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Journal Articles

Deciphering EZH2 Non-Canonical Activities in AML Resistance

Lia N'guyen, Emeline Boet, Camille Montersino, Claire Burny, Stéphane Audebert, Luc Camoin, Rémy Castellano, Sylvain Garciaz, Atsushi Iwama, Jean-Emmanuel Sarry, Estelle Duprez, Mathilde Poplineau

Blood (2024) 144 (Supplement 1): 4097.

https://doi.org/10.1182/blood-2024-200580

Published: 2024

Journal Articles

Serially Transplantable, Genetically Modified Patient Derived Xenograft Models of Acute Myeloid Leukemia Represent Primary Patients' Cells and Enable Reliable and Reproducible Preclinical Therapy Trials

Blood (2024) 144 (Supplement 1): 6085.

https://doi.org/10.1182/blood-2024-198652

Published: 2024

Journal Articles

Minimal Residual Disease in Acute Myeloid Leukemia Following Induction Chemotherapy Can be Effectively Eradicated By Targeting Mitochondrial Metabolism

Blood (2023) 142 (Supplement 1): 2952.

https://doi.org/10.1182/blood-2023-186514

Published: 2023

Journal Articles

Ferritinophagy Is a Druggable Vulnerability of Quiescent Leukemic Stem Cells

Clément Larrue, Sarah Mouche, Paolo Angelino, Petros Tsantoulis, Jean-Emmanuel Sarry, Jerome Tamburini

Blood (2023) 142 (Supplement 1): 407.

https://doi.org/10.1182/blood-2023-182780

Published: 2023

Journal Articles

Optimizing the Supportive Care of Intensive Chemotherapy in AML : Impact of Vitamin C and D Supplementation in Patients with NPM1 Mutation. a Dataml Registry Study

Pierre Luc Mouchel, Sarah Bertoli, Emilie Berard, Francois Vergez, Jean-Baptiste Rieu, Isabelle Luquet, Laetitia Largeaud, Nathan Guiraud, Jean-Emmanuel Sarry, Audrey Sarry, Francoise Huguet, Suzanne Tavitian, Christian Recher

Blood (2022) 140 (Supplement 1): 3239–3241.

https://doi.org/10.1182/blood-2022-166373

Published: 2022

Journal Articles

Single-Cell Proteomic Analysis Defines Metabolic Heterogeneity in Response to Venetoclax in AML

Lucille Stuani, Astraea Jager, Ambrine Sahal, Abhishek Koladiya, Jolanda Sarno, Pablo Domizi, Yuxuan Liu, Veronique De Mas, Christian Recher, Francois Vergez, Jean-Emmanuel Sarry, Kara L. Davis

Blood (2022) 140 (Supplement 1): 1028–1029.

https://doi.org/10.1182/blood-2022-171009

Published: 2022

Journal Articles

C/EBPα Confers Dependence to Fatty Acid Biosynthetic Pathways and Vulnerability to Lipid Oxidative Stress in FLT3-Mutant Leukemia

Marie Sabatier, Rudy Birsen, Laura Lauture, Léa Goupille, Clement Larrue, Sarah Mouche, Christian Recher, Jerome Tamburini, Jean-Emmanuel Sarry

Blood (2022) 140 (Supplement 1): 3084–3085.

https://doi.org/10.1182/blood-2022-159656

Published: 2022

Journal Articles

Combination of the MEK Inhibitor Trametinib and Pyrvinium Pamoate Efficiently Targets RAS Pathway-Mutated Acute Myeloid Leukemia in Preclinical Models

Blood (2019) 134 (Supplement_1): 2671.

https://doi.org/10.1182/blood-2019-123418

Published: 2019

Journal Articles

PKR-like Endoplasmic Reticulum Kinase Mediates Apoptosis Induced By Pharmacological AMP-Activated Protein Kinase Activation in Acute Myeloid Leukemia

Laury Poulain, PhD, Adrien Grenier, MD PhD, Johanna Mondesir, MD, Arnaud Jacquel, PhD, Claudie Bosc, Lucille Stuani, PhD, Rudy Birsen, MD, Sarah Mouche, Justine Decroocq, MD, Fetta Mazed, PhD, Benoit Viollet, PhD, Patrick Auberger, PhD, Pierre Sujobert, MD PhD, Didier Bouscary, MD PhD, Jean-Emmanuel Sarry, PhD, Jerome Tamburini, MD PhD

Blood (2019) 134 (Supplement_1): 2552.

https://doi.org/10.1182/blood-2019-123364

Published: 2019

Journal Articles

Help from outside: cysteine to survive in AML

Lucille Stuani, Jean-Emmanuel Sarry

Blood (2019) 134 (4): 336–338.

https://doi.org/10.1182/blood.2019001580

Published: 2019

Journal Articles

Extracellular ATP and CD39 Regulates Mitochondrial Function and Cytarabine Resistance through Intrinsic PKA-ATF-PGC1a Pathway in Acute Myeloid Leukemia

Jean-Emmanuel Sarry, PhD, Christian Recher, MD PhD, Nesrine Aroua, PhD

Blood (2018) 132 (Supplement 1): 2737.

https://doi.org/10.1182/blood-2018-99-112534

Published: 2018

Journal Articles

Catabolic Flexibility Enhances Drug Resistance but Induces Selective Vulnerability to New Mitochondrial-Targeted Therapeutic Combinations in IDH Mutant Leukemia

Jean-Emmanuel Sarry, PhD, Christian Recher, MD PhD, Lucille Stuani, PhD, Jean-Charles Portais, PhD

Blood (2018) 132 (Supplement 1): 5238.

https://doi.org/10.1182/blood-2018-99-112523

Published: 2018

Journal Articles

Adrenomedullin Receptor Calcrl Drives Drug Resistance of Leukemic Stem Cells in Acute Myeloid Leukemia

Jean-Emmanuel Sarry, PhD, Christian Recher, MD PhD, Clément Larrue, PhD

Blood (2018) 132 (Supplement 1): 1449.

https://doi.org/10.1182/blood-2018-99-112503

Published: 2018

Journal Articles

Utilization of a-Ketoglutarate for Synthesis of 2-Hydroxyglutarate Oncometabolite Promotes Catabolic Flexibility, Redox Perturbation and Mitochondrial Activity That Supports Chemoresistance in IDH1 Mutant Acute Myeloid Leukemia

Lucille Stuani, PhD, Christian Recher, MD PhD, Jean-Charles Portais, PhD, Jean-Emmanuel Sarry, PhD

Blood (2017) 130 (Supplement 1): 5080.

https://doi.org/10.1182/blood.V130.Suppl_1.5080.5080

Published: 2017

Journal Articles

Dexamethasone Reduces Incidence of Relapse and Improves Overall Survival in Hyperleucocytic Acute Myeloid Leukemia

Christian Récher, MD PhD, Sarah Bertoli, MD PhD, Muriel Picard, MD, Emilie Bérard, MD PhD, Clément Larrue, PhD, Suzanne Tavitian, MD, Francois Vergez, DVM, PhD, Edwige Yon, Jean Ruiz, MD, Eric Delabesse, PharmD, PhD, Isabelle Luquet, MD, Laetitia Linares, PhD, Martin Carroll, MD, Audrey Sarry, Françoise Huguet, MD, Jean-Emmanuel Sarry, PhD

Blood (2016) 128 (22): 1636.

https://doi.org/10.1182/blood.V128.22.1636.1636

Published: 2016

Journal Articles

Protective mitochondrial transfer from bone marrow stromal cells to acute myeloid leukemic cells during chemotherapy

Ruxanda Moschoi, Véronique Imbert, Marielle Nebout, Johanna Chiche, Didier Mary, Thomas Prebet, Estelle Saland, Rémy Castellano, Laurent Pouyet, Yves Collette, Norbert Vey, Christian Chabannon, Christian Recher, Jean-Emmanuel Sarry, Damien Alcor, Jean-François Peyron, Emmanuel Griessinger

Blood (2016) 128 (2): 253–264.

https://doi.org/10.1182/blood-2015-07-655860

Published: 2016

Includes: Supplemental data

Journal Articles

Proteasome inhibitors induce FLT3-ITD degradation through autophagy in AML cells

Clément Larrue, Estelle Saland, Héléna Boutzen, François Vergez, Marion David, Carine Joffre, Marie-Anne Hospital, Jérôme Tamburini, Eric Delabesse, Stéphane Manenti, Jean Emmanuel Sarry, Christian Récher

Blood (2016) 127 (7): 882–892.

https://doi.org/10.1182/blood-2015-05-646497

Published: 2016

Includes: Supplemental data

Journal Articles

Immunophenotypic-Defined Stage of Leukemia Differentiation Arrest Identifies Oncogenic and Metabolic Signatures in AML

Francois Vergez, DVM, PhD, Sarah Bertoli, MD PhD, Marina Bousquet, PhD, Marie-Laure Nicolau-Travers, Michael Peres, PharmD, Estelle Saland, Françoise Huguet, MD, Isabelle Luquet, MD, Veronique Mansat-de Mas, PharmD, PhD, Cecile Demur, MD, Eric Delabesse, MD PhD, Gwenn Danet-Desnoyers, PhD, Jean-Emmanuel Sarry, PhD, Christian Récher, MDPhD

Blood (2015) 126 (23): 90.

https://doi.org/10.1182/blood.V126.23.90.90

Published: 2015

Journal Articles

In Vivo Response to Cytarabine Chemotherapy Uncovers the Role of the Oxidative and Energetic Metabolism in the Chemoresistance of Human Primary AML Stem Cells

Nesrine Aroua, PhD, Jean-Emmanuel Sarry, PhD, Fabienne De Toni, PhD, Robin Carson, MD BA, Francois Vergez, VD PhD, Estelle Saland, Mayumi Sugita, MD, Martin Carroll, MD, Christian Recher, MDPhD, Gwenn Danet, PhD

Blood (2015) 126 (23): 4269.

https://doi.org/10.1182/blood.V126.23.4269.4269

Published: 2015

Journal Articles

The Combination of ATRA and Dasatinib for Differentiation Therapy in Acute Myeloid Leukemias with IDH Mutations

Helena Boutzen, PharmD PhD, Estelle Saland, Mathilde Cathebras, Clément Larrue, PhD, Thomas Farge, Nizar Serhan, PhD, Fabienne De Toni, PhD, Marion David, PhD, Lara Gales, Florence Castelli, Christophe Junot, PhD, Eric Delabesse, PharmD PhD, Demas Veronique, PharmD PhD, Jean-Charles Portais, PhD, Ouathek Ouerfelli, PhD, Yang Guangli, PhD, Francois Vergez, VD PhD, Christian Recher, MDPhD, Jean-Emmanuel Sarry, PhD

Blood (2015) 126 (23): 2542.

https://doi.org/10.1182/blood.V126.23.2542.2542

Published: 2015

NARROW

Deciphering EZH2 Non-Canonical Activities in AML Resistance

Serially Transplantable, Genetically Modified Patient Derived Xenograft Models of Acute Myeloid Leukemia Represent Primary Patients' Cells and Enable Reliable and Reproducible Preclinical Therapy Trials

Minimal Residual Disease in Acute Myeloid Leukemia Following Induction Chemotherapy Can be Effectively Eradicated By Targeting Mitochondrial Metabolism

Ferritinophagy Is a Druggable Vulnerability of Quiescent Leukemic Stem Cells

Optimizing the Supportive Care of Intensive Chemotherapy in AML : Impact of Vitamin C and D Supplementation in Patients with NPM1 Mutation. a Dataml Registry Study

Single-Cell Proteomic Analysis Defines Metabolic Heterogeneity in Response to Venetoclax in AML

C/EBPα Confers Dependence to Fatty Acid Biosynthetic Pathways and Vulnerability to Lipid Oxidative Stress in FLT3-Mutant Leukemia

Combination of the MEK Inhibitor Trametinib and Pyrvinium Pamoate Efficiently Targets RAS Pathway-Mutated Acute Myeloid Leukemia in Preclinical Models

PKR-like Endoplasmic Reticulum Kinase Mediates Apoptosis Induced By Pharmacological AMP-Activated Protein Kinase Activation in Acute Myeloid Leukemia

Help from outside: cysteine to survive in AML

Extracellular ATP and CD39 Regulates Mitochondrial Function and Cytarabine Resistance through Intrinsic PKA-ATF-PGC1a Pathway in Acute Myeloid Leukemia

Catabolic Flexibility Enhances Drug Resistance but Induces Selective Vulnerability to New Mitochondrial-Targeted Therapeutic Combinations in IDH Mutant Leukemia

Adrenomedullin Receptor Calcrl Drives Drug Resistance of Leukemic Stem Cells in Acute Myeloid Leukemia

Utilization of a-Ketoglutarate for Synthesis of 2-Hydroxyglutarate Oncometabolite Promotes Catabolic Flexibility, Redox Perturbation and Mitochondrial Activity That Supports Chemoresistance in IDH1 Mutant Acute Myeloid Leukemia

Dexamethasone Reduces Incidence of Relapse and Improves Overall Survival in Hyperleucocytic Acute Myeloid Leukemia

Protective mitochondrial transfer from bone marrow stromal cells to acute myeloid leukemic cells during chemotherapy

Proteasome inhibitors induce FLT3-ITD degradation through autophagy in AML cells

Immunophenotypic-Defined Stage of Leukemia Differentiation Arrest Identifies Oncogenic and Metabolic Signatures in AML

In Vivo Response to Cytarabine Chemotherapy Uncovers the Role of the Oxidative and Energetic Metabolism in the Chemoresistance of Human Primary AML Stem Cells

The Combination of ATRA and Dasatinib for Differentiation Therapy in Acute Myeloid Leukemias with IDH Mutations

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American Society of Hematology

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ASH Publications

American Society of Hematology

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