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Norman E. Sharpless
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Journal Articles

Constitutive Activation of Ras and Inactivation of Ink4a/Arf Allele Induce a Fully Penetrant B-Cell Acute Lymphoblastic Leukemia Phenotype in Mice

Tomasz Sewastianik, MSc,PhD, Meng Jiang, MD, Kumar Sukhdeo, MD PhD, Sanjay Patel, MD MPH, MSc, Yue Kang, Ahmad Alduaij, MD, Peter S. Dennis, Jessie Xiong, Geraldine S. Pinkus, Jeremy N. Rich, MD, Madeleine E. Lemieux, PhD, Norman E. Sharpless, MD, Ruben D. Carrasco, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1222.
https://doi.org/10.1182/blood.V130.Suppl_1.1222.1222
Published: 2017
Journal Articles

Dual Inhibition of Aurora Kinase and BRD4 Leads to Improved Anti-Tumor Activity in Myc-Overexpressing Lymphoma Cells

Steven I Park, MD, Carolina Lin, Lawrence J Druhan, PhD, Michael B Foote, Trevor Parton, Natalie Ren, Steven P Angus, Aadra P Bhatt, Scott C Jaros, Nilanjan Ghosh, MD PhD, Ryan Jacobs, MD, Belinda Rene Avalos, MD, Dirk P Dittmer, PhD, Norman E. Sharpless, MD, Blossom A Damania
Journal: Blood
Blood (2017) 130 (Supplement 1): 4109.
https://doi.org/10.1182/blood.V130.Suppl_1.4109.4109
Published: 2017
Journal Articles

Alisertib, an Aurora a Kinase Inhibitor, Induces Synthetic Lethality and Overcomes Chemoresistance in Myc-Overexpressing Lymphoma Cells

Steven I. Park, MD, Carolina P. Lin, MS, Dirk P. Dittmer, PhD, Steven P. Angus, PhD, Greg G. Wang, PhD, Yuri D. Fedoriw, MD, David B. Darr, BS, Daniel P. Roth, BS, Norman E. Sharpless, MD, Blossom Damania, PhD
Journal: Blood
Blood (2015) 126 (23): 1551.
https://doi.org/10.1182/blood.V126.23.1551.1551
Published: 2015
Journal Articles

Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner

Lijian Shao, Wei Feng, Hongliang Li, David Gardner, Yi Luo, Yong Wang, Lingbo Liu, Aimin Meng, Norman E. Sharpless, Daohong Zhou
Journal: Blood
Blood (2014) 123 (20): 3105–3115.
https://doi.org/10.1182/blood-2013-07-515619
Published: 2014
Includes: Supplemental data
Journal Articles

Expression of p16 INK4a prevents cancer and promotes aging in lymphocytes

Yan Liu, Soren M. Johnson, Yuri Fedoriw, Arlin B. Rogers, Hong Yuan, Janakiraman Krishnamurthy, Norman E. Sharpless
Journal: Blood
Blood (2011) 117 (12): 3257–3267.
https://doi.org/10.1182/blood-2010-09-304402
Published: 2011
Includes: Supplemental data