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Volume 125, Issue 17
April 23 2015
Issue Cover

Table of Contents

EDITORIAL

Introduction to a review series on hematopoietic stem cells
Margaret Goodell
View Articletitled, Introduction to a review series on hematopoietic stem cells

INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY
Sickle cell and silent spleen
Jakub Tolar
View Articletitled, Sickle cell and silent spleen
INSIDE BLOOD COMMENTARY
Osteoblast ablation burns out functional stem cells
Meng Zhao,Linheng Li
View Articletitled, Osteoblast ablation burns out functional stem cells
INSIDE BLOOD COMMENTARY
Disabling the platelet’s brakes to promote thrombosis
Roy L. Silverstein
View Articletitled, Disabling the platelet’s brakes to promote thrombosis
INSIDE BLOOD COMMENTARY
GVHD clears the Aire in thymic selection
Mojibade N. Hassan,Edmund K. Waller
View Articletitled, GVHD clears the Aire in thymic selection

PLENARY PAPER

GENE THERAPY
Correction of the sickle cell disease mutation in human hematopoietic stem/progenitor cells
Megan D. Hoban,Gregory J. Cost,Matthew C. Mendel,Zulema Romero,Michael L. Kaufman,Alok V. Joglekar,Michelle Ho,Dianne Lumaquin,David Gray,Georgia R. Lill,Aaron R. Cooper,Fabrizia Urbinati,Shantha Senadheera,Allen Zhu,Pei-Qi Liu,David E. Paschon,Lei Zhang,Edward J. Rebar,Andrew Wilber,Xiaoyan Wang,Philip D. Gregory,Michael C. Holmes,Andreas Reik,Roger P. Hollis,Donald B. Kohn
View Articletitled, Correction of the sickle cell disease mutation in human hematopoietic stem/progenitor cells
Supplemental data

REVIEW SERIES

Hematopoietic stem cells: concepts, definitions, and the new reality
Connie J. Eaves
View Articletitled, Hematopoietic stem cells: concepts, definitions, and the new reality

REVIEW SERIES

Regulatory network control of blood stem cells
Berthold Göttgens
View Articletitled, Regulatory network control of blood stem cells

REVIEW SERIES

Making sense of hematopoietic stem cell niches
Philip E. Boulais,Paul S. Frenette
View Articletitled, Making sense of hematopoietic stem cell niches

REVIEW SERIES

Xenograft models for normal and malignant stem cells
Susumu Goyama,Mark Wunderlich,James C. Mulloy
View Articletitled, Xenograft models for normal and malignant stem cells

REVIEW SERIES

De novo generation of HSCs from somatic and pluripotent stem cell sources
Linda T. Vo,George Q. Daley
View Articletitled, De novo generation of HSCs from somatic and pluripotent stem cell sources

CLINICAL TRIALS AND OBSERVATIONS

Results of a phase 2 study of pacritinib (SB1518), a JAK2/JAK2(V617F) inhibitor, in patients with myelofibrosis
Clinical Trials & Observations
Rami S. Komrokji,John F. Seymour,Andrew W. Roberts,Martha Wadleigh,L. Bik To,Robyn Scherber,Elyce Turba,Andrew Dorr,Joy Zhu,Lixia Wang,Tanya Granston,Mary S. Campbell,Ruben A. Mesa
View Articletitled, Results of a phase 2 study of pacritinib (SB1518), a JAK2/JAK2(V617F) inhibitor, in patients with myelofibrosis
Supplemental data
Randomized phase 2 study of GMI-1070 in SCD: reduction in time to resolution of vaso-occlusive events and decreased opioid use
Clinical Trials & Observations
Marilyn J. Telen,Ted Wun,Timothy L. McCavit,Laura M. De Castro,Lakshmanan Krishnamurti,Sophie Lanzkron,Lewis L. Hsu,Wally R. Smith,Seungshin Rhee,John L. Magnani,Helen Thackray
View Articletitled, Randomized phase 2 study of GMI-1070 in SCD: reduction in time to resolution of vaso-occlusive events and decreased opioid use
Supplemental data

IMMUNOBIOLOGY

Aberrant TCRδ rearrangement underlies the T-cell lymphocytopenia and t(12;14) translocation associated with ATM deficiency
Brief Report
Wenxia Jiang,Brian J. Lee,Chen Li,Richard L. Dubois,Monica Gostissa,Frederick W. Alt,Shan Zha
View Articletitled, Aberrant TCRδ rearrangement underlies the T-cell lymphocytopenia and t(12;14) translocation associated with ATM deficiency
Supplemental data

LYMPHOID NEOPLASIA

miR-18b overexpression identifies mantle cell lymphoma patients with poor outcome and improves the MIPI-B prognosticator
Simon Husby,Ulrik Ralfkiaer,Christian Garde,Roza Zandi,Sara Ek,Arne Kolstad,Mats Jerkeman,Anna Laurell,Riikka Räty,Lone B. Pedersen,Anja Pedersen,Mats Ehinger,Christer Sundström,Marja-Liisa Karjalainen-Lindsberg,Jan Delabie,Erik Clasen-Linde,Peter Brown,Jack B. Cowland,Christopher T. Workman,Christian H. Geisler,Kirsten Grønbæk
View Articletitled, miR-18b overexpression identifies mantle cell lymphoma patients with poor outcome and improves the MIPI-B prognosticator
Supplemental data

MYELOID NEOPLASIA

Osteoblast ablation reduces normal long-term hematopoietic stem cell self-renewal but accelerates leukemia development
Marisa Bowers,Bin Zhang,Yinwei Ho,Puneet Agarwal,Ching-Cheng Chen,Ravi Bhatia
View Articletitled, Osteoblast ablation reduces normal long-term hematopoietic stem cell self-renewal but accelerates leukemia development
Supplemental data
Decitabine priming enhances the antileukemic effects of exportin 1 (XPO1) selective inhibitor selinexor in acute myeloid leukemia
Brief Report
Parvathi Ranganathan,Xueyan Yu,Ramasamy Santhanam,Jessica Hofstetter,Alison Walker,Katherine Walsh,Bhavana Bhatnagar,Rebecca Klisovic,Sumithira Vasu,Mitch A. Phelps,Steven Devine,Sharon Shacham,Michael Kauffman,Guido Marcucci,William Blum,Ramiro Garzon
View Articletitled, Decitabine priming enhances the antileukemic effects of exportin 1 (XPO1) selective inhibitor selinexor in acute myeloid leukemia
Supplemental data

PLATELETS AND THROMBOPOIESIS

Oxidized LDL activates blood platelets through CD36/NOX2–mediated inhibition of the cGMP/protein kinase G signaling cascade
Simbarashe Magwenzi,Casey Woodward,Katie S. Wraith,Ahmed Aburima,Zaher Raslan,Huw Jones,Catriona McNeil,Stephen Wheatcroft,Nadira Yuldasheva,Maria Febbriao,Mark Kearney,Khalid M. Naseem
View Articletitled, Oxidized LDL activates blood platelets through CD36/NOX2–mediated inhibition of the cGMP/protein kinase G signaling cascade
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Merozoite surface protein 1 recognition of host glycophorin A mediates malaria parasite invasion of red blood cells
Michael R. Baldwin,Xuerong Li,Toshihiko Hanada,Shih-Chun Liu,Athar H. Chishti
View Articletitled, Merozoite surface protein 1 recognition of host glycophorin A mediates malaria parasite invasion of red blood cells

THROMBOSIS AND HEMOSTASIS

Arterial thrombosis is accelerated in mice deficient in histidine-rich glycoprotein
Trang T. Vu,Ji Zhou,Beverly A. Leslie,Alan R. Stafford,James C. Fredenburgh,Ran Ni,Shengjun Qiao,Nima Vaezzadeh,Willi Jahnen-Dechent,Brett P. Monia,Peter L. Gross,Jeffrey I. Weitz
View Articletitled, Arterial thrombosis is accelerated in mice deficient in histidine-rich glycoprotein
Supplemental data

TRANSPLANTATION

Impaired thymic expression of tissue-restricted antigens licenses the de novo generation of autoreactive CD4+ T cells in acute GVHD
Brief Report
Simone Dertschnig,Mathias M. Hauri-Hohl,Madeleine Vollmer,Georg A. Holländer,Werner Krenger
View Articletitled, Impaired thymic expression of tissue-restricted antigens licenses the de novo generation of autoreactive CD4<sup>+</sup> T cells in acute GVHD
Supplemental data
BET bromodomain inhibition suppresses graft-versus-host disease after allogeneic bone marrow transplantation in mice
Brief Report
Yaping Sun,Ying Wang,Tomomi Toubai,Katherine Oravecz-Wilson,Chen Liu,Nathan Mathewson,Julia Wu,Corinne Rossi,Emily Cummings,Depei Wu,Shaomeng Wang,Pavan Reddy
View Articletitled, BET bromodomain inhibition suppresses graft-versus-host disease after allogeneic bone marrow transplantation in mice

BLOOD WORK

Howell-Jolly–like bodies in neutrophils
R. Grant Rowe,Erica Esrick
View Articletitled, Howell-Jolly–like bodies in neutrophils

CORRESPONDENCE

CCMCL1: a new model of aggressive mantle cell lymphoma
Xiaoxian Zhao,Selina Chen-Kiang,Shashirekha Shetty,Maurizio Di Liberto,Juraj Bodo,Lisa Durkin,Ken Eng,Olivier Elemento,Mitchell R. Smith,Eric D. Hsi
View Articletitled, CCMCL1: a new model of aggressive mantle cell lymphoma
Supplemental data
NHLBI Strategic Visioning: setting an agenda together for the NHLBI of 2025
William Keith Hoots,James P. Kiley,Stephen C. Mockrin,Michael Lauer,George A. Mensah,Yasin Patel,Nakela L. Cook,Amy P. Patterson,Gary H. Gibbons
View Articletitled, NHLBI Strategic Visioning: setting an agenda together for the NHLBI of 2025

ERRATA

Smith SD, Redman M, Dunleavy K. FDG PET-CT in follicular lymphoma: a case-based evidence review. Blood. 2015;125(7):1078-1082.
View Articletitled, Smith SD, Redman M, Dunleavy K. FDG PET-CT in follicular lymphoma: a case-based evidence review. <em>Blood.</em> 2015;125(7):1078-1082.
Bernaudin F, Verlhac S, Arnaud C, et al. Chronic acute anemia and extracranial internal carotid stenosis are risk factors for silent cerebral infarcts in sickle cell anemia. Blood. 2015;125(10):1653-1661.
View Articletitled, Bernaudin F, Verlhac S, Arnaud C, et al. Chronic acute anemia and extracranial internal carotid stenosis are risk factors for silent cerebral infarcts in sickle cell anemia. <em>Blood.</em> 2015;125(10):1653-1661.
  • Cover Image

    Cover Image

    issue cover

    Thrombi induced by FeCl3 application to mouse carotid arteries are rich in platelets, fibrin, RNA, and histidine-rich glycoprotein (HRG). Extracellular RNA is a driver of coagulation via the contact pathway. HRG binds RNA and attenuates its procoagulant activities, an observation confirmed in HRG-deficient mice. The image is a carotid artery section from a wild-type mouse exposed to FeCl3-exhibiting fibrin (green) and a thrombus (magenta), composed of platelets (red) and HRG (blue). See the article by Vu et al on page 2712.

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