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Phase 2 clinical trial of rapamycin-resistant donor CD4+ Th2/Th1 (T-Rapa) cells after low-intensity allogeneic hematopoietic cell transplantation
Aryl hydrocarbon receptor contributes to the MEK/ERK-dependent maintenance of the immature state of human dendritic cells
Issue Archive
April 11 2013
In this Issue
Table of Contents
Inside Blood
Blood Work
Plenary Paper
Plenary Paper
Perspectives
Review Article
How I Treat
Clinical Trials and Observations
Phase 2 clinical trial of rapamycin-resistant donor CD4+ Th2/Th1 (T-Rapa) cells after low-intensity allogeneic hematopoietic cell transplantation
Clinical Trials & Observations
Daniel H. Fowler,Miriam E. Mossoba,Seth M. Steinberg,David C. Halverson,David Stroncek,Hahn M. Khuu,Frances T. Hakim,Luciano Castiello,Marianna Sabatino,Susan F. Leitman,Jacopo Mariotti,Juan C. Gea-Banacloche,Claude Sportes,Nancy M. Hardy,Dennis D. Hickstein,Steven Z. Pavletic,Scott Rowley,Andre Goy,Michele Donato,Robert Korngold,Andrew Pecora,Bruce L. Levine,Carl H. June,Ronald E. Gress,Michael R. Bishop
Hematopoiesis and Stem Cells
miR-21 mediates hematopoietic suppression in MDS by activating TGF-β signaling
Tushar D. Bhagat,Li Zhou,Lubomir Sokol,Rachel Kessel,Gisela Caceres,Krishna Gundabolu,Roni Tamari,Shanisha Gordon,Ioannis Mantzaris,Tomasz Jodlowski,Yiting Yu,Xiaohong Jing,Rahul Polineni,Kavi Bhatia,Andrea Pellagatti,Jacqueline Boultwood,Suman Kambhampati,Ulrich Steidl,Cy Stein,Wenjun Ju,Gang Liu,Paraic Kenny,Alan List,Markus Bitzer,Amit Verma
Genome-wide analysis shows that Ldb1 controls essential hematopoietic genes/pathways in mouse early development and reveals novel players in hematopoiesis
Athina Mylona,Charlotte Andrieu-Soler,Supat Thongjuea,Andrea Martella,Eric Soler,Ruud Jorna,Jun Hou,Christel Kockx,Wilfred van Ijcken,Boris Lenhard,Frank Grosveld
Immunobiology
Impaired T-cell responses to sphingosine-1-phosphate in HIV-1 infected lymph nodes
Joseph C. Mudd,Patrick Murphy,Maura Manion,Robert Debernardo,Jeffrey Hardacre,John Ammori,Gareth A. Hardy,Clifford V. Harding,Ganapati H. Mahabaleshwar,Mukesh K. Jain,Jeffrey M. Jacobson,Ari D. Brooks,Sharon Lewis,Timothy W. Schacker,Jodi Anderson,Elias K. Haddad,Rafael A. Cubas,Benigno Rodriguez,Scott F. Sieg,Michael M. Lederman
Neurokinin-1 receptor agonists bias therapeutic dendritic cells to induce type 1 immunity by licensing host dendritic cells to produce IL-12
Brian M. Janelsins,Tina L. Sumpter,Olga A. Tkacheva,Darling M. Rojas-Canales,Geza Erdos,Alicia R. Mathers,William J. Shufesky,Walter J. Storkus,Louis D. Falo, Jr,Adrian E. Morelli,Adriana T. Larregina
The risk of hemophagocytic lymphohistiocytosis in Hermansky-Pudlak syndrome type 2
Birthe Jessen,Sebastian F. N. Bode,Sandra Ammann,Subarna Chakravorty,Graham Davies,Jana Diestelhorst,Melissa Frei-Jones,William A. Gahl,Bernadette R. Gochuico,Matthias Griese,Gillian Griffiths,Gritta Janka,Christoph Klein,Tamara Kögl,Karin Kurnik,Kai Lehmberg,Andrea Maul-Pavicic,Andrew D. Mumford,David Pace,Nima Parvaneh,Nima Rezaei,Geneviève de Saint Basile,Annette Schmitt-Graeff,Klaus Schwarz,Gulsun T. Karasu,Barbara Zieger,Udo zur Stadt,Peter Aichele,Stephan Ehl
Aryl hydrocarbon receptor contributes to the MEK/ERK-dependent maintenance of the immature state of human dendritic cells
e-blood
Noemí Aguilera-Montilla,Sonia Chamorro,Concha Nieto,Fátima Sánchez-Cabo,Ana Dopazo,Pedro Maria Fernández-Salguero,Jose Luis Rodríguez-Fernández,Oscar M. Pello,Vicente Andrés,Ana Cuenda,Bárbara Alonso,Angeles Domínguez-Soto,Silvia Sánchez-Ramón,Angel L. Corbí
Lymphoid Neoplasia
Combined inhibition of PI3K-related DNA damage response kinases and mTORC1 induces apoptosis in MYC-driven B-cell lymphomas
Jake Shortt,Benjamin P. Martin,Andrea Newbold,Katherine M. Hannan,Jennifer R. Devlin,Adele J. Baker,Rachael Ralli,Carleen Cullinane,Clemens A. Schmitt,Maurice Reimann,Michael N. Hall,Meaghan Wall,Ross D. Hannan,Richard B. Pearson,Grant A. McArthur,Ricky W. Johnstone
Myeloid Neoplasia
Cooperating gene mutations in childhood acute myeloid leukemia with special reference on mutations of ASXL1, TET2, IDH1, IDH2, and DNMT3A
Der-Cherng Liang,Hsi-Che Liu,Chao-Ping Yang,Tang-Her Jaing,Iou-Jih Hung,Ting-Chi Yeh,Shih-Hsiang Chen,Jen-Yin Hou,Ying-Jung Huang,Yu-Shu Shih,Yu-Hui Huang,Tung-Huei Lin,Lee-Yung Shih
Development and validation of a prognostic scoring system for patients with chronic myelomonocytic leukemia
Esperanza Such,Ulrich Germing,Luca Malcovati,José Cervera,Andrea Kuendgen,Matteo G. Della Porta,Benet Nomdedeu,Leonor Arenillas,Elisa Luño,Blanca Xicoy,Mari L. Amigo,David Valcarcel,Kathrin Nachtkamp,Ilaria Ambaglio,Barbara Hildebrandt,Ignacio Lorenzo,Mario Cazzola,Guillermo Sanz
Red Cells, Iron, and Erythropoiesis
Circulatory hepcidin is associated with the anti-inflammatory response but not with iron or anemic status in childhood malaria
Florence Burté,Biobele J. Brown,Adebola E. Orimadegun,Wasiu A. Ajetunmobi,Nathaniel K. Afolabi,Francis Akinkunmi,Olayinka Kowobari,Samuel Omokhodion,Kikelomo Osinusi,Felix O. Akinbami,Wuraola A. Shokunbi,Olugbemiro Sodeinde,Delmiro Fernandez-Reyes
Thrombosis and Hemostasis
Angiotensin 1-7 and Mas decrease thrombosis in Bdkrb2−/− mice by increasing NO and prostacyclin to reduce platelet spreading and glycoprotein VI activation
Chao Fang,Evi Stavrou,Alec A. Schmaier,Nadja Grobe,Mariana Morris,Andrew Chen,Marvin T. Nieman,Gregory N. Adams,Gretchen LaRusch,Yihua Zhou,Matthew L. Bilodeau,Fakhri Mahdi,Mark Warnock,Alvin H. Schmaier
Transplantation
Vascular Biology
EGFL7 ligates αvβ3 integrin to enhance vessel formation
Iva Nikolić,Nevenka Dudvarski Stanković,Frank Bicker,Jeannette Meister,Helene Braun,Khader Awwad,Jan Baumgart,Kirsten Simon,Serge C. Thal,Chinmoy Patra,Patrick N. Harter,Karl H. Plate,Felix B. Engel,Stefanie Dimmeler,Johannes A. Eble,Michel Mittelbronn,Michael K. Schäfer,Benno Jungblut,Emmanouil Chavakis,Ingrid Fleming,Mirko H. H. Schmidt
Correspondence
Does increased red blood cell deformability raise the risk for osteonecrosis in sickle cell anemia?
Nathalie Lemonne,Yann Lamarre,Marc Romana,Martin Mukisi-Mukaza,Marie-Dominique Hardy-Dessources,Vanessa Tarer,Danielle Mougenel,Xavier Waltz,Benoît Tressières,Marie-Laure Lalanne-Mistrih,Maryse Etienne-Julan,Philippe Connes
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Cover Image
Cover Image
![issue cover]()
Viral micro RNAs render B cells hyperresponsive and induce marginal zone proliferation and reorganization. Shown is the immune fluorescence image of an enlarged germinal center from Kaposi sarcoma-associated herpesvirus transgenic mice. These mice express all viral micro RNAs as well as multiple viral proteins that are normally found in viral lymphoma. The B cells in green have expanded and reorganized into a clearly demarcated, elongated follicle surrounding an enlarged germinal center that stains brightly with the activation marker PNA. See the article by Sin and Dittmer on page 2952.
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