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Journal Articles

Ker-050 Treatment Reduced Iron Overload and Increased Bone Specific Alkaline Phosphatase in Participants with Lower-Risk MDS Supporting Potential to Restore Balance to the Osteohematopoietic Niche

Lynette C.Y. Chee, David M. Ross, Thomas Cluzeau, Shuhying Tan, Aristoteles Giagounidis, David Valcarcel, Montserrat Arnan, Maria Diez-Campelo, Christine Graham, Allie McGinty, Miranda Ross, Suresh Bobba, Wei Feng, Ying Jiang, Montagu Hankin, Christopher Rovaldi, Simon Cooper, Dena Grayson, Jen L. Salstrom

Blood (2023) 142 (Supplement 1): 1089.

https://doi.org/10.1182/blood-2023-186326

Published: 2023

Journal Articles

Durable Clinical Benefit with Ker-050 Treatment: Findings from an Ongoing Phase 2 Study in Participants with Lower-Risk MDS

Maria Diez-Campelo, David M. Ross, Aristoteles Giagounidis, Shuhying Tan, Thomas Cluzeau, Lynette C.Y. Chee, David Valcarcel, Montserrat Arnan, Christine Graham, Allie McGinty, Miranda Ross, Wei Feng, Ying Jiang, Suresh Bobba, Montagu Hankin, Christopher Rovaldi, Dena Grayson, Simon Cooper, Jen L. Salstrom

Blood (2023) 142 (Supplement 1): 196.

https://doi.org/10.1182/blood-2023-180974

Published: 2023

Journal Articles

Modulation of TGF-β Superfamily Signaling to Treat Myelofibrosis and Mitigate JAK Inhibitor Toxicity: A Report on the Phase 2 Study of Ker-050 in Participants with Myelofibrosis

Claire Harrison, Shuh Ying Tan, David M Ross, George Kannourakis, Allie McGinty, Wei Feng, Ying Jiang, Christine Graham, Chris Rovaldi, Simon Cooper, Jen L. Salstrom

Blood (2022) 140 (Supplement 1): 9702–9703.

https://doi.org/10.1182/blood-2022-162761

Published: 2022

Journal Articles

Effects of Ker-050 on Iron Metabolism: Exploratory Analyses from an Ongoing Phase 2 Study in Patients with Myelodysplastic Syndromes

Lynette C.Y. Chee, David M Ross, Shuh Ying Tan, Joel Wight, George Kannourakis, Miranda Ross, Wei Feng, Ying Jiang, Harveen Dhillon Natarajan, Christine Graham, Christopher Rovaldi, Simon Cooper, Jen L. Salstrom

Blood (2022) 140 (Supplement 1): 8181–8183.

https://doi.org/10.1182/blood-2022-166578

Published: 2022

Journal Articles

Timing of the loss of Pten protein determines disease severity in a mouse model of myeloid malignancy

Y. Lucy Liu, Yan Yan, Cody Webster, Lijian Shao, Shelly Y. Lensing, Hongyu Ni, Wei Feng, Natalia Colorado, Rupak Pathak, Zhifu Xiang, Martin Hauer-Jensen, Shaoguang Li, Daohong Zhou, Peter D. Emanuel

Blood (2016) 127 (15): 1912–1922.

https://doi.org/10.1182/blood-2015-05-646216

Published: 2016

Includes: Supplemental data

Journal Articles

Opposite Effects of M1 and M2 Macrophages on Hematopoietic Stem Cell Self-Renewal and Ex Vivo Expansion

Yi Luo, MD PhD, Lijian Shao, MD PhD, Jianhui Chang, MS, Wei Feng, MD, Chengcheng Li, PhDcandidate, Y. Lucy Liu, MD PhD, Michele Cottler-Fox, MD, Peter D Emanuel, MD, Peter Murray, PhD, Daohong Zhou, MD

Blood (2014) 124 (21): 2909.

https://doi.org/10.1182/blood.V124.21.2909.2909

Published: 2014

Journal Articles

Timing of the Loss of Pten Is Critical in Determining the Disease Phenotype in Mice- a Mouse Model for Pediatric Mixed MDS/MPN

Y. Lucy Liu, MD PhD, Yan Yan, MD, Cody Webster, BS, Lijian Shao, MD PhD, Shelly Y. Lensing, MS, Hongyu Ni, MD PhD, Wei Feng, MD, Daohong Zhou, MD, Zhifu Xiang, MD, Natalia Colorado, MD, Delli Robinson, Shaoguang Li, MD PhD, Peter D Emanuel, MD

Blood (2014) 124 (21): 3585.

https://doi.org/10.1182/blood.V124.21.3585.3585

Published: 2014

Journal Articles

Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner

Lijian Shao, Wei Feng, Hongliang Li, David Gardner, Yi Luo, Yong Wang, Lingbo Liu, Aimin Meng, Norman E. Sharpless, Daohong Zhou

Blood (2014) 123 (20): 3105–3115.

https://doi.org/10.1182/blood-2013-07-515619

Published: 2014

Includes: Supplemental data

Journal Articles

Platelet Depletion Causes Rapid But Transient Activation Of Mouse Bone Marrow Long-Term Hematopoietic Stem Cells To Participate In Stress Thrombopoiesis

Lijian Shao, MD, PhD, Di Hou, PhD, Wei Feng, MD, Jianhui Chang, Jerry Ware, PhD, Martin Hauer-Jensen, MD, PhD, Tao Cheng, M.D, Daohong Zhou, MD

Blood (2013) 122 (21): 2436.

https://doi.org/10.1182/blood.V122.21.2436.2436

Published: 2013

Journal Articles

A Sensitive and Quantitative Polymerase Chain Reaction-Based Non-Homologous End Joining in Vitro Assay for Hematopoietic Stem Cells

Lijian Shao, MD, PhD, Wei Feng, MD, Daohong Zhou, MD

Blood (2011) 118 (21): 4825.

https://doi.org/10.1182/blood.V118.21.4825.4825

Published: 2011

Journal Articles

Ionizing Radiation Induces Hematopoietic Stem Cell Senescence and Long-Term Bone Marrow Suppression in a p16Ink4a/Arf-Independent manner

Lijian Shao, MD, PhD, Wei Feng, MD, Hongliang Li, MD, PhD, Yong Wang, MD, PhD, Norman Sharpless, MD, PhD, Daohong Zhou, MD

Blood (2011) 118 (21): 1345.

https://doi.org/10.1182/blood.V118.21.1345.1345

Published: 2011

Journal Articles

Deletion of proapoptotic Puma selectively protects hematopoietic stem and progenitor cells against high-dose radiation

Lijian Shao, Yan Sun, Zhonghui Zhang, Wei Feng, Yongxing Gao, Zailong Cai, Zack Z. Wang, A. Thomas Look, Wen-Shu Wu

Blood (2010) 115 (23): 4707–4714.

https://doi.org/10.1182/blood-2009-10-248872

Published: 2010

Journal Articles

RIZ1 Tumor Suppressor Regulates IGF-1 Autocrine Loop To Control Cell Proliferation, Apoptosis, and Differentiation in Chronic Myeloid Leukemia Blast Crisis Cell Lines.

Naoto Takahashi, MD, PhD, Wei-Feng Dong, MD, PhD, Matthew Bainbridge, MSc, Andrea Hull, MD, Elodie Pastural, PhD, Derek Pearson, MD, David Sheridan, MD, John DeCoteau, MD, C. Ron Geyer, PhD

Blood (2005) 106 (11): 1208.

https://doi.org/10.1182/blood.V106.11.1208.1208

Published: 2005

Journal Articles

Identification of RIZ1 Targets Involvedin Erythroid Differentiation of K562 Human Erythroleukemia Cells Using Surface-Enhanced Laser Desorption Ionization Time-Of-Flight Mass Spectrometry (SELDI).

Naoto Takahashi, MD, PhD, Matthew Brainbridge, BSc, Stuart A. Scott, BSc, Ryo Ichinohasama, MD, PhD, Stephen E. Sanche, MD, Wei-Feng Dong, MD, PhD, John F. DeCoteau, MD, C. R. Geyer, PhD

Blood (2004) 104 (11): 2031.

https://doi.org/10.1182/blood.V104.11.2031.2031

Published: 2004

Journal Articles

cDNA Microarray Analysis of Genes Up-Regulated by Treatment with 5-AZA-2′-Deoxycytidine in Combination with Trichostatin A Identifies Aberrant Metallothionein 1H Promoter Methylation at a High Frequency Iin Human AML.

Stuart A. Scott, BSc, Derek S. Pearson, MD, Matthew N. Bainbridge, BSc, Wei-Feng Dong, MD, PhD, Naoto Takahashi, MD, PhD, David P. Sheridan, MD, Ryo Ichinohasama, MD, PhD, C. R. Geyer, PhD, John F. DeCoteau, MD

Blood (2004) 104 (11): 2036.

https://doi.org/10.1182/blood.V104.11.2036.2036

Published: 2004

Journal Articles

Identification of Target Genes for the Tumor Suppressor RIZ1 Using Gene Expression Profiling.

Wei-Feng Dong, MD, PhD, Naoto Takahashi, MD, PhD, Matthew N. Bainbridge, BSc, Andrea R. Hull, BSc, Stuart A. Scott, BSc, C. R. Geyer, PhD, John F. DeCoteau, MD

Blood (2004) 104 (11): 4351.

https://doi.org/10.1182/blood.V104.11.4351.4351

Published: 2004

Journal Articles

Defects of the Mismatch Repair Gene MSH2 Are Implicated in the Development of Murine and Human Lymphoblastic Lymphomas and Are Associated With the Aberrant Expression of Rhombotin-2 (Lmo-2) and Tal-1 (SCL)

Robert Lowsky, John F. DeCoteau, Armin H. Reitmair, Ryo Ichinohasama, Wei-Feng Dong, Yi Xu, Tak W. Mak, Marshall E. Kadin, Mark D. Minden

Blood (1997) 89 (7): 2276–2282.

https://doi.org/10.1182/blood.V89.7.2276

Published: 1997

NARROW

Ker-050 Treatment Reduced Iron Overload and Increased Bone Specific Alkaline Phosphatase in Participants with Lower-Risk MDS Supporting Potential to Restore Balance to the Osteohematopoietic Niche

Durable Clinical Benefit with Ker-050 Treatment: Findings from an Ongoing Phase 2 Study in Participants with Lower-Risk MDS

Modulation of TGF-β Superfamily Signaling to Treat Myelofibrosis and Mitigate JAK Inhibitor Toxicity: A Report on the Phase 2 Study of Ker-050 in Participants with Myelofibrosis

Effects of Ker-050 on Iron Metabolism: Exploratory Analyses from an Ongoing Phase 2 Study in Patients with Myelodysplastic Syndromes

Timing of the loss of Pten protein determines disease severity in a mouse model of myeloid malignancy

Opposite Effects of M1 and M2 Macrophages on Hematopoietic Stem Cell Self-Renewal and Ex Vivo Expansion

Timing of the Loss of Pten Is Critical in Determining the Disease Phenotype in Mice- a Mouse Model for Pediatric Mixed MDS/MPN

Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner

Platelet Depletion Causes Rapid But Transient Activation Of Mouse Bone Marrow Long-Term Hematopoietic Stem Cells To Participate In Stress Thrombopoiesis

A Sensitive and Quantitative Polymerase Chain Reaction-Based Non-Homologous End Joining in Vitro Assay for Hematopoietic Stem Cells

Ionizing Radiation Induces Hematopoietic Stem Cell Senescence and Long-Term Bone Marrow Suppression in a p16Ink4a/Arf-Independent manner

Deletion of proapoptotic Puma selectively protects hematopoietic stem and progenitor cells against high-dose radiation

RIZ1 Tumor Suppressor Regulates IGF-1 Autocrine Loop To Control Cell Proliferation, Apoptosis, and Differentiation in Chronic Myeloid Leukemia Blast Crisis Cell Lines.

Identification of RIZ1 Targets Involvedin Erythroid Differentiation of K562 Human Erythroleukemia Cells Using Surface-Enhanced Laser Desorption Ionization Time-Of-Flight Mass Spectrometry (SELDI).

cDNA Microarray Analysis of Genes Up-Regulated by Treatment with 5-AZA-2′-Deoxycytidine in Combination with Trichostatin A Identifies Aberrant Metallothionein 1H Promoter Methylation at a High Frequency Iin Human AML.

Identification of Target Genes for the Tumor Suppressor RIZ1 Using Gene Expression Profiling.

Defects of the Mismatch Repair Gene MSH2 Are Implicated in the Development of Murine and Human Lymphoblastic Lymphomas and Are Associated With the Aberrant Expression of Rhombotin-2 (Lmo-2) and Tal-1 (SCL)

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American Society of Hematology

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ASH Publications

American Society of Hematology

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