On page 1828 in the 20 March 2014 issue, there is an error in the text. In the second paragraph of the “Patients and treatment” section, the value “75%” should have read “74%.” The third sentence reads, “The median number of prior therapies was 5 (range, 1-13); all patients had received prior LEN and BORT, 99% had received prior DEX, 67% had received prior thalidomide, 75% had undergone prior stem cell transplantation, and 23% had received prior carfilzomib (CFZ).” The sentence should have read, “The median number of prior therapies was 5 (range, 1-13); all patients had received prior LEN and BORT, 99% had received prior DEX, 67% had received prior thalidomide, 74% had undergone prior stem cell transplantation, and 23% had received prior carfilzomib (CFZ).”

Also on page 1828, there are errors in Table 1. In the row “Stem cell transplantation,” the entries corresponding to the columns “POM+LoDEX” and “Total” read “74” and “75.” They should have read “72” and “74,” respectively. The corrected Table 1 is shown.

Table 1

Baseline patient characteristics

POM+LoDEX (n = 113)POM alone (n = 108)Total (N = 221)
Median age, y (range) 64 (34-88) 61 (37-88) 63 (34-88) 
Age distribution, %    
 ≤65 y 55 64 59 
 >65 y 45 36 41 
 ≤75 y 88 88 88 
 >75 y 12 12 12 
Male, % 55 53 54 
MM stage, %    
 I 
 II 26 27 26 
 III 67 66 67 
ECOG performance status score, %    
 0 28 22 25 
 1 60 66 63 
 2 12 10 11 
 3 
Cytogenetic profile, %    
 High risk* 27 28 27 
 Standard risk 50 40 45 
Missing data 23 32 28 
Median number of prior therapies (range) 5 (2-13) 5 (1-12) 5 (1-13) 
Number of prior treatments, %    
 ≤2 
 >2 95 95 95 
Prior therapies, %    
 LEN and BORT 100 100 100 
 DEX 99 99 99 
 Thalidomide 67 67 67 
 Stem cell transplantation 72 76 74 
 CFZ 17 29 23 
Prior thalidomide exposure, %    
 Yes 67 67 67 
 No 33 33 33 
LEN as last prior therapy, % 39 31 35 
Refractory to LEN, % 78 80 79 
Refractory to BORT, % 71 70 71 
Refractory to both LEN and BORT, %§ 62 61 62 
POM+LoDEX (n = 113)POM alone (n = 108)Total (N = 221)
Median age, y (range) 64 (34-88) 61 (37-88) 63 (34-88) 
Age distribution, %    
 ≤65 y 55 64 59 
 >65 y 45 36 41 
 ≤75 y 88 88 88 
 >75 y 12 12 12 
Male, % 55 53 54 
MM stage, %    
 I 
 II 26 27 26 
 III 67 66 67 
ECOG performance status score, %    
 0 28 22 25 
 1 60 66 63 
 2 12 10 11 
 3 
Cytogenetic profile, %    
 High risk* 27 28 27 
 Standard risk 50 40 45 
Missing data 23 32 28 
Median number of prior therapies (range) 5 (2-13) 5 (1-12) 5 (1-13) 
Number of prior treatments, %    
 ≤2 
 >2 95 95 95 
Prior therapies, %    
 LEN and BORT 100 100 100 
 DEX 99 99 99 
 Thalidomide 67 67 67 
 Stem cell transplantation 72 76 74 
 CFZ 17 29 23 
Prior thalidomide exposure, %    
 Yes 67 67 67 
 No 33 33 33 
LEN as last prior therapy, % 39 31 35 
Refractory to LEN, % 78 80 79 
Refractory to BORT, % 71 70 71 
Refractory to both LEN and BORT, %§ 62 61 62 

CFZ, carfilzomib; ECOG, Eastern Cooperative Oncology Group; PD, progressive disease.

*

High-risk cytogenetic profiles defined as del(17p13) and/or t(4p16/14q32).

Defined as patients who experienced PD during or within 60 d (measured from the last dose) of completing treatment with LEN.

Defined as patients who experienced PD during or within 60 d (measured from the last dose) of completing treatment with BORT.

§

Defined as patients who experienced PD during or within 60 d (measured from the last dose) of completing treatment with LEN and BORT.

On page 1829, there are errors in the text. In the “LEN as last prior therapy” section, the values “6.2” and “8.4” should have read “6.5” and “11.4,” respectively. The third sentence reads, “The median response duration was 6.2 months with POM+LoDEX and 8.4 months with POM alone, and the median OS was 16.6 and 8.5 months, respectively (HR = 0.71, 95% CI = 0.42-1.21, P = .205).” The sentence should have read, “The median response duration was 6.5 months with POM+LoDEX and 11.4 months with POM alone, and the median OS was 16.6 and 8.5 months, respectively (HR = 0.71, 95% CI = 0.42-1.21, P = .205).”

On page 1831, there is an error in Table 3. In the row “Pyrexia,” the entry corresponding to “POM+LoDEX” reads “6.” It should have read “8.” The corrected Table 3 is shown.

Table 3

Grade 3-4 AEs leading to treatment modifications, and supportive care

POM+LoDEX (n = 112)POM alone (n = 107)
Hematologic AEs occurring in ≥5% of patients, %   
 Neutropenia 41 48 
 Anemia 22 24 
 Thrombocytopenia 19 22 
 Leukopenia 10 
 Lymphopenia 
 Febrile neutropenia 
Nonhematologic AEs occurring in ≥5% of patients, % 
 Pneumonia 22 15 
 Fatigue 14 11 
 Dyspnea 13 
 Back pain 10 14 
 Urinary tract infection 
 Sepsis 
 Dehydration 
 Acute renal failure 
 Muscular weakness 
 Blood creatinine increase 
 Confusional state 
 Hypercalcemia 10 
AEs leading to dose reduction in ≥5% of patients, %   
 Thrombocytopenia 
 Neutropenia 
AEs leading to dose interruption in ≥5% of patients, % 
 Neutropenia 14 
 Thrombocytopenia 11 
 Pneumonia 18 12 
 Upper respiratory tract infection 
 Fatigue 
 Pyrexia 
Most common AEs leading to discontinuation in patients, %   
 Increased blood creatinine 
 Acute renal failure 
Supportive-care use during study treatment, % 
 G-CSF 46 58 
 Epoetin alfa 18 23 
 Darbepoetin alfa 12 26 
 Red blood cell transfusion 45 49 
 Platelet transfusion 14 20 
POM+LoDEX (n = 112)POM alone (n = 107)
Hematologic AEs occurring in ≥5% of patients, %   
 Neutropenia 41 48 
 Anemia 22 24 
 Thrombocytopenia 19 22 
 Leukopenia 10 
 Lymphopenia 
 Febrile neutropenia 
Nonhematologic AEs occurring in ≥5% of patients, % 
 Pneumonia 22 15 
 Fatigue 14 11 
 Dyspnea 13 
 Back pain 10 14 
 Urinary tract infection 
 Sepsis 
 Dehydration 
 Acute renal failure 
 Muscular weakness 
 Blood creatinine increase 
 Confusional state 
 Hypercalcemia 10 
AEs leading to dose reduction in ≥5% of patients, %   
 Thrombocytopenia 
 Neutropenia 
AEs leading to dose interruption in ≥5% of patients, % 
 Neutropenia 14 
 Thrombocytopenia 11 
 Pneumonia 18 12 
 Upper respiratory tract infection 
 Fatigue 
 Pyrexia 
Most common AEs leading to discontinuation in patients, %   
 Increased blood creatinine 
 Acute renal failure 
Supportive-care use during study treatment, % 
 G-CSF 46 58 
 Epoetin alfa 18 23 
 Darbepoetin alfa 12 26 
 Red blood cell transfusion 45 49 
 Platelet transfusion 14 20 

Treatment-emergent AEs are defined as any AE occurring or worsening on or after the first treatment of the study medication and within 30 days after treatment phase end date.

Sign in via your Institution