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Issue Archive

Volume 127, Issue 7
February 18 2016
Issue Cover

Table of Contents

EDITORIAL

Sickle cell disease: challenges and progress
Leslie V. Parise,Nancy Berliner
View Articletitled, Sickle cell disease: challenges and progress

BLOOD FLASHBACK

Singer K, Fisher B. Studies on abnormal hemoglobins, VI: electrophoretic demonstration of type S (sickle cell) hemoglobin in erythrocytes incapable of showing the sickle cell phenomenon. Blood. 1953;8(3):270-275.
View Articletitled, Singer K, Fisher B. Studies on abnormal hemoglobins, VI: electrophoretic demonstration of type S (sickle cell) hemoglobin in erythrocytes incapable of showing the sickle cell phenomenon. <em>Blood</em>. 1953;8(3):<span class="related-article">270-275</span>.

INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY
Breast cancer and thrombosis: timing matters
Clinical Trials & Observations
Jessica K. Paulus,Aaron S. Rosenberg
View Articletitled, Breast cancer and thrombosis: timing matters
INSIDE BLOOD COMMENTARY
Shooting the messenger (RNA) in B-cell lymphoma
Alison Yeomans,Graham Packham
View Articletitled, Shooting the messenger (RNA) in B-cell lymphoma
INSIDE BLOOD COMMENTARY
Not only TKI! Targeting FLT3-ITD by autophagy
Guido Marcucci,Ling Li
View Articletitled, Not only TKI! Targeting FLT3-ITD by autophagy
INSIDE BLOOD COMMENTARY
Platelet production: new players in the field
Fred G. Pluthero,Walter H. A. Kahr
View Articletitled, Platelet production: new players in the field
INSIDE BLOOD COMMENTARY
Might haplo “be the (better) match”?
Jennifer A. Kanakry,Leo Luznik
View Articletitled, Might haplo “be the (better) match”?

REVIEW SERIES

Neutrophils, platelets, and inflammatory pathways at the nexus of sickle cell disease pathophysiology
Dachuan Zhang,Chunliang Xu,Deepa Manwani,Paul S. Frenette
View Articletitled, Neutrophils, platelets, and inflammatory pathways at the nexus of sickle cell disease pathophysiology

REVIEW SERIES

Beyond hydroxyurea: new and old drugs in the pipeline for sickle cell disease
Clinical Trials & Observations
Marilyn J. Telen
View Articletitled, Beyond hydroxyurea: new and old drugs in the pipeline for sickle cell disease

REVIEW SERIES

Pathophysiology and treatment of pulmonary hypertension in sickle cell disease
Clinical Trials & Observations
Victor R. Gordeuk,Oswaldo L. Castro,Roberto F. Machado
View Articletitled, Pathophysiology and treatment of pulmonary hypertension in sickle cell disease

REVIEW SERIES

Central nervous system complications and management in sickle cell disease
Clinical Trials & Observations
Michael R. DeBaun,Fenella J. Kirkham
View Articletitled, Central nervous system complications and management in sickle cell disease
Supplemental data

REVIEW SERIES

Genetic treatment of a molecular disorder: gene therapy approaches to sickle cell disease
Megan D. Hoban,Stuart H. Orkin,Daniel E. Bauer
View Articletitled, Genetic treatment of a molecular disorder: gene therapy approaches to sickle cell disease

CLINICAL TRIALS AND OBSERVATIONS

When are breast cancer patients at highest risk of venous thromboembolism? A cohort study using English health care data
CME Clinical Trials & Observations
Alex J. Walker,Joe West,Tim R. Card,Colin Crooks,Cliona C. Kirwan,Matthew J. Grainge
View Articletitled, When are breast cancer patients at highest risk of venous thromboembolism? A cohort study using English health care data

LYMPHOID NEOPLASIA

Combinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphomas
Biljana Culjkovic-Kraljacic,Tharu M. Fernando,Rossella Marullo,Nieves Calvo-Vidal,Akanksha Verma,ShaoNing Yang,Fabrizio Tabbò,Marcello Gaudiano,Hiba Zahreddine,Rebecca L. Goldstein,Jayeshkumar Patel,Tony Taldone,Gabriela Chiosis,Marco Ladetto,Paola Ghione,Rodolfo Machiorlatti,Olivier Elemento,Giorgio Inghirami,Ari Melnick,Katherine L. B. Borden,Leandro Cerchietti
View Articletitled, Combinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphomas
Supplemental data
Targetable genetic features of primary testicular and primary central nervous system lymphomas
Bjoern Chapuy,Margaretha G. M. Roemer,Chip Stewart,Yuxiang Tan,Ryan P. Abo,Liye Zhang,Andrew J. Dunford,David M. Meredith,Aaron R. Thorner,Ekaterina S. Jordanova,Gang Liu,Friedrich Feuerhake,Matthew D. Ducar,Gerald Illerhaus,Daniel Gusenleitner,Erica A. Linden,Heather H. Sun,Heather Homer,Miyuki Aono,Geraldine S. Pinkus,Azra H. Ligon,Keith L. Ligon,Judith A. Ferry,Gordon J. Freeman,Paul van Hummelen,Todd R. Golub,Gad Getz,Scott J. Rodig,Daphne de Jong,Stefano Monti,Margaret A. Shipp
View Articletitled, Targetable genetic features of primary testicular and primary central nervous system lymphomas
Supplemental data

MYELOID NEOPLASIA

Proteasome inhibitors induce FLT3-ITD degradation through autophagy in AML cells
Clément Larrue,Estelle Saland,Héléna Boutzen,François Vergez,Marion David,Carine Joffre,Marie-Anne Hospital,Jérôme Tamburini,Eric Delabesse,Stéphane Manenti,Jean Emmanuel Sarry,Christian Récher
View Articletitled, Proteasome inhibitors induce FLT3-ITD degradation through autophagy in AML cells
Supplemental data
Rapid expansion of preexisting nonleukemic hematopoietic clones frequently follows induction therapy for de novo AML
Brief Report
Terrence N. Wong,Christopher A. Miller,Jeffery M. Klco,Allegra Petti,Ryan Demeter,Nichole M. Helton,Tiandao Li,Robert S. Fulton,Sharon E. Heath,Elaine R. Mardis,Peter Westervelt,John F. DiPersio,Matthew J. Walter,John S. Welch,Timothy A. Graubert,Richard K. Wilson,Timothy J. Ley,Daniel C. Link
View Articletitled, Rapid expansion of preexisting nonleukemic hematopoietic clones frequently follows induction therapy for de novo AML
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

ICAM-1–expressing neutrophils exhibit enhanced effector functions in murine models of endotoxemia
Abigail Woodfin,Martina Beyrau,Mathieu-Benoit Voisin,Bin Ma,James R. Whiteford,Peter L. Hordijk,Nancy Hogg,Sussan Nourshargh
View Articletitled, ICAM-1–expressing neutrophils exhibit enhanced effector functions in murine models of endotoxemia
Supplemental data

PLATELETS AND THROMBOPOIESIS

Apelin: an antithrombotic factor that inhibits platelet function
Frédéric Adam,Abdel-Majid Khatib,Jose Javier Lopez,Camille Vatier,Sabrina Turpin,Adeline Muscat,Fabienne Soulet,Anne Aries,Isaac Jardin,Régis Bobe,Alain Stepanian,Dominique de Prost,Cédric Dray,Juan Antonio Rosado,Philippe Valet,Bruno Feve,Geraldine Siegfried
View Articletitled, Apelin: an antithrombotic factor that inhibits platelet function
Supplemental data
CCL5 derived from platelets increases megakaryocyte proplatelet formation
Brief Report
Kellie R. Machlus,Kelly E. Johnson,Rajesh Kulenthirarajan,Jodi A. Forward,Mason D. Tippy,Thomas S. Soussou,Saleh H. El-Husayni,Stephen K. Wu,Suming Wang,Randolph S. Watnick,Joseph E. Italiano, Jr,Elisabeth M. Battinelli
View Articletitled, CCL5 derived from platelets increases megakaryocyte proplatelet formation

THROMBOSIS AND HEMOSTASIS

Misshapen/NIK-related kinase (MINK1) is involved in platelet function, hemostasis, and thrombus formation
Ming Yue,Dongjiao Luo,Shanshan Yu,Pu Liu,Qi Zhou,Mengjiao Hu,Yangyang Liu,Shuai Wang,Qian Huang,Yuxi Niu,Linrong Lu,Hu Hu
View Articletitled, Misshapen/NIK-related kinase (MINK1) is involved in platelet function, hemostasis, and thrombus formation
Supplemental data

TRANSPLANTATION

Reduced-intensity transplantation for lymphomas using haploidentical related donors vs HLA-matched unrelated donors
Clinical Trials & Observations
Abraham S. Kanate,Alberto Mussetti,Mohamed A. Kharfan-Dabaja,Kwang W. Ahn,Alyssa DiGilio,Amer Beitinjaneh,Saurabh Chhabra,Timothy S. Fenske,Cesar Freytes,Robert Peter Gale,Siddhartha Ganguly,Mark Hertzberg,Evgeny Klyuchnikov,Hillard M. Lazarus,Richard Olsson,Miguel-Angel Perales,Andrew Rezvani,Marcie Riches,Ayman Saad,Shimon Slavin,Sonali M. Smith,Anna Sureda,Jean Yared,Stefan Ciurea,Philippe Armand,Rachel Salit,Javier Bolaños-Meade,Mehdi Hamadani
View Articletitled, Reduced-intensity transplantation for lymphomas using haploidentical related donors vs HLA-matched unrelated donors
Supplemental data

LETTERS TO BLOOD

Identification of a gain-of-function STAT3 mutation (p.Y640F) in lymphocytic variant hypereosinophilic syndrome
Sarah Walker,Chen Wang,Trent Walradt,Bok Sil Hong,Justin R. Tanner,Jonathan L. Levinsohn,Gerald Goh,Antonio Subtil,Stuart R. Lessin,Warren R. Heymann,Eric C. Vonderheid,Brett A. King,Richard P. Lifton,Jaehyuk Choi
View Articletitled, Identification of a gain-of-function <em>STAT3</em> mutation (p.Y640F) in lymphocytic variant hypereosinophilic syndrome
Supplemental data

BLOOD WORK

Pure red cell aplasia revealing nonnodal mantle cell lymphoma
Eric Durot,Martine Patey
View Articletitled, Pure red cell aplasia revealing nonnodal mantle cell lymphoma

CONTINUING MEDICAL EDUCATION (CME) QUESTIONS

VTE in breast cancer
CME
View Articletitled, VTE in breast cancer
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