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Volume 94, Issue 5

September 1 1999

In this Issue

PLENARY PAPERS
REVIEW ARTICLES
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
TRANSPLANTATION
BRIEF REPORTS
CORRESPONDENCE

PLENARY PAPERS

Functional and Molecular Analysis of Hematopoietic Progenitors Derived From the Aorta-Gonad-Mesonephros Region of the Mouse Embryo

Sylvie Delassus,Ian Titley,Tariq Enver

View Articletitled, Functional and Molecular Analysis of Hematopoietic Progenitors Derived From the Aorta-Gonad-Mesonephros Region of the Mouse Embryo

Activation of Granulocyte-Macrophage Colony-Stimulating Factor and Interleukin-3 Receptor Subunits in a Multipotential Hematopoietic Progenitor Cell Line Leads to Differential Effects on Development

Caroline A. Evans,Andrew Pierce,Sandra A. Winter,Elaine Spooncer,Clare M. Heyworth,Anthony D. Whetton

View Articletitled, Activation of Granulocyte-Macrophage Colony-Stimulating Factor and Interleukin-3 Receptor Subunits in a Multipotential Hematopoietic Progenitor Cell Line Leads to Differential Effects on Development

REVIEW ARTICLES

The Evidence-Based Analysis of Treatment for Chronic Myeloid Leukemia: An Introduction to Its Methods and Clinical Implications

James N. George,Steven H. Woolf,Gary E. Raskob

View Articletitled, The Evidence-Based Analysis of Treatment for Chronic Myeloid Leukemia: An Introduction to Its Methods and Clinical Implications

An Evidence-Based Analysis of the Effect of Busulfan, Hydroxyurea, Interferon, and Allogeneic Bone Marrow Transplantation in Treating the Chronic Phase of Chronic Myeloid Leukemia: Developed for the American Society of Hematology: Presented in part at the Education Session of the American Society of Hematology, December 5, 1998, Miami Beach, FL.

Richard T. Silver,Steven H. Woolf,Rüdiger Hehlmann,Frederick R. Appelbaum,James Anderson,Charles Bennett,John M. Goldman,Francois Guilhot,Hagop M. Kantarjian,Alan E. Lichtin,Moshe Talpaz,Sante Tura

View Articletitled, An Evidence-Based Analysis of the Effect of Busulfan, Hydroxyurea, Interferon, and Allogeneic Bone Marrow Transplantation in Treating the Chronic Phase of Chronic Myeloid Leukemia: Developed for the American Society of Hematology: Presented in part at the Education Session of the American Society of Hematology, December 5, 1998, Miami Beach, FL.

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Association of Chromosome Arm 9p Abnormalities With Adverse Risk in Childhood Acute Lymphoblastic Leukemia: A Report From the Children’s Cancer Group

Nyla A. Heerema,Harland N. Sather,Martha G. Sensel,Wen Liu-Mares,Beverly J. Lange,Bruce C. Bostrom,James B. Nachman,Peter G. Steinherz,Raymond Hutchinson,Paul S. Gaynon,Diane C. Arthur,Fatih M. Uckun

View Articletitled, Association of Chromosome Arm 9p Abnormalities With Adverse Risk in Childhood Acute Lymphoblastic Leukemia: A Report From the Children’s Cancer Group

Inheritance of Chromosomally Integrated Human Herpesvirus 6 DNA

Masanori Daibata,Takahiro Taguchi,Yuiko Nemoto,Hirokuni Taguchi,Isao Miyoshi

View Articletitled, Inheritance of Chromosomally Integrated Human Herpesvirus 6 DNA

Safety of Hydroxyurea in Children With Sickle Cell Anemia: Results of the HUG-KIDS Study, a Phase I/II Trial

Thomas R. Kinney,Ronald W. Helms,Erin E. O’Branski,Kwaku Ohene-Frempong,Winfred Wang,Charles Daeschner,Elliott Vichinsky,Rupa Redding-Lallinger,Beatrice Gee,Orah S. Platt,Russell E. Ware,for the Pediatric Hydroxyurea Group

View Articletitled, Safety of Hydroxyurea in Children With Sickle Cell Anemia: Results of the HUG-KIDS Study, a Phase I/II Trial

Sickle Cell Acute Chest Syndrome: Pathogenesis and Rationale for Treatment

Marie J. Stuart,B.N. Yamaja Setty

View Articletitled, Sickle Cell Acute Chest Syndrome: Pathogenesis and Rationale for Treatment

HEMATOPOIESIS

Interleukin-1β and Tumor Necrosis Factor- Stimulate DNA Binding of Hypoxia-Inducible Factor-1

Thomas Hellwig-Bürgel,Karen Rutkowski,Eric Metzen,Joachim Fandrey,Wolfgang Jelkmann

View Articletitled, Interleukin-1β and Tumor Necrosis Factor- Stimulate DNA Binding of Hypoxia-Inducible Factor-1

Phosphatidylinositol 3-Kinase Is Involved in the Protection of Primary Cultured Human Erythroid Precursor Cells From Apoptosis

Yoshihito Haseyama,Ken-ichi Sawada,Atsushi Oda,Kazuki Koizumi,Hina Takano,Takashi Tarumi,Mitsufumi Nishio,Makoto Handa,Yasuo Ikeda,Takao Koike

View Articletitled, Phosphatidylinositol 3-Kinase Is Involved in the Protection of Primary Cultured Human Erythroid Precursor Cells From Apoptosis

c-Maf Induces Monocytic Differentiation and Apoptosis in Bipotent Myeloid Progenitors

Shrikanth P. Hegde,JingFeng Zhao,Richard A. Ashmun,Linda H. Shapiro

View Articletitled, c-Maf Induces Monocytic Differentiation and Apoptosis in Bipotent Myeloid Progenitors

Lineage-Specific Expression of Human Immunodeficiency Virus (HIV) Receptor/Coreceptors in Differentiating Hematopoietic Precursors: Correlation With Susceptibility to T- and M-Tropic HIV and Chemokine-Mediated HIV Resistance

C. Chelucci,I. Casella,M. Federico,U. Testa,G. Macioce,E. Pelosi,R. Guerriero,G. Mariani,A. Giampaolo,H.J. Hassan,C. Peschle

View Articletitled, Lineage-Specific Expression of Human Immunodeficiency Virus (HIV) Receptor/Coreceptors in Differentiating Hematopoietic Precursors: Correlation With Susceptibility to T- and M-Tropic HIV and Chemokine-Mediated HIV Resistance

Megakaryocyte Growth and Development Factor-Induced Proliferation and Differentiation Are Regulated by the Mitogen-Activated Protein Kinase Pathway in Primitive Cord Blood Hematopoietic Progenitors

Serge Fichelson,Jean-Marc Freyssinier,Françoise Picard,Michaela Fontenay-Roupie,Martine Guesnu,Mustapha Cherai,Sylvie Gisselbrecht,Françoise Porteu

View Articletitled, Megakaryocyte Growth and Development Factor-Induced Proliferation and Differentiation Are Regulated by the Mitogen-Activated Protein Kinase Pathway in Primitive Cord Blood Hematopoietic Progenitors

Heterodimerization of the  and β Chains of the Interleukin-3 (IL-3) Receptor Is Necessary and Sufficient for IL-3–Induced Mitogenesis

Paul C. Orban,Megan K. Levings,John W. Schrader

View Articletitled, Heterodimerization of the  and β Chains of the Interleukin-3 (IL-3) Receptor Is Necessary and Sufficient for IL-3–Induced Mitogenesis

Long-Term Ex Vivo Maintenance and Expansion of Transplantable Human Hematopoietic Stem Cells

Chu-Chih Shih,Mickey C.-T. Hu,Jun Hu,Jeffrey Medeiros,Stephen J. Forman

View Articletitled, Long-Term Ex Vivo Maintenance and Expansion of Transplantable Human Hematopoietic Stem Cells

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Evidence for Extracellular Processing of Pro-von Willebrand Factor After Infusion in Animals With and Without Severe von Willebrand Disease

P.L. Turecek,L. Pichler,W. Auer,G. Eder,K. Varadi,A. Mitterer,W. Mundt,U. Schlokat,F. Dorner,L.O. Drouet,J. Roussi,J.A. van Mourik,H.P. Schwarz

View Articletitled, Evidence for Extracellular Processing of Pro-von Willebrand Factor After Infusion in Animals With and Without Severe von Willebrand Disease

Glycoprotein Ib-V-IX, a Receptor for von Willebrand Factor, Couples Physically and Functionally to the Fc Receptor γ-Chain, Fyn, and Lyn to Activate Human Platelets

Shahrokh Falati,Christine E. Edmead,Alastair W. Poole

View Articletitled, Glycoprotein Ib-V-IX, a Receptor for von Willebrand Factor, Couples Physically and Functionally to the Fc Receptor γ-Chain, Fyn, and Lyn to Activate Human Platelets

Discordant Expression of Tissue Factor and Its Activity in Polarized Epithelial Cells. Asymmetry in Anionic Phospholipid Availability as a Possible Explanation

Carsten B. Hansen,Bo van Deurs,Lars C. Petersen,L. Vijaya Mohan Rao

View Articletitled, Discordant Expression of Tissue Factor and Its Activity in Polarized Epithelial Cells. Asymmetry in Anionic Phospholipid Availability as a Possible Explanation

Dichotomous Regulation of Myosin Phosphorylation and Shape Change by Rho-Kinase and Calcium in Intact Human Platelets

Markus Bauer,Michaela Retzer,Jonathan I. Wilde,Petra Maschberger,Markus Essler,Martin Aepfelbacher,Steve P. Watson,Wolfgang Siess

View Articletitled, Dichotomous Regulation of Myosin Phosphorylation and Shape Change by Rho-Kinase and Calcium in Intact Human Platelets

Induction of Decay-Accelerating Factor by Cytokines or the Membrane-Attack Complex Protects Vascular Endothelial Cells Against Complement Deposition

Justin C. Mason,Helen Yarwood,Katharine Sugars,B. Paul Morgan,Kevin A. Davies,Dorian O. Haskard

View Articletitled, Induction of Decay-Accelerating Factor by Cytokines or the Membrane-Attack Complex Protects Vascular Endothelial Cells Against Complement Deposition

Calpain Functions in a Caspase-Independent Manner to Promote Apoptosis-Like Events During Platelet Activation

Beni B. Wolf,Joshua C. Goldstein,Henning R. Stennicke,Helen Beere,Gustavo P. Amarante-Mendes,Guy S. Salvesen,Douglas R. Green

View Articletitled, Calpain Functions in a Caspase-Independent Manner to Promote Apoptosis-Like Events During Platelet Activation

Unique Antiplatelet Effects of a Novel S-Nitrosoderivative of a Recombinant Fragment of von Willebrand Factor, AR545C: In Vitro and Ex Vivo Inhibition of Platelet Function

Aida Inbal,Osnat Gurevitz,Ilia Tamarin,Regina Eskaraev,Angela Chetrit,Ilia Novicov,Monica Feldman,David Varon,Michael Eldar,Joseph Loscalzo

View Articletitled, Unique Antiplatelet Effects of a Novel S-Nitrosoderivative of a Recombinant Fragment of von Willebrand Factor, AR545C: In Vitro and Ex Vivo Inhibition of Platelet Function

IMMUNOBIOLOGY

Interleukin-9–Induced Expression of M-Ras/R-Ras3 Oncogene in T-Helper Clones

Jamila Louahed,Luigi Grasso,Charles De Smet,Emiel Van Roost,Claude Wildmann,Nicholas C. Nicolaides,Roy C. Levitt,Jean-Christophe Renauld

View Articletitled, Interleukin-9–Induced Expression of M-Ras/R-Ras3 Oncogene in T-Helper Clones

IκB Kinase Complex Is an Intracellular Target for Endotoxic Lipopolysaccharide in Human Monocytic Cells

Jacek Hawiger,Ruth Ann Veach,Xue-Yan Liu,Sheila Timmons,Dean W. Ballard

View Articletitled, IκB Kinase Complex Is an Intracellular Target for Endotoxic Lipopolysaccharide in Human Monocytic Cells

Suppression of Interleukin-12 Production by Human Monocytes After Preincubation With Lipopolysaccharide

Miriam Wittmann,Vivi-Ann Larsson,Petra Schmidt,Gabriele Begemann,Alexander Kapp,Thomas Werfel

View Articletitled, Suppression of Interleukin-12 Production by Human Monocytes After Preincubation With Lipopolysaccharide

NEOPLASIA

Modulation of Caspase-8 and FLICE-Inhibitory Protein Expression as a Potential Mechanism of Epstein-Barr Virus Tumorigenesis in Burkitt’s Lymphoma

Clifford G. Tepper,Michael F. Seldin

View Articletitled, Modulation of Caspase-8 and FLICE-Inhibitory Protein Expression as a Potential Mechanism of Epstein-Barr Virus Tumorigenesis in Burkitt’s Lymphoma

V_H Gene Sequences From Primary Central Nervous System Lymphomas Indicate Derivation From Highly Mutated Germinal Center B Cells With Ongoing Mutational Activity

Andrew R. Thompsett,David W. Ellison,Freda K. Stevenson,Delin Zhu

View Articletitled, VH Gene Sequences From Primary Central Nervous System Lymphomas Indicate Derivation From Highly Mutated Germinal Center B Cells With Ongoing Mutational Activity

Human Immunodeficiency Virus-1 (HIV-1)-Tat Protein Promotes Migration of Acquired Immunodeficiency Syndrome–Related Lymphoma Cells and Enhances Their Adhesion to Endothelial Cells

Renato G.S. Chirivi,Giulia Taraboletti,Maria Rosa Bani,Luca Barra,Giampiero Piccinini,Mauro Giacca,Federico Bussolino,Raffaella Giavazzi

View Articletitled, Human Immunodeficiency Virus-1 (HIV-1)-Tat Protein Promotes Migration of Acquired Immunodeficiency Syndrome–Related Lymphoma Cells and Enhances Their Adhesion to Endothelial Cells

Mutation of the p53 Gene Is Not a Typical Feature of Hodgkin and Reed-Sternberg Cells in Hodgkin’s Disease

Manuel Montesinos-Rongen,Axel Roers,Ralf Küppers,Klaus Rajewsky,Martin-Leo Hansmann

View Articletitled, Mutation of the p53 Gene Is Not a Typical Feature of Hodgkin and Reed-Sternberg Cells in Hodgkin’s Disease

Growth Characteristics of Acute Myelogenous Leukemia Progenitors That Initiate Malignant Hematopoiesis in Nonobese Diabetic/Severe Combined Immunodeficient Mice

Laurie E. Ailles,Brigitte Gerhard,Hiroyuki Kawagoe,Donna E. Hogge

View Articletitled, Growth Characteristics of Acute Myelogenous Leukemia Progenitors That Initiate Malignant Hematopoiesis in Nonobese Diabetic/Severe Combined Immunodeficient Mice

Frequent Methylation Silencing of p15^INK4b(MTS2) and p16^INK4a (MTS1) in B-Cell and T-Cell Lymphomas

Audrey S. Baur,Phil Shaw,Nathalie Burri,Françoise Delacrétaz,Fred T. Bosman,Pascal Chaubert

View Articletitled, Frequent Methylation Silencing of p15INK4b(MTS2) and p16INK4a (MTS1) in B-Cell and T-Cell Lymphomas

PHAGOCYTES

Enhanced B7-2 Gene Expression by Interferon-γ in Human Monocytic Cells Is Controlled Through Transcriptional and Posttranscriptional Mechanisms

R.E. Curiel,C.S. Garcia,S. Rottschafer,M.C. Bosco,I. Espinoza-Delgado

View Articletitled, Enhanced B7-2 Gene Expression by Interferon-γ in Human Monocytic Cells Is Controlled Through Transcriptional and Posttranscriptional Mechanisms

Functional Association of FcɛRIγ With Arginine⁶³² of Paired Immunoglobulin-Like Receptor (PIR)-A3 in Murine Macrophages

Lynn S. Taylor,Daniel W. McVicar

View Articletitled, Functional Association of FcɛRIγ With Arginine632 of Paired Immunoglobulin-Like Receptor (PIR)-A3 in Murine Macrophages

Neutrophil Antibody Specificity in Different Types of Childhood Autoimmune Neutropenia

Marrie C.A. Bruin,Albert E.G.Kr von dem Borne,Rienk Y.J. Tamminga,Marion Kleijer,Lica Buddelmeijer,Masja de Haas

View Articletitled, Neutrophil Antibody Specificity in Different Types of Childhood Autoimmune Neutropenia

TRANSPLANTATION

Peripheral Blood T Cells Generated After Allogeneic Bone Marrow Transplantation: Lower Levels of Bcl-2 Protein and Enhanced Sensitivity to Spontaneous and CD95-Mediated Apoptosis In Vitro. Abrogation of the Apoptotic Phenotype Coincides With the Recovery of Normal Naive/Primed T-Cell Profiles

Nadia Chafika Hebib,Olivier Déas,Matthieu Rouleau,Antoine Durrbach,Bernard Charpentier,Françoise Beaujean,Jean-Paul Vernant,Anna Senik

View Articletitled, Peripheral Blood T Cells Generated After Allogeneic Bone Marrow Transplantation: Lower Levels of Bcl-2 Protein and Enhanced Sensitivity to Spontaneous and CD95-Mediated Apoptosis In Vitro. Abrogation of the Apoptotic Phenotype Coincides With the Recovery of Normal Naive/Primed T-Cell Profiles

Detection of Abnormal Pretransplant Clones in Progenitor Cells of Patients Who Developed Myelodysplasia After Autologous Transplantation

Elisabetta Abruzzese,James E. Radford,Jeffrey S. Miller,James J. Vredenburgh,P. Nagesh Rao,Mark J. Pettenati,Julia M. Cruz,James J. Perry,Sergio Amadori,David D. Hurd

View Articletitled, Detection of Abnormal Pretransplant Clones in Progenitor Cells of Patients Who Developed Myelodysplasia After Autologous Transplantation

BRIEF REPORTS

Fusion of a Novel Gene, BTL, to ETV6 in Acute Myeloid Leukemias With a t(4;12)(q11-q12;p13)
Brief Report

Jan Cools,Chrystèle Bilhou-Nabera,Iwona Wlodarska,Christine Cabrol,Pascaline Talmant,Philippe Bernard,Anne Hagemeijer,Peter Marynen

View Articletitled, Fusion of a Novel Gene, BTL, to ETV6 in Acute Myeloid Leukemias With a t(4;12)(q11-q12;p13)

Identification of the Molecular Genetic Defect of Patients With Methemoglobin M Kankakee (M-Iwate), 87 (F8) His → Tyr: Evidence for an Electrostatic Model of M Hemoglobin Assembly
Brief Report

A. Ameri,V.F. Fairbanks,G.A. Yanik,F. Mahdi,S.N. Thibodeau,D.J. McCormick,L.A. Boxer,K.T. McDonagh

View Articletitled, Identification of the Molecular Genetic Defect of Patients With Methemoglobin M Kankakee (M-Iwate), 87 (F8) His → Tyr: Evidence for an Electrostatic Model of M Hemoglobin Assembly

CORRESPONDENCE

A Combination of Retinoic Acid and Proteasome Inhibitors for the Treatment of Leukemias Is Potentially Dangerous

Cezary Wójcik,Izabella Młynarczuk,Graz˙yna Hoser,Jerzy Kawiak,Tomasz Stokłosa,Jakub Gołab,Sherwin Wilk

View Articletitled, A Combination of Retinoic Acid and Proteasome Inhibitors for the Treatment of Leukemias Is Potentially Dangerous

Double-Homozygosity for Factor V Leiden and the Prothrombin Gene G20210A Variant in a Young Patient With Idiopathic Venous Thrombosis

Johan R. Meinardi,Peter M. Pelsma,Hans Koning,Jan van der Meer,Saskia Middledorp,Harry R. Büller,Karly Hamulyák

View Articletitled, Double-Homozygosity for Factor V Leiden and the Prothrombin Gene G20210A Variant in a Young Patient With Idiopathic Venous Thrombosis

Sensitivity of CD4⁺ Peripheral Blood T Cells Toward Spontaneous and CD95 (APO-1/Fas)-Induced Apoptosis in Pediatric Human Immunodeficiency Virus Infection

Thomas Böhler,Klaus-Michael Debatin,Richard Linde

View Articletitled, Sensitivity of CD4+ Peripheral Blood T Cells Toward Spontaneous and CD95 (APO-1/Fas)-Induced Apoptosis in Pediatric Human Immunodeficiency Virus Infection

Treatment Results in Aplastic Anemia Trials Need To Be Analyzed Separately for Pediatric and Adult Populations

Vijay Reddy,Shahab Khan,John R. Wingard

View Articletitled, Treatment Results in Aplastic Anemia Trials Need To Be Analyzed Separately for Pediatric and Adult Populations

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