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Journal Articles

DR-01, a Non-Fucosylated Anti-CD94 Antibody, Depletes Leukemic Cells in Ex Vivo and In Vivo Models of Large Granular Lymphocyte Leukemia

Kelly Shi, Cindy Tan, Lu Bai, Jennifer Richardson, Andy Deng, Matthias Will, Michael Brehm, Dale Greiner, Leonard Shultz, Antonella Teramo, Renato Zambello, David J Feith, Thomas P. Loughran, Jr., Nenad Tomasevic

Blood (2022) 140 (Supplement 1): 2259–2260.

https://doi.org/10.1182/blood-2022-159242

Published: 2022

Journal Articles

The NSG-hIL6 Mouse As a Novel Murine Patient Derived Xenograft Model of Plasma Cell Dyscrasias for Study of Disease Biology and Therapeutic Development

Zainul Hasanali, Alfred L. Garfall, Martin P. Carroll, Anthony Secreto, Nicolas Skuli, Carly Roman, Leonard Shultz, Neil Sheppard, Edward A. Stadtmauer, David Allman

Blood (2022) 140 (Supplement 1): 9921–9922.

https://doi.org/10.1182/blood-2022-167751

Published: 2022

Journal Articles

Development of Humanized Diffuse Large B-Cell Lymphoma Mouse Models

Syed Mehdi, Ying-Zhi Xu, Leonard Shultz, Samantha L. Kendrick, Donghoon Yoon

Blood (2021) 138 (Supplement 1): 4501.

https://doi.org/10.1182/blood-2021-153592

Published: 2021

Journal Articles

CXCR4-Expressing Anti-CD25 CAR T-Cells Effectively Eliminate Human AML Cells In Vivo

Ari Itoh-Nakadai, PhD, Yoriko Saito, MD, Mariko Murasawa-Tomizawa, Hiroshi Kajita, Takehisa Matsumoto, PhD, Masashi Matsuda, PhD, Takashi Watanabe, PhD, Mikako Shirouzu, Osamu Ohara, PhD, Haruhiko Koseki, MD PhD, Leonard Shultz, PhD, Fumihiko Ishikawa, MDPhD

Blood (2020) 136 (Supplement 1): 35–36.

https://doi.org/10.1182/blood-2020-142228

Published: 2020

Journal Articles

Targeting Critical Kinases and Anti-Apoptotic Molecules Overcomes Steroid Resistance in Infant MLL-Rearranged Leukemia

Anne Pieta De Groot, Yoriko Saito, MD, Eiryo Kawakami, Mari Hashimoto, Yuki Aoki, Rintaro Ono, MD PhD, Ikuko Ogahara, Saera Fujiki, Akiko Kaneko, Takashi Watanabe, PhD, Masatoshi Takagi, MD PhD, Daisuke Tomizawa, MD PhD, Katsuyoshi Koh, MD, Mariko Eguchi, MD, Eiichi Ishii, MD PhD, Osamu Ohara, Leonard Shultz, PhD, Shuki Mizutani, Fumihiko Ishikawa, MD PhD

Blood (2019) 134 (Supplement_1): 3885.

https://doi.org/10.1182/blood-2019-129719

Published: 2019

Journal Articles

Patient-Derived Xenografts (PDX) of B Cell Lymphoma in NSG Mice: A Mouse Avatar for Developing Personalized Medicine

Rachel Gerstein, PhD, Zheng Zhou, MD PhD, Hong Zhang, PhD, Andrew Evens, DO, MSc, FACP, Nicole Walsh, PhD, Leonard Shultz, Rita Bortell, PhD, Michael Brehm, PhD, Jan Cerny, MD PhD, Giles Whalen, MD, Jack Leonard, PhD, Bruce Woda, MD, Dale Greiner, PhD, Alan G. Rosmarin, MD

Blood (2015) 126 (23): 5408.

https://doi.org/10.1182/blood.V126.23.5408.5408

Published: 2015

Journal Articles

Development Of a Preclinical Human Xenograft Model For Myelodysplastic Syndrome In Immunodeficient Mice Expressing Human Growth Factors

George Scaria, MD, PhD, Laura Bendzick, BS, Leonard Shultz, PhD, Dan S. Kaufman, M.D., Ph.D.

Blood (2013) 122 (21): 1534.

https://doi.org/10.1182/blood.V122.21.1534.1534

Published: 2013

Journal Articles

Microenvironmental protection of CML stem and progenitor cells from tyrosine kinase inhibitors through N-cadherin and Wnt–β-catenin signaling

Bin Zhang, Min Li, Tinisha McDonald, Tessa L. Holyoake, Randall T. Moon, Dario Campana, Leonard Shultz, Ravi Bhatia

Blood (2013) 121 (10): 1824–1838.

https://doi.org/10.1182/blood-2012-02-412890

Published: 2013

Includes: Supplemental data

Journal Articles

Microenvironmental Protection of CML Stem and Progenitor Cells From Tyrosine Kinase Inhibitors Through N-Cadherin and Wnt Signaling

Bin Zhang, Tinisha McDonald, B.S., Tessa L. Holyoake, PhD, FRCP, FRCPath, Randall T Moon, PHD, Dario Campana, MD, PhD, Leonard Shultz, PhD, Ravi Bhatia, MD

Blood (2012) 120 (21): 912.

https://doi.org/10.1182/blood.V120.21.912.912

Published: 2012

Journal Articles

Membrane-Bound Human Stem Cell Factor Promotes Differentiation of Human Granulocytes and Mast Cells In Vivo,

Shinsuke Takagi, MD, Yoriko Saito, MD, Atsushi Hijikata, PhD, Satoshi Tanaka, Takashi Watanabe, PhD, Haruhiko Koseki, MD, PhD, Osamu Ohara, PhD, Takashi Saito, PhD, Shuichi Taniguchi, MD, PhD, Leonard Shultz, PhD, Fumihiko Ishikawa, MD, PhD

Blood (2011) 118 (21): 3419.

https://doi.org/10.1182/blood.V118.21.3419.3419

Published: 2011

Journal Articles

In Childhood ALL, Both Blasts with a CD20 −/Low and a CD20 High Immunophenotype Have the Ability to Transfer the Leukemia Onto Immune-Deficient NOD/Scid Y −/− Mice.

Kerrie Wilson, BSc(Hons), Klaus Rehe, MD, Simon Bomken, MD, Marian Case, MSc, Leonard Shultz, PhD, Julie Irving, PhD, Josef Vormoor, MD, FRCPCH

Blood (2008) 112 (11): 1348.

https://doi.org/10.1182/blood.V112.11.1348.1348

Published: 2008

Journal Articles

Growth of p210Bcr-Abl Transformed Human Hematopoietic Stem Cells in Immunodeficient Mice.

Hardik V Modi, MSc, Leonard Shultz, PhD, Ravi Bhatia, MD

Blood (2008) 112 (11): 1072.

https://doi.org/10.1182/blood.V112.11.1072.1072

Published: 2008

Journal Articles

Human Embryonic Stem Cell-Derived CD34+ Cells Preferentially Develop into Endothelial Cells When Transplanted into Neonatal Immunodeficient Mice

Xinghui Tian, PhD, Melinda K. Hexum, Vesselin R. Penchev, Russell J. Taylor, Leonard Shultz, PhD, Dan S. Kaufman, MD, PhD

Blood (2008) 112 (11): 69.

https://doi.org/10.1182/blood.V112.11.69.69

Published: 2008

Journal Articles

Analysis of Idiopathic Myelofibrosis Initiating Cell in NOD/SCID/IL2rgKO Mice

Noriyuki Saito, MD, Fumihiko Ishikawa, MD, PhD, Kazuya Shimoda, MD, PhD, Shuro Yoshida, MD, PhD, Yoriko Saito, MD, Mitsuhiro Fukata, MD, Chika Iwamoto, Noriaki Kawano, MD, PhD, Leonard Shultz, PhD, Mine Harada, MD, Koichi Akashi, MD, PhD

Blood (2008) 112 (11): 3715.

https://doi.org/10.1182/blood.V112.11.3715.3715

Published: 2008

Journal Articles

Normal Short-Term but Reduced Long-Term Engraftment Capacity of CML Hematopoietic Cells with Skewed Myeloid Lineage Differentiation Is Seen in an Improved Mouse Model of Human Hematopoiesis.

Jeff Tauer, Leonard Shultz, PhD, Tessa Holyoake, MD, Ravi Bhatia, MD

Blood (2007) 110 (11): 3383.

https://doi.org/10.1182/blood.V110.11.3383.3383

Published: 2007

Journal Articles

CD34+CD19−, CD34+CD19+ and CD34−CD19+ Cells May All Have Leukemia-Initiating Potential in NOD/ Scid Mice.

Christoph Le Viseur, Marc Hotfilder, PhD, Annegret Rosemann, Ronald Stam, PhD, Andre Schrauder, MD, Leonard Shultz, PhD, Martin Schrappe, MD, Rob Pieters, MD, Josef Vormoor, MD

Blood (2006) 108 (11): 2542.

https://doi.org/10.1182/blood.V108.11.2542.2542

Published: 2006

Journal Articles

Human Lymphoid and Myeloid Cell Development in NOD/LtSz- scid IL2r γ null Mice Engrafted with Mobilized Human Hematopoietic Stem Cells.

Leonard Shultz, Ph.D., Bonnie L. Lyons, D.V.M., Lisa M. Burzenski, B.S., Bruce Gott, X. Chen, Ph.D., Stanley Chaleff, M.D., Malak Kotb, Ph.D., Stephen D. Gillies, Ph.D., Dale L. Greiner, Ph.D., Rupert Handgretinger, M.D., Ph.D.

Blood (2004) 104 (11): 248.

https://doi.org/10.1182/blood.V104.11.248.248

Published: 2004

Journal Articles

β2 Microglobulin-deficient (B2m null ) NOD/SCID mice are excellent recipients for studying human stem cell function

Orit Kollet, Amnon Peled, Tamara Byk, Herzl Ben-Hur, Dale Greiner, Leonard Shultz, Tsvee Lapidot

Blood (2000) 95 (10): 3102–3105.

https://doi.org/10.1182/blood.V95.10.3102

Published: 2000

Journal Articles

The Soluble Interleukin-6 (IL-6) Receptor/IL-6 Fusion Protein Enhances In Vitro Maintenance and Proliferation of Human CD34 + CD38 −/low Cells Capable of Repopulating Severe Combined Immunodeficiency Mice

Orit Kollet, Ronit Aviram, Judith Chebath, Herzl ben-Hur, Arnon Nagler, Leonard Shultz, Michel Revel, Tsvee Lapidot

Blood (1999) 94 (3): 923–931.

https://doi.org/10.1182/blood.V94.3.923.415k08_923_931

Published: 1999

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DR-01, a Non-Fucosylated Anti-CD94 Antibody, Depletes Leukemic Cells in Ex Vivo and In Vivo Models of Large Granular Lymphocyte Leukemia

The NSG-hIL6 Mouse As a Novel Murine Patient Derived Xenograft Model of Plasma Cell Dyscrasias for Study of Disease Biology and Therapeutic Development

Development of Humanized Diffuse Large B-Cell Lymphoma Mouse Models

CXCR4-Expressing Anti-CD25 CAR T-Cells Effectively Eliminate Human AML Cells In Vivo

Targeting Critical Kinases and Anti-Apoptotic Molecules Overcomes Steroid Resistance in Infant MLL-Rearranged Leukemia

Patient-Derived Xenografts (PDX) of B Cell Lymphoma in NSG Mice: A Mouse Avatar for Developing Personalized Medicine

Development Of a Preclinical Human Xenograft Model For Myelodysplastic Syndrome In Immunodeficient Mice Expressing Human Growth Factors

Microenvironmental protection of CML stem and progenitor cells from tyrosine kinase inhibitors through N-cadherin and Wnt–β-catenin signaling

Microenvironmental Protection of CML Stem and Progenitor Cells From Tyrosine Kinase Inhibitors Through N-Cadherin and Wnt Signaling

Membrane-Bound Human Stem Cell Factor Promotes Differentiation of Human Granulocytes and Mast Cells In Vivo,

In Childhood ALL, Both Blasts with a CD20 −/Low and a CD20 High Immunophenotype Have the Ability to Transfer the Leukemia Onto Immune-Deficient NOD/Scid Y −/− Mice.

Growth of p210Bcr-Abl Transformed Human Hematopoietic Stem Cells in Immunodeficient Mice.

Human Embryonic Stem Cell-Derived CD34+ Cells Preferentially Develop into Endothelial Cells When Transplanted into Neonatal Immunodeficient Mice

Analysis of Idiopathic Myelofibrosis Initiating Cell in NOD/SCID/IL2rgKO Mice

Normal Short-Term but Reduced Long-Term Engraftment Capacity of CML Hematopoietic Cells with Skewed Myeloid Lineage Differentiation Is Seen in an Improved Mouse Model of Human Hematopoiesis.

CD34+CD19−, CD34+CD19+ and CD34−CD19+ Cells May All Have Leukemia-Initiating Potential in NOD/ Scid Mice.

Human Lymphoid and Myeloid Cell Development in NOD/LtSz- scid IL2r γ null Mice Engrafted with Mobilized Human Hematopoietic Stem Cells.

β2 Microglobulin-deficient (B2m null ) NOD/SCID mice are excellent recipients for studying human stem cell function

The Soluble Interleukin-6 (IL-6) Receptor/IL-6 Fusion Protein Enhances In Vitro Maintenance and Proliferation of Human CD34 + CD38 −/low Cells Capable of Repopulating Severe Combined Immunodeficiency Mice

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