On page 1828 in the 20 March 2014 issue, there is an error in the text. In the second paragraph of the “Patients and treatment” section, the value “75%” should have read “74%.” The third sentence reads, “The median number of prior therapies was 5 (range, 1-13); all patients had received prior LEN and BORT, 99% had received prior DEX, 67% had received prior thalidomide, 75% had undergone prior stem cell transplantation, and 23% had received prior carfilzomib (CFZ).” The sentence should have read, “The median number of prior therapies was 5 (range, 1-13); all patients had received prior LEN and BORT, 99% had received prior DEX, 67% had received prior thalidomide, 74% had undergone prior stem cell transplantation, and 23% had received prior carfilzomib (CFZ).”
Also on page 1828, there are errors in Table 1. In the row “Stem cell transplantation,” the entries corresponding to the columns “POM+LoDEX” and “Total” read “74” and “75.” They should have read “72” and “74,” respectively. The corrected Table 1 is shown.
. | POM+LoDEX (n = 113) . | POM alone (n = 108) . | Total (N = 221) . |
---|---|---|---|
Median age, y (range) | 64 (34-88) | 61 (37-88) | 63 (34-88) |
Age distribution, % | |||
≤65 y | 55 | 64 | 59 |
>65 y | 45 | 36 | 41 |
≤75 y | 88 | 88 | 88 |
>75 y | 12 | 12 | 12 |
Male, % | 55 | 53 | 54 |
MM stage, % | |||
I | 7 | 7 | 7 |
II | 26 | 27 | 26 |
III | 67 | 66 | 67 |
ECOG performance status score, % | |||
0 | 28 | 22 | 25 |
1 | 60 | 66 | 63 |
2 | 12 | 10 | 11 |
3 | 0 | 2 | 1 |
Cytogenetic profile, % | |||
High risk* | 27 | 28 | 27 |
Standard risk | 50 | 40 | 45 |
Missing data | 23 | 32 | 28 |
Median number of prior therapies (range) | 5 (2-13) | 5 (1-12) | 5 (1-13) |
Number of prior treatments, % | |||
≤2 | 5 | 5 | 5 |
>2 | 95 | 95 | 95 |
Prior therapies, % | |||
LEN and BORT | 100 | 100 | 100 |
DEX | 99 | 99 | 99 |
Thalidomide | 67 | 67 | 67 |
Stem cell transplantation | 72 | 76 | 74 |
CFZ | 17 | 29 | 23 |
Prior thalidomide exposure, % | |||
Yes | 67 | 67 | 67 |
No | 33 | 33 | 33 |
LEN as last prior therapy, % | 39 | 31 | 35 |
Refractory to LEN, %† | 78 | 80 | 79 |
Refractory to BORT, %‡ | 71 | 70 | 71 |
Refractory to both LEN and BORT, %§ | 62 | 61 | 62 |
. | POM+LoDEX (n = 113) . | POM alone (n = 108) . | Total (N = 221) . |
---|---|---|---|
Median age, y (range) | 64 (34-88) | 61 (37-88) | 63 (34-88) |
Age distribution, % | |||
≤65 y | 55 | 64 | 59 |
>65 y | 45 | 36 | 41 |
≤75 y | 88 | 88 | 88 |
>75 y | 12 | 12 | 12 |
Male, % | 55 | 53 | 54 |
MM stage, % | |||
I | 7 | 7 | 7 |
II | 26 | 27 | 26 |
III | 67 | 66 | 67 |
ECOG performance status score, % | |||
0 | 28 | 22 | 25 |
1 | 60 | 66 | 63 |
2 | 12 | 10 | 11 |
3 | 0 | 2 | 1 |
Cytogenetic profile, % | |||
High risk* | 27 | 28 | 27 |
Standard risk | 50 | 40 | 45 |
Missing data | 23 | 32 | 28 |
Median number of prior therapies (range) | 5 (2-13) | 5 (1-12) | 5 (1-13) |
Number of prior treatments, % | |||
≤2 | 5 | 5 | 5 |
>2 | 95 | 95 | 95 |
Prior therapies, % | |||
LEN and BORT | 100 | 100 | 100 |
DEX | 99 | 99 | 99 |
Thalidomide | 67 | 67 | 67 |
Stem cell transplantation | 72 | 76 | 74 |
CFZ | 17 | 29 | 23 |
Prior thalidomide exposure, % | |||
Yes | 67 | 67 | 67 |
No | 33 | 33 | 33 |
LEN as last prior therapy, % | 39 | 31 | 35 |
Refractory to LEN, %† | 78 | 80 | 79 |
Refractory to BORT, %‡ | 71 | 70 | 71 |
Refractory to both LEN and BORT, %§ | 62 | 61 | 62 |
CFZ, carfilzomib; ECOG, Eastern Cooperative Oncology Group; PD, progressive disease.
High-risk cytogenetic profiles defined as del(17p13) and/or t(4p16/14q32).
Defined as patients who experienced PD during or within 60 d (measured from the last dose) of completing treatment with LEN.
Defined as patients who experienced PD during or within 60 d (measured from the last dose) of completing treatment with BORT.
Defined as patients who experienced PD during or within 60 d (measured from the last dose) of completing treatment with LEN and BORT.
On page 1829, there are errors in the text. In the “LEN as last prior therapy” section, the values “6.2” and “8.4” should have read “6.5” and “11.4,” respectively. The third sentence reads, “The median response duration was 6.2 months with POM+LoDEX and 8.4 months with POM alone, and the median OS was 16.6 and 8.5 months, respectively (HR = 0.71, 95% CI = 0.42-1.21, P = .205).” The sentence should have read, “The median response duration was 6.5 months with POM+LoDEX and 11.4 months with POM alone, and the median OS was 16.6 and 8.5 months, respectively (HR = 0.71, 95% CI = 0.42-1.21, P = .205).”
On page 1831, there is an error in Table 3. In the row “Pyrexia,” the entry corresponding to “POM+LoDEX” reads “6.” It should have read “8.” The corrected Table 3 is shown.
. | POM+LoDEX (n = 112) . | POM alone (n = 107) . |
---|---|---|
Hematologic AEs occurring in ≥5% of patients, % | ||
Neutropenia | 41 | 48 |
Anemia | 22 | 24 |
Thrombocytopenia | 19 | 22 |
Leukopenia | 10 | 7 |
Lymphopenia | 7 | 2 |
Febrile neutropenia | 3 | 5 |
Nonhematologic AEs occurring in ≥5% of patients, % | ||
Pneumonia | 22 | 15 |
Fatigue | 14 | 11 |
Dyspnea | 13 | 8 |
Back pain | 10 | 14 |
Urinary tract infection | 9 | 2 |
Sepsis | 5 | 6 |
Dehydration | 5 | 5 |
Acute renal failure | 5 | 8 |
Muscular weakness | 4 | 6 |
Blood creatinine increase | 3 | 6 |
Confusional state | 3 | 7 |
Hypercalcemia | 1 | 10 |
AEs leading to dose reduction in ≥5% of patients, % | ||
Thrombocytopenia | 5 | 9 |
Neutropenia | 4 | 7 |
AEs leading to dose interruption in ≥5% of patients, % | ||
Neutropenia | 9 | 14 |
Thrombocytopenia | 5 | 11 |
Pneumonia | 18 | 12 |
Upper respiratory tract infection | 5 | 9 |
Fatigue | 8 | 4 |
Pyrexia | 8 | 2 |
Most common AEs leading to discontinuation in patients, % | ||
Increased blood creatinine | 1 | 1 |
Acute renal failure | 1 | 2 |
Supportive-care use during study treatment, % | ||
G-CSF | 46 | 58 |
Epoetin alfa | 18 | 23 |
Darbepoetin alfa | 12 | 26 |
Red blood cell transfusion | 45 | 49 |
Platelet transfusion | 14 | 20 |
. | POM+LoDEX (n = 112) . | POM alone (n = 107) . |
---|---|---|
Hematologic AEs occurring in ≥5% of patients, % | ||
Neutropenia | 41 | 48 |
Anemia | 22 | 24 |
Thrombocytopenia | 19 | 22 |
Leukopenia | 10 | 7 |
Lymphopenia | 7 | 2 |
Febrile neutropenia | 3 | 5 |
Nonhematologic AEs occurring in ≥5% of patients, % | ||
Pneumonia | 22 | 15 |
Fatigue | 14 | 11 |
Dyspnea | 13 | 8 |
Back pain | 10 | 14 |
Urinary tract infection | 9 | 2 |
Sepsis | 5 | 6 |
Dehydration | 5 | 5 |
Acute renal failure | 5 | 8 |
Muscular weakness | 4 | 6 |
Blood creatinine increase | 3 | 6 |
Confusional state | 3 | 7 |
Hypercalcemia | 1 | 10 |
AEs leading to dose reduction in ≥5% of patients, % | ||
Thrombocytopenia | 5 | 9 |
Neutropenia | 4 | 7 |
AEs leading to dose interruption in ≥5% of patients, % | ||
Neutropenia | 9 | 14 |
Thrombocytopenia | 5 | 11 |
Pneumonia | 18 | 12 |
Upper respiratory tract infection | 5 | 9 |
Fatigue | 8 | 4 |
Pyrexia | 8 | 2 |
Most common AEs leading to discontinuation in patients, % | ||
Increased blood creatinine | 1 | 1 |
Acute renal failure | 1 | 2 |
Supportive-care use during study treatment, % | ||
G-CSF | 46 | 58 |
Epoetin alfa | 18 | 23 |
Darbepoetin alfa | 12 | 26 |
Red blood cell transfusion | 45 | 49 |
Platelet transfusion | 14 | 20 |
Treatment-emergent AEs are defined as any AE occurring or worsening on or after the first treatment of the study medication and within 30 days after treatment phase end date.
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