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Issue Archive

Volume 123, Issue 23
June 5 2014
Issue Cover

Table of Contents

INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY
Worming along in amyloid cardiotoxicity
Ronglih Liao
View Articletitled, Worming along in amyloid cardiotoxicity
INSIDE BLOOD COMMENTARY
PDGFRB disease: right diagnosis to prolong survival
Clinical Trials & Observations
Francesco Passamonti
View Articletitled, PDGFRB disease: right diagnosis to prolong survival
INSIDE BLOOD COMMENTARY
AML drug resistance: c-Myc comes into play
Cyril Fauriat,Daniel Olive
View Articletitled, AML drug resistance: c-Myc comes into play
INSIDE BLOOD COMMENTARY
Socioeconomic disparities in lymphoma
Christopher R. Flowers,Loretta J. Nastoupil
View Articletitled, Socioeconomic disparities in lymphoma
INSIDE BLOOD COMMENTARY
Is glutamine depletion needed in ALL disease?
Vassilios I. Avramis
View Articletitled, Is glutamine depletion needed in ALL disease?
INSIDE BLOOD COMMENTARY
CLL cells under flow
Tanja N. Hartmann
View Articletitled, CLL cells under flow
INSIDE BLOOD COMMENTARY
Liver not making hepcidin? Hemochromatosis!
Thomas Benedict Bartnikas
View Articletitled, Liver not making hepcidin? Hemochromatosis!
INSIDE BLOOD COMMENTARY
Me or not me? The danger of spontaneity
Andreas Greinacher
View Articletitled, Me or not me? The danger of spontaneity
INSIDE BLOOD COMMENTARY
The donor’s dilemma
Shernan G. Holtan,Daniel J. Weisdorf
View Articletitled, The donor’s dilemma

BLOOD WORK

Crystal-storing histiocytosis with IgD κ–associated plasma cell neoplasm
Beenu Thakral,Elizabeth Courville
View Articletitled, Crystal-storing histiocytosis with IgD κ–associated plasma cell neoplasm
Cytospin preparation of AML in pleural fluid
Justin Hanenberg,Steven Marionneaux
View Articletitled, Cytospin preparation of AML in pleural fluid

PLENARY PAPER

A Caenorhabditis elegans–based assay recognizes immunoglobulin light chains causing heart amyloidosis
Luisa Diomede,Paola Rognoni,Francesca Lavatelli,Margherita Romeo,Elena del Favero,Laura Cantù,Elena Ghibaudi,Andrea di Fonzo,Alessandro Corbelli,Fabio Fiordaliso,Giovanni Palladini,Veronica Valentini,Vittorio Perfetti,Mario Salmona,Giampaolo Merlini
View Articletitled, A <em>Caenorhabditis elegans–</em>based assay recognizes immunoglobulin light chains causing heart amyloidosis
Supplemental data

PLENARY PAPER

Socioeconomic disparities in mortality after diffuse large B-cell lymphoma in the modern treatment era
Li Tao,James M. Foran,Christina A. Clarke,Scarlett L. Gomez,Theresa H. M. Keegan
View Articletitled, Socioeconomic disparities in mortality after diffuse large B-cell lymphoma in the modern treatment era

BLOOD SPOTLIGHT

Neutrophil homeostasis and its regulation by danger signaling
Stefan Wirths,Stefanie Bugl,Hans-Georg Kopp
View Articletitled, Neutrophil homeostasis and its regulation by danger signaling

CLINICAL TRIALS AND OBSERVATIONS

Advanced-stage nodular lymphocyte predominant Hodgkin lymphoma compared with classical Hodgkin lymphoma: a matched pair outcome analysis
Clinical Trials & Observations
Katharine H. Xing,Joseph M. Connors,Anky Lai,Mubarak Al-Mansour,Laurie H. Sehn,Diego Villa,Richard Klasa,Tamara Shenkier,Randy D. Gascoyne,Brian Skinnider,Kerry J. Savage
View Articletitled, Advanced-stage nodular lymphocyte predominant Hodgkin lymphoma compared with classical Hodgkin lymphoma: a matched pair outcome analysis
Patients with myeloid malignancies bearing PDGFRB fusion genes achieve durable long-term remissions with imatinib
Clinical Trials & Observations Brief Report
Chan Y. Cheah,Kate Burbury,Jane F. Apperley,Francoise Huguet,Vincenzo Pitini,Martine Gardembas,David M. Ross,Donna Forrest,Philippe Genet,Philippe Rousselot,Nigel Patton,Graeme Smith,Cynthia E. Dunbar,Sawa Ito,Ricardo C. T. Aguiar,Olatoyosi Odenike,Alla Gimelfarb,Nicholas C. P. Cross,John F. Seymour
View Articletitled, Patients with myeloid malignancies bearing <em>PDGFRB</em> fusion genes achieve durable long-term remissions with imatinib

GENE THERAPY

Intravenous injection of a foamy virus vector to correct canine SCID-X1
Christopher R. Burtner,Brian C. Beard,Douglas R. Kennedy,Martin E. Wohlfahrt,Jennifer E. Adair,Grant D. Trobridge,Andrew M. Scharenberg,Troy R. Torgerson,David J. Rawlings,Peter J. Felsburg,Hans-Peter Kiem
View Articletitled, Intravenous injection of a foamy virus vector to correct canine SCID-X1
Supplemental data

IMMUNOBIOLOGY

c-Myc regulates expression of NKG2D ligands ULBP1/2/3 in AML and modulates their susceptibility to NK-mediated lysis
Arash Nanbakhsh,Cécile Pochon,Aude Mallavialle,Sophie Amsellem,Jean Henri Bourhis,Salem Chouaib
View Articletitled, c-Myc regulates expression of NKG2D ligands ULBP1/2/3 in AML and modulates their susceptibility to NK-mediated lysis

LYMPHOID NEOPLASIA

The glutaminase activity of l-asparaginase is not required for anticancer activity against ASNS-negative cells
Wai Kin Chan,Philip L. Lorenzi,Andriy Anishkin,Preeti Purwaha,David M. Rogers,Sergei Sukharev,Susan B. Rempe,John N. Weinstein
View Articletitled, The glutaminase activity of <span class="small-caps">l</span>-asparaginase is not required for anticancer activity against ASNS-negative cells
Supplemental data
Development and characterization of a physiologically relevant model of lymphocyte migration in chronic lymphocytic leukemia
Elisabeth Walsby,Andrea Buggins,Stephen Devereux,Ceri Jones,Guy Pratt,Paul Brennan,Chris Fegan,Chris Pepper
View Articletitled, Development and characterization of a physiologically relevant model of lymphocyte migration in chronic lymphocytic leukemia
Supplemental data
Next-generation sequencing of peripheral B-lineage cells pinpoints the circulating clonotypic cell pool in multiple myeloma
Brief Report
Benjamin Thiele,Marie Kloster,Malik Alawi,Daniela Indenbirken,Martin Trepel,Adam Grundhoff,Mascha Binder
View Articletitled, Next-generation sequencing of peripheral B-lineage cells pinpoints the circulating clonotypic cell pool in multiple myeloma
Supplemental data

MYELOID NEOPLASIA

The core autophagy protein ATG4B is a potential biomarker and therapeutic target in CML stem/progenitor cells
Katharina Rothe,Hanyang Lin,Kevin B. L. Lin,Amy Leung,Hui Mi Wang,Mehrnoush Malekesmaeili,Ryan R. Brinkman,Donna L. Forrest,Sharon M. Gorski,Xiaoyan Jiang
View Articletitled, The core autophagy protein ATG4B is a potential biomarker and therapeutic target in CML stem/progenitor cells
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

RhoA determines disease progression by controlling neutrophil motility and restricting hyperresponsiveness
Richard T. Jennings,Monika Strengert,Patti Hayes,Jamel El-Benna,Cord Brakebusch,Malgorzata Kubica,Ulla G. Knaus
View Articletitled, RhoA determines disease progression by controlling neutrophil motility and restricting hyperresponsiveness
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Targeted disruption of hepcidin in the liver recapitulates the hemochromatotic phenotype
Brief Report
Sara Zumerle,Jacques R. R. Mathieu,Stéphanie Delga,Mylène Heinis,Lydie Viatte,Sophie Vaulont,Carole Peyssonnaux
View Articletitled, Targeted disruption of hepcidin in the liver recapitulates the hemochromatotic phenotype
Supplemental data

THROMBOSIS AND HEMOSTASIS

Spontaneous heparin-induced thrombocytopenia syndrome: 2 new cases and a proposal for defining this disorder
Brief Report
Theodore E. Warkentin,Paul A. Basciano,Jared Knopman,Richard A. Bernstein
View Articletitled, Spontaneous heparin-induced thrombocytopenia syndrome: 2 new cases and a proposal for defining this disorder

TRANSFUSION MEDICINE

Lower risk for serious adverse events and no increased risk for cancer after PBSC vs BM donation
Michael A. Pulsipher,Pintip Chitphakdithai,Brent R. Logan,Willis H. Navarro,John E. Levine,John P. Miller,Bronwen E. Shaw,Paul V. O’Donnell,Navneet S. Majhail,Dennis L. Confer
View Articletitled, Lower risk for serious adverse events and no increased risk for cancer after PBSC vs BM donation
Supplemental data

TRANSPLANTATION

Validation and refinement of the Disease Risk Index for allogeneic stem cell transplantation
Philippe Armand,Haesook T. Kim,Brent R. Logan,Zhiwei Wang,Edwin P. Alyea,Matt E. Kalaycio,Richard T. Maziarz,Joseph H. Antin,Robert J. Soiffer,Daniel J. Weisdorf,J. Douglas Rizzo,Mary M. Horowitz,Wael Saber
View Articletitled, Validation and refinement of the Disease Risk Index for allogeneic stem cell transplantation

CORRESPONDENCE

The PRDX2 gene is transcriptionally silenced and de novo methylated in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma
Markus Schneider,Marcin Szaumkessel,Julia Richter,Ole Ammerpohl,Martin-Leo Hansmann,Ralf Küppers,Reiner Siebert,Maciej Giefing
View Articletitled, The <em>PRDX2</em> gene is transcriptionally silenced and de novo methylated in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma
Phenotypically aberrant clonal T cells in the lungs of patients with type II refractory celiac disease
Jean Pastré,Karine Juvin,Georgia Malamut,Coralie Derrieux,Christophe Cellier,Dominique Israël-Biet
View Articletitled, Phenotypically aberrant clonal T cells in the lungs of patients with type II refractory celiac disease
ETV6 and signaling gene mutations are associated with secondary transformation of myelodysplastic syndromes to chronic myelomonocytic leukemia
Eric Padron,Sean Yoder,Sateesh Kunigal,Tania Mesa,Jamie K. Teer,Najla Al Ali,Mikkael A. Sekeres,Jeffrey S. Painter,Ling Zhang,Jeffrey Lancet,Jaroslaw P. Maciejewski,Pearlie K. Epling-Burnette,Eduardo Sotomayor,Rami S. Komrokji,Alan F. List
View Articletitled, ETV6 and signaling gene mutations are associated with secondary transformation of myelodysplastic syndromes to chronic myelomonocytic leukemia
Supplemental data
CALR mutations in patients with essential thrombocythemia diagnosed in childhood and adolescence
Fiorina Giona,Luciana Teofili,Sara Capodimonti,Marica Laurino,Maurizio Martini,Deborah Marzella,Giovanna Palumbo,Daniela Diverio,Robin Foà,Luigi Maria Larocca
View Articletitled, <em>CALR</em> mutations in patients with essential thrombocythemia diagnosed in childhood and adolescence
Prospective detection of chikungunya virus in blood donors, Caribbean 2014
Pierre Gallian,Xavier de Lamballerie,Nicolas Salez,Geraldine Piorkowski,Pascale Richard,Laure Paturel,Rachid Djoudi,Isabelle Leparc-Goffart,Pierre Tiberghien,Jacques Chiaroni,Remi N. Charrel
View Articletitled, Prospective detection of chikungunya virus in blood donors, Caribbean 2014

ERRATA

Cassani B, Mirolo M, Cattaneo F, et al. Altered intracellular and extracellular signaling leads to impaired T-cell functions in ADA-SCID patients. Blood. 2008;111(8):4209-4219.
View Articletitled, Cassani B, Mirolo M, Cattaneo F, et al. Altered intracellular and extracellular signaling leads to impaired T-cell functions in ADA-SCID patients. <em>Blood</em>. 2008;111(8):<span class="related-article">4209-4219</span>.
Fang J, Rhyasen G, Bolanos L, et al. Cytotoxic effects of bortezomib in myelodysplastic syndrome/acute myeloid leukemia depend on autophagy-mediated lysosomal degradation of TRAF6 and repression of PSMA1. Blood. 2012;120(4):858-867.
View Articletitled, Fang J, Rhyasen G, Bolanos L, et al. Cytotoxic effects of bortezomib in myelodysplastic syndrome/acute myeloid leukemia depend on autophagy-mediated lysosomal degradation of TRAF6 and repression of PSMA1. <em>Blood</em>. 2012;120(4):<span class="related-article">858-867</span>.
Amirache F, Lévy C, Costa C, et al. Mystery solved: VSV-G-LVs do not allow efficient gene transfer into unstimulated T cells, B cells, and HSCs because they lack the LDL receptor. Blood. 2014;123(9):1422-1424.
View Articletitled, Amirache F, Lévy C, Costa C, et al. Mystery solved: VSV-G-LVs do not allow efficient gene transfer into unstimulated T cells, B cells, and HSCs because they lack the LDL receptor. <em>Blood</em>. 2014;123(9):<span class="related-article">1422-1424</span>.
  • Cover Image

    Cover Image

    issue cover

    This is a scanning electron micrograph (SEM) of HUVEC cells adhered to the interior of a hollow fiber after 5 hours of exposure to 5 dynes/cm2 shear force. The endothelial cells show initial evidence of flattening and spreading which resulted in almost complete coverage of the interior of the hollow fiber after 24 hours. The image was obtained from a JEOL 840A scanning electron microscope operating at 5kV and recorded using SIS digital software. See the article by Walsby et al on page 3607.

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