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Volume 132, Issue 6

August 9 2018

In this Issue

BLOOD COMMENTARIES
BLOOD SPOTLIGHT
HEMATOPOIESIS AND STEM CELLS
LYMPHOID NEOPLASIA
MYELOID NEOPLASIA
PLATELETS AND THROMBOPOIESIS
THROMBOSIS AND HEMOSTASIS
LETTERS TO BLOOD
BLOOD WORK

Table of Contents

BLOOD COMMENTARIES

Hematopoiesis and Stem Cells

CASIN the joint: immune aging at the stem cell level

Graham P. Pawelec

View Articletitled, CASIN the joint: immune aging at the stem cell level

Lymphoid Neoplasia

Detailing the genomic landscape of myeloma

P. Leif Bergsagel,W. Michael Kuehl

View Articletitled, Detailing the genomic landscape of myeloma

PLATELETS AND THROMBOPOIESIS

TPO-logy accepted

Karin M. Hoffmeister

View Articletitled, TPO-logy accepted

CLINICAL TRIALS AND OBSERVATIONS

Endosome trafficking: blood and more
Clinical Trials & Observations

Gary M. Kupfer

View Articletitled, Endosome trafficking: blood and more

BLOOD SPOTLIGHT

Hematopoiesis and the bacterial microbiome

Hannah Yan,Megan T. Baldridge,Katherine Y. King

View Articletitled, Hematopoiesis and the bacterial microbiome

HEMATOPOIESIS AND STEM CELLS

Aged murine hematopoietic stem cells drive aging-associated immune remodeling

Hanna Leins,Medhanie Mulaw,Karina Eiwen,Vadim Sakk,Ying Liang,Michael Denkinger,Hartmut Geiger,Reinhold Schirmbeck

View Articletitled, Aged murine hematopoietic stem cells drive aging-associated immune remodeling

Supplemental data

LYMPHOID NEOPLASIA

CK1α and IRF4 are essential and independent effectors of immunomodulatory drugs in primary effusion lymphoma

Ajinkya Patil,Mark Manzano,Eva Gottwein

View Articletitled, CK1α and IRF4 are essential and independent effectors of immunomodulatory drugs in primary effusion lymphoma

Supplemental data

Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma

Brian A. Walker,Konstantinos Mavrommatis,Christopher P. Wardell,T. Cody Ashby,Michael Bauer,Faith E. Davies,Adam Rosenthal,Hongwei Wang,Pingping Qu,Antje Hoering,Mehmet Samur,Fadi Towfic,Maria Ortiz,Erin Flynt,Zhinuan Yu,Zhihong Yang,Dan Rozelle,John Obenauer,Matthew Trotter,Daniel Auclair,Jonathan Keats,Niccolo Bolli,Mariateresa Fulciniti,Raphael Szalat,Philippe Moreau,Brian Durie,A. Keith Stewart,Hartmut Goldschmidt,Marc S. Raab,Hermann Einsele,Pieter Sonneveld,Jesus San Miguel,Sagar Lonial,Graham H. Jackson,Kenneth C. Anderson,Herve Avet-Loiseau,Nikhil Munshi,Anjan Thakurta,Gareth J. Morgan

View Articletitled, Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma

Supplemental data

MYELOID NEOPLASIA

Phase 2b study of 2 dosing regimens of quizartinib monotherapy in FLT3-ITD–mutated, relapsed or refractory AML
Clinical Trials & Observations

Jorge E. Cortes,Martin S. Tallman,Gary J. Schiller,Denise Trone,Guy Gammon,Stuart L. Goldberg,Alexander E. Perl,Jean-Pierre Marie,Giovanni Martinelli,Hagop M. Kantarjian,Mark J. Levis

View Articletitled, Phase 2b study of 2 dosing regimens of quizartinib monotherapy in <em>FLT3</em>-ITD–mutated, relapsed or refractory AML

Supplemental data

Srsf2^P95H initiates myeloid bias and myelodysplastic/myeloproliferative syndrome from hemopoietic stem cells

Monique F. Smeets,Shuh Ying Tan,Jane Jialu Xu,Govardhan Anande,Ashwin Unnikrishnan,Alistair M. Chalk,Scott R. Taylor,John E. Pimanda,Meaghan Wall,Louise E. Purton,Carl R. Walkley

View Articletitled, <em>Srsf2</em><em><sup>P95H</sup></em> initiates myeloid bias and myelodysplastic/myeloproliferative syndrome from hemopoietic stem cells

Supplemental data

PLATELETS AND THROMBOPOIESIS

GPIbα is required for platelet-mediated hepatic thrombopoietin generation

Miao Xu,June Li,Miguel Antonio Dias Neves,Guangheng Zhu,Naadiya Carrim,Ruoying Yu,Sahil Gupta,John Marshall,Ori Rotstein,Jun Peng,Ming Hou,Shinji Kunishima,Jerry Ware,Donald R. Branch,Alan H. Lazarus,Zaverio M. Ruggeri,John Freedman,Heyu Ni

View Articletitled, GPIbα is required for platelet-mediated hepatic thrombopoietin generation

Supplemental data

ADAP deficiency impairs megakaryocyte polarization with ectopic proplatelet release and causes microthrombocytopenia

Markus Spindler,Judith M. M. van Eeuwijk,Yvonne Schurr,Paquita Nurden,Bernhard Nieswandt,David Stegner,Annegret Reinhold,Markus Bender

View Articletitled, ADAP deficiency impairs megakaryocyte polarization with ectopic proplatelet release and causes microthrombocytopenia

Supplemental data

THROMBOSIS AND HEMOSTASIS

Warfarin and vitamin K epoxide reductase: a molecular accounting for observed inhibition

Sangwook Wu,Xuejie Chen,Da-Yun Jin,Darrel W. Stafford,Lee G. Pedersen,Jian-Ke Tie

View Articletitled, Warfarin and vitamin K epoxide reductase: a molecular accounting for observed inhibition

Supplemental data

LETTERS TO BLOOD

Syndromic congenital myelofibrosis associated with a loss-of-function variant in RBSN
Clinical Trials & Observations

Pilar L. Magoulas,Oleg A. Shchelochkov,Matthew N. Bainbridge,Shay Ben-Shachar,Svetlana Yatsenko,Lorraine Potocki,Richard A. Lewis,Charles Searby,Andrea N. Marcogliese,M. Tarek Elghetany,Gladys Zapata,Paula P. Hernández,Manasi Gadkari,Derek Einhaus,Donna M. Muzny,Richard A. Gibbs,Alison A. Bertuch,Daryl A. Scott,Silvia Corvera,Luis M. Franco

View Articletitled, Syndromic congenital myelofibrosis associated with a loss-of-function variant in <em>RBSN</em>

Supplemental data

Improved CNS exposure to tocilizumab after cerebrospinal fluid compared to intravenous administration in rhesus macaques

Anandani Nellan,Cynthia M. Lester McCully,Rafael Cruz Garcia,Nalini Jayaprakash,Brigitte C. Widemann,Daniel W. Lee,Katherine E. Warren

View Articletitled, Improved CNS exposure to tocilizumab after cerebrospinal fluid compared to intravenous administration in rhesus macaques

Rituximab monotherapy in splenic marginal zone lymphoma: prolonged responses and potential benefit from maintenance

Christina Kalpadakis,Gerassimos A. Pangalis,Sotirios Sachanas,Pantelis Tsirkinidis,Flora N. Kontopidou,Maria Moschogiannis,Xanthi Yiakoumis,Efstathios Koulieris,Maria N. Dimopoulou,Stella I. Kokkoris,Marie-Christine Kyrtsonis,Marina P. Siakantaris,Gerassimos Tsourouflis,Penelope Korkolopoulou,Dimitra Rontogianni,Panagiotis Tsaftaridis,Eleni Plata,Helen A. Papadaki,Panagiotis Panagiotidis,Maria K. Angelopoulou,Theodoros P. Vassilakopoulos

View Articletitled, Rituximab monotherapy in splenic marginal zone lymphoma: prolonged responses and potential benefit from maintenance

A universal solution for eliminating false positives in myeloma due to therapeutic monoclonal antibody interference

John R. Mills,Mindy C. Kohlhagen,Maria A. V. Willrich,Taxiarchis Kourelis,Angela Dispenzieri,David L. Murray

View Articletitled, A universal solution for eliminating false positives in myeloma due to therapeutic monoclonal antibody interference

BLOOD WORK

Rasburicase-induced hemolytic anemia in previously undiagnosed G6PD deficiency

Donna Ferguson,Alexandra E. Kovach

View Articletitled, Rasburicase-induced hemolytic anemia in previously undiagnosed G6PD deficiency

Cover Image

Cover Image

Immunofluorescence confocal image for probing the membrane topology of human vitamin K epoxide reductase (VKOR) in live COS-7 cells. The location of the disputed loop sequence of VKOR was probed by selectively permeabilization and immunostaining of VKOR (red) and the cell organelle markers (green). See the article by Wu et al on page 647.
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