Claudia R. Morris,on behalf of the Thalassemia Clinical Research Network,Hae-Young Kim,on behalf of the Thalassemia Clinical Research Network,Felicia Trachtenberg,on behalf of the Thalassemia Clinical Research Network,John Wood,on behalf of the Thalassemia Clinical Research Network,Charles T. Quinn,on behalf of the Thalassemia Clinical Research Network,Nancy Sweeters,on behalf of the Thalassemia Clinical Research Network,Janet L. Kwiatkowski,on behalf of the Thalassemia Clinical Research Network,Alexis A. Thompson,on behalf of the Thalassemia Clinical Research Network,Patricia J. Giardina,on behalf of the Thalassemia Clinical Research Network,Jeanne Boudreaux,on behalf of the Thalassemia Clinical Research Network,Nancy F. Olivieri,on behalf of the Thalassemia Clinical Research Network,John B. Porter,on behalf of the Thalassemia Clinical Research Network,Ellis J. Neufeld,on behalf of the Thalassemia Clinical Research Network,Elliott P. Vichinsky,on behalf of the Thalassemia Clinical Research Network

View Articletitled, Risk factors and mortality associated with an elevated tricuspid regurgitant jet velocity measured by Doppler-echocardiography in thalassemia: a Thalassemia Clinical Research Network report

Thrombosis and Hemostasis

Factor XIIa regulates the structure of the fibrin clot independently of thrombin generation through direct interaction with fibrin

Joke Konings,José W. P. Govers-Riemslag,Helen Philippou,Nicola J. Mutch,Julian I. Borissoff,Peter Allan,Sumitra Mohan,Guido Tans,Hugo ten Cate,Robert A. S. Ariëns

View Articletitled, Factor XIIa regulates the structure of the fibrin clot independently of thrombin generation through direct interaction with fibrin

Supplemental data

Procoagulant activity induced by vascular injury determines contribution of elevated factor VIII to thrombosis and thrombus stability in mice

Kellie R. Machlus,Feng-Chang Lin,Alisa S. Wolberg

View Articletitled, Procoagulant activity induced by vascular injury determines contribution of elevated factor VIII to thrombosis and thrombus stability in mice

Supplemental data

Transplantation

HLA mismatch direction in cord blood transplantation: impact on outcome and implications for cord blood unit selection
Clinical Trials & Observations

Cladd E. Stevens,Carmelita Carrier,Carol Carpenter,Dorothy Sung,Andromachi Scaradavou

View Articletitled, HLA mismatch direction in cord blood transplantation: impact on outcome and implications for cord blood unit selection

Vascular Biology

Activated protein C inhibits high mobility group box 1 signaling in endothelial cells

Jong-Sup Bae,Alireza R. Rezaie

View Articletitled, Activated protein C inhibits high mobility group box 1 signaling in endothelial cells

Lysyl oxidase-like protein-2 regulates sprouting angiogenesis and type IV collagen assembly in the endothelial basement membrane

Marine Bignon,Cathy Pichol-Thievend,Julie Hardouin,Marilyne Malbouyres,Nicolas Bréchot,Luiz Nasciutti,Alain Barret,Jérémie Teillon,Emilie Guillon,Eric Etienne,Michel Caron,Raymonde Joubert-Caron,Catherine Monnot,Florence Ruggiero,Laurent Muller,Stéphane Germain

View Articletitled, Lysyl oxidase-like protein-2 regulates sprouting angiogenesis and type IV collagen assembly in the endothelial basement membrane

Supplemental data

ANGPTL4 modulates vascular junction integrity by integrin signaling and disruption of intercellular VE-cadherin and claudin-5 clusters

Royston-Luke Huang,Ziqiang Teo,Han Chung Chong,Pengcheng Zhu,Ming Jie Tan,Chek Kun Tan,Chee Ren Ivan Lam,Ming Keat Sng,David Tai Wei Leong,Suet Mien Tan,Sander Kersten,Jeak Ling Ding,Hoi Yeung Li,Nguan Soon Tan

View Articletitled, ANGPTL4 modulates vascular junction integrity by integrin signaling and disruption of intercellular VE-cadherin and claudin-5 clusters

Supplemental data

Vascular endothelial growth factor–induced elimination of the type 1 interferon receptor is required for efficient angiogenesis
Brief Report

Hui Zheng,Juan Qian,Christopher J. Carbone,N. Adrian Leu,Darren P. Baker,Serge Y. Fuchs

View Articletitled, Vascular endothelial growth factor–induced elimination of the type 1 interferon receptor is required for efficient angiogenesis

Cover Image

Cover Image

Epithelial-derived cytokine TSLP triggers chemokinesis of resting primary human dendritic cells (DCs) in a cell-autonomous manner. TSLP induces human DC to acquire a very polarized morphology. Myosin II heavy chain (green) shows a cortical distribution and is found to be preferentially associated to actin filaments (red) in the cell. Moreover, myosin II accumulates in the nuclear edge of DCs, suggesting contractibility of this area. Individual cell images collected from the same slide at the same time were grouped to create this cover image. See the article by Fernandez et al on page 3862.
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Inside Blood

Blood Work

Plenary Paper

A randomized phase 3 study of lenalidomide versus placebo in RBC transfusion-dependent patients with Low-/Intermediate-1-risk myelodysplastic syndromes with del5q Clinical Trials & Observations

Review Article

Pathogenesis and treatment of xanthomatosis associated with monoclonal gammopathy Clinical Trials & Observations

How I Treat

Hematopoiesis and Stem Cells

Immunobiology

Partial immune reconstitution of X-linked hyper IgM syndrome with recombinant CD40 ligand Clinical Trials & Observations

Lymphoid Neoplasia

Phase 2 study of cladribine followed by rituximab in patients with hairy cell leukemia Clinical Trials & Observations

Myeloid Neoplasia

TET2 mutation is an unfavorable prognostic factor in acute myeloid leukemia patients with intermediate-risk cytogenetics Clinical Trials & Observations

Molecular predictors of response to decitabine in advanced chronic myelomonocytic leukemia: a phase 2 trial Clinical Trials & Observations

A randomized trial comparing standard versus high-dose daunorubicin induction in patients with acute myeloid leukemia Clinical Trials & Observations

Platelets and Thrombopoiesis

Genome-wide RNA-seq analysis of human and mouse platelet transcriptomes e-blood

Red Cells, Iron, and Erythropoiesis

Risk factors and mortality associated with an elevated tricuspid regurgitant jet velocity measured by Doppler-echocardiography in thalassemia: a Thalassemia Clinical Research Network report Clinical Trials & Observations

Thrombosis and Hemostasis

Transplantation

HLA mismatch direction in cord blood transplantation: impact on outcome and implications for cord blood unit selection Clinical Trials & Observations

Vascular Biology

Vascular endothelial growth factor–induced elimination of the type 1 interferon receptor is required for efficient angiogenesis Brief Report

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A randomized phase 3 study of lenalidomide versus placebo in RBC transfusion-dependent patients with Low-/Intermediate-1-risk myelodysplastic syndromes with del5q
Clinical Trials & Observations

Pathogenesis and treatment of xanthomatosis associated with monoclonal gammopathy
Clinical Trials & Observations

Partial immune reconstitution of X-linked hyper IgM syndrome with recombinant CD40 ligand
Clinical Trials & Observations

Phase 2 study of cladribine followed by rituximab in patients with hairy cell leukemia
Clinical Trials & Observations

TET2 mutation is an unfavorable prognostic factor in acute myeloid leukemia patients with intermediate-risk cytogenetics
Clinical Trials & Observations

Molecular predictors of response to decitabine in advanced chronic myelomonocytic leukemia: a phase 2 trial
Clinical Trials & Observations

A randomized trial comparing standard versus high-dose daunorubicin induction in patients with acute myeloid leukemia
Clinical Trials & Observations

Genome-wide RNA-seq analysis of human and mouse platelet transcriptomes
e-blood

Risk factors and mortality associated with an elevated tricuspid regurgitant jet velocity measured by Doppler-echocardiography in thalassemia: a Thalassemia Clinical Research Network report
Clinical Trials & Observations

HLA mismatch direction in cord blood transplantation: impact on outcome and implications for cord blood unit selection
Clinical Trials & Observations

Vascular endothelial growth factor–induced elimination of the type 1 interferon receptor is required for efficient angiogenesis
Brief Report