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Issue Archive

Volume 122, Issue 6
August 8 2013
Issue Cover

Table of Contents

INSIDE BLOOD

CLINICAL TRIALS & OBSERVATIONS
Genetic engineering of T-cell receptors: TCR takes to titin
Clinical Trials & Observations
Helen E. Heslop
View Articletitled, Genetic engineering of T-cell receptors: TCR takes to titin
HEMATOPOIESIS & STEM CELLS
Long-range control of T-cell development
Dominic van Essen
View Articletitled, Long-range control of T-cell development
HEMATOPOIESIS & STEM CELLS
Defects in DBA: more than meets the eye
Lydie Da Costa
View Articletitled, Defects in DBA: more than meets the eye
IMMUNOBIOLOGY
Inhibiting inhibitory pathways in human γδ T cells
Richard D. Lopez
View Articletitled, Inhibiting inhibitory pathways in human γδ T cells
TRANSFUSION MEDICINE
Ideal donors, imperfect results in sickle cell disease
Alexis A. Thompson
View Articletitled, Ideal donors, imperfect results in sickle cell disease
TRANSPLANTATION
Hemoglobin disorders: a look to the future
David G. Nathan
View Articletitled, Hemoglobin disorders: a look to the future

BLOOD WORK

A myeloproliferative neoplasm with translocation t(8;9)(p22;p24) involving JAK2 gene
Nakhle Saba,Hana Safah
View Articletitled, A myeloproliferative neoplasm with translocation t(8;9)(p22;p24) involving <em>JAK2</em> gene
Invasive mucormycosis without radiological alterations
Francesca Labbadia,Andrés Sanchez-Salinas
View Articletitled, Invasive mucormycosis without radiological alterations

PLENARY PAPER

Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma
Gerald P. Linette,Edward A. Stadtmauer,Marcela V. Maus,Aaron P. Rapoport,Bruce L. Levine,Lyndsey Emery,Leslie Litzky,Adam Bagg,Beatriz M. Carreno,Patrick J. Cimino,Gwendolyn K. Binder-Scholl,Dominic P. Smethurst,Andrew B. Gerry,Nick J. Pumphrey,Alan D. Bennett,Joanna E. Brewer,Joseph Dukes,Jane Harper,Helen K. Tayton-Martin,Bent K. Jakobsen,Namir J. Hassan,Michael Kalos,Carl H. June
View Articletitled, Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma
Supplemental data

REVIEW ARTICLE

European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013
Michele Baccarani,Michael W. Deininger,Gianantonio Rosti,Andreas Hochhaus,Simona Soverini,Jane F. Apperley,Francisco Cervantes,Richard E. Clark,Jorge E. Cortes,François Guilhot,Henrik Hjorth-Hansen,Timothy P. Hughes,Hagop M. Kantarjian,Dong-Wook Kim,Richard A. Larson,Jeffrey H. Lipton,François-Xavier Mahon,Giovanni Martinelli,Jiri Mayer,Martin C. Müller,Dietger Niederwieser,Fabrizio Pane,Jerald P. Radich,Philippe Rousselot,Giuseppe Saglio,Susanne Saußele,Charles Schiffer,Richard Silver,Bengt Simonsson,Juan-Luis Steegmann,John M. Goldman,Rüdiger Hehlmann
View Articletitled, European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013
Supplemental data
The gut in iron homeostasis: role of HIF-2 under normal and pathological conditions
Maria Mastrogiannaki,Pavle Matak,Carole Peyssonnaux
View Articletitled, The gut in iron homeostasis: role of HIF-2 under normal and pathological conditions

CLINICAL TRIALS AND OBSERVATIONS

Molecular analysis of patients with polycythemia vera or essential thrombocythemia receiving pegylated interferon α-2a
Clinical Trials & Observations
Alfonso Quintás-Cardama,Omar Abdel-Wahab,Taghi Manshouri,Outi Kilpivaara,Jorge Cortes,Anne-Laure Roupie,Su-Jiang Zhang,David Harris,Zeev Estrov,Hagop Kantarjian,Ross L. Levine,Srdan Verstovsek
View Articletitled, Molecular analysis of patients with polycythemia vera or essential thrombocythemia receiving pegylated interferon α-2a
Supplemental data

HEMATOPOIESIS AND STEM CELLS

A far downstream enhancer for murine Bcl11b controls its T-cell specific expression
Long Li,Jingli A. Zhang,Marei Dose,Hao Yuan Kueh,Ruzbeh Mosadeghi,Fotini Gounari,Ellen V. Rothenberg
View Articletitled, A far downstream enhancer for murine <em>Bcl11b</em> controls its T-cell specific expression
Supplemental data
Ribosomal and hematopoietic defects in induced pluripotent stem cells derived from Diamond Blackfan anemia patients
Loïc Garçon,Jingping Ge,Shwetha H. Manjunath,Jason A. Mills,Marisa Apicella,Shefali Parikh,Lisa M. Sullivan,Gregory M. Podsakoff,Paul Gadue,Deborah L. French,Philip J. Mason,Monica Bessler,Mitchell J. Weiss
View Articletitled, Ribosomal and hematopoietic defects in induced pluripotent stem cells derived from Diamond Blackfan anemia patients
Supplemental data

IMMUNOBIOLOGY

The co-receptor BTLA negatively regulates human Vγ9Vδ2 T-cell proliferation: a potential way of immune escape for lymphoma cells
Julie Gertner-Dardenne,Cyril Fauriat,Florence Orlanducci,Marie-Laure Thibult,Sonia Pastor,Jude Fitzgibbon,Reda Bouabdallah,Luc Xerri,Daniel Olive
View Articletitled, The co-receptor BTLA negatively regulates human Vγ9Vδ2 T-cell proliferation: a potential way of immune escape for lymphoma cells
Supplemental data
Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses
Giulia Nizzoli,Jana Krietsch,Anja Weick,Svenja Steinfelder,Federica Facciotti,Paola Gruarin,Annalisa Bianco,Bodo Steckel,Monica Moro,Mariacristina Crosti,Chiara Romagnani,Katharina Stölzel,Sara Torretta,Lorenzo Pignataro,Carmen Scheibenbogen,Petra Neddermann,Raffaele De Francesco,Sergio Abrignani,Jens Geginat
View Articletitled, Human CD1c<sup>+</sup> dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses
Supplemental data

LYMPHOID NEOPLASIA

Elucidating the role of interleukin-17F in cutaneous T-cell lymphoma
Thorbjørn Krejsgaard,Ivan V. Litvinov,Yang Wang,Lixin Xia,Andreas Willerslev-Olsen,Sergei B. Koralov,Katharina L. Kopp,Charlotte M. Bonefeld,Mariusz A. Wasik,Carsten Geisler,Anders Woetmann,Youwen Zhou,Denis Sasseville,Niels Odum
View Articletitled, Elucidating the role of interleukin-17F in cutaneous T-cell lymphoma
Supplemental data
A prospective study of 67 serum immune and inflammation markers and risk of non-Hodgkin lymphoma
Mark P. Purdue,Jonathan N. Hofmann,Troy J. Kemp,Anil K. Chaturvedi,Qing Lan,Ju-Hyun Park,Ruth M. Pfeiffer,Allan Hildesheim,Ligia A. Pinto,Nathaniel Rothman
View Articletitled, A prospective study of 67 serum immune and inflammation markers and risk of non-Hodgkin lymphoma
Supplemental data
Integrated phosphoproteomic and metabolomic profiling reveals NPM-ALK–mediated phosphorylation of PKM2 and metabolic reprogramming in anaplastic large cell lymphoma
Scott R. P. McDonnell,Steven R. Hwang,Delphine Rolland,Carlos Murga-Zamalloa,Venkatesha Basrur,Kevin P. Conlon,Damian Fermin,Thomas Wolfe,Alexander Raskind,Chunhai Ruan,Jian-Kang Jiang,Craig J. Thomas,Cory M. Hogaboam,Charles F. Burant,Kojo S. J. Elenitoba-Johnson,Megan S. Lim
View Articletitled, Integrated phosphoproteomic and metabolomic profiling reveals NPM-ALK–mediated phosphorylation of PKM2 and metabolic reprogramming in anaplastic large cell lymphoma
Supplemental data
PPARα and fatty acid oxidation mediate glucocorticoid resistance in chronic lymphocytic leukemia
Stephanie Tung,Yonghong Shi,Karry Wong,Fang Zhu,Reg Gorczynski,Robert C. Laister,Mark Minden,Anne-Kareen Blechert,Yvonne Genzel,Udo Reichl,David E. Spaner
View Articletitled, PPARα and fatty acid oxidation mediate glucocorticoid resistance in chronic lymphocytic leukemia
Supplemental data
Improvements in observed and relative survival in follicular grade 1-2 lymphoma during 4 decades: the Stanford University experience
Daryl Tan,Sandra J. Horning,Richard T. Hoppe,Ronald Levy,Saul A. Rosenberg,Bronislava M. Sigal,Roger A. Warnke,Yasodha Natkunam,Summer S. Han,Alan Yuen,Sylvia K. Plevritis,Ranjana H. Advani
View Articletitled, Improvements in observed and relative survival in follicular grade 1-2 lymphoma during 4 decades: the Stanford University experience
Supplemental data

MYELOID NEOPLASIA

Perturbation of fetal hematopoiesis in a mouse model of Down syndrome’s transient myeloproliferative disorder
Yehudit Birger,Liat Goldberg,Timothy M. Chlon,Benjamin Goldenson,Inna Muler,Ginette Schiby,Jasmin Jacob-Hirsch,Gideon Rechavi,John D. Crispino,Shai Izraeli
View Articletitled, Perturbation of fetal hematopoiesis in a mouse model of Down syndrome’s transient myeloproliferative disorder
Supplemental data
Patterns of missplicing due to somatic U2AF1 mutations in myeloid neoplasms
Bartlomiej Przychodzen,Andres Jerez,Kathryn Guinta,Mikkael A. Sekeres,Richard Padgett,Jaroslaw P. Maciejewski,Hideki Makishima
View Articletitled, Patterns of missplicing due to somatic U2AF1 mutations in myeloid neoplasms
Supplemental data
Dysregulated signaling pathways in the development of CNTRL-FGFR1–induced myeloid and lymphoid malignancies associated with FGFR1 in human and mouse models
Mingqiang Ren,Haiyan Qin,Eiko Kitamura,John K. Cowell
View Articletitled, Dysregulated signaling pathways in the development of CNTRL-FGFR1–induced myeloid and lymphoid malignancies associated with FGFR1 in human and mouse models
Supplemental data
Potent inhibition of DOT1L as treatment of MLL-fusion leukemia
Scott R. Daigle,Edward J. Olhava,Carly A. Therkelsen,Aravind Basavapathruni,Lei Jin,P. Ann Boriack-Sjodin,Christina J. Allain,Christine R. Klaus,Alejandra Raimondi,Margaret Porter Scott,Nigel J. Waters,Richard Chesworth,Mikel P. Moyer,Robert A. Copeland,Victoria M. Richon,Roy M. Pollock
View Articletitled, Potent inhibition of DOT1L as treatment of MLL-fusion leukemia
Supplemental data

PLATELETS AND THROMBOPOIESIS

Dietary α-linolenic acid increases the platelet count in ApoE−/− mice by reducing clearance
Simona Stivala,Martin F. Reiner,Christine Lohmann,Thomas F. Lüscher,Christian M. Matter,Juerg H. Beer
View Articletitled, Dietary α-linolenic acid increases the platelet count in ApoE<sup>−/−</sup> mice by reducing clearance
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

LIN28B-mediated expression of fetal hemoglobin and production of fetal-like erythrocytes from adult human erythroblasts ex vivo
Y. Terry Lee,Jaira F. de Vasconcellos,Joan Yuan,Colleen Byrnes,Seung-Jae Noh,Emily R. Meier,Ki Soon Kim,Antoinette Rabel,Megha Kaushal,Stefan A. Muljo,Jeffery L. Miller
View Articletitled, <em>LIN28B</em>-mediated expression of fetal hemoglobin and production of fetal-like erythrocytes from adult human erythroblasts ex vivo
Supplemental data

THROMBOSIS AND HEMOSTASIS

cAMP-induced secretion of endothelial von Willebrand factor is regulated by a phosphorylation/dephosphorylation switch in annexin A2
Ines Brandherm,Jennifer Disse,Dagmar Zeuschner,Volker Gerke
View Articletitled, cAMP-induced secretion of endothelial von Willebrand factor is regulated by a phosphorylation/dephosphorylation switch in annexin A2
Supplemental data
Platelet protein disulfide isomerase is required for thrombus formation but not for hemostasis in mice
Kyungho Kim,Eunsil Hahm,Jing Li,Lisa-Marie Holbrook,Parvathy Sasikumar,Ronald G. Stanley,Masuko Ushio-Fukai,Jonathan M. Gibbins,Jaehyung Cho
View Articletitled, Platelet protein disulfide isomerase is required for thrombus formation but not for hemostasis in mice
Supplemental data

TRANSFUSION MEDICINE

High prevalence of red blood cell alloimmunization in sickle cell disease despite transfusion from Rh-matched minority donors
Stella T. Chou,Tannoa Jackson,Sunitha Vege,Kim Smith-Whitley,David F. Friedman,Connie M. Westhoff
View Articletitled, High prevalence of red blood cell alloimmunization in sickle cell disease despite transfusion from Rh-matched minority donors
Supplemental data

TRANSPLANTATION

Outcome of patients with hemoglobinopathies given either cord blood or bone marrow transplantation from an HLA-identical sibling
Franco Locatelli,Nabil Kabbara,Annalisa Ruggeri,Ardeshir Ghavamzadeh,Irene Roberts,Chi Kong Li,Françoise Bernaudin,Christiane Vermylen,Jean-Hugues Dalle,Jerry Stein,Robert Wynn,Catherine Cordonnier,Fernando Pinto,Emanuele Angelucci,Gérard Socié,Eliane Gluckman,Mark C. Walters,Vanderson Rocha,on behalf of Eurocord and European Blood and Marrow Transplantation (EBMT) group
View Articletitled, Outcome of patients with hemoglobinopathies given either cord blood or bone marrow transplantation from an HLA-identical sibling
Supplemental data
Hepatitis E virus: an underestimated opportunistic pathogen in recipients of allogeneic hematopoietic stem cell transplantation
Jurjen Versluis,Suzan D. Pas,Hendrik J. Agteresch,Robert A. de Man,Jolanda Maaskant,Marguerite E. I. Schipper,Albert D. M. E. Osterhaus,Jan J. Cornelissen,Annemiek A. van der Eijk
View Articletitled, Hepatitis E virus: an underestimated opportunistic pathogen in recipients of allogeneic hematopoietic stem cell transplantation

CORRESPONDENCE

Immune responses against the mutated region of cytoplasmatic NPM1 might contribute to the favorable clinical outcome of AML patients with NPM1 mutations (NPM1mut)
Jochen Greiner,Vanessa Schneider,Michael Schmitt,Marlies Götz,Konstanze Döhner,Markus Wiesneth,Hartmut Döhner,Susanne Hofmann
View Articletitled, Immune responses against the mutated region of cytoplasmatic NPM1 might contribute to the favorable clinical outcome of AML patients with <em>NPM1</em> mutations (<em>NPM1</em><sup><em>mut</em></sup>)
Minimal residual disease testing in multiple myeloma by flow cytometry: major heterogeneity
Aaron Flanders,Maryalice Stetler-Stevenson,Ola Landgren
View Articletitled, Minimal residual disease testing in multiple myeloma by flow cytometry: major heterogeneity
Detection of an NRAS mutation in Erdheim-Chester disease
Eli L. Diamond,Omar Abdel-Wahab,Elena Pentsova,Laetitia Borsu,April Chiu,Julie Teruya-Feldstein,David M. Hyman,Marc Rosenblum
View Articletitled, Detection of an <em>NRAS</em> mutation in Erdheim-Chester disease
Lactate dehydrogenase and hemolysis in sickle cell disease
Gregory J. Kato,Seyed Mehdi Nouraie,Mark T. Gladwin
View Articletitled, Lactate dehydrogenase and hemolysis in sickle cell disease
All Issues

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