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Issue Archive

Volume 115, Issue 13
April 1 2010
Issue Cover

Table of Contents

INSIDE BLOOD

CLINICAL TRIALS
Syk [sic] of the same old chemotherapy?
Bruce D. Cheson
View Articletitled, Syk [sic] of the same old chemotherapy?
HEMATOPOIESIS & STEM CELLS
There's many a CLP on the path to B
J. Jeremiah Bell,Avinash Bhandoola
View Articletitled, There's many a CLP on the path to B
INSIDE BLOOD
The 3 Rs in CLL immune dysfunction
Alan G. Ramsay,John G. Gribben
View Articletitled, The 3 Rs in CLL immune dysfunction
THROMBOSIS & HEMOSTASIS
Sugar targets VWF for the chop
Derrick John Bowen
View Articletitled, Sugar targets VWF for the chop

BLOOD WORK

Fauxcoll gradient
View Articletitled, Fauxcoll gradient
Crystal-storing histiocytosis
View Articletitled, Crystal-storing histiocytosis

REVIEW ARTICLES

Structure and function of factor XI
Jonas Emsley,Paul A. McEwan,David Gailani
View Articletitled, Structure and function of factor XI
Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia
Clinical Trials & Observations
Jonathan W. Friedberg,Jeff Sharman,John Sweetenham,Patrick B. Johnston,Julie M. Vose,Ann LaCasce,Julia Schaefer-Cutillo,Sven De Vos,Rajni Sinha,John P. Leonard,Larry D. Cripe,Stephanie A. Gregory,Michael P. Sterba,Ann M. Lowe,Ronald Levy,Margaret A. Shipp
View Articletitled, Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia
Gemtuzumab ozogamicin as postremission treatment in AML at 60 years of age or more: results of a multicenter phase 3 study
Clinical Trials & Observations
Bob Löwenberg,Joachim Beck,Carlos Graux,Wim van Putten,Harry C. Schouten,Leo F. Verdonck,Augustin Ferrant,Pieter Sonneveld,Mojca Jongen-Lavrencic,Marie von Lilienfeld-Toal,Bart J. Biemond,Edo Vellenga,Dimitri Breems,Hilde de Muijnck,Ron Schaafsma,Gregor Verhoef,Hartmut Döhner,Alois Gratwohl,Thomas Pabst,Gert J. Ossenkoppele,Johan Maertens,for the Dutch-Belgian Hemato-Oncology Cooperative Group (HOVON),German Austrian AML Study Group (AMLSG),Swiss Group for Clinical Cancer Research Collaborative Group (SAKK)
View Articletitled, Gemtuzumab ozogamicin as postremission treatment in AML at 60 years of age or more: results of a multicenter phase 3 study

HEMATOPOIESIS AND STEM CELLS

An in vivo model to study and manipulate the hematopoietic stem cell niche
Junhui Song,Mark J. Kiel,Zhou Wang,Jingcheng Wang,Russell S. Taichman,Sean J. Morrison,Paul H. Krebsbach
View Articletitled, An in vivo model to study and manipulate the hematopoietic stem cell niche
Supplemental data
Single-cell analysis of the common lymphoid progenitor compartment reveals functional and molecular heterogeneity
Robert Mansson,Sasan Zandi,Eva Welinder,Panagiotis Tsapogas,Nobuo Sakaguchi,David Bryder,Mikael Sigvardsson
View Articletitled, Single-cell analysis of the common lymphoid progenitor compartment reveals functional and molecular heterogeneity
Supplemental data
Cellular barcoding tool for clonal analysis in the hematopoietic system
Alice Gerrits,Brad Dykstra,Olga J. Kalmykowa,Karin Klauke,Evgenia Verovskaya,Mathilde J. C. Broekhuis,Gerald de Haan,Leonid V. Bystrykh
View Articletitled, Cellular barcoding tool for clonal analysis in the hematopoietic system

LYMPHOID NEOPLASIA

Lenalidomide treatment promotes CD154 expression on CLL cells and enhances production of antibodies by normal B cells through a PI3-kinase–dependent pathway
Rosa Lapalombella,Leslie Andritsos,Qing Liu,Sarah E. May,Rebekah Browning,Lan V. Pham,Kristie A. Blum,William Blum,Asha Ramanunni,Chelsey A. Raymond,Lisa L. Smith,Amy Lehman,Xiaokui Mo,David Jarjoura,Ching-Shih Chen,Richard Ford, Jr,Christoph Rader,Natarajan Muthusamy,Amy J. Johnson,John C. Byrd
View Articletitled, Lenalidomide treatment promotes CD154 expression on CLL cells and enhances production of antibodies by normal B cells through a PI3-kinase–dependent pathway
Supplemental data
microRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma
Jian-Jun Zhao,Jianhong Lin,Tint Lwin,Hua Yang,Jianping Guo,William Kong,Sophie Dessureault,Lynn C. Moscinski,Dorna Rezania,William S. Dalton,Eduardo Sotomayor,Jianguo Tao,Jin Q. Cheng
View Articletitled, microRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma
Supplemental data
Adult T-cell leukemia/lymphoma development in HTLV-1–infected humanized SCID mice
Prabal Banerjee,Adam Tripp,Michael D. Lairmore,Lindsey Crawford,Michelle Sieburg,Juan Carlos Ramos,William Harrington, Jr,Mark A. Beilke,Gerold Feuer
View Articletitled, Adult T-cell leukemia/lymphoma development in HTLV-1–infected humanized SCID mice

PLATELETS AND THROMBOPOIESIS

Abnormal VWF modifies megakaryocytopoiesis: studies of platelets and megakaryocyte cultures from patients with von Willebrand disease type 2B
Paquita Nurden,Giuliana Gobbi,Alan Nurden,Jocelyne Enouf,Ibtissam Youlyouz-Marfak,Cecilia Carubbi,Silvia La Marca,Margherita Punzo,Luciano Baronciani,Luigi De Marco,Marco Vitale,Augusto B. Federici
View Articletitled, Abnormal VWF modifies megakaryocytopoiesis: studies of platelets and megakaryocyte cultures from patients with von Willebrand disease type 2B

RED CELLS, IRON, AND ERYTHROPOIESIS

SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression
Katarzyna Mleczko-Sanecka,Guillem Casanovas,Anan Ragab,Katja Breitkopf,Alexandra Müller,Michael Boutros,Steven Dooley,Matthias W. Hentze,Martina U. Muckenthaler
View Articletitled, SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression
Supplemental data

THROMBOSIS AND HEMOSTASIS

Expression of terminal α2-6–linked sialic acid on von Willebrand factor specifically enhances proteolysis by ADAMTS13
Rachel T. McGrath,Thomas A. J. McKinnon,Barry Byrne,Richard O'Kennedy,Virginie Terraube,Emily McRae,Roger J. S. Preston,Mike A. Laffan,James S. O'Donnell
View Articletitled, Expression of terminal α2-6–linked sialic acid on von Willebrand factor specifically enhances proteolysis by ADAMTS13
Association of coagulation factor XIII-A with Golgi proteins within monocyte-macrophages: implications for subcellular trafficking and secretion
Paul A. Cordell,Benjamin T. Kile,Kristina F. Standeven,Emma C. Josefsson,Richard J. Pease,Peter J. Grant
View Articletitled, Association of coagulation factor XIII-A with Golgi proteins within monocyte-macrophages: implications for subcellular trafficking and secretion
Supplemental data
Induction of heme oxygenase-1 in factor VIII–deficient mice reduces the immune response to therapeutic factor VIII
Brief Report
Jordan D. Dimitrov,Suryasarathi Dasgupta,Ana-Maria Navarrete,Sandrine Delignat,Yohann Repesse,Yann Meslier,Cyril Planchais,Maud Teyssandier,Roberto Motterlini,Jagadeesh Bayry,Srinivas V. Kaveri,Sébastien Lacroix-Desmazes
View Articletitled, Induction of heme oxygenase-1 in factor VIII–deficient mice reduces the immune response to therapeutic factor VIII
Supplemental data

TRANSPLANTATION

NK cells expressing inhibitory KIR for non–self-ligands remain tolerant in HLA-matched sibling stem cell transplantation
Andreas T. Björklund,Marie Schaffer,Cyril Fauriat,Olle Ringdén,Mats Remberger,Christina Hammarstedt,A. John Barrett,Per Ljungman,Hans-Gustaf Ljunggren,Karl-Johan Malmberg
View Articletitled, NK cells expressing inhibitory KIR for non–self-ligands remain tolerant in HLA-matched sibling stem cell transplantation
Derivation of human T lymphocytes from cord blood and peripheral blood with antiviral and antileukemic specificity from a single culture as protection against infection and relapse after stem cell transplantation
Kenneth P. Micklethwaite,Barbara Savoldo,Patrick J. Hanley,Ann M. Leen,Gail J. Demmler-Harrison,Laurence J. N. Cooper,Hao Liu,Adrian P. Gee,Elizabeth J. Shpall,Cliona M. Rooney,Helen E. Heslop,Malcolm K. Brenner,Catherine M. Bollard,Gianpietro Dotti
View Articletitled, Derivation of human T lymphocytes from cord blood and peripheral blood with antiviral and antileukemic specificity from a single culture as protection against infection and relapse after stem cell transplantation
Supplemental data
The detection of donor-directed, HLA-specific alloantibodies in recipients of unrelated hematopoietic cell transplantation is predictive of graft failure
Brief Report
Stephen Spellman,Robert Bray,Sandra Rosen-Bronson,Michael Haagenson,John Klein,Susan Flesch,Cynthia Vierra-Green,Claudio Anasetti
View Articletitled, The detection of donor-directed, HLA-specific alloantibodies in recipients of unrelated hematopoietic cell transplantation is predictive of graft failure

VASCULAR BIOLOGY

c-Abl mediates endothelial apoptosis induced by inhibition of integrins αvβ3 and αvβ5 and by disruption of actin
Jingying Xu,Melissa Millard,Xiuhai Ren,Orla T. Cox,Anat Erdreich-Epstein
View Articletitled, c-Abl mediates endothelial apoptosis induced by inhibition of integrins αvβ3 and αvβ5 and by disruption of actin
Supplemental data

CORRESPONDENCE

Validation of cytogenetic-based risk stratification in primary myelofibrosis
Elisa Rumi,Francesco Passamonti,Paolo Bernasconi,Luca Arcaini,Daniela Pietra,Chiara Elena,Emanuela Boveri,Cristiana Pascutto,Mario Cazzola,Mario Lazzarino
View Articletitled, Validation of cytogenetic-based risk stratification in primary myelofibrosis
Proposal for a revised classification of systemic mastocytosis
Animesh Pardanani,Ayalew Tefferi
View Articletitled, Proposal for a revised classification of systemic mastocytosis
Induction of p53 and up-regulation of the p53 pathway in the human 5q− syndrome
Andrea Pellagatti,Teresa Marafioti,Jennifer C. Paterson,Jillian L. Barlow,Lesley F. Drynan,Aristoteles Giagounidis,Stefano A. Pileri,Mario Cazzola,Andrew N. J. McKenzie,James S. Wainscoat,Jacqueline Boultwood
View Articletitled, Induction of p53 and up-regulation of the p53 pathway in the human 5q− syndrome
Rapid improvement of life-threatening capillary leak syndrome after stem cell transplantation by bevacizumab
Hiromasa Yabe,Miharu Yabe,Takashi Koike,Takashi Shimizu,Tsuyoshi Morimoto,Shunichi Kato
View Articletitled, Rapid improvement of life-threatening capillary leak syndrome after stem cell transplantation by bevacizumab
All Issues

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Cardiac complete response in AL amyloidosis has similar survival to matched general population
Randomized Bendamustine-Rituximab(R) + Bortezomib Induction and R + Lenalidomide Maintenance for Mantle Cell Lymphoma
Heme induced loss of renovascular endothelial protein C receptor promotes chronic kidney disease in sickle mice
Interleukin-1 mediated hyperinflammation in XIAP-deficiency is associated with defective autophagy.
NOVEL THERAPEUTIC APPROACHES IN THALASSEMIAS, SICKLE CELL DISEASE AND OTHER RED CELL DISORDERS

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