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Issue Archive

Volume 124, Issue 26
December 18 2014
Issue Cover

Table of Contents

INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY
Transplant for CLL: still an option?
Samantha M. Jaglowski
View Articletitled, Transplant for CLL: still an option?
INSIDE BLOOD COMMENTARY
GlycoPEGylated factor IX: a new step forward
Clinical Trials & Observations
Maria Elisa Mancuso
View Articletitled, GlycoPEGylated factor IX: a new step forward
INSIDE BLOOD COMMENTARY
HMGB1 takes a “Toll” in sickle cell disease
Kalpna Gupta
View Articletitled, HMGB1 takes a “Toll” in sickle cell disease
INSIDE BLOOD COMMENTARY
HLA allotype expressivity in transplantation
Marcelo Aníbal Fernández-Viña
View Articletitled, HLA allotype expressivity in transplantation

PERSPECTIVES

Managing high-risk CLL during transition to a new treatment era: stem cell transplantation or novel agents?
Clinical Trials & Observations
Peter Dreger,Johannes Schetelig,Niels Andersen,Paolo Corradini,Michel van Gelder,John Gribben,Eva Kimby,Mauricette Michallet,Carol Moreno,Stephan Stilgenbauer,Emili Montserrat,on behalf of the European Research Initiative on CLL (ERIC) and the European Society for Blood and Marrow Transplantation (EBMT)
View Articletitled, Managing high-risk CLL during transition to a new treatment era: stem cell transplantation or novel agents?

EVIDENCE-BASED FOCUSED REVIEW

Update on the use of hydroxyurea therapy in sickle cell disease
CME Clinical Trials & Observations
Trisha E. Wong,Amanda M. Brandow,Wendy Lim,Richard Lottenberg
View Articletitled, Update on the use of hydroxyurea therapy in sickle cell disease
Supplemental data

HOW I TREAT

How we treat invasive fungal diseases in patients with acute leukemia: the importance of an individualized approach
Clinical Trials & Observations
Marcio Nucci,Elias Anaissie
View Articletitled, How we treat invasive fungal diseases in patients with acute leukemia: the importance of an individualized approach

CLINICAL TRIALS AND OBSERVATIONS

Improved outcome of adult Burkitt lymphoma/leukemia with rituximab and chemotherapy: report of a large prospective multicenter trial
Clinical Trials & Observations
Dieter Hoelzer,Jan Walewski,Hartmut Döhner,Andreas Viardot,Wolfgang Hiddemann,Karsten Spiekermann,Hubert Serve,Ulrich Dührsen,Andreas Hüttmann,Eckhard Thiel,Jolanta Dengler,Michael Kneba,Markus Schaich,Ingo G. H. Schmidt-Wolf,Joachim Beck,Bernd Hertenstein,Albrecht Reichle,Katarzyna Domanska-Czyz,Rainer Fietkau,Heinz-August Horst,Harald Rieder,Stefan Schwartz,Thomas Burmeister,Nicola Gökbuget,for the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia
View Articletitled, Improved outcome of adult Burkitt lymphoma/leukemia with rituximab and chemotherapy: report of a large prospective multicenter trial
Supplemental data
Recombinant long-acting glycoPEGylated factor IX in hemophilia B: a multinational randomized phase 3 trial
Clinical Trials & Observations
Peter W. Collins,Guy Young,Karin Knobe,Faraizah Abdul Karim,Pantep Angchaisuksiri,Claus Banner,Türkiz Gürsel,Johnny Mahlangu,Tadashi Matsushita,Eveline P. Mauser-Bunschoten,Johannes Oldenburg,Christopher E. Walsh,Claude Negrier,for the paradigm 2 Investigators
View Articletitled, Recombinant long-acting glycoPEGylated factor IX in hemophilia B: a multinational randomized phase 3 trial
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Caspase-9 is required for normal hematopoietic development and protection from alkylator-induced DNA damage in mice
Elise Peterson Lu,Michael McLellan,Li Ding,Robert Fulton,Elaine R. Mardis,Richard K. Wilson,Christopher A. Miller,Peter Westervelt,John F. DiPersio,Daniel C. Link,Matthew J. Walter,Timothy J. Ley,Timothy A. Graubert
View Articletitled, Caspase-9 is required for normal hematopoietic development and protection from alkylator-induced DNA damage in mice
Supplemental data

IMMUNOBIOLOGY

Activation of lymphoma-associated MyD88 mutations via allostery-induced TIR-domain oligomerization
Monika Avbelj,Olaf-Oliver Wolz,Ota Fekonja,Mojca Benčina,Matej Repič,Janez Mavri,Jens Krüger,Charlotta Schärfe,Magno Delmiro Garcia,Gabriela Panter,Oliver Kohlbacher,Alexander N. R. Weber,Roman Jerala
View Articletitled, Activation of lymphoma-associated MyD88 mutations via allostery-induced TIR-domain oligomerization
Supplemental data
TOX2 regulates human natural killer cell development by controlling T-BET expression
Queenie P. Vong,Wai-Hang Leung,Jim Houston,Ying Li,Barbara Rooney,Martha Holladay,Robert A. J. Oostendorp,Wing Leung
View Articletitled, TOX2 regulates human natural killer cell development by controlling T-BET expression
Supplemental data

LYMPHOID NEOPLASIA

Both mature KIR+ and immature KIR− NK cells control pediatric acute B-cell precursor leukemia in NOD.Cg-Prkdcscid IL2rgtmWjl/Sz mice
Ayline Kübler,Jeanette Woiterski,Kai-Erik Witte,Hans-Jörg Bühring,Udo F. Hartwig,Martin Ebinger,Lena Oevermann,Markus Mezger,Wolfgang Herr,Peter Lang,Rupert Handgretinger,Christian Münz,Maya C. André
View Articletitled, Both mature KIR<sup>+</sup> and immature KIR<sup>−</sup> NK cells control pediatric acute B-cell precursor leukemia in NOD.Cg-Prkdc<sup>scid</sup> IL2rg<sup>tmWjl</sup>/Sz mice
Supplemental data
Cooperating JAK1 and JAK3 mutants increase resistance to JAK inhibitors
Lorraine Springuel,Tekla Hornakova,Elisabeth Losdyck,Fanny Lambert,Emilie Leroy,Stefan N. Constantinescu,Elisabetta Flex,Marco Tartaglia,Laurent Knoops,Jean-Christophe Renauld
View Articletitled, Cooperating JAK1 and JAK3 mutants increase resistance to JAK inhibitors
Supplemental data
Obesity is associated with residual leukemia following induction therapy for childhood B-precursor acute lymphoblastic leukemia
Etan Orgel,Jonathan Tucci,Waseem Alhushki,Jemily Malvar,Richard Sposto,Cecilia H. Fu,David R. Freyer,Hisham Abdel-Azim,Steven D. Mittelman
View Articletitled, Obesity is associated with residual leukemia following induction therapy for childhood B-precursor acute lymphoblastic leukemia
Supplemental data
MCL-1 but not BCL-XL is critical for the development and sustained expansion of thymic lymphoma in p53-deficient mice
Stephanie Grabow,Alex R. D. Delbridge,Liz J. Valente,Andreas Strasser
View Articletitled, MCL-1 but not BCL-XL is critical for the development and sustained expansion of thymic lymphoma in p53-deficient mice
Supplemental data

MYELOID NEOPLASIA

Preclinical efficacy of MEK inhibition in Nras-mutant AML
Michael R. Burgess,Eugene Hwang,Ari J. Firestone,Tannie Huang,Jin Xu,Johannes Zuber,Natacha Bohin,Tiffany Wen,Scott C. Kogan,Kevin M. Haigis,Deepak Sampath,Scott Lowe,Kevin Shannon,Qing Li
View Articletitled, Preclinical efficacy of MEK inhibition in <em>Nras</em>-mutant AML
Supplemental data
The thrombopoietin receptor, MPL, is critical for development of a JAK2V617F-induced myeloproliferative neoplasm
Veena Sangkhae,S. Leah Etheridge,Kenneth Kaushansky,Ian S. Hitchcock
View Articletitled, The thrombopoietin receptor, MPL, is critical for development of a <em>JAK2</em>V<sub>617</sub>F-induced myeloproliferative neoplasm
Supplemental data
Presence of calreticulin mutations in JAK2-negative polycythemia vera
Clinical Trials & Observations Brief Report
Julien Broséus,Ji-Hye Park,Serge Carillo,Sylvie Hermouet,François Girodon
View Articletitled, Presence of calreticulin mutations in <em>JAK2</em>-negative polycythemia vera

PLATELETS AND THROMBOPOIESIS

The formin DIAPH1 (mDia1) regulates megakaryocyte proplatelet formation by remodeling the actin and microtubule cytoskeletons
Jiajia Pan,Larissa Lordier,Deborah Meyran,Philippe Rameau,Yann Lecluse,Susan Kitchen-Goosen,Idinath Badirou,Hayat Mokrani,Shuh Narumiya,Arthur S. Alberts,William Vainchenker,Yunhua Chang
View Articletitled, The formin DIAPH1 (mDia1) regulates megakaryocyte proplatelet formation by remodeling the actin and microtubule cytoskeletons
Supplemental data
TAILS N-terminomics of human platelets reveals pervasive metalloproteinase-dependent proteolytic processing in storage
e-blood
Anna Prudova,Katherine Serrano,Ulrich Eckhard,Nikolaus Fortelny,Dana V. Devine,Christopher M. Overall
View Articletitled, TAILS N-terminomics of human platelets reveals pervasive metalloproteinase-dependent proteolytic processing in storage
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Sickle cell disease increases high mobility group box 1: a novel mechanism of inflammation
Brief Report
Hao Xu,Nancy J. Wandersee,YiHe Guo,Deron W. Jones,Sandra L. Holzhauer,Madelyn S. Hanson,Evans Machogu,David C. Brousseau,Neil Hogg,John C. Densmore,Sushma Kaul,Cheryl A. Hillery,Kirkwood A. Pritchard, Jr
View Articletitled, Sickle cell disease increases high mobility group box 1: a novel mechanism of inflammation
Supplemental data

THROMBOSIS AND HEMOSTASIS

Functional factor XIII-A is exposed on the stimulated platelet surface
Joanne L. Mitchell,Ausra S. Lionikiene,Steven R. Fraser,Claire S. Whyte,Nuala A. Booth,Nicola J. Mutch
View Articletitled, Functional factor XIII-A is exposed on the stimulated platelet surface
Supplemental data
Ibrutinib treatment affects collagen and von Willebrand factor-dependent platelet functions
Brief Report
Marie Levade,Elodie David,Cédric Garcia,Pierre-Alexandre Laurent,Sarah Cadot,Anne-Sophie Michallet,Jean-Claude Bordet,Constantine Tam,Pierre Sié,Loïc Ysebaert,Bernard Payrastre
View Articletitled, Ibrutinib treatment affects collagen and von Willebrand factor-dependent platelet functions
Supplemental data

TRANSPLANTATION

HLA-C expression levels define permissible mismatches in hematopoietic cell transplantation
Effie W. Petersdorf,Theodore A. Gooley,Mari Malkki,Andrea P. Bacigalupo,Anne Cesbron,Ernette Du Toit,Gerhard Ehninger,Torstein Egeland,Gottfried F. Fischer,Thibaut Gervais,Michael D. Haagenson,Mary M. Horowitz,Katharine Hsu,Pavel Jindra,Alejandro Madrigal,Machteld Oudshoorn,Olle Ringdén,Marlis L. Schroeder,Stephen R. Spellman,Jean-Marie Tiercy,Andrea Velardi,Campbell S. Witt,Colm O’Huigin,Richard Apps,Mary Carrington,for the International Histocompatibility Working Group in Hematopoietic Cell Transplantation
View Articletitled, HLA-C expression levels define permissible mismatches in hematopoietic cell transplantation
Supplemental data

CONTINUING MEDICAL EDUCATION (CME) QUESTIONS

Hydroxyurea therapy
CME
View Articletitled, Hydroxyurea therapy
All Issues

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Data mining for second malignancies after CAR-T
Silva A, Almeida ARM, Cachucho A, et al. Overexpression of wild-type IL-7Rα promotes T-cell acute lymphoblastic leukemia/lymphoma. Blood. 2021;138(12):1040-1052.
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