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Issue Archive

Volume 126, Issue 8
August 20 2015
Issue Cover

Table of Contents

INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY
FVIII-VWF dos-à-dos
Sriram Krishnaswamy
View Articletitled, FVIII-VWF dos-à-dos
INSIDE BLOOD COMMENTARY
Quantitative FDG-PET: a new biomarker in PMBCL
Clinical Trials & Observations
Michel Meignan
View Articletitled, Quantitative FDG-PET: a new biomarker in PMBCL
INSIDE BLOOD COMMENTARY
Small clots with large impact
Clinical Trials & Observations
Jan Beyer-Westendorf,Walter Ageno
View Articletitled, Small clots with large impact
INSIDE BLOOD COMMENTARY
Engineered T cells can fight malignant T cells
Hans J. Stauss
View Articletitled, Engineered T cells can fight malignant T cells
INSIDE BLOOD COMMENTARY
Dicing up T-ALL
Jon C. Aster
View Articletitled, Dicing up T-ALL
INSIDE BLOOD COMMENTARY
New mutation in hairy cell leukemia
Tadeusz Robak,Piotr Smolewski
View Articletitled, New mutation in hairy cell leukemia
INSIDE BLOOD COMMENTARY
Cladribine for mastocytosis: benefits and risks
Cem Akin
View Articletitled, Cladribine for mastocytosis: benefits and risks
INSIDE BLOOD COMMENTARY
Platelet GPVI repairs its own damage
Julie Rayes,Steve P. Watson
View Articletitled, Platelet GPVI repairs its own damage

PLENARY PAPER

THROMBOSIS AND HEMOSTASIS
Mapping the interaction between factor VIII and von Willebrand factor by electron microscopy and mass spectrometry
Brief Report
Po-Lin Chiu,George M. Bou-Assaf,Ekta Seth Chhabra,Melissa G. Chambers,Robert T. Peters,John D. Kulman,Thomas Walz
View Articletitled, Mapping the interaction between factor VIII and von Willebrand factor by electron microscopy and mass spectrometry
Supplemental data

PLENARY PAPER

THROMBOSIS AND HEMOSTASIS
Visualization of an N-terminal fragment of von Willebrand factor in complex with factor VIII
Brief Report
Andrew Yee,Austin N. Oleskie,Anne M. Dosey,Colin A. Kretz,Robert D. Gildersleeve,Somnath Dutta,Min Su,David Ginsburg,Georgios Skiniotis
View Articletitled, Visualization of an N-terminal fragment of von Willebrand factor in complex with factor VIII
Supplemental data

BLOOD SPOTLIGHT

The biology of pediatric acute megakaryoblastic leukemia
Tanja A. Gruber,James R. Downing
View Articletitled, The biology of pediatric acute megakaryoblastic leukemia

CLINICAL TRIALS AND OBSERVATIONS

Utility of baseline 18FDG-PET/CT functional parameters in defining prognosis of primary mediastinal (thymic) large B-cell lymphoma
Clinical Trials & Observations
Luca Ceriani,Maurizio Martelli,Pier Luigi Zinzani,Andrés J. M. Ferreri,Barbara Botto,Caterina Stelitano,Manuel Gotti,Maria Giuseppina Cabras,Luigi Rigacci,Livio Gargantini,Francesco Merli,Graziella Pinotti,Donato Mannina,Stefano Luminari,Anastasios Stathis,Eleonora Russo,Franco Cavalli,Luca Giovanella,Peter W. M. Johnson,Emanuele Zucca
View Articletitled, Utility of baseline 18FDG-PET/CT functional parameters in defining prognosis of primary mediastinal (thymic) large B-cell lymphoma
Supplemental data
Splanchnic venous thrombosis is a marker of cancer and a prognostic factor for cancer survival
Clinical Trials & Observations
Kirstine K. Søgaard,Dóra K. Farkas,Lars Pedersen,Henrik T. Sørensen
View Articletitled, Splanchnic venous thrombosis is a marker of cancer and a prognostic factor for cancer survival
Supplemental data
Prognostic significance of minimal residual disease in high risk B-ALL: a report from Children’s Oncology Group study AALL0232
Clinical Trials & Observations
Michael J. Borowitz,Brent L. Wood,Meenakshi Devidas,Mignon L. Loh,Elizabeth A. Raetz,Wanda L. Salzer,James B. Nachman,Andrew J. Carroll,Nyla A. Heerema,Julie M. Gastier-Foster,Cheryl L. Willman,Yunfeng Dai,Naomi J. Winick,Stephen P. Hunger,William L. Carroll,Eric Larsen
View Articletitled, Prognostic significance of minimal residual disease in high risk B-ALL: a report from Children’s Oncology Group study AALL0232
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Lipocalin produced by myelofibrosis cells affects the fate of both hematopoietic and marrow microenvironmental cells
Min Lu,Lijuan Xia,Yen-Chun Liu,Tsivia Hochman,Laetizia Bizzari,Daniel Aruch,Jane Lew,Rona Weinberg,Judith D. Goldberg,Ronald Hoffman
View Articletitled, Lipocalin produced by myelofibrosis cells affects the fate of both hematopoietic and marrow microenvironmental cells
Supplemental data

IMMUNOBIOLOGY

A T-cell–directed chimeric antigen receptor for the selective treatment of T-cell malignancies
Maksim Mamonkin,Rayne H. Rouce,Haruko Tashiro,Malcolm K. Brenner
View Articletitled, A T-cell–directed chimeric antigen receptor for the selective treatment of T-cell malignancies
Supplemental data
Live cell evaluation of granzyme delivery and death receptor signaling in tumor cells targeted by human natural killer cells
e-blood
Alexandra C. Vrazo,Adrianne E. Hontz,Sarah K. Figueira,Braeden L. Butler,Julie M. Ferrell,Brock F. Binkowski,Jinzhu Li,Kimberly A. Risma
View Articletitled, Live cell evaluation of granzyme delivery and death receptor signaling in tumor cells targeted by human natural killer cells
Supplemental data

LYMPHOID NEOPLASIA

Dicer1 imparts essential survival cues in Notch-driven T-ALL via miR-21–mediated tumor suppressor Pdcd4 repression
Fabian Junker,Antoine Chabloz,Ute Koch,Freddy Radtke
View Articletitled, Dicer1 imparts essential survival cues in Notch-driven T-ALL via miR-21–mediated tumor suppressor Pdcd4 repression
Supplemental data
Recurrent CDKN1B (p27) mutations in hairy cell leukemia
Brief Report
Sascha Dietrich,Jennifer Hüllein,Stanley Chun-Wei Lee,Barbara Hutter,David Gonzalez,Sandrine Jayne,Martin J. S. Dyer,Małgorzata Oleś,Monica Else,Xiyang Liu,Mikołaj Słabicki,Bian Wu,Xavier Troussard,Jan Dürig,Mindaugas Andrulis,Claire Dearden,Christof von Kalle,Martin Granzow,Anna Jauch,Stefan Fröhling,Wolfgang Huber,Manja Meggendorfer,Torsten Haferlach,Anthony D. Ho,Daniela Richter,Benedikt Brors,Hanno Glimm,Estella Matutes,Omar Abdel Wahab,Thorsten Zenz
View Articletitled, Recurrent <em>CDKN1B</em> (p27) mutations in hairy cell leukemia
Supplemental data

MYELOID NEOPLASIA

Long-term efficacy and safety of cladribine (2-CdA) in adult patients with mastocytosis
CME
Stéphane Barete,Olivier Lortholary,Gandhi Damaj,Isabelle Hirsch,Marie Olivia Chandesris,Caroline Elie,Mohamed Hamidou,Isabelle Durieu,Felipe Suarez,Bernard Grosbois,Nicolas Limal,Emmanuel Gyan,Claire Larroche,Gérard Guillet,Jean Emmanuel Kahn,Philippe Casassus,Karima Amazzough,Hélène Coignard-Biehler,Sophie Georgin-Lavialle,Ludovic Lhermitte,Sylvie Fraitag,Danielle Canioni,Patrice Dubreuil,Olivier Hermine
View Articletitled, Long-term efficacy and safety of cladribine (2-CdA) in adult patients with mastocytosis
Supplemental data

PLATELETS AND THROMBOPOIESIS

Single platelets seal neutrophil-induced vascular breaches via GPVI during immune-complex–mediated inflammation in mice
Angèle Gros,Varouna Syvannarath,Lamia Lamrani,Véronique Ollivier,Stéphane Loyau,Tobias Goerge,Bernhard Nieswandt,Martine Jandrot-Perrus,Benoît Ho-Tin-Noé
View Articletitled, Single platelets seal neutrophil-induced vascular breaches via GPVI during immune-complex–mediated inflammation in mice
Supplemental data

TRANSPLANTATION

Impact of ATG-containing reduced-intensity conditioning after single- or double-unit allogeneic cord blood transplantation
Laurent Pascal,Luciana Tucunduva,Annalisa Ruggeri,Didier Blaise,Patrice Ceballos,Patrice Chevallier,Jan Cornelissen,Natacha Maillard,Reza Tabrizi,Eefke Petersen,Werner Linkesch,Henrik Sengeloev,Chantal Kenzey,Antonio Pagliuca,Ernst Holler,Hermann Einsele,Eliane Gluckman,Vanderson Rocha,Ibrahim Yakoub-Agha,on behalf of Eurocord and the European Society for Blood and Marrow Transplantation
View Articletitled, Impact of ATG-containing reduced-intensity conditioning after single- or double-unit allogeneic cord blood transplantation
Supplemental data
Haploidentical transplant with posttransplant cyclophosphamide vs matched unrelated donor transplant for acute myeloid leukemia
Clinical Trials & Observations
Stefan O. Ciurea,Mei-Jie Zhang,Andrea A. Bacigalupo,Asad Bashey,Frederick R. Appelbaum,Omar S. Aljitawi,Philippe Armand,Joseph H. Antin,Junfang Chen,Steven M. Devine,Daniel H. Fowler,Leo Luznik,Ryotaro Nakamura,Paul V. O’Donnell,Miguel-Angel Perales,Sai Ravi Pingali,David L. Porter,Marcie R. Riches,Olle T. H. Ringdén,Vanderson Rocha,Ravi Vij,Daniel J. Weisdorf,Richard E. Champlin,Mary M. Horowitz,Ephraim J. Fuchs,Mary Eapen
View Articletitled, Haploidentical transplant with posttransplant cyclophosphamide vs matched unrelated donor transplant for acute myeloid leukemia
Supplemental data

BLOOD WORK

Small cell lung cancer mimicking high-grade lymphoma in a patient with concurrent B-cell lymphoproliferative disorder
Ioannis Politikos,Yuri Sheikine
View Articletitled, Small cell lung cancer mimicking high-grade lymphoma in a patient with concurrent B-cell lymphoproliferative disorder
Diagnosing Plasmodium falciparum in a teenage traveler by peripheral blood smear
Lori D. Racsa,Marcos Coutinho Schechter
View Articletitled, Diagnosing <em>Plasmodium falciparum</em> in a teenage traveler by peripheral blood smear

CORRESPONDENCE

Prognostic relevance of MYD88 mutations in CLL: the jury is still out
Clinical Trials & Observations
Panagiotis Baliakas,Anastasia Hadzidimitriou,Andreas Agathangelidis,Davide Rossi,Lesley-Ann Sutton,Jana Kminkova,Lydia Scarfo,Sarka Pospisilova,Gianluca Gaidano,Kostas Stamatopoulos,Paolo Ghia,Richard Rosenquist
View Articletitled, Prognostic relevance of <em>MYD88</em> mutations in CLL: the jury is still out
Supplemental data
The predictive strength of next-generation sequencing MRD detection for relapse compared with current methods in childhood ALL
Clinical Trials & Observations
Michaela Kotrova,Katerina Muzikova,Ester Mejstrikova,Michaela Novakova,Violeta Bakardjieva-Mihaylova,Karel Fiser,Jan Stuchly,Mathieu Giraud,Mikaël Salson,Christiane Pott,Monika Brüggemann,Marc Füllgrabe,Jan Stary,Jan Trka,Eva Fronkova
View Articletitled, The predictive strength of next-generation sequencing MRD detection for relapse compared with current methods in childhood ALL
Supplemental data

ERRATA

Lee DW, Gardner R, Porter DL, et al. Current concepts in the diagnosis and management of cytokine release syndrome. Blood. 2014;124(2):188-195.
View Articletitled, Lee DW, Gardner R, Porter DL, et al. Current concepts in the diagnosis and management of cytokine release syndrome. <em>Blood.</em> 2014;124(2):188-195.
Cervantes F. How I treat myelofibrosis. Blood. 2014;124(17):2635-2642.
View Articletitled, Cervantes F. How I treat myelofibrosis. <em>Blood</em>. 2014;124(17):2635-2642.
Cho B-S, Zeng Z, Mu H, et al. Antileukemia activity of the novel peptidic CXCR4 antagonist LY2510924 as monotherapy and in combination with chemotherapy. Blood. 2015;126(2):222-232.
View Articletitled, Cho B-S, Zeng Z, Mu H, et al. Antileukemia activity of the novel peptidic CXCR4 antagonist LY2510924 as monotherapy and in combination with chemotherapy. <em>Blood</em>. 2015;126(2):222-232.

CONTINUING MEDICAL EDUCATION (CME) QUESTIONS

Efficacy and safety of 2-CdA for mastocytosis
CME
View Articletitled, Efficacy and safety of 2-CdA for mastocytosis
  • Cover Image

    Cover Image

    issue cover

    Normal human bone marrow (BM) mesenchymal stem cells (MSC) are able to differentiate toward cells of different lineages, including adipogenic, osteogenic, and chondrogenic cells. The figure shows the adipocytes that differentiated from normal BM-derived MSCs after incubation for 14 days in medium that favored adipocyte formation. Adipocytes were stained with the fatty acid–binding protein 4 (FABP4) antibody as green, and the nuclei were stained with 4′,6-diamidino-2-phenylindole as blue. See the article by Lu et al on page 972.

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