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iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL
How I safely transfuse patients with sickle-cell disease and manage delayed hemolytic transfusion reactions
High NPM1-mutant allele burden at diagnosis predicts unfavorable outcomes in de novo AML
Phase 1 clinical trial evaluating abatacept in patients with steroid-refractory chronic graft-versus-host disease
MAGIC biomarkers predict long-term outcomes for steroid-resistant acute GVHD
Prolonged remissions after anti-PD-1 discontinuation in patients with Hodgkin lymphoma
Issue Archive
June 21 2018
Table of Contents
BLOOD COMMENTARIES
SPECIAL REPORT
iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL
Clinical Trials & Observations
Michael Hallek,Bruce D. Cheson,Daniel Catovsky,Federico Caligaris-Cappio,Guillermo Dighiero,Hartmut Döhner,Peter Hillmen,Michael Keating,Emili Montserrat,Nicholas Chiorazzi,Stephan Stilgenbauer,Kanti R. Rai,John C. Byrd,Barbara Eichhorst,Susan O’Brien,Tadeusz Robak,John F. Seymour,Thomas J. Kipps
REVIEW ARTICLE
HOW I TREAT
How I safely transfuse patients with sickle-cell disease and manage delayed hemolytic transfusion reactions
Clinical Trials & Observations
CLINICAL TRIALS AND OBSERVATIONS
LYMPHOID NEOPLASIA
TRRAP is essential for regulating the accumulation of mutant and wild-type p53 in lymphoma
Alexander Jethwa,Mikołaj Słabicki,Jennifer Hüllein,Marius Jentzsch,Vineet Dalal,Sophie Rabe,Lena Wagner,Tatjana Walther,Wolfram Klapper,MMML Network Project,Hanibal Bohnenberger,Mandy Rettel,Junyan Lu,Arne H. Smits,Frank Stein,Mikhail M. Savitski,Wolfgang Huber,Yael Aylon,Moshe Oren,Thorsten Zenz
MYELOID NEOPLASIA
High NPM1-mutant allele burden at diagnosis predicts unfavorable outcomes in de novo AML
Clinical Trials & Observations
Sanjay S. Patel,Frank C. Kuo,Christopher J. Gibson,David P. Steensma,Robert J. Soiffer,Edwin P. Alyea, III,Yi-Bin A. Chen,Amir T. Fathi,Timothy A. Graubert,Andrew M. Brunner,Martha Wadleigh,Richard M. Stone,Daniel J. DeAngelo,Valentina Nardi,Robert P. Hasserjian,Olga K. Weinberg
THROMBOSIS AND HEMOSTASIS
TRANSPLANTATION
Phase 1 clinical trial evaluating abatacept in patients with steroid-refractory chronic graft-versus-host disease
Clinical Trials & Observations
Myrna R. Nahas,Robert J. Soiffer,Haesook T. Kim,Edwin P. Alyea, III,Jon Arnason,Robin Joyce,Joseph H. Antin,Vincent T. Ho,Dina Stroopinsky,Shuli Li,James D. Levine,Malgorzata McMasters,Salvia Jain,Ayad Hamdan,Dimitrios Tzachanis,Mary Paty Bryant,Emma K. Logan,Josie Bazemore,Jeremy Stewart,Amy Joyce,Susan Stephenson,Abigail Washington,Leandra Cole,Athalia Pyzer,Rebecca Karp Leaf,David E. Avigan,Jacalyn Rosenblatt
MAGIC biomarkers predict long-term outcomes for steroid-resistant acute GVHD
CME
Clinical Trials & Observations
Hannah Major-Monfried,Anne S. Renteria,Attaphol Pawarode,Pavan Reddy,Francis Ayuk,Ernst Holler,Yvonne A. Efebera,William J. Hogan,Matthias Wölfl,Muna Qayed,Elizabeth O. Hexner,Kitsada Wudhikarn,Rainer Ordemann,Rachel Young,Jay Shah,Matthew J. Hartwell,Mohammed S. Chaudhry,Mina Aziz,Aaron Etra,Gregory A. Yanik,Nicolaus Kröger,Daniela Weber,Yi-Bin Chen,Ryotaro Nakamura,Wolf Rösler,Carrie L. Kitko,Andrew C. Harris,Michael Pulsipher,Ran Reshef,Steven Kowalyk,George Morales,Ivan Torres,Umut Özbek,James L. M. Ferrara,John E. Levine
LETTERS TO BLOOD
Prolonged remissions after anti-PD-1 discontinuation in patients with Hodgkin lymphoma
Clinical Trials & Observations
Guillaume Manson,on behalf of the Lymphoma Study Association,Charles Herbaux,on behalf of the Lymphoma Study Association,Pauline Brice,on behalf of the Lymphoma Study Association,Krimo Bouabdallah,on behalf of the Lymphoma Study Association,Aspasia Stamatoullas,on behalf of the Lymphoma Study Association,Jean-Marc Schiano,on behalf of the Lymphoma Study Association,Hervé Ghesquieres,on behalf of the Lymphoma Study Association,Laurent Dercle,on behalf of the Lymphoma Study Association,Roch Houot,on behalf of the Lymphoma Study Association
A common TCN1 loss-of-function variant is associated with lower vitamin B12 concentration in African Americans
Yao Hu,Laura M. Raffield,Linda M. Polfus,Arden Moscati,Girish Nadkarni,Michael H. Preuss,Xue Zhong,Qiang Wei,Stephen S. Rich,Yun Li,James G. Wilson,Adolfo Correa,Ruth J. F. Loos,Bingshan Li,Paul L. Auer,Alex P. Reiner,the NHLBI Trans-Omics for Precision Medicine Consortium
BLOOD WORK
ERRATUM
CONTINUING MEDICAL EDUCATION (CME) QUESTIONS
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Cover Image
Cover Image
NF-κB p50 immunocytochemical staining in CD8+ cells from a patient with large granular lymphocyte leukemia. Brown staining indicates nuclear localization of NF-κB p50 protein after treatment with TRAIL. See the article by Yang et al on page 2803.
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