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Issue Archive

Volume 120, Issue 22
November 22 2012
Issue Cover

Table of Contents

Inside Blood

CLINICAL TRIALS
Safety of ovarian autotransplantation
Marie-Madeleine Dolmans
View Articletitled, Safety of ovarian autotransplantation
CLINICAL TRIALS
Haplo-BMT: cure or back to sickle cell?
Françoise Bernaudin,Mathieu Kuentz
View Articletitled, Haplo-BMT: cure or back to sickle cell?
GENE THERAPY
Addressing the envelope for gene delivery
Richard J. O'Reilly
View Articletitled, Addressing the envelope for gene delivery
HEMATOPOIESIS & STEM CELLS
Stem cells need their T
Gregor B. Adams
View Articletitled, Stem cells need their T
INSIDE BLOOD
Clone wars: IgH subclones in preB-ALL
Patrick A. Zweidler-McKay
View Articletitled, Clone wars: IgH subclones in preB-ALL

Blood Work

Empty, but heavy, plasma cells
Konstantinos Liapis,John Apostolidis
View Articletitled, Empty, but heavy, plasma cells
Sitosterolemia's stomatocytosis and macrothrombocytopenia
Anne T. Neff
View Articletitled, Sitosterolemia's stomatocytosis and macrothrombocytopenia

Plenary Paper

Red Cells, Iron, and Erythropoiesis
HLA-haploidentical bone marrow transplantation with posttransplant cyclophosphamide expands the donor pool for patients with sickle cell disease
Clinical Trials & Observations
Javier Bolaños-Meade,Ephraim J. Fuchs,Leo Luznik,Sophie M. Lanzkron,Christopher J. Gamper,Richard J. Jones,Robert A. Brodsky
View Articletitled, HLA-haploidentical bone marrow transplantation with posttransplant cyclophosphamide expands the donor pool for patients with sickle cell disease

Perspectives

Monoclonal gammopathy of renal significance: when MGUS is no longer undetermined or insignificant
Nelson Leung,Frank Bridoux,Colin A. Hutchison,Samih H. Nasr,Paul Cockwell,Jean-Paul Fermand,Angela Dispenzieri,Kevin W. Song,Robert A. Kyle,on behalf of the International Kidney and Monoclonal Gammopathy Research Group,on behalf of the International Kidney and Monoclonal Gammopathy Research Group,on behalf of the International Kidney and Monoclonal Gammopathy Research Group,on behalf of the International Kidney and Monoclonal Gammopathy Research Group,on behalf of the International Kidney and Monoclonal Gammopathy Research Group,on behalf of the International Kidney and Monoclonal Gammopathy Research Group,on behalf of the International Kidney and Monoclonal Gammopathy Research Group,on behalf of the International Kidney and Monoclonal Gammopathy Research Group,on behalf of the International Kidney and Monoclonal Gammopathy Research Group
View Articletitled, Monoclonal gammopathy of renal significance: when MGUS is no longer undetermined or insignificant

Review Article

In vivo roles of factor XII
Thomas Renné,Alvin H. Schmaier,Katrin F. Nickel,Margareta Blombäck,Coen Maas
View Articletitled, In vivo roles of factor XII

Clinical Trials and Observations

Impact of hydroxyurea on clinical events in the BABY HUG trial
CME Clinical Trials & Observations
Courtney D. Thornburg,Beatrice A. Files,Zhaoyu Luo,Scott T. Miller,Ram Kalpatthi,Rathi Iyer,Phillip Seaman,Jeffrey Lebensburger,Ofelia Alvarez,Bruce Thompson,Russell E. Ware,Winfred C. Wang,for the BABY HUG Investigators,for the BABY HUG Investigators,for the BABY HUG Investigators,for the BABY HUG Investigators,for the BABY HUG Investigators,for the BABY HUG Investigators,for the BABY HUG Investigators,for the BABY HUG Investigators,for the BABY HUG Investigators,for the BABY HUG Investigators,for the BABY HUG Investigators,for the BABY HUG Investigators
View Articletitled, Impact of hydroxyurea on clinical events in the BABY HUG trial

Gene Therapy

T-cell receptor gene transfer exclusively to human CD8+ cells enhances tumor cell killing
Qi Zhou,Irene C. Schneider,Inan Edes,Annemarie Honegger,Patricia Bach,Kurt Schönfeld,Axel Schambach,Winfried S. Wels,Sabrina Kneissl,Wolfgang Uckert,Christian J. Buchholz
View Articletitled, T-cell receptor gene transfer exclusively to human CD8<sup>+</sup> cells enhances tumor cell killing
Supplemental data

Hematopoiesis and Stem Cells

Human hematopoietic stem/progenitor cells overexpressing Smad4 exhibit impaired reconstitution potential in vivo
Emma Rörby,Matilda Nifelt Hägerström,Ulrika Blank,Göran Karlsson,Stefan Karlsson
View Articletitled, Human hematopoietic stem/progenitor cells overexpressing Smad4 exhibit impaired reconstitution potential in vivo
Supplemental data
PTH expands short-term murine hemopoietic stem cells through T cells
Jau-Yi Li,Jonathan Adams,Laura M. Calvi,Timothy F. Lane,Richard DiPaolo,M. Neale Weitzmann,Roberto Pacifici
View Articletitled, PTH expands short-term murine hemopoietic stem cells through T cells
Supplemental data

Immunobiology

The signal transducers STAT5 and STAT3 control expression of Id2 and E2-2 during dendritic cell development
Haiyan S. Li,Cliff Y. Yang,Kalyan C. Nallaparaju,Huiyuan Zhang,Yong-Jun Liu,Ananda W. Goldrath,Stephanie S. Watowich
View Articletitled, The signal transducers STAT5 and STAT3 control expression of Id2 and E2-2 during dendritic cell development
Supplemental data
SOCS3 promotes interleukin-17 expression of human T cells
Katja Kleinsteuber,Kerrin Heesch,Stefanie Schattling,Claudia Sander-Juelch,Ulrike Mock,Kristoffer Riecken,Boris Fehse,Bernhard Fleischer,Marc Jacobsen
View Articletitled, SOCS3 promotes interleukin-17 expression of human T cells
Supplemental data
Memory CD4+CCR5+ T cells are abundantly present in the gut of newborn infants to facilitate mother-to-child transmission of HIV-1
Madeleine J. Bunders,Chris M. van der Loos,Paul L. Klarenbeek,John L. van Hamme,Kees Boer,Jim C. H. Wilde,Niek de Vries,Rene A. W. van Lier,Neeltje Kootstra,Steven T. Pals,Taco W. Kuijpers
View Articletitled, Memory CD4<sup>+</sup>CCR5<sup>+</sup> T cells are abundantly present in the gut of newborn infants to facilitate mother-to-child transmission of HIV-1
Supplemental data

Lymphoid Neoplasia

A phase 1 trial of the anti-KIR antibody IPH2101 in patients with relapsed/refractory multiple myeloma
Clinical Trials & Observations
Don M. Benson, Jr,Craig C. Hofmeister,Swaminathan Padmanabhan,Attaya Suvannasankha,Sundar Jagannath,Rafat Abonour,Courtney Bakan,Pascale Andre,Yvonne Efebera,Jérôme Tiollier,Michael A. Caligiuri,Sherif S. Farag
View Articletitled, A phase 1 trial of the anti-KIR antibody IPH2101 in patients with relapsed/refractory multiple myeloma
S1P1 expression is controlled by the pro-oxidant activity of p66Shc and is impaired in B-CLL patients with unfavorable prognosis
Nagaja Capitani,Laura Patrussi,Livio Trentin,Orso Maria Lucherini,Enrica Cannizzaro,Enrica Migliaccio,Federica Frezzato,Cristina Gattazzo,Francesco Forconi,Piergiuseppe Pelicci,Gianpietro Semenzato,Cosima T. Baldari
View Articletitled, S1P1 expression is controlled by the pro-oxidant activity of p66Shc and is impaired in B-CLL patients with unfavorable prognosis
Supplemental data
Expression of Myc, but not pSTAT3, is an adverse prognostic factor for diffuse large B-cell lymphoma treated with epratuzumab/R-CHOP
Clinical Trials & Observations
Mamta Gupta,Matthew J. Maurer,Linda E. Wellik,Mark E. Law,Jing Jing Han,Nazan Ozsan,Ivana N. Micallef,Ahmet Dogan,Thomas E. Witzig
View Articletitled, Expression of Myc, but not pSTAT3, is an adverse prognostic factor for diffuse large B-cell lymphoma treated with epratuzumab/R-CHOP
Supplemental data
Massive evolution of the immunoglobulin heavy chain locus in children with B precursor acute lymphoblastic leukemia
Charles Gawad,Francois Pepin,Victoria E. H. Carlton,Mark Klinger,Aaron C. Logan,David B. Miklos,Malek Faham,Gary Dahl,Norman Lacayo
View Articletitled, Massive evolution of the immunoglobulin heavy chain locus in children with B precursor acute lymphoblastic leukemia
Supplemental data
A prospective study of circulating adipokine levels and risk of multiple myeloma
Brief Report
Jonathan N. Hofmann,Linda M. Liao,Michael N. Pollak,Ye Wang,Ruth M. Pfeiffer,Dalsu Baris,Gabriella Andreotti,Qing Lan,Ola Landgren,Nathaniel Rothman,Mark P. Purdue
View Articletitled, A prospective study of circulating adipokine levels and risk of multiple myeloma
Supplemental data

Myeloid Neoplasia

Cryopreserved ovarian cortex from patients with leukemia in complete remission contains no apparent viable malignant cells
Clinical Trials & Observations
Tine Greve,Erik Clasen-Linde,Morten T. Andersen,Mette K. Andersen,Stine D. Sørensen,Mikkel Rosendahl,Elisabeth Ralfkiær,Claus Yding Andersen
View Articletitled, Cryopreserved ovarian cortex from patients with leukemia in complete remission contains no apparent viable malignant cells
Supplemental data
A phase 1 trial of the anti-inhibitory KIR mAb IPH2101 for AML in complete remission
Clinical Trials & Observations
Norbert Vey,Jean-Henri Bourhis,Nicolas Boissel,Dominique Bordessoule,Thomas Prebet,Aude Charbonnier,Anne Etienne,Pascale Andre,François Romagne,Don Benson,Herve Dombret,Daniel Olive
View Articletitled, A phase 1 trial of the anti-inhibitory KIR mAb IPH2101 for AML in complete remission
Supplemental data

Phagocytes, Granulocytes, and Myelopoiesis

Endocytosis of soluble immune complexes leads to their clearance by FcγRIIIB but induces neutrophil extracellular traps via FcγRIIA in vivo
Kan Chen,Hiroshi Nishi,Richard Travers,Naotake Tsuboi,Kimberly Martinod,Denisa D. Wagner,Radu Stan,Kevin Croce,Tanya N. Mayadas
View Articletitled, Endocytosis of soluble immune complexes leads to their clearance by FcγRIIIB but induces neutrophil extracellular traps via FcγRIIA in vivo
Supplemental data

Platelets and Thrombopoiesis

NPP4 is a procoagulant enzyme on the surface of vascular endothelium
Ronald A. Albright,William C. Chang,Donna Robert,Deborah L. Ornstein,Wenxiang Cao,Lynn Liu,Meredith E. Redick,J. Isaac Young,Enrique M. De La Cruz,Demetrios T. Braddock
View Articletitled, NPP4 is a procoagulant enzyme on the surface of vascular endothelium
Supplemental data

Correspondence

Episomal amplification of NUP214-ABL1 fusion gene in B-cell acute lymphoblastic leukemia
Toby Eyre,Claire J. Schwab,Ross Kinstrie,Ann Keen McGuire,Jen Strefford,Andrew Peniket,Adam Mead,Tim Littlewood,Tessa L. Holyoake,Mhairi Copland,Anthony V. Moorman,Christine J. Harrison,Paresh Vyas
View Articletitled, Episomal amplification of <em>NUP214-ABL1</em> fusion gene in B-cell acute lymphoblastic leukemia
Role of fecal calprotectin as biomarker of gastrointestinal GVHD after allogeneic stem cell transplantation
Patrizia Chiusolo,Elisabetta Metafuni,Sabrina Giammarco,Silvia Bellesi,Nicola Piccirillo,Chiara Fanali,Massimo Castagnola,Cecilia Zuppi,Teresa De Michele,Giuseppe Leone,Simona Sica
View Articletitled, Role of fecal calprotectin as biomarker of gastrointestinal GVHD after allogeneic stem cell transplantation
High-dose melphalan and stem cell transplantation for patients with AL amyloidosis: trends in treatment-related mortality over the past 17 years at a single referral center
Stephanie B. Tsai,David C. Seldin,Karen Quillen,John L. Berk,Frederick L. Ruberg,Hans Meier-Ewert,J. Mark Sloan,Gheorghe Doros,Kathleen T. Finn,Martha Skinner,Vaishali Sanchorawala
View Articletitled, High-dose melphalan and stem cell transplantation for patients with AL amyloidosis: trends in treatment-related mortality over the past 17 years at a single referral center

Errata

Johnson RM, Ravindranath Y, El-Alfy M, Goyette G Jr. Oxidant damage to erythrocyte membrane in glucose-6-phosphate dehydrogenase deficiency: correlation with in vivo reduced glutathione concentration and membrane protein oxidation. Blood. 1994;83(4):1117–1123.
View Articletitled, Johnson RM, Ravindranath Y, El-Alfy M, Goyette G Jr. Oxidant damage to erythrocyte membrane in glucose-6-phosphate dehydrogenase deficiency: correlation with in vivo reduced glutathione concentration and membrane protein oxidation. <em>Blood</em>. 1994;83(4):<span class="related-article">1117–1123</span>.
Munari F, Lonardi S, Cassatella MA, et al. Tumor-associated macrophages as major source of APRIL in gastric MALT lymphoma. Blood. 2011;117(24):6612–6616.
View Articletitled, Munari F, Lonardi S, Cassatella MA, et al. Tumor-associated macrophages as major source of APRIL in gastric MALT lymphoma. <em>Blood</em>. 2011;117(24):<span class="related-article">6612–6616</span>.
Swierczek SI, Piterkova L, Jelinek J, et al. Methylation of AR locus does not always reflect X chromosome inactivation state. Blood. 2012;119(13):e100–e109.
View Articletitled, Swierczek SI, Piterkova L, Jelinek J, et al. Methylation of <em>AR</em> locus does not always reflect X chromosome inactivation state. <em>Blood</em>. 2012;119(13):<span class="related-article">e100–e109</span>.
Duhen T, Duhen R, Lanzavecchia A, Sallusto F, Campbell DJ. Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector Th cells. Blood. 2012;119(19):4430–4440.
View Articletitled, Duhen T, Duhen R, Lanzavecchia A, Sallusto F, Campbell DJ. Functionally distinct subsets of human FOXP3<sup>+</sup> Treg cells that phenotypically mirror effector Th cells. <em>Blood</em>. 2012;119(19):<span class="related-article">4430–4440</span>.

Other Departments

Continuing Medical Education (CME) questions: BABY HUG events
CME
View Articletitled, Continuing Medical Education (CME) questions: BABY HUG events
  • Cover Image

    Cover Image

    issue cover

    Surface analysis of a confocal image of postcapillary venules (shown in red) in the cremaster muscle of wild-type mice reveals engagement of Fcγ receptors by immune complexes deposited in tissue results in the generation of sytox-green positive neutrophil extracellular traps (NETs). These are present primarily in the extravascular space (shown in blue), with a small fraction also localizing within vessels (shown in green). See the article by Chen et al on page 4421.

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