rodriguez Veiga, Sarah Bertoli, Cristina Gil, Celestine Simand, Fernando Jesús Ramos-Ortega, Pierre Peterlin, Josefina Serrano, Rudy Birsen, Teresa Bernal Del Castillo, Emmanuelle Tavernier, Mar Tormo, Martin Carre, Maria Jose Garcia, Adrien Contejean, Rosalia Riaza Grau, Corentin Orvain, Jose Antonio Pérez-Simón, Esther Perez Santaolla, Lauren Veronese, Beatriz De Rueda Ciller, Eric Delabesse, Antonio Gutiérrez, Ariane Mineur, Adolfo De La Fuente Burguera, Romain Guieze, Arnaud Pigneux, Pau Montesinos, Christian Recher, David Matínez-Cuadrón
Journal: Blood
Blood (2023) 142 (Supplement 1): 2864.
https://doi.org/10.1182/blood-2023-190128
Published: 2023
Journal Articles

Trial in Progress: A Phase 1b Single-Arm, Open-Label Study of Emavusertib (CA-4948) in Combination with Azacitidine and Venetoclax in Acute Myeloid Leukemia Patients in Complete Response with Measurable Residual Disease

Adolfo De La Fuente Burguera, Claudio Cerchione, Sebastian Scholl, Jan Moritz Middeke, Gaurav S Choudhary, Reinhard von Roemeling, Uwe Platzbecker
Journal: Blood
Blood (2023) 142 (Supplement 1): 5975.
https://doi.org/10.1182/blood-2023-190125
Published: 2023
Journal Articles

Molecular Characterization of Clinical Response and Relapse in Patients with IDH1 m ND-AML Treated with Ivo+AZA in the AGILE Study

Hartmut Döhner, Dylan M. Marchione, Sung Choe, Pau Montesinos, Christian Recher, Susana Vives, Ewa Zarzycka, Jianxiang Wang, Claudio Cerchione, Michael Heuser, Rodrigo T. Calado, Andre C. Schuh, Su-Peng Yeh, Adolfo De La Fuente, Jianan Hui, Prapti Patel, Diego A. Gianolio, Scott R. Daigle, Courtney D. DiNardo, Stephane De Botton
Journal: Blood
Blood (2022) 140 (Supplement 1): 539–542.
https://doi.org/10.1182/blood-2022-159473
Published: 2022
Journal Articles

Broad Activity for the Pivekimab Sunirine (PVEK, IMGN632), Azacitidine, and Venetoclax Triplet in High-Risk Patients with Relapsed/Refractory Acute Myeloid Leukemia (AML)

Naval Daver, Pau Montesinos, Ahmed Aribi, Giovanni Marconi, Jessica K. Altman, Eunice S. Wang, Gail J. Roboz, Patrick W. Burke, Gianluca Gaidano, Roland B. Walter, Xavier Thomas, Deepa Jeyakumar, Daniel J. DeAngelo, Harry P. Erba, Elisabetta Todisco, Kebede H. Begna, Anjali Advani, Lauris Gastaud, Adolfo De La Fuente, Antonio Curti, Lourdes M. Mendez, Paresh Vyas, Nicolas Boissel, Norbert Vey, Christian Recher, Thomas Longval, Uwe Platzbecker, Silke Kapp-Schwoerer, Christoph Schliemann, Marina Konopleva, Laura Torres, David A. Sallman, Guido Marcucci, Naveen Pemmaraju, Giovanni Martinelli, Hagop Kantarjian, Callum M Sloss, Kara E Malcolm, Patrick A Zweidler-McKay, Kendra Sweet
Journal: Blood
Blood (2022) 140 (Supplement 1): 145–149.
https://doi.org/10.1182/blood-2022-158030
Published: 2022
Journal Articles

Rituximab Maintenance after R-Bendamustine or R-CHOP in First-Line Treatment of Low-Grade Follicular Lymphoma: A Multicentre, Retrospective Study of the Spanih Group Geltamo

Mariana Bastos-Oreiro, Antonio Gutierrez, Almudena Cabero Martínez, Javier López Jiménez, Paola Sandra Villafuerte Gutierrez, Ana Jimenez-Ubieto, Adolfo De La Fuente, Belén Navarro, Maria Stefania Infante, Raul Cordoba, Jaime Perez De Oteyza, Sonia González de Villambrosia, Raquel Del Campo, Daniel Garcia, Antonio Salar, Juan-Manuel Sancho
Journal: Blood
Blood (2022) 140 (Supplement 1): 3618–3619.
https://doi.org/10.1182/blood-2022-166027
Published: 2022
Journal Articles

Long-Term Survival after Intensive Chemotherapy or Hypomethylating Agents in AML Patients Aged 70 Years and Older: A Large Patient Data Set Study from Dataml, SAL and Pethema European Registries

Christian Recher, Christoph Rollig, Emilie Berard, Sarah Bertoli, Pierre-Yves Dumas, Suzanne Tavitian, Hubert Serve, Martin Bornhäuser, Uwe Platzbecker, Carsten Müller-Tidow, Claudia D. Baldus, David Martínez-Cuadrón, Josefina Serrano, Pilar Martínez, Eduardo Rodríguez-Arbolí, Cristina Gil, Juan-Miguel Bergua, Teresa Bernal, Adolfo de la Fuente, Eric Delabesse, Audrey Bidet, Arnaud Pigneux, Pau Montesinos, Michael Kramer
Journal: Blood
Blood (2021) 138 (Supplement 1): 872.
https://doi.org/10.1182/blood-2021-147735
Published: 2021
Journal Articles

Patterns of Salvage Therapy in Patients with Acute Myeloid Leukemia Treated Upfront with Azacitidine or Decitabine: Results from the Pethema AML Registry

Jorge Labrador, Adolfo de la Fuente, David Martínez-Cuadrón, Rebeca Rodríguez-Veiga, Josefina Serrano, Mar Tormo, Jose Pérez-Simón, Fernando Ramos, Teresa Bernal del Castillo, Maria López-Pavía, Fernanda Trigo, Pilar Martinez Sanchez, Juan Ignacio Rodriguez-Gutierrez, Carlos Rodriguez, Cristina Gil, Daniel Garcia, Susana Vives, Maria Angeles Foncillas, Manuel Perez Encinas, Andrés Novo, Isabel Recio, Gabriela Rodriguez Macias, Juan Miguel Bergua Burgues, Victor Noriega Concepcion, Esperanza Lavilla, Alicia Roldán Pérez, Miguel A. Sanz, Pau Montesinos
Journal: Blood
Blood (2021) 138 (Supplement 1): 1255.
https://doi.org/10.1182/blood-2021-150544
Published: 2021
Journal Articles

Long-Term Subgroup Analyses from Azacitidine Vs. Decitabine in Unfit Newly Diagnosed Acute Myeloid Leukemia Patients: Results from the Pethema Registry

Jorge Labrador, Adolfo de la Fuente, David Martínez-Cuadrón, Rebeca Rodríguez-Veiga, Josefina Serrano, Mar Tormo, Jose Pérez-Simón, Fernando Ramos, Teresa Bernal del Castillo, Maria López-Pavía, Fernanda Trigo, Pilar Martinez Sanchez, Juan Ignacio Rodriguez-Gutierrez, Carlos Rodriguez, Cristina Gil, Daniel Garcia, Susana Vives, Maria Angeles Foncillas, Manuel Perez Encinas, Andrés Novo, Isabel Recio, Gabriela Rodriguez Macias, Juan Miguel Bergua Burgues, Victor Noriega Concepcion, Esperanza Lavilla, Alicia Roldán Pérez, Miguel A. Sanz, Pau Montesinos
Journal: Blood
Blood (2021) 138 (Supplement 1): 1256.
https://doi.org/10.1182/blood-2021-150649
Published: 2021
Journal Articles

Acute and Post-Acute COVID-19 Severity and Mortality in Patients with Hematologic Malignancies: A Population-Based Registry Study

Joaquin Martinez-Lopez, Javier De La Cruz, Rodrigo Gil-Manso, Angel Cedillo, Adrian Alegre, Maria Pilar Llamas Sillero, Rafael F. Duarte, Víctor Jiménez-Yuste, jose Angel Hernandez, Mi Kwon, Pedro Sanchez Godoy, Pilar Martinez-Barranco, Blanca Colás Lahuerta, Pilar Herrera Puente, Lauren Benito, Alberto Velasco, Arturo Matilla, Concha Alaez, Rafael Martos, Carmen Martínez-Chamorro, Keina Quiroz, Juan F del Campo, Adolfo De La Fuente, Maria Regina Herraez, Adriana Pascual, Elvira Gomez, Jaime Perez De Oteyza, Elena Ruiz, Jose Luis Diez Martin, Julio Garcia-Suarez
Journal: Blood
Blood (2021) 138 (Supplement 1): 186.
https://doi.org/10.1182/blood-2021-152539
Published: 2021
Journal Articles

A Phase 1b/2 Study of the CD123-Targeting Antibody-Drug Conjugate IMGN632 As Monotherapy or in Combination with Venetoclax and Azacitidine for Patients with CD123-Positive Acute Myeloid Leukemia

Naval Daver, Ahmed Aribi, Pau Montesinos, Gail J. Roboz, Eunice S. Wang, Roland B. Walter, Deepa Jeyakumar, Daniel J. DeAngelo, Harry P. Erba, Anjali Advani, Patrick W. Burke, Giovanni Martinelli, Lauris Gastaud, Xavier Thomas, Jessica K. Altman, Lourdes M. Mendez, Adolfo de la Fuente, Elisabetta Todisco, Gianluca Gaidano, Antonio Curti, Nicolas Boissel, Christian Recher, Christoph Schliemann, Callum M Sloss, Jiuzhou Wang, Kara E Malcolm, Patrick A Zweidler-McKay, Kendra Sweet
Journal: Blood
Blood (2021) 138 (Supplement 1): 4440.
https://doi.org/10.1182/blood-2021-146585
Published: 2021
Journal Articles

Safety and Efficacy from a Phase 1b/2 Study of IMGN632 in Combination with Azacitidine and Venetoclax for Patients with CD123-Positive Acute Myeloid Leukemia

Naval Daver, Ahmed Aribi, Pau Montesinos, Gail J. Roboz, Eunice S. Wang, Roland B. Walter, Deepa Jeyakumar, Daniel J. DeAngelo, Harry P. Erba, Anjali Advani, Patrick W. Burke, Giovanni Martinelli, Lauris Gastaud, Xavier Thomas, Jessica K. Altman, Lourdes M. Mendez, Adolfo de la Fuente, Elisabetta Todisco, Gianluca Gaidano, Antonio Curti, Nicolas Boissel, Christian Recher, Christoph Schliemann, Marina Konopleva, David A. Sallman, Laura Torres, Guido Marcucci, Hagop Kantarjian, Callum M Sloss, Kara E Malcolm, Patrick A Zweidler-McKay, Kendra Sweet
Journal: Blood
Blood (2021) 138 (Supplement 1): 372.
https://doi.org/10.1182/blood-2021-146503
Published: 2021
Journal Articles

Ibrutinib in Combination with R-Gemox-D in Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma: Phase II Clinical Trial of the Geltamo Group

Beatriz Rey Búa, Ana Jiménez Ubieto, MDPhD, Jose Javier Sanchez Blanco, Pau Abrisqueta, MD PhD, Antonio Gutierrez, Angel Ramirez Payer, Eva Giné, MD PhD, Izaskun Cebeiro, Sr., Maria Jose Terol, Fatima De la Cruz, MD, Rafael Andreu, María José Ramírez Sánchez, Adolfo de la Fuente, Ma Cruz Viguria, Maria Jesús Peñarrubia, Carlos Grande, Dolores Caballero, MD PhD, Alejandro Martin Garcia-Sancho, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 16–17.
https://doi.org/10.1182/blood-2020-140786
Published: 2020
Journal Articles

Biomarker-Driven Phase Ib Clinical Trial of OPB-111077 in Acute Myeloid Leukemia Increases Overall Response Rates

Joaquin Martinez-Lopez, MD PhD, Pau Montesinos, MD PhD, Pilar Martinez Sanchez, Julian Gorrochategui, Jose Luis Rojas, Daniel Primo, PhD, Juan-Miguel Bergua, MD, Rosa M M. Ayala, MD PhD, Maria Calbacho, MD, Nieves López-Muñoz, Evelyn Acuña, MD, Jose Antonio Pérez-Simón, MD, Adolfo de la Fuente, Jaime Perez De Oteyza, MDPhD, Rebeca Rodríguez-Veiga, MD, Blanca Boluda, Isabel Cano, MD, Joan Ballesteros, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 18–19.
https://doi.org/10.1182/blood-2020-134336
Published: 2020
Journal Articles

Azacitidine Vs. Decitabine in Unfit Newly Diagnosed Acute Myeloid Leukemia Patients: Results from the Pethema Registry

Jorge Labrador, David Martínez-Cuadrón, MD, Adolfo de la Fuente, Rebeca Rodríguez-Veiga, MD, Josefina Serrano, MD, Mar Tormo, MD, Jose Antonio Pérez-Simón, MD, Fernando Ramos, Teresa Bernal del Castillo, MD PhD, Maria López-Pavía, Fernanda Trigo, Pilar Martinez Sanchez, Juan Ignacio Rodriguez-Gutierrez, Carlos Rodriguez, Cristina Gil, Daniel Garcia, Susana Vives, MD, Maria Angeles Foncillas, Manuel Perez Encinas, MD, Andrés Novo, MD, Isabel Recio, Gabriela Rodriguez-Macías, MD, Juan Miguel Bergua Burgues, MD, Victor Noriega Concepcion, Esperanza Lavilla, Alicia Roldán Pérez, Miguel A. Sanz, MD, Pau Montesinos, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 25–27.
https://doi.org/10.1182/blood-2020-141213
Published: 2020
Journal Articles

Efficacy and Safety of Ibrutinib in Combination with Rituximab As Frontline Treatment for Indolent Clinical Forms of Mantle Cell Lymphoma (MCL): Preliminary Results of Geltamo IMCL-2015 Phase II Trial

Eva Gine, MD, Maria de Fatima De La Cruz, MD, Carlos Grande, MD, Javier Lopez Jimenez, MD PhD, Alejandro Martín, MD PhD, Maria Jose Terol, Eva González-Barca, MD PhD, Adolfo de la Fuente, Ana Marin Niebla, PhD, Maria Casanova, MD, Ana Muntañola Prat, MD, Tomás José González-López, MD, Marta Aymerich, Lucia Palacios, MSC, Xavier Setoain, Montserrat Cortés-Romera, MD, Amanda Rotger, MD, Alejandro Medina, MD, Ramón García-Sanz, MD PhD, Elias Campo, Armando Lopez-Guillermo
Journal: Blood
Blood (2019) 134 (Supplement_1): 752.
https://doi.org/10.1182/blood-2019-122191
Published: 2019
Journal Articles

A Predictive Model for Early Death after Frontline Hypomethylating Agents in Elderly Unfit Acute Myeloid Leukemia Patients: Results from the Pethema Group

Fernando Ramos, David Martinez-Cuadron, Josefina Serrano, Maria Lopez-Pavia, Marta Fuertes-Nuñez, Teresa Bernal, Juan Ignacio Rodriguez-Gutierrez, Isabel Recio, Ana Garrido, Daniel Garcia, Claudia Lucia Sossa, MD, Cristina Gil, Rosario Varela, Pilar Martinez-Sanchez, Maria Angeles Foncillas, Mar Tormo, Antonia Cladera, Graca Esteves, José F. Falantes, Adolfo de la Fuente, Blanca Boluda, Miguel A. Sanz, Pau Montesinos Fernandez, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 648.
https://doi.org/10.1182/blood-2019-125053
Published: 2019
Journal Articles

Precision Medicine Test Is Similar but Faster Than Conventional Cytogenetics Predicting Response in AML Patients and Provides Alternative Treatments

Joan Ballesteros, PhD, David Martínez-Cuadron, MD, Joaquin Martinez Lopez, MD PhD, Juan Miguel Miguel Bergua Burgues, Mar Tormo, MD PhD, Josefina Serrano, MD, Ataulfo González, MD, Jaime Perez De Oteyza, MDPhD, Susana Vives, MD, Maria-Belen Vidriales, MD, Pilar Herrera, MD, Juan Antonio Vera, MD, Aurelio Lopez Martinez, MD, Adolfo de la Fuente, MD, Lourdes Amador Barciela, MD, Jose Angel Hernandez-Rivas, MD, Maria Angeles Fernandez Fernandez, MD, Carlos Cervero, MD, Daniel Morillo, MD, Pilar Hernandez, PhD, Daniel Primo, PhD, Julian Gorrochategui, Jose Luis Rojas, Iñaki Troconiz, PhD, Jesús Villoria, Miguel Sanz, Pau Montesinos, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1493.
https://doi.org/10.1182/blood-2018-99-115849
Published: 2018