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Issue Archive

Volume 123, Issue 20
May 15 2014
Issue Cover

Table of Contents

INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY
Lymphomania
Robert K. Andrews,Elizabeth E. Gardiner
View Articletitled, Lymphomania
INSIDE BLOOD COMMENTARY
Time has come for immunotherapy in PTCL
Clinical Trials & Observations
Emmanuel Bachy,Bertrand Coiffier
View Articletitled, Time has come for immunotherapy in PTCL
INSIDE BLOOD COMMENTARY
HSC senescence upon irradiation
Hartmut Geiger
View Articletitled, HSC senescence upon irradiation
INSIDE BLOOD COMMENTARY
Down to the bitter end
Sagar Lonial,Charise Gleason
View Articletitled, Down to the bitter end
INSIDE BLOOD COMMENTARY
Engineering more efficacious antibody therapy for myeloma
Frits van Rhee
View Articletitled, Engineering more efficacious antibody therapy for myeloma
INSIDE BLOOD COMMENTARY
A(nother) RAF mutation in LCH
Kevin Shannon,Michelle Hermiston
View Articletitled, A(nother) RAF mutation in LCH
INSIDE BLOOD COMMENTARY
Platelet αIIbβ3 activation: filling in the pieces
Joel S. Bennett
View Articletitled, Platelet αIIbβ3 activation: filling in the pieces
INSIDE BLOOD COMMENTARY
Bacteria exploit platelets
Ulhas P. Naik
View Articletitled, Bacteria exploit platelets
INSIDE BLOOD COMMENTARY
A David promoter with Goliath strength
David M. Markusic,Roland W. Herzog
View Articletitled, A David promoter with Goliath strength

BLOOD WORK

Disseminated cryptococcosis in bone marrow
Ludovic Suner,Stéphanie Mathis
View Articletitled, Disseminated cryptococcosis in bone marrow
Acute basophilic leukemia
Marion Eveillard,Alexandre Desjonqueres
View Articletitled, Acute basophilic leukemia

PLENARY PAPER

Prognostic value of deep sequencing method for minimal residual disease detection in multiple myeloma
Clinical Trials & Observations
Joaquin Martinez-Lopez,Juan J. Lahuerta,François Pepin,Marcos González,Santiago Barrio,Rosa Ayala,Noemí Puig,María A. Montalban,Bruno Paiva,Li Weng,Cristina Jiménez,María Sopena,Martin Moorhead,Teresa Cedena,Immaculada Rapado,María Victoria Mateos,Laura Rosiñol,Albert Oriol,María J. Blanchard,Rafael Martínez,Joan Bladé,Jesús San Miguel,Malek Faham,Ramón García-Sanz
View Articletitled, Prognostic value of deep sequencing method for minimal residual disease detection in multiple myeloma

REVIEW ARTICLE

Erythro-megakaryocytic transcription factors associated with hereditary anemia
John D. Crispino,Mitchell J. Weiss
View Articletitled, Erythro-megakaryocytic transcription factors associated with hereditary anemia

EVIDENCE-BASED FOCUSED REVIEW

Evidence-based focused review of the status of hematopoietic stem cell transplantation as treatment of sickle cell disease and thalassemia
CME
Allison King,Shalini Shenoy
View Articletitled, Evidence-based focused review of the status of hematopoietic stem cell transplantation as treatment of sickle cell disease and thalassemia
Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

Objective responses in relapsed T-cell lymphomas with single-agent brentuximab vedotin
Clinical Trials & Observations
Steven M. Horwitz,Ranjana H. Advani,Nancy L. Bartlett,Eric D. Jacobsen,Jeff P. Sharman,Owen A. O’Connor,Tanya Siddiqi,Dana A. Kennedy,Yasuhiro Oki
View Articletitled, Objective responses in relapsed T-cell lymphomas with single-agent brentuximab vedotin
Microvascular oxygen consumption during sickle cell pain crisis
Clinical Trials & Observations Brief Report
Carol A. Rowley,Allison K. Ikeda,Miles Seidel,Tiffany C. Anaebere,Matthew D. Antalek,Catherine Seamon,Anna K. Conrey,Laurel Mendelsohn,James Nichols,Alexander M. Gorbach,Gregory J. Kato,Hans Ackerman
View Articletitled, Microvascular oxygen consumption during sickle cell pain crisis
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner
Lijian Shao,Wei Feng,Hongliang Li,David Gardner,Yi Luo,Yong Wang,Lingbo Liu,Aimin Meng,Norman E. Sharpless,Daohong Zhou
View Articletitled, Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner
Supplemental data

LYMPHOID NEOPLASIA

Interleukin-15 enhances cellular proliferation and upregulates CNS homing molecules in pre-B acute lymphoblastic leukemia
Mark T. S. Williams,Yasar Yousafzai,Charlotte Cox,Allison Blair,Ruaidhrí Carmody,Shuji Sai,Karen E. Chapman,Rachel McAndrew,Angela Thomas,Alison Spence,Brenda Gibson,Gerard J. Graham,Christina Halsey
View Articletitled, Interleukin-15 enhances cellular proliferation and upregulates CNS homing molecules in pre-B acute lymphoblastic leukemia
Supplemental data
Novel anti–B-cell maturation antigen antibody-drug conjugate (GSK2857916) selectively induces killing of multiple myeloma
Yu-Tzu Tai,Patrick A. Mayes,Chirag Acharya,Mike Y. Zhong,Michele Cea,Antonia Cagnetta,Jenny Craigen,John Yates,Louise Gliddon,William Fieles,Bao Hoang,James Tunstead,Amanda L. Christie,Andrew L. Kung,Paul Richardson,Nikhil C. Munshi,Kenneth C. Anderson
View Articletitled, Novel anti–B-cell maturation antigen antibody-drug conjugate (GSK2857916) selectively induces killing of multiple myeloma
Supplemental data

MYELOID NEOPLASIA

JAK2V617F homozygosity drives a phenotypic switch in myeloproliferative neoplasms, but is insufficient to sustain disease
Juan Li,David G. Kent,Anna L. Godfrey,Harriet Manning,Jyoti Nangalia,Athar Aziz,Edwin Chen,Kourosh Saeb-Parsy,Juergen Fink,Rachel Sneade,Tina L. Hamilton,Dean C. Pask,Yvonne Silber,Xiaodong Zhao,Cedric Ghevaert,Pentao Liu,Anthony R. Green
View Articletitled, <em>JAK2V617F</em> homozygosity drives a phenotypic switch in myeloproliferative neoplasms, but is insufficient to sustain disease
Supplemental data
Somatic activating ARAF mutations in Langerhans cell histiocytosis
Brief Report
David S. Nelson,Willemijn Quispel,Gayane Badalian-Very,Astrid G. S. van Halteren,Cor van den Bos,Judith V. M. G. Bovée,Sara Y. Tian,Paul Van Hummelen,Matthew Ducar,Laura E. MacConaill,R. Maarten Egeler,Barrett J. Rollins
View Articletitled, Somatic activating ARAF mutations in Langerhans cell histiocytosis
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Alternatively activated macrophages derived from monocytes and tissue macrophages are phenotypically and functionally distinct
e-blood
Uma Mahesh Gundra,Natasha M. Girgis,Dominik Ruckerl,Stephen Jenkins,Lauren N. Ward,Zachary D. Kurtz,Kirsten E. Wiens,Mei San Tang,Upal Basu-Roy,Alka Mansukhani,Judith E. Allen,P’ng Loke
View Articletitled, Alternatively activated macrophages derived from monocytes and tissue macrophages are phenotypically and functionally distinct
Supplemental data

PLATELETS AND THROMBOPOIESIS

ADAP interactions with talin and kindlin promote platelet integrin αIIbβ3 activation and stable fibrinogen binding
Ana Kasirer-Friede,Jian Kang,Bryan Kahner,Feng Ye,Mark H. Ginsberg,Sanford J. Shattil
View Articletitled, ADAP interactions with talin and kindlin promote platelet integrin αIIbβ3 activation and stable fibrinogen binding
Supplemental data
Amplification of bacteria-induced platelet activation is triggered by FcγRIIA, integrin αIIbβ3, and platelet factor 4
Mònica Arman,Krystin Krauel,Dorothea O. Tilley,Claudia Weber,Dermot Cox,Andreas Greinacher,Steven W. Kerrigan,Steve P. Watson
View Articletitled, Amplification of bacteria-induced platelet activation is triggered by FcγRIIA, integrin αIIbβ3, and platelet factor 4
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Corepressor Rcor1 is essential for murine erythropoiesis
Huilan Yao,Devorah C. Goldman,Tamilla Nechiporuk,Sunita Kawane,Shannon K. McWeeney,Jeffrey W. Tyner,Guang Fan,Marc A. Kerenyi,Stuart H. Orkin,William H. Fleming,Gail Mandel
View Articletitled, Corepressor Rcor1 is essential for murine erythropoiesis
Supplemental data

THROMBOSIS AND HEMOSTASIS

STXBP1 promotes Weibel-Palade body exocytosis through its interaction with the Rab27A effector Slp4-a
Dorothee van Breevoort,Ambrosius P. Snijders,Nicola Hellen,Sarah Weckhuysen,Kathinka W. E. M. van Hooren,Jeroen Eikenboom,Karine Valentijn,Mar Fernandez-Borja,Berten Ceulemans,Peter De Jonghe,Jan Voorberg,Matthew Hannah,Tom Carter,Ruben Bierings
View Articletitled, STXBP1 promotes Weibel-Palade body exocytosis through its interaction with the Rab27A effector Slp4-a
Supplemental data
Computationally designed liver-specific transcriptional modules and hyperactive factor IX improve hepatic gene therapy
Brief Report
Nisha Nair,Melvin Y. Rincon,Hanneke Evens,Shilpita Sarcar,Sumitava Dastidar,Emira Samara-Kuko,Omid Ghandeharian,Hiu Man Viecelli,Beat Thöny,Pieter De Bleser,Thierry VandenDriessche,Marinee K. Chuah
View Articletitled, Computationally designed liver-specific transcriptional modules and hyperactive factor IX improve hepatic gene therapy
Supplemental data

VASCULAR BIOLOGY

CLEC-2 is required for development and maintenance of lymph nodes
Cécile Bénézech,Saba Nayar,Brenda A. Finney,David R. Withers,Kate Lowe,Guillaume E. Desanti,Clare L. Marriott,Steve P. Watson,Jorge H. Caamaño,Christopher D. Buckley,Francesca Barone
View Articletitled, CLEC-2 is required for development and maintenance of lymph nodes
Supplemental data

ERRATA

Richardson PG, Siegel DS, Vij R, et al. Pomalidomide alone or in combination with low-dose dexamethasone in relapsed and refractory multiple myeloma: a randomized phase 2 study. Blood. 2014;123(12):1826-1832.
View Articletitled, Richardson PG, Siegel DS, Vij R, et al. Pomalidomide alone or in combination with low-dose dexamethasone in relapsed and refractory multiple myeloma: a randomized phase 2 study. <em>Blood</em>. 2014;123(12):1826-1832.

CONTINUING MEDICAL EDUCATION (CME) QUESTIONS

Transplant for sickle cell disease and thalassemia
CME
View Articletitled, Transplant for sickle cell disease and thalassemia
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