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Issue Archive

Volume 125, Issue 8
February 19 2015
Issue Cover

Table of Contents

INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY
Removing a hair of doubt about BRAF targeting
Robert J. Kreitman
View Articletitled, Removing a hair of doubt about BRAF targeting
INSIDE BLOOD COMMENTARY
NKT-dependent B-cell activation in Gaucher disease
Mariolina Salio,Vincenzo Cerundolo
View Articletitled, NKT-dependent B-cell activation in Gaucher disease
INSIDE BLOOD COMMENTARY
A 2-way miRror of red blood cells and leukemia
H. Leighton Grimes,Sara E. Meyer
View Articletitled, A 2-way miRror of red blood cells and leukemia
INSIDE BLOOD COMMENTARY
Bone marrow reticulocytes: a Plasmodium vivax affair?
Alfredo Mayor,Pietro Alano
View Articletitled, Bone marrow reticulocytes: a <em>Plasmodium vivax</em> affair?

PLENARY PAPER

PLENARY PAPER
BRAF inhibitors reverse the unique molecular signature and phenotype of hairy cell leukemia and exert potent antileukemic activity
Clinical Trials & Observations
Valentina Pettirossi,Alessia Santi,Elisa Imperi,Guido Russo,Alessandra Pucciarini,Barbara Bigerna,Gianluca Schiavoni,Elisabetta Fortini,Ariele Spanhol-Rosseto,Paolo Sportoletti,Roberta Mannucci,Maria Paola Martelli,Ludger Klein-Hitpass,Brunangelo Falini,Enrico Tiacci
View Articletitled, BRAF inhibitors reverse the unique molecular signature and phenotype of hairy cell leukemia and exert potent antileukemic activity
Supplemental data

REVIEW ARTICLE

Polycomb genes, miRNA, and their deregulation in B-cell malignancies
Gang Greg Wang,Kyle D. Konze,Jianguo Tao
View Articletitled, Polycomb genes, miRNA, and their deregulation in B-cell malignancies

HOW I TREAT

How I treat classical Hodgkin lymphoma in patients infected with human immunodeficiency virus
CME Clinical Trials & Observations
Thomas S. Uldrick,Richard F. Little
View Articletitled, How I treat classical Hodgkin lymphoma in patients infected with human immunodeficiency virus

CLINICAL TRIALS AND OBSERVATIONS

Durable remissions in a pivotal phase 2 study of brentuximab vedotin in relapsed or refractory Hodgkin lymphoma
Clinical Trials & Observations
Ajay K. Gopal,Robert Chen,Scott E. Smith,Stephen M. Ansell,Joseph D. Rosenblatt,Kerry J. Savage,Joseph M. Connors,Andreas Engert,Emily K. Larsen,Xuedong Chi,Eric L. Sievers,Anas Younes
View Articletitled, Durable remissions in a pivotal phase 2 study of brentuximab vedotin in relapsed or refractory Hodgkin lymphoma
Supplemental data

HEMATOPOIESIS AND STEM CELLS

MRTF-SRF signaling is required for seeding of HSC/Ps in bone marrow during development
Patrick Costello,Mathew Sargent,Diane Maurice,Cyril Esnault,Katie Foster,Fernando Anjos-Afonso,Richard Treisman
View Articletitled, MRTF-SRF signaling is required for seeding of HSC/Ps in bone marrow during development
Supplemental data

IMMUNOBIOLOGY

Type II NKT-TFH cells against Gaucher lipids regulate B-cell immunity and inflammation
Shiny Nair,Chandra Sekhar Boddupalli,Rakesh Verma,Jun Liu,Ruhua Yang,Gregory M. Pastores,Pramod K. Mistry,Madhav V. Dhodapkar
View Articletitled, Type II NKT-T<sub>FH</sub> cells against Gaucher lipids regulate B-cell immunity and inflammation
Supplemental data

LYMPHOID NEOPLASIA

Loss of PRDM11 promotes MYC-driven lymphomagenesis
Cathrine Kolster Fog,Fazila Asmar,Christophe Côme,Klaus Thorleif Jensen,Jens Vilstrup Johansen,Tony Bou Kheir,Linda Jacobsen,Carsten Friis,Alison Louw,Louise Rosgaard,Nina Friesgaard Øbro,Hanne Vibeke Marquart,Kristian Anthonsen,Arie Koen Braat,Maarten van Lohuizen,Elisabeth Ralfkiaer,Kirsten Grønbæk,Anders Henrik Lund
View Articletitled, Loss of PRDM11 promotes MYC-driven lymphomagenesis
Supplemental data
The role of the Janus-faced transcription factor PAX5-JAK2 in acute lymphoblastic leukemia
Dagmar Schinnerl,Klaus Fortschegger,Maximilian Kauer,João R. M. Marchante,Reinhard Kofler,Monique L. Den Boer,Sabine Strehl
View Articletitled, The role of the Janus-faced transcription factor PAX5-JAK2 in acute lymphoblastic leukemia
Supplemental data

MYELOID NEOPLASIA

MicroRNA-486-5p is an erythroid oncomiR of the myeloid leukemias of Down syndrome
Lital Shaham,Elena Vendramini,Yubin Ge,Yaron Goren,Yehudit Birger,Marloes R. Tijssen,Maureen McNulty,Ifat Geron,Omer Schwartzman,Liat Goldberg,Stella T. Chou,Holly Pitman,Mitchell J. Weiss,Shulamit Michaeli,Benjamin Sredni,Berthold Göttgens,John D. Crispino,Jeffrey W. Taub,Shai Izraeli
View Articletitled, MicroRNA-486-5p is an erythroid oncomiR of the myeloid leukemias of Down syndrome
Supplemental data
MicroRNA-486 regulates normal erythropoiesis and enhances growth and modulates drug response in CML progenitors
Li-Sheng Wang,Ling Li,Liang Li,Su Chu,Keh-Dong Shiang,Min Li,Hui-Yan Sun,Jun Xu,Feng-Jun Xiao,Guihua Sun,John J. Rossi,YinWei Ho,Ravi Bhatia
View Articletitled, MicroRNA-486 regulates normal erythropoiesis and enhances growth and modulates drug response in CML progenitors
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Colony stimulating factor-1 receptor signaling networks inhibit mouse macrophage inflammatory responses by induction of microRNA-21
e-blood
Cristina I. Caescu,Xingyi Guo,Lydia Tesfa,Tushar D. Bhagat,Amit Verma,Deyou Zheng,E. Richard Stanley
View Articletitled, Colony stimulating factor-1 receptor signaling networks inhibit mouse macrophage inflammatory responses by induction of microRNA-21
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Plasmodium vivax: restricted tropism and rapid remodeling of CD71-positive reticulocytes
Benoit Malleret,Ang Li,Rou Zhang,Kevin S. W. Tan,Rossarin Suwanarusk,Carla Claser,Jee Sun Cho,Esther Geok Liang Koh,Cindy S. Chu,Sasithon Pukrittayakamee,Mah Lee Ng,Florent Ginhoux,Lai Guan Ng,Chwee Teck Lim,François Nosten,Georges Snounou,Laurent Rénia,Bruce Russell
View Articletitled, <em>Plasmodium vivax:</em> restricted tropism and rapid remodeling of CD71-positive reticulocytes
Supplemental data

THROMBOSIS AND HEMOSTASIS

Innovative thrombolytic strategy using a heterodimer diabody against TAFI and PAI-1 in mouse models of thrombosis and stroke
Tine Wyseure,Marina Rubio,Frederik Denorme,Sara Martinez de Lizarrondo,Miet Peeters,Ann Gils,Simon F. De Meyer,Denis Vivien,Paul J. Declerck
View Articletitled, Innovative thrombolytic strategy using a heterodimer diabody against TAFI and PAI-1 in mouse models of thrombosis and stroke
Supplemental data

TRANSPLANTATION

Composite end point of graft-versus-host disease-free, relapse-free survival after allogeneic hematopoietic cell transplantation
Clinical Trials & Observations
Shernan G. Holtan,Todd E. DeFor,Aleksandr Lazaryan,Nelli Bejanyan,Mukta Arora,Claudio G. Brunstein,Bruce R. Blazar,Margaret L. MacMillan,Daniel J. Weisdorf
View Articletitled, Composite end point of graft-versus-host disease-free, relapse-free survival after allogeneic hematopoietic cell transplantation
Supplemental data

VASCULAR BIOLOGY

Intraperitoneal administration of activated protein C prevents postsurgical adhesion band formation
Peyman Dinarvand,Seyed Mahdi Hassanian,Hartmut Weiler,Alireza R. Rezaie
View Articletitled, Intraperitoneal administration of activated protein C prevents postsurgical adhesion band formation
Supplemental data

BLOOD WORK

Metastatic prostate cancer mimicking thrombotic thrombocytopenic purpura
Patrick T. Griffin,Michael Jaglal
View Articletitled, Metastatic prostate cancer mimicking thrombotic thrombocytopenic purpura

CORRESPONDENCE

Effect of viral decontamination measures on Wright-stained blood smears
Clinical Trials & Observations
Jay N. Lozier,Katherine R. Calvo
View Articletitled, Effect of viral decontamination measures on Wright-stained blood smears
Natural killer (NK) cell function in paroxysmal nocturnal hemoglobinuria: a deficiency of NK cells, but not an NK cell deficiency
Yasser M. El-Sherbiny,Gina M. Doody,Richard J. Kelly,Anita Hill,Peter Hillmen,Graham P. Cook
View Articletitled, Natural killer (NK) cell function in paroxysmal nocturnal hemoglobinuria: a deficiency of NK cells, but not an NK cell deficiency
Supplemental data
Comparison of transplantation with reduced and myeloablative conditioning for children with acute lymphoblastic leukemia
Koji Kato,Motohiro Kato,Daiichiro Hasegawa,Hirohide Kawasaki,Hiroyuki Ishida,Yasuhiro Okamoto,Katsuyoshi Koh,Masami Inoue,Jiro Inagaki,Keisuke Kato,Hisashi Sakamaki,Hiromasa Yabe,Keisei Kawa,Ritsuro Suzuki,Yoshiko Atsuta
View Articletitled, Comparison of transplantation with reduced and myeloablative conditioning for children with acute lymphoblastic leukemia

CONTINUING MEDICAL EDUCATION (CME) QUESTIONS

How I treat HIV-Hodgkin lymphoma
CME
View Articletitled, How I treat HIV-Hodgkin lymphoma
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