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Volume 93, Issue 1

January 1 1999

In this Issue

REVIEW ARTICLES
RAPID COMMUNICATIONS
CHEMOKINES
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSFUSION MEDICINE
TRANSPLANTATION
CORRESPONDENCE
ERRATA

REVIEW ARTICLES

Src-Related Protein Tyrosine Kinases in Hematopoiesis

Seth J. Corey,Steven M. Anderson

View Articletitled, Src-Related Protein Tyrosine Kinases in Hematopoiesis

RAPID COMMUNICATIONS

Identification of a Novel Stat3 Recruitment and Activation Motif Within the Granulocyte Colony-Stimulating Factor Receptor

Arup Chakraborty,Kevin F. Dyer,Michael Cascio,Timothy A. Mietzner,David J. Tweardy

View Articletitled, Identification of a Novel Stat3 Recruitment and Activation Motif Within the Granulocyte Colony-Stimulating Factor Receptor

Inhibition of Human Umbilical Vein Endothelial Cell Proliferation by the CXC Chemokine, Platelet Factor 4 (PF4), Is Associated With Impaired Downregulation of p21^Cip1/WAF1

Grazia Gentilini,Nancy E. Kirschbaum,James A. Augustine,Richard H. Aster,Gian Paolo Visentin

View Articletitled, Inhibition of Human Umbilical Vein Endothelial Cell Proliferation by the CXC Chemokine, Platelet Factor 4 (PF4), Is Associated With Impaired Downregulation of p21Cip1/WAF1

CHEMOKINES

CC Chemokine Receptors, CCR-1 and CCR-3, Are Potentially Involved in Antigen-Presenting Cell Function of Human Peripheral Blood Monocyte-Derived Dendritic Cells

Katsuaki Sato,Hiroshi Kawasaki,Hitomi Nagayama,Ryo Serizawa,Junji Ikeda,Chikao Morimoto,Kunio Yasunaga,Noboru Yamaji,Kenji Tadokoro,Takeo Juji,Tsuneo A. Takahashi

View Articletitled, CC Chemokine Receptors, CCR-1 and CCR-3, Are Potentially Involved in Antigen-Presenting Cell Function of Human Peripheral Blood Monocyte-Derived Dendritic Cells

Murine T Lymphocytes Incapable of Producing Macrophage Inhibitory Protein-1 Are Impaired in Causing Graft-Versus-Host Disease Across a Class I But Not Class II Major Histocompatibility Complex Barrier

Jonathan S. Serody,Donald N. Cook,Suzanne L. Kirby,Elizabeth Reap,Thomas C. Shea,Jeffrey A. Frelinger

View Articletitled, Murine T Lymphocytes Incapable of Producing Macrophage Inhibitory Protein-1 Are Impaired in Causing Graft-Versus-Host Disease Across a Class I But Not Class II Major Histocompatibility Complex Barrier

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Age Is Not a Prognostic Variable With Autotransplants for Multiple Myeloma

D.S. Siegel,K.R. Desikan,J. Mehta,S. Singhal,A. Fassas,N. Munshi,E. Anaissie,S. Naucke,D. Ayers,D. Spoon,D. Vesole,G. Tricot,B. Barlogie

View Articletitled, Age Is Not a Prognostic Variable With Autotransplants for Multiple Myeloma

Total Therapy With Tandem Transplants for Newly Diagnosed Multiple Myeloma

B. Barlogie,S. Jagannath,K.R. Desikan,S. Mattox,D. Vesole,D. Siegel,G. Tricot,N. Munshi,A. Fassas,S. Singhal,J. Mehta,E. Anaissie,D. Dhodapkar,S. Naucke,J. Cromer,J. Sawyer,J. Epstein,D. Spoon,D. Ayers,B. Cheson,J. Crowley

View Articletitled, Total Therapy With Tandem Transplants for Newly Diagnosed Multiple Myeloma

Etretinate Therapy for Refractory Sclerodermatous Chronic Graft-Versus-Host Disease

D.C. Marcellus,V.L. Altomonte,E.R. Farmer,T.D. Horn,C.S. Freemer,J. Grant,G.B. Vogelsang

View Articletitled, Etretinate Therapy for Refractory Sclerodermatous Chronic Graft-Versus-Host Disease

Cerebral Vasculopathy in Sickle Cell Anemia: Diagnostic Contribution of Positron Emission Tomography

Darleen R. Powars,Peter S. Conti,Wing-Yen Wong,Paula Groncy,Carol Hyman,Elaine Smith,Nadia Ewing,Robert N. Keenan,Chi-Shing Zee,Yvonne Harold,Alan L. Hiti,Evelyn L. Teng,Linda S. Chan

View Articletitled, Cerebral Vasculopathy in Sickle Cell Anemia: Diagnostic Contribution of Positron Emission Tomography

GENE THERAPY

Fluorescence-Based Selection of Gene-Corrected Hematopoietic Stem and Progenitor Cells From Acid Sphingomyelinase-Deficient Mice: Implications for Niemann-Pick Disease Gene Therapy and the Development of Improved Stem Cell Gene Transfer Procedures

Shai Erlich,Silvia R.P. Miranda,Jan W.M. Visser,Arie Dagan,Shimon Gatt,Edward H. Schuchman

View Articletitled, Fluorescence-Based Selection of Gene-Corrected Hematopoietic Stem and Progenitor Cells From Acid Sphingomyelinase-Deficient Mice: Implications for Niemann-Pick Disease Gene Therapy and the Development of Improved Stem Cell Gene Transfer Procedures

HEMATOPOIESIS

Definitive But Not Primitive Hematopoiesis Is Impaired injumonji Mutant Mice

Kenji Kitajima,Mizuyo Kojima,Kuniko Nakajima,Shunzo Kondo,Takahiko Hara,Atsushi Miyajima,Takashi Takeuchi

View Articletitled, Definitive But Not Primitive Hematopoiesis Is Impaired injumonji Mutant Mice

Single Adult Human CD34⁺/Lin⁻/CD38⁻ Progenitors Give Rise to Natural Killer Cells, B-Lineage Cells, Dendritic Cells, and Myeloid Cells

Jeffrey S. Miller,Valarie McCullar,Michael Punzel,Ihor R. Lemischka,Kateri A. Moore

View Articletitled, Single Adult Human CD34+/Lin−/CD38− Progenitors Give Rise to Natural Killer Cells, B-Lineage Cells, Dendritic Cells, and Myeloid Cells

Murine Hematopoietic Progenitor Cells With Colony-Forming or Radioprotective Capacity Lack Expression of the β₂-Integrin LFA-1

Johannes F.M. Pruijt,Yvette van Kooyk,Carl G. Figdor,Roel Willemze,Willem E. Fibbe

View Articletitled, Murine Hematopoietic Progenitor Cells With Colony-Forming or Radioprotective Capacity Lack Expression of the β2-Integrin LFA-1

Tyrosine-Dependent and -Independent Mechanisms of STAT3 Activation by the Human Granulocyte Colony-Stimulating Factor (G-CSF) Receptor Are Differentially Utilized Depending on G-CSF Concentration

Alister C. Ward,Mirjam H.A. Hermans,Louise Smith,Yvette M. van Aesch,Anita M. Schelen,Claudia Antonissen,Ivo P. Touw

View Articletitled, Tyrosine-Dependent and -Independent Mechanisms of STAT3 Activation by the Human Granulocyte Colony-Stimulating Factor (G-CSF) Receptor Are Differentially Utilized Depending on G-CSF Concentration

Autonomous Megakaryocyte Growth in Essential Thrombocythemia and Idiopathic Myelofibrosis Is Not Related to a c-mpl Mutation or to an Autocrine Stimulation by Mpl-L

Anne Laure Taksin,Jean-Pierre Le Couedic,Isabelle Dusanter-Fourt,Aline Massé,Stéphane Giraudier,André Katz,Françoise Wendling,William Vainchenker,Nicole Casadevall,Najet Debili

View Articletitled, Autonomous Megakaryocyte Growth in Essential Thrombocythemia and Idiopathic Myelofibrosis Is Not Related to a c-mpl Mutation or to an Autocrine Stimulation by Mpl-L

Heparan Sulfate Proteoglycans Mediate Interleukin-7– Dependent B Lymphopoiesis

Lisa A. Borghesi,Yoshio Yamashita,Paul W. Kincade

View Articletitled, Heparan Sulfate Proteoglycans Mediate Interleukin-7– Dependent B Lymphopoiesis

Selective Transendothelial Migration of Hematopoietic Progenitor Cells: A Role in Homing of Progenitor Cells

Kiyotoshi Imai,Masanobu Kobayashi,Jingxin Wang,Yoichi Ohiro,Jun-ichi Hamada,Yuko Cho,Masahiro Imamura,Manabu Musashi,Takeshi Kondo,Masuo Hosokawa,Masahiro Asaka

View Articletitled, Selective Transendothelial Migration of Hematopoietic Progenitor Cells: A Role in Homing of Progenitor Cells

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Antithrombin Reduces Ischemia/Reperfusion Injury of Rat Liver by Increasing the Hepatic Level of Prostacyclin

Naoaki Harada,Kenji Okajima,Shigeki Kushimoto,Hirotaka Isobe,Keiichi Tanaka

View Articletitled, Antithrombin Reduces Ischemia/Reperfusion Injury of Rat Liver by Increasing the Hepatic Level of Prostacyclin

Biochemical Characterization and Molecular Cloning of a Novel Endothelial-Specific Sialomucin

Suzanne Marie Morgan,Ulrike Samulowitz,Liz Darley,David L. Simmons,Dietmar Vestweber

View Articletitled, Biochemical Characterization and Molecular Cloning of a Novel Endothelial-Specific Sialomucin

Mild Hemophilia A Caused by Increased Rate of Factor VIII A2 Subunit Dissociation: Evidence for Nonproteolytic Inactivation of Factor VIIIa In Vivo

S.W. Pipe,A.N. Eickhorst,S.H. McKinley,E.L. Saenko,R.J. Kaufman

View Articletitled, Mild Hemophilia A Caused by Increased Rate of Factor VIII A2 Subunit Dissociation: Evidence for Nonproteolytic Inactivation of Factor VIIIa In Vivo

The Vascular Endothelial-Cadherin Promoter Directs Endothelial-Specific Expression in Transgenic Mice

S. Gory,M. Vernet,M. Laurent,E. Dejana,J. Dalmon,P. Huber

View Articletitled, The Vascular Endothelial-Cadherin Promoter Directs Endothelial-Specific Expression in Transgenic Mice

von Willebrand Factor Elevates Plasma Factor VIII Without Induction of Factor VIII Messenger RNA in the Liver

Randal J. Kaufman,Andrew J. Dorner,David N. Fass

View Articletitled, von Willebrand Factor Elevates Plasma Factor VIII Without Induction of Factor VIII Messenger RNA in the Liver

IMMUNOBIOLOGY

Light Chain Shifting: Identification of a Human Plasma Cell Line Actively Undergoing Light Chain Replacement

Hirofumi Tachibana,Hirotaka Haruta,Koji Yamada

View Articletitled, Light Chain Shifting: Identification of a Human Plasma Cell Line Actively Undergoing Light Chain Replacement

Mechanism of Interleukin-10 Inhibition of T-Helper Cell Activation by Superantigen at the Level of the Cell Cycle

George Q. Perrin,Howard M. Johnson,Prem S. Subramaniam

View Articletitled, Mechanism of Interleukin-10 Inhibition of T-Helper Cell Activation by Superantigen at the Level of the Cell Cycle

Ceramide and Cyclic Adenosine Monophosphate (cAMP) Induce cAMP Response Element Binding Protein Phosphorylation via Distinct Signaling Pathways While Having Opposite Effects on Myeloid Cell Survival

Michael P. Scheid,Ian N. Foltz,Peter R. Young,John W. Schrader,Vincent Duronio

View Articletitled, Ceramide and Cyclic Adenosine Monophosphate (cAMP) Induce cAMP Response Element Binding Protein Phosphorylation via Distinct Signaling Pathways While Having Opposite Effects on Myeloid Cell Survival

Marginal-Zone B Cells in the Human Lymph Node and Spleen Show Somatic Hypermutations and Display Clonal Expansion

Anne Tierens,Jan Delabie,Lieve Michiels,Peter Vandenberghe,Chris De Wolf-Peeters

View Articletitled, Marginal-Zone B Cells in the Human Lymph Node and Spleen Show Somatic Hypermutations and Display Clonal Expansion

Insulin-Like Growth Factor-1 Acts as a Chemoattractant Factor for 5T2 Multiple Myeloma Cells

Karin Vanderkerken,Kewal Asosingh,Filip Braet,Ivan Van Riet,Ben Van Camp

View Articletitled, Insulin-Like Growth Factor-1 Acts as a Chemoattractant Factor for 5T2 Multiple Myeloma Cells

T-Cell Receptor Analysis in Omenn’s Syndrome: Evidence for Defects in Gene Rearrangement and Assembly

Edward G. Brooks,Alexandra H. Filipovich,John W. Padgett,Robert Mamlock,Randall M. Goldblum

View Articletitled, T-Cell Receptor Analysis in Omenn’s Syndrome: Evidence for Defects in Gene Rearrangement and Assembly

Hairy Cell Leukemia-Specific Recognition by Multiple Autologous HLA-DQ or DP-Restricted T-Cell Clones

Lisette van de Corput,Hanneke C. Kluin-Nelemans,Michel G.D. Kester,Roel Willemze,J.H. Frederik Falkenburg

View Articletitled, Hairy Cell Leukemia-Specific Recognition by Multiple Autologous HLA-DQ or DP-Restricted T-Cell Clones

NEOPLASIA

Constitutive and Interleukin-7/Interleukin-15 Stimulated DNA Binding of Myc, Jun, and Novel Myc-Like Proteins in Cutaneous T-Cell Lymphoma Cells

J-Z. Qin,R. Dummer,G. Burg,U. Döbbeling

View Articletitled, Constitutive and Interleukin-7/Interleukin-15 Stimulated DNA Binding of Myc, Jun, and Novel Myc-Like Proteins in Cutaneous T-Cell Lymphoma Cells

Malignant Cells Can Be Sensitized to Undergo Growth Inhibition and Apoptosis by Arsenic Trioxide Through Modulation of the Glutathione Redox System

Jie Dai,Rona S. Weinberg,Samuel Waxman,Yongkui Jing

View Articletitled, Malignant Cells Can Be Sensitized to Undergo Growth Inhibition and Apoptosis by Arsenic Trioxide Through Modulation of the Glutathione Redox System

Arsenic Trioxide and Interferon- Synergize to Induce Cell Cycle Arrest and Apoptosis in Human T-Cell Lymphotropic Virus Type I–Transformed Cells

Ali Bazarbachi,Marwan E. El-Sabban,Rihab Nasr,Frédérique Quignon,Christian Awaraji,Joelle Kersual,Laurent Dianoux,Yael Zermati,Joud H. Haidar,Olivier Hermine,Hughes de Thé

View Articletitled, Arsenic Trioxide and Interferon- Synergize to Induce Cell Cycle Arrest and Apoptosis in Human T-Cell Lymphotropic Virus Type I–Transformed Cells

BCR/ABL⁻ CD34⁺HLA-DR⁻Progenitor Cells in Early Chronic Phase, But Not in More Advanced Phases, of Chronic Myelogenous Leukemia Are Polyclonal

Michel Delforge,Marc A. Boogaerts,Philip B. McGlave,Catherine M. Verfaillie

View Articletitled, BCR/ABL− CD34+HLA-DR−Progenitor Cells in Early Chronic Phase, But Not in More Advanced Phases, of Chronic Myelogenous Leukemia Are Polyclonal

ETV6-AML1 Translocation Breakpoints Cluster Near a Purine/Pyrimidine Repeat Region in the ETV6 Gene

Srinivas P. Thandla,Jonathan E. Ploski,Samina Z. Raza-Egilmez,Pradheepkumar P. Chhalliyil,AnneMarie W. Block,Pieter J. de Jong,Peter D. Aplan

View Articletitled, ETV6-AML1 Translocation Breakpoints Cluster Near a Purine/Pyrimidine Repeat Region in the ETV6 Gene

Comparison of Interleukin-1β Expression by In Situ Hybridization in Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma

Martha Q. Lacy,Kathleen A. Donovan,Julie K. Heimbach,Gregory J. Ahmann,John A. Lust

View Articletitled, Comparison of Interleukin-1β Expression by In Situ Hybridization in Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma

Efflux of Rhodamine From CD56⁺ Cells as a Surrogate Marker for Reversal of P-Glycoprotein–Mediated Drug Efflux by PSC 833

Robert Robey,Susan Bakke,Wilfred Stein,Beverly Meadows,Thomas Litman,Sheela Patil,Tom Smith,Tito Fojo,Susan Bates

View Articletitled, Efflux of Rhodamine From CD56+ Cells as a Surrogate Marker for Reversal of P-Glycoprotein–Mediated Drug Efflux by PSC 833

Hyperdiploid Acute Lymphoblastic Leukemia With 51 to 65 Chromosomes: A Distinct Biological Entity With a Marked Propensity to Undergo Apoptosis

Chikako Ito,Masa-aki Kumagai,Atsushi Manabe,Elaine Coustan-Smith,Susana C. Raimondi,Frederick G. Behm,K. Gopal Murti,Jeffrey E. Rubnitz,Ching-Hon Pui,Dario Campana

View Articletitled, Hyperdiploid Acute Lymphoblastic Leukemia With 51 to 65 Chromosomes: A Distinct Biological Entity With a Marked Propensity to Undergo Apoptosis

Two Candidate Downstream Target Genes for E2A-HLF

Hidemitsu Kurosawa,Kumiko Goi,Takeshi Inukai,Toshiya Inaba,Kun-San Chang,Tetsuharu Shinjyo,Karen M. Rakestraw,Clayton W. Naeve,A. Thomas Look

View Articletitled, Two Candidate Downstream Target Genes for E2A-HLF

PHAGOCYTES

Nitric Oxide–Mediated Augmentation of Polymorphonuclear Free Radical Generation After Hypoxia-Reoxygenation

Sonia Sethi,Mahendra Pratap Singh,Madhu Dikshit

View Articletitled, Nitric Oxide–Mediated Augmentation of Polymorphonuclear Free Radical Generation After Hypoxia-Reoxygenation

Cytokine-Specific Activation of Distinct Mitogen-Activated Protein Kinase Subtype Cascades in Human Neutrophils Stimulated by Granulocyte Colony-Stimulating Factor, Granulocyte-Macrophage Colony-Stimulating Factor, and Tumor Necrosis Factor-

Kenichi Suzuki,Masayuki Hino,Fumihiko Hato,Noriyuki Tatsumi,Seiichi Kitagawa

View Articletitled, Cytokine-Specific Activation of Distinct Mitogen-Activated Protein Kinase Subtype Cascades in Human Neutrophils Stimulated by Granulocyte Colony-Stimulating Factor, Granulocyte-Macrophage Colony-Stimulating Factor, and Tumor Necrosis Factor-

Activation of the Human Immunodeficiency Virus-1 Long Terminal Repeat by Respiratory Burst Oxidants of Neutrophils

Seymour J. Klebanoff,Catherine M. Headley

View Articletitled, Activation of the Human Immunodeficiency Virus-1 Long Terminal Repeat by Respiratory Burst Oxidants of Neutrophils

The Use of Allele-Specific Recombinant Fcγ Receptor IIIb Antigens for the Detection of Granulocyte Antibodies

Juergen Bux,Karin Kissel,Christine Hofmann,Sentot Santoso

View Articletitled, The Use of Allele-Specific Recombinant Fcγ Receptor IIIb Antigens for the Detection of Granulocyte Antibodies

RED CELLS

Protein Replacement by Receptor-Mediated Endocytosis Corrects the Sensitivity of Fanconi Anemia Group C Cells to Mitomycin C

Hagop Youssoufian,Frank A.E. Kruyt,Xiaotong Li

View Articletitled, Protein Replacement by Receptor-Mediated Endocytosis Corrects the Sensitivity of Fanconi Anemia Group C Cells to Mitomycin C

HBED: The Continuing Development of a Potential Alternative to Deferoxamine for Iron-Chelating Therapy

Raymond J. Bergeron,Jan Wiegand,Gary M. Brittenham

View Articletitled, HBED: The Continuing Development of a Potential Alternative to Deferoxamine for Iron-Chelating Therapy

Evaluation of Biochemical Changes During In Vivo Erythrocyte Senescence in the Dog

Michael P. Rettig,Philip S. Low,J. Aura Gimm,Narla Mohandas,Jiazhen Wang,John A. Christian

View Articletitled, Evaluation of Biochemical Changes During In Vivo Erythrocyte Senescence in the Dog

TRANSFUSION MEDICINE

Molecular Basis of Weak D Phenotypes: Presented at the 25th Congress of the International Society of Blood Transfusion held in Oslo on June 29, 1998 and published in abstract form in Vox Sang 74:55, 1998 (suppl).

Franz F. Wagner,Christoph Gassner,Thomas H. Müller,Diether Schönitzer,Friedrich Schunter,Willy A. Flegel

View Articletitled, Molecular Basis of Weak D Phenotypes: Presented at the 25th Congress of the International Society of Blood Transfusion held in Oslo on June 29, 1998 and published in abstract form in Vox Sang 74:55, 1998 (suppl).

Peripheral Blood CD14⁺ Cells From Healthy Subjects Carry a Circular Conformation of Latent Cytomegalovirus Genome

Cynthia A. Bolovan-Fritts,Edward S. Mocarski,Jean A. Wiedeman

View Articletitled, Peripheral Blood CD14+ Cells From Healthy Subjects Carry a Circular Conformation of Latent Cytomegalovirus Genome

TRANSPLANTATION

DNA Typing for HLA-A and HLA-B Identifies Disparities Between Patients and Unrelated Donors Matched by HLA-A and HLA-B Serology and HLA-DRB1

Vinod K. Prasad,Nancy A. Kernan,Glenn Heller,Richard J. O’Reilly,Soo Young Yang

View Articletitled, DNA Typing for HLA-A and HLA-B Identifies Disparities Between Patients and Unrelated Donors Matched by HLA-A and HLA-B Serology and HLA-DRB1

CORRESPONDENCE

Identification of Fibronectin IIICS Variants in Human Bone Marrow Stroma

Karen P. Schofield,Martin J. Humphries

View Articletitled, Identification of Fibronectin IIICS Variants in Human Bone Marrow Stroma

ERRATA

Erratum for vol. 91, p. 3623

View Articletitled, Erratum for vol. 91, p. 3623

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Cardiac complete response in AL amyloidosis has similar survival to matched general population

Randomized Bendamustine-Rituximab(R) + Bortezomib Induction and R + Lenalidomide Maintenance for Mantle Cell Lymphoma

Heme induced loss of renovascular endothelial protein C receptor promotes chronic kidney disease in sickle mice

Interleukin-1 mediated hyperinflammation in XIAP-deficiency is associated with defective autophagy.

NOVEL THERAPEUTIC APPROACHES IN THALASSEMIAS, SICKLE CELL DISEASE AND OTHER RED CELL DISORDERS

Issue Archive

Table of Contents

REVIEW ARTICLES

RAPID COMMUNICATIONS

CHEMOKINES

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

GENE THERAPY

HEMATOPOIESIS

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

IMMUNOBIOLOGY

NEOPLASIA

PHAGOCYTES

RED CELLS

TRANSFUSION MEDICINE

TRANSPLANTATION

CORRESPONDENCE

ERRATA

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