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Results of a phase 2 study of pacritinib (SB1518), a JAK2/JAK2(V617F) inhibitor, in patients with myelofibrosis
Randomized phase 2 study of GMI-1070 in SCD: reduction in time to resolution of vaso-occlusive events and decreased opioid use
Decitabine priming enhances the antileukemic effects of exportin 1 (XPO1) selective inhibitor selinexor in acute myeloid leukemia
Issue Archive
April 23 2015
In this Issue
Table of Contents
EDITORIAL
INSIDE BLOOD COMMENTARIES
PLENARY PAPER
GENE THERAPY
Correction of the sickle cell disease mutation in human hematopoietic stem/progenitor cells
Megan D. Hoban,Gregory J. Cost,Matthew C. Mendel,Zulema Romero,Michael L. Kaufman,Alok V. Joglekar,Michelle Ho,Dianne Lumaquin,David Gray,Georgia R. Lill,Aaron R. Cooper,Fabrizia Urbinati,Shantha Senadheera,Allen Zhu,Pei-Qi Liu,David E. Paschon,Lei Zhang,Edward J. Rebar,Andrew Wilber,Xiaoyan Wang,Philip D. Gregory,Michael C. Holmes,Andreas Reik,Roger P. Hollis,Donald B. Kohn
REVIEW SERIES
REVIEW SERIES
REVIEW SERIES
REVIEW SERIES
REVIEW SERIES
CLINICAL TRIALS AND OBSERVATIONS
Results of a phase 2 study of pacritinib (SB1518), a JAK2/JAK2(V617F) inhibitor, in patients with myelofibrosis
Clinical Trials & Observations
Rami S. Komrokji,John F. Seymour,Andrew W. Roberts,Martha Wadleigh,L. Bik To,Robyn Scherber,Elyce Turba,Andrew Dorr,Joy Zhu,Lixia Wang,Tanya Granston,Mary S. Campbell,Ruben A. Mesa
Randomized phase 2 study of GMI-1070 in SCD: reduction in time to resolution of vaso-occlusive events and decreased opioid use
Clinical Trials & Observations
Marilyn J. Telen,Ted Wun,Timothy L. McCavit,Laura M. De Castro,Lakshmanan Krishnamurti,Sophie Lanzkron,Lewis L. Hsu,Wally R. Smith,Seungshin Rhee,John L. Magnani,Helen Thackray
IMMUNOBIOLOGY
LYMPHOID NEOPLASIA
miR-18b overexpression identifies mantle cell lymphoma patients with poor outcome and improves the MIPI-B prognosticator
Simon Husby,Ulrik Ralfkiaer,Christian Garde,Roza Zandi,Sara Ek,Arne Kolstad,Mats Jerkeman,Anna Laurell,Riikka Räty,Lone B. Pedersen,Anja Pedersen,Mats Ehinger,Christer Sundström,Marja-Liisa Karjalainen-Lindsberg,Jan Delabie,Erik Clasen-Linde,Peter Brown,Jack B. Cowland,Christopher T. Workman,Christian H. Geisler,Kirsten Grønbæk
MYELOID NEOPLASIA
Decitabine priming enhances the antileukemic effects of exportin 1 (XPO1) selective inhibitor selinexor in acute myeloid leukemia
Brief Report
Parvathi Ranganathan,Xueyan Yu,Ramasamy Santhanam,Jessica Hofstetter,Alison Walker,Katherine Walsh,Bhavana Bhatnagar,Rebecca Klisovic,Sumithira Vasu,Mitch A. Phelps,Steven Devine,Sharon Shacham,Michael Kauffman,Guido Marcucci,William Blum,Ramiro Garzon
PLATELETS AND THROMBOPOIESIS
Oxidized LDL activates blood platelets through CD36/NOX2–mediated inhibition of the cGMP/protein kinase G signaling cascade
Simbarashe Magwenzi,Casey Woodward,Katie S. Wraith,Ahmed Aburima,Zaher Raslan,Huw Jones,Catriona McNeil,Stephen Wheatcroft,Nadira Yuldasheva,Maria Febbriao,Mark Kearney,Khalid M. Naseem
RED CELLS, IRON, AND ERYTHROPOIESIS
THROMBOSIS AND HEMOSTASIS
TRANSPLANTATION
BLOOD WORK
CORRESPONDENCE
ERRATA
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Cover Image
Cover Image
Thrombi induced by FeCl3 application to mouse carotid arteries are rich in platelets, fibrin, RNA, and histidine-rich glycoprotein (HRG). Extracellular RNA is a driver of coagulation via the contact pathway. HRG binds RNA and attenuates its procoagulant activities, an observation confirmed in HRG-deficient mice. The image is a carotid artery section from a wild-type mouse exposed to FeCl3-exhibiting fibrin (green) and a thrombus (magenta), composed of platelets (red) and HRG (blue). See the article by Vu et al on page 2712.
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