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David J. Feith
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Journal Articles

Characterization of Cellular Heterogeneity in NK Large Granular Lymphocyte Leukemia Using Cite-Seq

Jisu Shin, Jeff C Xing, Thomas P. Loughran, Jr., David J Feith, Aakrosh Ratan
Journal: Blood
Blood (2024) 144 (Supplement 1): 4363.
https://doi.org/10.1182/blood-2024-205311
Published: 2024
Journal Articles

Anti-Inflammatory Response to Anti-Folate and Vitamin D Analog Combination in Large Granular Lymphocyte Leukemia

Katie Moosic, Kristine Olson, David J Feith, Thomas P. Loughran, Jr.
Journal: Blood
Blood (2023) 142 (Supplement 1): 4194.
https://doi.org/10.1182/blood-2023-190063
Published: 2023
Journal Articles

The Novel Nano-Formulation of the HDAC Inhibitor, Romidepsin, for the Treatment of Relapsed, Refractory Peripheral T-Cell Lymphoma

Ipsita Pal, Anuradha Illendula, John Sanil Manavalan, Todd P Fox, Owen A. O'Connor, Thomas P. Loughran, Jr., Mark Kester, David J Feith, Enrica Marchi
Journal: Blood
Blood (2022) 140 (Supplement 1): 8848–8849.
https://doi.org/10.1182/blood-2022-167628
Published: 2022
Journal Articles

Tolinapant, a Non-Peptidomimetic Antagonist of Inhibitors of Apoptosis Proteins, cIAP1/2 and XIAP, in Combination with the Hypomethylating Agents, Azacytidine and Decitabine Are Highly Synergistic in in Vitro Models of T Cell Lymphoma

John Sanil Manavalan, Ipsita Pal, Aidan Pursley, George A. Ward, Tomoko Smyth, Martin Sims, Jason A. Taylor, David J Feith, Thomas P. Loughran, Jr., Owen A. O'Connor, Enrica Marchi
Journal: Blood
Blood (2022) 140 (Supplement 1): 11552–11553.
https://doi.org/10.1182/blood-2022-169906
Published: 2022
Journal Articles

KLRG1 Depletion Is a Novel Therapeutic Strategy for Patients with Mature T and NK/T-Cell Lymphomas

Bimarzhan Assatova, Christopher Trevisani, Robert Willim, Jessica Duffy, Abner Louissaint, Jr., Won-Seog Kim, David J Feith, Thomas Loughran, Jr., Foster Powers, Elizabeth A Morgan, Lei Yang, Brandy Pinckney, Garrett Haskett, Matthew J Cotton, Andrew Crabbe, Jessica Beth Ziemba, Ian Brain, Tayla B. Heavican-Foral, Nora Scanlan, Gail Newton, Jaehyuk Choi, Jeffrey A Barnes, Patrick Connor Johnson, Eric D Jacobsen, Steven Greenberg, David M. Weinstock, Salvia Jain
Journal: Blood
Blood (2022) 140 (Supplement 1): 2253–2255.
https://doi.org/10.1182/blood-2022-162583
Published: 2022
Journal Articles

DR-01, a Non-Fucosylated Anti-CD94 Antibody, Depletes Leukemic Cells in Ex Vivo and In Vivo Models of Large Granular Lymphocyte Leukemia

Kelly Shi, Cindy Tan, Lu Bai, Jennifer Richardson, Andy Deng, Matthias Will, Michael Brehm, Dale Greiner, Leonard Shultz, Antonella Teramo, Renato Zambello, David J Feith, Thomas P. Loughran, Jr., Nenad Tomasevic
Journal: Blood
Blood (2022) 140 (Supplement 1): 2259–2260.
https://doi.org/10.1182/blood-2022-159242
Published: 2022
Journal Articles

Presence of Activating STAT3 Mutations in the CD8+ T Cells of Rheumatoid Arthritis Patients

Katharine B. Moosic, Thomas L. Olson, Mark Freijat, Samara Khalique, Cait E. Hamele, Bryna Shemo, Jesse Boodoo, William Baker, Matthew W. Schmachtenberg, Erika Darrah, Felipe Andrade, Kristine C. Olson, David J. Feith, Donald L. Kimpel, Thomas P. Loughran, Jr.
Journal: Blood
Blood (2022) 140 (Supplement 1): 11192–11193.
https://doi.org/10.1182/blood-2022-168069
Published: 2022
Journal Articles

Genomic landscape of TCRαβ and TCRγδ T-large granular lymphocyte leukemia

CME
HeeJin Cheon, Jeffrey C. Xing, Katharine B. Moosic, Johnson Ung, Vivian W. Chan, David S. Chung, Mariella F. Toro, Omar Elghawy, John S. Wang, Cait E. Hamele, Ross C. Hardison, Thomas L. Olson, Su-Fern Tan, David J. Feith, Aakrosh Ratan, Thomas P. Loughran, Jr
Journal: Blood
Blood (2022) 139 (20): 3058–3072.
https://doi.org/10.1182/blood.2021013164
Published: 2022
Includes: Supplemental data
Journal Articles

Tolinapant (ASTX660), a Non-Peptidomimetic Antagonist of cIAP1/2 and XIAP, and the HDAC Inhibitor Romidepsin Are Synergistic in in Vitro Models of T Cell Lymphoma

John S Manavalan, Ipsita Pal, Aidan Pursley, George A. Ward, Tomoko Smyth, Martin Sims, David J Feith, Thomas P. Loughran, Jr., Owen A. O'Connor, Enrica Marchi
Journal: Blood
Blood (2021) 138 (Supplement 1): 4356.
https://doi.org/10.1182/blood-2021-153451
Published: 2021
Journal Articles

Manifestation of Large Granular Lymphocyte Leukemia in Pediatric and Young Adult Population Is Distinct from Older Adult Cohorts

Heejin Cheon, Vivian Chan, Farid Ghamsari, Omar Elghawy, John Wang, David J Feith, Aakrosh Ratan, Thomas P. Loughran, Jr.
Journal: Blood
Blood (2021) 138 (Supplement 1): 2464.
https://doi.org/10.1182/blood-2021-151172
Published: 2021
Journal Articles

Frequent somatic TET2 mutations in chronic NK-LGL leukemia with distinct patterns of cytopenias

Clinical Trials & Observations
Thomas L. Olson, HeeJin Cheon, Jeffrey C. Xing, Kristine C. Olson, Umadevi Paila, Cait E. Hamele, Yaseswini Neelamraju, Bryna C. Shemo, Matt Schmachtenberg, Shriram K. Sundararaman, Mariella F. Toro, Cheryl A. Keller, Emily A. Farber, Suna Onengut-Gumuscu, Francine E. Garrett-Bakelman, Ross C. Hardison, David J. Feith, Aakrosh Ratan, Thomas P. Loughran, Jr
Journal: Blood
Blood (2021) 138 (8): 662–673.
https://doi.org/10.1182/blood.2020005831
Published: 2021
Includes: Supplemental data
Journal Articles

Recurrent Mutations of the C-C Motif Chemokine Ligand 22 ( CCL22 ) Define a Distinct Subgroup of Chronic Lymphoproliferative Disorder of NK Cells (CLPD-NK)

Constance Baer, PhD, Shunsuke Kimura, Ilaria Iacobucci, David J Feith, BS, PhD, Wencke Walter, PhD, Manja Meggendorfer, PhD, Thomas L. Olson, PhD, Aakrosh Ratan, PhD, Martha-Lena Müller, PhD, Mitra Rana, Chunxu Qu, PhD, Ravi Kalathur, Claudia Haferlach, MD, Wolfgang Kern, MD, Thomas P. Loughran, Jr., MD, Charles G Mullighan, MBBS, MD, Torsten Haferlach, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 19.
https://doi.org/10.1182/blood-2020-140695
Published: 2020
Journal Articles

Analysis of Genomic Landscape of Large Granular Lymphocyte Leukemia Reveals Etiologic Insights

HeeJin Cheon, BSc, Jeffrey C Xing, BS, David S Chung, BS, Mariella F Toro, BA, Cait E Hamele, BS, Thomas L. Olson, PhD, David J Feith, PhD, Aakrosh Ratan, PhD, Thomas P. Loughran, Jr., MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 27–28.
https://doi.org/10.1182/blood-2020-137269
Published: 2020
Journal Articles

TRAIL mediates and sustains constitutive NF-κB activation in LGL leukemia

Jun Yang, Francis R. LeBlanc, Shubha A. Dighe, Cait E. Hamele, Thomas L. Olson, David J. Feith, Thomas P. Loughran, Jr
Journal: Blood
Blood (2018) 131 (25): 2803–2815.
https://doi.org/10.1182/blood-2017-09-808816
Published: 2018
Includes: Supplemental data
Journal Articles

Blockade of IL-2 and IL-15 Gamma Chain Receptor Signaling Decreases Leukemic Cell Viability in T-Cell Large Granular Lymphocyte Leukemia and Adult T-Cell Leukemia

Tracy Tiffany Wang, BS, Jun Yang, MD, Yong Zhang, PhD, Meili Zhang, PhD, Kevin C Conlon, MD, Yutaka Tagaya, B.M., PhD, Thomas L Olson, PhD, David J Feith, PhD, Nazli Azimi, Pharm.D., PhD, Thomas A. Waldmann, MD, Thomas P Loughran, Jr., MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3585.
https://doi.org/10.1182/blood.V130.Suppl_1.3585.3585
Published: 2017
Journal Articles

Therapeutic Efficacy of Mcl-1 Antagonism in Large Granular Lymphocyte Leukemia

Francis R LeBlanc, PhD, Jun Yang, MD, John H Heller, B.S., Shubha Dighe, M.S., Alejandro A. Gru, MD, Marya Dunlap-Brown, M.S., Hong-Gang Wang, PhD, David J Feith, PhD, Thomas P Loughran, Jr., MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1217.
https://doi.org/10.1182/blood.V130.Suppl_1.1217.1217
Published: 2017
Journal Articles

Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) Mediates and Sustains NF-κb Constitutive Activation in LGL Leukemia Cells

Jun Yang, MD, Francis R Leblanc, PhD, Shubha Dighe, MS, Susan B. Nyland, PhD, David J. Feith, PhD, Thomas P. Loughran, Jr., MD
Journal: Blood
Blood (2016) 128 (22): 2762.
https://doi.org/10.1182/blood.V128.22.2762.2762
Published: 2016
Journal Articles

Acid Ceramidase Inhibition Impairs Tumor Progression in a Rat Model of LGL Leukemia

Su-Fern Tan, PhD, Xin Liu, MD PhD, Kathleen Broeg, B.S., Todd E. Fox, PhD, David J. Feith, PhD, Thomas P. Loughran, Jr., MD
Journal: Blood
Blood (2015) 126 (23): 1246.
https://doi.org/10.1182/blood.V126.23.1246.1246
Published: 2015
Journal Articles

FTY720 (Fingolimod) Targets the Sphingolipid Pathway and Induces Autophagy-Related Apoptosis in Human Natural Killer Large Granular Lymphocyte Leukemia

Francis Roland LeBlanc, B.S., Hong-Gang Wang, MD PhD, David J. Feith, PhD, Thomas P. Loughran, Jr., MD
Journal: Blood
Blood (2015) 126 (23): 1288.
https://doi.org/10.1182/blood.V126.23.1288.1288
Published: 2015