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Volume 92, Issue 1

July 1 1998

In this Issue

SPECIAL FOCUS INTRODUCTION
SPECIAL FOCUS
RAPID COMMUNICATIONS
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
CORRESPONDENCE
ERRATA

SPECIAL FOCUS INTRODUCTION

Thrombopoietin and the Hematopoietic Stem Cell

Kenneth Kaushansky

View Articletitled, Thrombopoietin and the Hematopoietic Stem Cell

SPECIAL FOCUS

Role of c-mpl in Early Hematopoiesis

Gregg P. Solar,William G. Kerr,Francis C. Zeigler,Darren Hess,Christopher Donahue,Frederic J. de Sauvage,Dan L. Eaton

View Articletitled, Role of c-mpl in Early Hematopoiesis

RAPID COMMUNICATIONS

Intracellular Cytokine Profile of Cord and Adult Blood Lymphocytes

I.M.H. Chalmers,G. Janossy,M. Contreras,C. Navarrete

View Articletitled, Intracellular Cytokine Profile of Cord and Adult Blood Lymphocytes

Antileukemic HLA-Restricted T-Cell Clones Generated With Naturally Processed Peptides Eluted From Acute Myeloblastic Leukemia Blasts

Marina Ostankovitch,Agnès Buzyn,Delphine Bonhomme,Francine Connan,Didier Bouscary,Fahrad Heshmati,François Dreyfus,Jeannine Choppin,Jean-Gérard Guillet

View Articletitled, Antileukemic HLA-Restricted T-Cell Clones Generated With Naturally Processed Peptides Eluted From Acute Myeloblastic Leukemia Blasts

Protease-Activated Receptor Genes Are Clustered on 5q13

Véronique Guyonnet Dupérat,Béatrice Jacquelin,Pierre Boisseau,Benoı̂t Arveiler,Alan T. Nurden

View Articletitled, Protease-Activated Receptor Genes Are Clustered on 5q13

Perturbed Granulopoiesis in Mice With a Targeted Mutation in the Granulocyte Colony-Stimulating Factor Receptor Gene Associated With Severe Chronic Neutropenia

Mirjam H.A. Hermans,Alister C. Ward,Claudia Antonissen,Alar Karis,Bob Löwenberg,Ivo P. Touw

View Articletitled, Perturbed Granulopoiesis in Mice With a Targeted Mutation in the Granulocyte Colony-Stimulating Factor Receptor Gene Associated With Severe Chronic Neutropenia

Prostaglandin E₂ Induces Resistance to Human Immunodeficiency Virus-1 Infection in Monocyte-Derived Macrophages: Downregulation of CCR5 Expression by Cyclic Adenosine Monophosphate

Maryse Thivierge,Christian Le Gouill,Michel J. Tremblay,Jana Stanková,Marek Rola-Pleszczynski

View Articletitled, Prostaglandin E2 Induces Resistance to Human Immunodeficiency Virus-1 Infection in Monocyte-Derived Macrophages: Downregulation of CCR5 Expression by Cyclic Adenosine Monophosphate

Concentrations of Thrombopoietin in Bone Marrow in Normal Subjects and in Patients With Idiopathic Thrombocytopenic Purpura, Aplastic Anemia, and Essential Thrombocythemia Correlate With Its mRNA Expression of Bone Marrow Stromal Cells

Yasuo Hirayama,Sumio Sakamaki,Takuya Matsunaga,Takashi Kuga,Hiroyuki Kuroda,Toshiro Kusakabe,Katsunori Sasaki,Koshi Fujikawa,Junji Kato,Katsuhisa Kogawa,Ryuzo Koyama,Yoshiro Niitsu

View Articletitled, Concentrations of Thrombopoietin in Bone Marrow in Normal Subjects and in Patients With Idiopathic Thrombocytopenic Purpura, Aplastic Anemia, and Essential Thrombocythemia Correlate With Its mRNA Expression of Bone Marrow Stromal Cells

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Detection and Titration of Human Herpesvirus-8–Specific Antibodies in Sera From Blood Donors, Acquired Immunodeficiency Syndrome Patients, and Kaposi's Sarcoma Patients Using a Whole Virus Enzyme-Linked Immunosorbent Assay

Louise G. Chatlynne,William Lapps,Michael Handy,Yao Q. Huang,Rizwan Masood,Ann S. Hamilton,Jonathan W. Said,H.P. Koeffler,Mark H. Kaplan,Alvin Friedman-Kien,Parkash S. Gill,James E. Whitman,Dharam V. Ablashi

View Articletitled, Detection and Titration of Human Herpesvirus-8–Specific Antibodies in Sera From Blood Donors, Acquired Immunodeficiency Syndrome Patients, and Kaposi's Sarcoma Patients Using a Whole Virus Enzyme-Linked Immunosorbent Assay

The Redox State as a Correlate of Senescence and Wasting and as a Target for Therapeutic Intervention

Volker Hack,Raoul Breitkreutz,Ralf Kinscherf,Helmut Röhrer,Peter Bärtsch,Friedemann Taut,Axel Benner,Wulf Dröge

View Articletitled, The Redox State as a Correlate of Senescence and Wasting and as a Target for Therapeutic Intervention

Treatment of Anemia in Myelodysplastic Syndromes With Granulocyte Colony-Stimulating Factor Plus Erythropoietin: Results From a Randomized Phase II Study and Long-Term Follow-Up of 71 Patients

Eva Hellström-Lindberg,Tomas Ahlgren,Yves Beguin,Magnus Carlsson,Jan Carneskog,Inger Marie Dahl,Ingunn Dybedal,Gunnar Grimfors,Lena Kanter-Lewensohn,Olle Linder,Michaela Luthman,Eva Löfvenberg,Herman Nilsson-Ehle,Jan Samuelsson,Jon-Magnus Tangen,Ingemar Winqvist,Gunnar Öberg,Anders Österborg,Åke Öst

View Articletitled, Treatment of Anemia in Myelodysplastic Syndromes With Granulocyte Colony-Stimulating Factor Plus Erythropoietin: Results From a Randomized Phase II Study and Long-Term Follow-Up of 71 Patients

Prognostic Significance of T-Cell Phenotype in Aggressive Non-Hodgkin's Lymphomas

Christian Gisselbrecht,Philippe Gaulard,Eric Lepage,Bertrand Coiffier,Josette Brière,Corinne Haioun,Dominique Cazals-Hatem,André Bosly,Luc Xerri,Hervé Tilly,Françoise Berger,Reda Bouhabdallah,Jacques Diebold,for the Groupe d'Etudes des Lymphomes de l'Adulte (GELA)

View Articletitled, Prognostic Significance of T-Cell Phenotype in Aggressive Non-Hodgkin's Lymphomas

Sustained Gene Expression in Retrovirally Transduced, Engrafting Human Hematopoietic Stem Cells and Their Lympho-Myeloid Progeny

Linzhao Cheng,Changchun Du,Catherine Lavau,Shirley Chen,Jie Tong,Benjamin P. Chen,Roland Scollay,Robert G. Hawley,Beth Hill

View Articletitled, Sustained Gene Expression in Retrovirally Transduced, Engrafting Human Hematopoietic Stem Cells and Their Lympho-Myeloid Progeny

HEMATOPOIESIS

Interleukin-7 Influences the Development of Thymic Dendritic Cells

Alberto Varas,Angeles Vicente,Rosa Sacedón,Agustı́n G. Zapata

View Articletitled, Interleukin-7 Influences the Development of Thymic Dendritic Cells

Involvement of Fas-Mediated Apoptosis in the Hematopoietic Progenitor Cells of Graft-Versus-Host Reaction-Associated Myelosuppression

Takehiko Mori,Takashi Nishimura,Yasuo Ikeda,Tomomitsu Hotta,Hideo Yagita,Kiyoshi Ando

View Articletitled, Involvement of Fas-Mediated Apoptosis in the Hematopoietic Progenitor Cells of Graft-Versus-Host Reaction-Associated Myelosuppression

Growth Disturbance in Fetal Liver Hematopoiesis of Mll-Mutant Mice

Hideshi Yagi,Kenji Deguchi,Atsufumi Aono,Yoshihiko Tani,Tadamitsu Kishimoto,Toshihisa Komori

View Articletitled, Growth Disturbance in Fetal Liver Hematopoiesis of Mll-Mutant Mice

Bifurcated Dendritic Cell Differentiation In Vitro From Murine Lineage Phenotype-Negative c-kit⁺ Bone Marrow Hematopoietic Progenitor Cells

Yi Zhang,Akihisa Harada,Jian-bin Wang,Yan-yun Zhang,Shin-ichi Hashimoto,Makoto Naito,Kouji Matsushima

View Articletitled, Bifurcated Dendritic Cell Differentiation In Vitro From Murine Lineage Phenotype-Negative c-kit+ Bone Marrow Hematopoietic Progenitor Cells

Induction of Synaptosomal-Associated Protein-23 kD (SNAP-23) by Various Cytokines

Yoshihiro Morikawa,Hitoshi Nishida,Kazuhide Misawa,Tetsuya Nosaka,Atsushi Miyajima,Emiko Senba,Toshio Kitamura

View Articletitled, Induction of Synaptosomal-Associated Protein-23 kD (SNAP-23) by Various Cytokines

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Some Human Inhibitor Antibodies Interfere With Factor VIII Binding to Factor IX

Degang Zhong,Evgueni L. Saenko,Midori Shima,Matthew Felch,Dorothea Scandella

View Articletitled, Some Human Inhibitor Antibodies Interfere With Factor VIII Binding to Factor IX

Cancer Procoagulant and Tissue Factor Are Differently Modulated by All-trans-Retinoic Acid in Acute Promyelocytic Leukemia Cells

A. Falanga,R. Consonni,M. Marchetti,G. Locatelli,E. Garattini,C. Gambacorti Passerini,S.G. Gordon,T. Barbui

View Articletitled, Cancer Procoagulant and Tissue Factor Are Differently Modulated by All-trans-Retinoic Acid in Acute Promyelocytic Leukemia Cells

The P2Y₁ Receptor Is Necessary for Adenosine 5′-Diphosphate–Induced Platelet Aggregation

Béatrice Hechler,Catherine Léon,Catherine Vial,Paul Vigne,Christian Frelin,Jean-Pierre Cazenave,Christian Gachet

View Articletitled, The P2Y1 Receptor Is Necessary for Adenosine 5′-Diphosphate–Induced Platelet Aggregation

Anticoagulant Effects of 1α,25-Dihydroxyvitamin D₃ on Human Myelogenous Leukemia Cells and Monocytes

Takatoshi Koyama,Misako Shibakura,Mai Ohsawa,Ryuichi Kamiyama,Shinsaku Hirosawa

View Articletitled, Anticoagulant Effects of 1α,25-Dihydroxyvitamin D3 on Human Myelogenous Leukemia Cells and Monocytes

Targeted Inactivation of the Coagulation Factor IX Gene Causes Hemophilia B in Mice

Ramendra Krishna Kundu,Frank Sangiorgi,Lang-Ying Wu,Kotoku Kurachi,W. French Anderson,Robert Maxson,Erlinda M. Gordon

View Articletitled, Targeted Inactivation of the Coagulation Factor IX Gene Causes Hemophilia B in Mice

Naturally Occurring Mutations in Glycoprotein Ibα That Result in Defective Ligand Binding and Synthesis of a Truncated Protein

Dermot Kenny,Ólafur G. Jónsson,Patricia A. Morateck,Robert R. Montgomery

View Articletitled, Naturally Occurring Mutations in Glycoprotein Ibα That Result in Defective Ligand Binding and Synthesis of a Truncated Protein

IMMUNOBIOLOGY

Construction and Characterization of a Fusion Protein of Single-Chain Anti-CD20 Antibody and Human β-Glucuronidase for Antibody-Directed Enzyme Prodrug Therapy

Hidde J. Haisma,M. Fleur Sernee,Erik Hooijberg,Ruud H. Brakenhoff,Ida H. v.d. Meulen-Muileman,Herbert M. Pinedo,Epie Boven

View Articletitled, Construction and Characterization of a Fusion Protein of Single-Chain Anti-CD20 Antibody and Human β-Glucuronidase for Antibody-Directed Enzyme Prodrug Therapy

Localization of Receptors for Vasoactive Intestinal Peptide, Somatostatin, and Substance P in Distinct Compartments of Human Lymphoid Organs

Jean Claude Reubi,Ursula Horisberger,Andreas Kappeler,Jean A. Laissue

View Articletitled, Localization of Receptors for Vasoactive Intestinal Peptide, Somatostatin, and Substance P in Distinct Compartments of Human Lymphoid Organs

Expression of the CD8αβ-Heterodimer on CD8⁺ T Lymphocytes in Peripheral Blood Lymphocytes of Human Immunodeficiency Virus⁻ and Human Immunodeficiency Virus⁺Individuals

Jörn E. Schmitz,Meryl A. Forman,Michelle A. Lifton,Orlando Concepción, Jr,Keith A. Reimann,Clyde S. Crumpacker,John F. Daley,Rebecca S. Gelman,Norman L. Letvin

View Articletitled, Expression of the CD8αβ-Heterodimer on CD8+ T Lymphocytes in Peripheral Blood Lymphocytes of Human Immunodeficiency Virus− and Human Immunodeficiency Virus+Individuals

Adhesion, Transendothelial Migration, and Reverse Transmigration of In Vitro Cultured Dendritic Cells

Giovanna D'Amico,Giancarlo Bianchi,Sergio Bernasconi,Laura Bersani,Lorenzo Piemonti,Silvano Sozzani,Alberto Mantovani,Paola Allavena

View Articletitled, Adhesion, Transendothelial Migration, and Reverse Transmigration of In Vitro Cultured Dendritic Cells

Production of Interleukin-10 by Granulocyte Colony-Stimulating Factor–Mobilized Blood Products: A Mechanism for Monocyte-Mediated Suppression of T-Cell Proliferation

Marco Mielcarek,Lynn Graf,Gretchen Johnson,Beverly Torok-Storb

View Articletitled, Production of Interleukin-10 by Granulocyte Colony-Stimulating Factor–Mobilized Blood Products: A Mechanism for Monocyte-Mediated Suppression of T-Cell Proliferation

Differential Effects of Chondroitin Sulfates A and B on Monocyte and B-Cell Activation: Evidence for B-Cell Activation Via a CD44-Dependent Pathway

Jacob Rachmilewitz,Mark L. Tykocinski

View Articletitled, Differential Effects of Chondroitin Sulfates A and B on Monocyte and B-Cell Activation: Evidence for B-Cell Activation Via a CD44-Dependent Pathway

NEOPLASIA

Microsatellite Instability and Frameshift Mutations in BAX and Transforming Growth Factor-β RII Genes Are Very Uncommon in Acute Lymphoblastic Leukemia In Vivo But Not in Cell Lines

Jan J. Molenaar,Bénédicte Gérard,Cécile Chambon-Pautas,Hélène Cavé,Michel Duval,Etienne Vilmer,Bernard Grandchamp

View Articletitled, Microsatellite Instability and Frameshift Mutations in BAX and Transforming Growth Factor-β RII Genes Are Very Uncommon in Acute Lymphoblastic Leukemia In Vivo But Not in Cell Lines

Chromosomal and Gene Amplification in Diffuse Large B-Cell Lymphoma

Pulivarthi H. Rao,Jane Houldsworth,Katerina Dyomina,Nasser Z. Parsa,Juan C. Cigudosa,Diane C. Louie,Leslie Popplewell,Kenneth Offit,Suresh C. Jhanwar,R.S.K. Chaganti

View Articletitled, Chromosomal and Gene Amplification in Diffuse Large B-Cell Lymphoma

Interleukin-6–Induced Inhibition of Multiple Myeloma Cell Apoptosis: Support for the Hypothesis That Protection Is Mediated Via Inhibition of the JNK/SAPK Pathway

Feng-hao Xu,Sanjesh Sharma,Agnes Gardner,Yiping Tu,Arthur Raitano,Charles Sawyers,Alan Lichtenstein

View Articletitled, Interleukin-6–Induced Inhibition of Multiple Myeloma Cell Apoptosis: Support for the Hypothesis That Protection Is Mediated Via Inhibition of the JNK/SAPK Pathway

Interleukin-15 Is an Autocrine/Paracrine Viability Factor for Cutaneous T-Cell Lymphoma Cells

Udo Döbbeling,Reinhard Dummer,Elisabeth Laine,Natascha Potoczna,Jian-Zhong Qin,Günter Burg

View Articletitled, Interleukin-15 Is an Autocrine/Paracrine Viability Factor for Cutaneous T-Cell Lymphoma Cells

Prednisolone Resistance in Childhood Acute Lymphoblastic Leukemia: Vitro-Vivo Correlations and Cross-Resistance to Other Drugs

G.J.L. Kaspers,R. Pieters,C.H. Van Zantwijk,E.R. VanWering,A. Van Der Does-Van Den Berg,A.J.P. Veerman

View Articletitled, Prednisolone Resistance in Childhood Acute Lymphoblastic Leukemia: Vitro-Vivo Correlations and Cross-Resistance to Other Drugs

Mutations of the NF1 Gene in Children With Juvenile Myelomonocytic Leukemia Without Clinical Evidence of Neurofibromatosis, Type 1

Lucy E. Side,Peter D. Emanuel,Brigit Taylor,Janet Franklin,Patricia Thompson,Robert P. Castleberry,Kevin M. Shannon

View Articletitled, Mutations of the NF1 Gene in Children With Juvenile Myelomonocytic Leukemia Without Clinical Evidence of Neurofibromatosis, Type 1

The Evolution of B Precursor Leukemia in the Eμ-ret Mouse

Robert Wasserman,Xiang-Xing Zeng,Richard R. Hardy

View Articletitled, The Evolution of B Precursor Leukemia in the Eμ-ret Mouse

PHAGOCYTES

Complement Fragment-Induced Release of Neutrophils From Bone Marrow and Sequestration Within Pulmonary Capillaries in Rabbits

Hiroshi Kubo,Lori Graham,Nicholas A. Doyle,William M. Quinlan,James C. Hogg,Claire M. Doerschuk

View Articletitled, Complement Fragment-Induced Release of Neutrophils From Bone Marrow and Sequestration Within Pulmonary Capillaries in Rabbits

Epstein-Barr Virus Infects and Induces Apoptosis in Human Neutrophils

Bernard Larochelle,Louis Flamand,Pierrette Gourde,Denis Beauchamp,Jean Gosselin

View Articletitled, Epstein-Barr Virus Infects and Induces Apoptosis in Human Neutrophils

Intracellular Storage and Regulated Plasma Membrane Expression of Human Complement Receptor Type 1 in Rat Basophil Leukemia Cell Transfectants

Carolina Jost,Lloyd Klickstein,Erica Wetzler,Anoopa Kumar,Melvin Berger

View Articletitled, Intracellular Storage and Regulated Plasma Membrane Expression of Human Complement Receptor Type 1 in Rat Basophil Leukemia Cell Transfectants

RED CELLS

An Erythroid-Specific Transcript Generates the Soluble Form of NADH-Cytochrome b₅ Reductase in Humans

Alessandra Bulbarelli,Alessandra Valentini,Marcella DeSilvestris,M. Domenica Cappellini,Nica Borgese

View Articletitled, An Erythroid-Specific Transcript Generates the Soluble Form of NADH-Cytochrome b5 Reductase in Humans

Analysis of the Human Ferrochelatase Promoter in Transgenic Mice

Scott T. Magness,Antonio Tugores,Edward S. Diala,David A. Brenner

View Articletitled, Analysis of the Human Ferrochelatase Promoter in Transgenic Mice

Temporal Synthesis of Band 3 Oligomers During Terminal Maturation of Mouse Erythroblasts. Dimers and Tetramers Exist in the Membrane as Preformed Stable Species

Manjit Hanspal,David E. Golan,Yva Smockova,Scott J. Yi,Michael R. Cho,Shih-Chun Liu,Jiri Palek

View Articletitled, Temporal Synthesis of Band 3 Oligomers During Terminal Maturation of Mouse Erythroblasts. Dimers and Tetramers Exist in the Membrane as Preformed Stable Species

CORRESPONDENCE

To GpIb or not to GpIb

Sandor S. Shapiro,Barbara A. Konkle,Dorothy A. Beacham

View Articletitled, To GpIb or not to GpIb

ERRATA

Erratum for vol. 91, p. 2847

View Articletitled, Erratum for vol. 91, p. 2847

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Issue Archive

Table of Contents

SPECIAL FOCUS INTRODUCTION

SPECIAL FOCUS

RAPID COMMUNICATIONS

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

HEMATOPOIESIS

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

IMMUNOBIOLOGY

NEOPLASIA

PHAGOCYTES

RED CELLS

CORRESPONDENCE

ERRATA

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American Society of Hematology

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