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Shernan G. Holtan
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Journal Articles

JAK2/mTOR inhibition fails to prevent acute GVHD despite reduced Th1/Th17 cells: final phase 2 trial results

Clinical Trials & Observations
Joseph Pidala, Shernan G. Holtan, Kelly Walton, Jongphil Kim, Biwei Cao, Hany Elmariah, Asmita Mishra, Nelli Bejanyan, Taiga Nishihori, Farhad Khimani, Lia Perez, Rawan G. Faramand, Marco L. Davila, Shannon McSain, Jordan Pleskow, Jeffrey Baron, Claudio Anasetti, Carlos Moran Segura, Daniel J. Weisdorf, Bruce R. Blazar, Jeffrey S. Miller, Veronika Bachanova, Najla El Jurdi, Brian C. Betts
Journal: Blood
Blood (2024) 144 (22): 2295–2307.
https://doi.org/10.1182/blood.2024024789
Published: 2024
Includes: Supplemental data
Journal Articles

Should Transplant Centers Prioritize Further Stem Cell Collection for Future CAR T-Cell Therapy Boosts? an Economic and Clinical Assessment

Ehsan Malek, Marco Davila, Hector Tirado, Shernan G. Holtan, Brian Betts, Han Yu
Journal: Blood
Blood (2024) 144 (Supplement 1): 7252.
https://doi.org/10.1182/blood-2024-200893
Published: 2024
Journal Articles

Superiority of Post-Transplant Cyclophosphamide-Based Graft Versus Host Disease (GvHD) Prophylaxis in Patients 70 Years and Older: A BMT CTN 1703 Post-Hoc Analysis

Sameem Abedin, Qinghua Lian, Michael J Martens, MHD Monzr M. Al Malki, Hany Elmariah, Mahasweta Gooptu, Karilyn T. Larkin, Brian C. Shaffer, Alison W Loren, Melhem M. Solh, Amin M. Alousi, Omer Jamy, Janny M. Yao, Kristy Applegate, Miguel Angel Perales, Leslie Kean, Yvonne A. Efebera, Ran Reshef, William Clark, Eric Leifer, Mary M. Horowitz, Richard J. Jones, Javier Bolanos-Meade, Shernan G. Holtan, Mehdi Hamadani
Journal: Blood
Blood (2024) 144 (Supplement 1): 1042.
https://doi.org/10.1182/blood-2024-193827
Published: 2024
Journal Articles

Influence of Myeloma Cell Expressed CD28 and CD86 on BCMA CAR T Cell Efficacy and Immune Effector Cell Associated Neurotoxicity Syndrome (ICANS)

Ehsan Malek, Kimberly Crasti, Grant Schofield, Shernan G. Holtan, Megan M Herr, Marco Davila, You-Wen Qian, Brian Betts, Mackenzie Lieberman, Jason Tong, Colin Chavel, Kelvin P. Lee, Scott Olejniczak
Journal: Blood
Blood (2024) 144 (Supplement 1): 3445.
https://doi.org/10.1182/blood-2024-198255
Published: 2024
Journal Articles

Dynamics of Fecal Antibiotic-Resistance Genes after Fecal Microbiota Transplantation in Allogeneic Hematopoietic Cell Transplant Recipients and AML Patients: Results from a Randomized Placebo-Controlled Trial

Armin Rashidi, Maryam Ebadi, Tauseef Ur Rehman, Heba Elhusseini, David Kazadi, Hossam Halaweish, Chang Liu, Mohammad H Khan, Andrea Hoeschen, Qing Cao, Xianghua Luo, Amanda Kabage, Sharon Lopez, Shernan G. Holtan, Daniel Weisdorf, Alexander Khoruts, Satoshi Ishii, Christopher M Staley
Journal: Blood
Blood (2023) 142 (Supplement 1): 4936.
https://doi.org/10.1182/blood-2023-182998
Published: 2023
Journal Articles

Treatment- Sensitive, Dependent, and Refractory Chronic Gvhd: Incidence and Clinical Outcomes

Shannon Herzog, Ryan Shanley, Shernan G. Holtan, Margaret L. MacMillan, Daniel Weisdorf, Najla H El Jurdi
Journal: Blood
Blood (2023) 142 (Supplement 1): 4935.
https://doi.org/10.1182/blood-2023-178693
Published: 2023
Journal Articles

Phase I Study of FT538 + Daratumumab for Treatment of r/r AML

Joseph E. Maakaron, Cassie Seichter, Rose Wangen, Andrea Hoeschen, Deepa Kolaseri Krishnadas, Kateryna Kent, Ryan Shanley, Daniel O'Leary, Najla H El Jurdi, Shernan G. Holtan, Brian Betts, Mark Juckett, Jeffrey S Miller
Journal: Blood
Blood (2023) 142 (Supplement 1): 4842.
https://doi.org/10.1182/blood-2023-189132
Published: 2023
Journal Articles

Patient-Reported Outcomes of BMT CTN 1703: A Randomized Phase III Study for Gvhd Prophylaxis - a Quality of Life Evaluation

Shernan G. Holtan, Michael J Martens, Monzr M. Al Malki, Yvonne Efebera, Carrie L. Kitko, Ran Reshef, Andrew R. Rezvani, Brian C. Shaffer, Melhem M. Solh, Janny M. Yao, Lyndsey Runaas, Hany Elmariah, Karilyn T. Larkin, Najla H El Jurdi, Mahasweta Gooptu, Alison W Loren, Aric C. Hall, Amin Alousi, Omer Jamy, William Clark, Leslie Kean, Ami S. Bhatt, Miguel-Angel Perales, Kristy Applegate, Juan WU, Eric Liefer, Nancy DiFronzo, Richard J. Jones, Mary M. Horowitz, Deborah Mattila, Mehdi Hamadani, Javier Bolanos-Meade
Journal: Blood
Blood (2023) 142 (Supplement 1): 897.
https://doi.org/10.1182/blood-2023-187859
Published: 2023
Journal Articles

Large-Scale Post-Transplant TCR Deep Sequencing Reveals a Major T Cell Diversity Bottleneck with Post-Transplant Cyclophosphamide with Implications for Both Efficacy and Toxicity: Results of the BMT CTN 1801 Study

Leslie Kean, Steven J Siegel, Joseph T Schmalz, Stephanie A Bien, Danielle Scheffey, Catherine Sanders, Harlan Robins, Kristy Applegate, Merav Bar, Saurabh Chhabra, Sung W. Choi, William Clark, Suman r Das, Robert R. Jenq, Richard J. Jones, John Levine, Brent R. Logan, Hemant S. Murthy, Armin Rashidi, Marcie L. Riches, Wael Saber, Karamjeet S. Sandhu, Anthony D. Sung, Karilyn Larkin, Monzr M. Al Malki, Mahasweta Gooptu, Hany Elmariah, Amin Alousi, Lyndsey Runaas, Brian C. Shaffer, Andrew R. Rezvani, Najla El Jurdi, Alison Loren, Mary M. Horowitz, Javier Bolanos-Meade, Shernan G. Holtan, Ami S. Bhatt, Miguel-Angel Perales, Susan DeWolf
Journal: Blood
Blood (2023) 142 (Supplement 1): 475.
https://doi.org/10.1182/blood-2023-188032
Published: 2023
Journal Articles

JAK2/mTOR Inhibition Fails to Prevent Acute Gvhd Despite Reduced Th1/Th17 Cells: Final Phase II Trial Results

Joseph Pidala, Shernan G. Holtan, Kelly Walton, Jongphil Kim, Hany Elmariah, Asmita Mishra, Nelli Bejanyan, Taiga Nishihori, Farhad Khimani, Lia Perez, Rawan Faramand, Marco Davila, Claudio Anasetti, Daniel Weisdorf, Bruce R Blazar, Jeffrey S Miller, Veronika Bachanova, Najla H El Jurdi, Brian C Betts
Journal: Blood
Blood (2023) 142 (Supplement 1): 2177.
https://doi.org/10.1182/blood-2023-173376
Published: 2023
Journal Articles

Aurora Kinase a Inhibition for Gvhd and Relapse Prevention after Allogeneic HCT: Phase I Trial in Combination with Ptcy/Sirolimus

Shernan G. Holtan, Kelly Walton, Najla H El Jurdi, Joseph E. Maakaron, Mark Juckett, Veronika Bachanova, Thomas Myers, Linda J. Paradiso, Todd DeFor, Qing Cao, Brian Betts
Journal: Blood
Blood (2023) 142 (Supplement 1): 4925.
https://doi.org/10.1182/blood-2023-181292
Published: 2023
Journal Articles

Simvastatin with Intrathecal Dexamethasone Reduces Neurotoxicity in Adults Receiving Chimeric Antigen Receptor (CAR) T-Cells Treatment

Nuttavut Sumransub, Cassie Seichter, Kateryna Kent, Ryan Shanley, Marie Hu, Daniel O'Leary, Najla H El Jurdi, Shernan G. Holtan, Brian Betts, Mark Juckett, Jeremy R. Allred, Veronika Bachanova, Jeffrey S Miller, Joseph E. Maakaron
Journal: Blood
Blood (2023) 142 (Supplement 1): 3493.
https://doi.org/10.1182/blood-2023-187070
Published: 2023
Journal Articles

Post-Transplant Cyclophosphamide, Tacrolimus, and Mycophenolate Mofetil As the New Standard for Graft-Versus-Host Disease (GVHD) Prophylaxis in Reduced Intensity Conditioning: Results from Phase III BMT CTN 1703

Shernan G Holtan, Mehdi Hamadani, Juan WU, Monzr M. AL Malki, Lyndsey Runaas, Hany Elmariah, Andrew R. Rezvani, Mahasweta Gooptu, Karilyn T. Larkin, Brian C. Shaffer, Najla H El Jurdi, Alison W. Loren, Melhem Solh, Aric C. Hall, Amin M Alousi, Omer H Jamy, Miguel-Angel Perales, Janny M. Yao, Kristy Applegate, Ami S. Bhatt, Leslie S. Kean, Yvonne A. Efebera, Carrie Lynn Kitko, Ran Reshef, William Clark, Nancy L. DiFronzo, Lori Henderson, Richard J. Jones, Eric Liefer, Michael J Martens, Mary M. Horowitz, Javier Bolanos-Meade
Journal: Blood
Blood (2022) 140 (Supplement 2): LBA-4.
https://doi.org/10.1182/blood-2022-171463
Published: 2022
Journal Articles

Patient-Reported Outcomes in Long-Term Survivors of Autologous Hematopoietic Cell Transplantation for Hodgkin and Non-Hodgkin Lymphoma: Secondary Analysis from Two Multi-Center Randomized Controlled Trials of Hematopoietic Cell Transplant Survivorship Interventions

Agrima Mian, Wei Wei, Rajshekhar Chakraborty, Jean C. Yi, Jaime M. Preussler, Brian T. Hill, Jan Cerny, Abhinav Deol, Theresa E. Hahn, Shahrukh K. Hashmi, Samantha Jaglowski, Heather S.L. Jim, Nandita Khera, Alison W. Loren, Joseph P. McGuirk, Bipin N. Savani, Patrick Stiff, Joseph P. Uberti, Victoria Whalen, John R. Wingard, Jana Reynolds, Shernan G Holtan, William A. Wood, K. Scott Baker, Karen L. Syrjala, Betty K. Hamilton, Navneet S. Majhail
Journal: Blood
Blood (2022) 140 (Supplement 1): 8019–8021.
https://doi.org/10.1182/blood-2022-167411
Published: 2022
Journal Articles

Neihulizumab (ALTB-168) in Patients with Steroid-Refractory Acute Graft-Versus-Host-Disease (SR-aGVHD) or Treatment-Refractory Acute Graft-Versus-Host-Disease (TR-aGVHD)

Sameem Abedin, Mehdi Hamadani, Shernan G Holtan, Gary J. Schiller, Molly Gallogly, Edmund K. Waller, Satyajit Kosuri, Sunil H Abhyankar, Sarah M. Anand, Mahasweta Gooptu, Iming Cho, Simona Reed, Shih-Yao Lin, Jesse W Hall, Paul J Martin
Journal: Blood
Blood (2022) 140 (Supplement 1): 10495–10497.
https://doi.org/10.1182/blood-2022-163027
Published: 2022
Journal Articles

Chronic Gvhd Following Steroid Sensitive, Dependent, and Refractory Acute Gvhd: Incidence and Clinical Outcomes

Shannon Herzog, Daniel J. Weisdorf, Ryan Shanley, Margaret L. MacMillan, Shernan G Holtan, Najla El Jurdi
Journal: Blood
Blood (2022) 140 (Supplement 1): 10493–10494.
https://doi.org/10.1182/blood-2022-158814
Published: 2022
Journal Articles

Phase II Study of Myeloablative 8/8- or 7/8-Matched Allotransplantation with Post-Transplant Cyclophosphamide, Tacrolimus, and Mycophenolate Mofetil: Marked Reduction in Gvhd Risk without Increased Relapse Risk Compared to Historical Cyclosporine/Methotrexate

Alex Hoover, Daniel O'Leary, Qing Cao, Ashish O. Gupta, Christen L. Ebens, Joseph E. Maakaron, Brian C. Betts, Mark Juckett, Troy C. Lund, Veronika Bachanova, Margaret L. MacMillan, Jeffrey S. Miller, MD, Paul J. Orchard, John E Wagner, Gregory M. Vercellotti, Daniel J. Weisdorf, Kathryn Dusenbery, Stephanie Terezakis, Shernan G Holtan, Najla H El Jurdi
Journal: Blood
Blood (2022) 140 (Supplement 1): 282–283.
https://doi.org/10.1182/blood-2022-165782
Published: 2022
Journal Articles

Radiation Sparing Reduced Intensity Conditioning for Allogeneic Cell Transplantation in Patients with Dyskeratosis Congenita Comparable to Standard of Care: A Phase III Single Institution Trial

Marketa Dimitrov, Svatava Merkle, Gregory M. Vercellotti, Shernan G Holtan, Jakub Tolar, Christen L. Ebens
Journal: Blood
Blood (2022) 140 (Supplement 1): 7611–7612.
https://doi.org/10.1182/blood-2022-165290
Published: 2022
Journal Articles

Low Incidence of Chronic Graft-Versus-Host Disease in Myeloablative Allogeneic Hematopoietic Cell Transplantation with Post-Transplant Cyclophosphamide Using Matched Related or Unrelated Donors: Phase II Study Interim Analysis

Najla H El Jurdi, Daniel O'Leary, Fiona He, Todd E. DeFor, Armin Rashidi, Erica D. Warlick, Ashish O. Gupta, Joseph E. Maakaron, Mukta Arora, Murali Janakiram, Arne Slungaard, Angela R. Smith, Veronika Bachanova, Claudio G. Brunstein, Margaret L. MacMillan, Jeffrey S. Miller, Brian C. Betts, Christen L. Ebens, Heather Stefanski, Troy C Lund, Paul Orchard, Gregory M. Vercellotti, Daniel J. Weisdorf, Shernan G Holtan
Journal: Blood
Blood (2021) 138 (Supplement 1): 1811.
https://doi.org/10.1182/blood-2021-147569
Published: 2021
Journal Articles

Circulating Metabolomics Suggest Neutropenic Fever As a Metabolic Derangement Related to Intestinal Tissue Damage and Gut Dysbiosis

Armin Rashidi, Maryam Ebadi, Tauseef Ur Rehman, Heba Elhusseini, Harika Nalluri, Thomas Kaiser, Sivapriya Ramamoorthy, Shernan G Holtan, Alexander Khoruts, Daniel J. Weisdorf, Christopher Staley
Journal: Blood
Blood (2021) 138 (Supplement 1): 688.
https://doi.org/10.1182/blood-2021-146644
Published: 2021