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Journal Articles

The mTORC1 inhibitor everolimus has antitumor activity in vitro and produces tumor responses in patients with relapsed T-cell lymphoma

Clinical Trials & Observations
Thomas E. Witzig, Craig Reeder, Jing Jing Han, Betsy LaPlant, Mary Stenson, Han W. Tun, William Macon, Stephen M. Ansell, Thomas M. Habermann, David J. Inwards, Ivana N. Micallef, Patrick B. Johnston, Luis F. Porrata, Joseph P. Colgan, Svetomir Markovic, Grzegorz S. Nowakowski, Mamta Gupta
Journal: Blood
Blood (2015) 126 (3): 328–335.
https://doi.org/10.1182/blood-2015-02-629543
Published: 2015
Includes: Supplemental data
Journal Articles

SHP1 Suppression In Diffuse Large B Cell Lymphoma Is Regulated Through Promoter Hypermethylation At Novel CpG2 Island and H3K27 Trimethylation Histone Mark

Mamta Gupta, Ph.D, Guangzhen Hu, Linda E Wellik, Jing Jing Han, Mary Stenson, B.S, Ahmet Dogan, MD, PhD, Thomas E Witzig, MD
Journal: Blood
Blood (2013) 122 (21): 632.
https://doi.org/10.1182/blood.V122.21.632.632
Published: 2013
Journal Articles

Repression Of Cap-Dependent Translation With a Next-Generation mTOR Inhibitor Attenuates c-Myc Transcription and Survival In Lymphoma Cells

Mamta Gupta, Ph.D, Jing Jing Han, Mary Stenson, B.S, Linda E Wellik, Thomas E Witzig, MD
Journal: Blood
Blood (2013) 122 (21): 636.
https://doi.org/10.1182/blood.V122.21.636.636
Published: 2013
Journal Articles

In-Vivo Activation Of STAT3 In Angioimmunoblastic T Cell Lymphoma, PTCL Not Otherwise Specified, and ALK Negative Anaplastic Large Cell Lymphoma: Implications For Therapy

Mamta Gupta, Ph.D, Matthew J. Maurer, MS, Mary Stenson, B.S, Linda E. Wellik, Jing Jing Han, Andrew L. Feldman, Thomas M. Habermann, MD, Thomas E. Witzig, MD
Journal: Blood
Blood (2013) 122 (21): 844.
https://doi.org/10.1182/blood.V122.21.844.844
Published: 2013
Journal Articles

Expression of Myc, but not pSTAT3, is an adverse prognostic factor for diffuse large B-cell lymphoma treated with epratuzumab/R-CHOP

Clinical Trials & Observations
Mamta Gupta, Matthew J. Maurer, Linda E. Wellik, Mark E. Law, Jing Jing Han, Nazan Ozsan, Ivana N. Micallef, Ahmet Dogan, Thomas E. Witzig
Journal: Blood
Blood (2012) 120 (22): 4400–4406.
https://doi.org/10.1182/blood-2012-05-428466
Published: 2012
Includes: Supplemental data
Journal Articles

Expression of MYC but Not pSTAT3 Is an Adverse Prognostic Factor for Diffuse Large B Cell Lymphoma (DLBCL) Treated with Epratuzumab/R-CHOP

Mamta Gupta, Ph.D, Matthew J Maurer, MS, Linda Wellik, Mark E Law, Jing Jing Han, Ivana N. Micallef, MD, Ahmet Dogan, MD, PhD, Thomas E. Witzig, MD
Journal: Blood
Blood (2012) 120 (21): 1575.
https://doi.org/10.1182/blood.V120.21.1575.1575
Published: 2012
Journal Articles

Expression but Not Promoter Hypermethylation of the Tyrosine Phosphatase PTPN6 Is Associated with Activated STAT3 and Inferior Prognosis in Diffuse Large B Cell Lymphoma Molecular Subtypes.

Mamta Gupta, Ph.D, Guangzhen Hu, Steven Offer, Matthew J Maurer, MS, Linda Wellik, Jing Jing Han, Ahmet Dogan, MD, PhD, Robert B. Diasio, MD, Thomas E. Witzig, MD
Journal: Blood
Blood (2012) 120 (21): 2655.
https://doi.org/10.1182/blood.V120.21.2655.2655
Published: 2012
Journal Articles

Elevated serum IL-10 levels in diffuse large B-cell lymphoma: a mechanism of aberrant JAK2 activation

Mamta Gupta, Jing Jing Han, Mary Stenson, Matthew Maurer, Linda Wellik, Guangzhen Hu, Steve Ziesmer, Ahmet Dogan, Thomas E. Witzig
Journal: Blood
Blood (2012) 119 (12): 2844–2853.
https://doi.org/10.1182/blood-2011-10-388538
Published: 2012
Includes: Supplemental data
Journal Articles

Dual mTORC1/mTORC2 inhibition diminishes Akt activation and induces Puma-dependent apoptosis in lymphoid malignancies

Mamta Gupta, Andrea E. Wahner Hendrickson, Seong Seok Yun, Jing Jing Han, Paula A. Schneider, Brian D. Koh, Mary J. Stenson, Linda E. Wellik, Jennifer C. Shing, Kevin L. Peterson, Karen S. Flatten, Allan D. Hess, B. Douglas Smith, Judith E. Karp, Sharon Barr, Thomas E. Witzig, Scott H. Kaufmann
Journal: Blood
Blood (2012) 119 (2): 476–487.
https://doi.org/10.1182/blood-2011-04-346601
Published: 2012
Includes: Supplemental data
Journal Articles

Elevated Serum IL-10 Levels in Patients with Diffuse Large B Cell Lymphoma: A Mechanism of Aberrant JAK2 Kinase Activation

Mamta Gupta, Ph.D, Mary Stenson, Jing Jing Han, Matthew J Maurer, MS, Linda Wellik, Steven C. Ziesmer, Ahmet Dogan, Thomas E. Witzig, MD
Journal: Blood
Blood (2011) 118 (21): 960.
https://doi.org/10.1182/blood.V118.21.960.960
Published: 2011
Journal Articles

Dual Inhibition of mTORC1/mTORC2 Induces Apoptosis of Mantle Cell Lymphoma by Preventing Rictor Mediated AKT S473 Phosphorylation by Potentiating AKT2-PHLPP1 Association

Mamta Gupta, Ph.D, Andrea Wahner Hendrickson, Jing Jing Han, Mary Stenson, Linda Wellik, Sharon Barr, Scott H. Kaufmann, MD, PhD, Thomas E. Witzig, MD
Journal: Blood
Blood (2010) 116 (21): 772.
https://doi.org/10.1182/blood.V116.21.772.772
Published: 2010
Journal Articles

HDAC Class I Inhibition Acetylates a Non-Histone Protein STAT3 by Modulating p300-STAT3-HDAC1 Interaction In Activated B- Cell Like (ABC) Diffuse Large B Cell Lymphoma

Mamta Gupta, Ph.D, Jing Jing Han, Mary Stenson, Linda Wellik, Thomas E. Witzig, MD
Journal: Blood
Blood (2010) 116 (21): 115.
https://doi.org/10.1182/blood.V116.21.115.115
Published: 2010