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Volume 90, Issue 6

September 15 1997

In this Issue

EDITORIAL
REVIEW ARTICLES
RAPID COMMUNICATIONS
CLINICAL INTERVENTION AND THERAPEUTIC TRIALS
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
RED CELLS
TRANSFUSION MEDICINE
TRANSPLANTATION
ERRATA

EDITORIAL

Intensifying Induction Therapy in Acute Myeloid Leukemia: Has a New Standard of Care Emerged?

Jacob M. Rowe,Martin S. Tallman

View Articletitled, Intensifying Induction Therapy in Acute Myeloid Leukemia: Has a New Standard of Care Emerged?

REVIEW ARTICLES

Magnetic Resonance Imaging of the Bone Marrow in Hematologic Malignancies

Lia A. Moulopoulos,Meletios A. Dimopoulos

View Articletitled, Magnetic Resonance Imaging of the Bone Marrow in Hematologic Malignancies

RAPID COMMUNICATIONS

Adult Mice With Targeted Mutation of the Interleukin-11 Receptor (IL11Ra) Display Normal Hematopoiesis

Harshal H. Nandurkar,Lorraine Robb,David Tarlinton,Louise Barnett,Frank Köntgen,C. Glenn Begley

View Articletitled, Adult Mice With Targeted Mutation of the Interleukin-11 Receptor (IL11Ra) Display Normal Hematopoiesis

Retrovirally Transduced Human Dendritic Cells Express a Normal Phenotype and Potent T-Cell Stimulatory Capacity

Paul Szabolcs,H.F. Gallardo,David H. Ciocon,Michel Sadelain,James W. Young

View Articletitled, Retrovirally Transduced Human Dendritic Cells Express a Normal Phenotype and Potent T-Cell Stimulatory Capacity

A BCR-ABL^p190 Fusion Gene Made by Homologous Recombination Causes B-Cell Acute Lymphoblastic Leukemias in Chimeric Mice With Independence of the Endogenous bcr Product

A. Castellanos,B. Pintado,E. Weruaga,R. Arévalo,A. López,A. Orfao,I. Sánchez-Garcı́a

View Articletitled, A BCR-ABLp190 Fusion Gene Made by Homologous Recombination Causes B-Cell Acute Lymphoblastic Leukemias in Chimeric Mice With Independence of the Endogenous bcr Product

Hematopoietic Cell Phosphatase Negatively Regulates Erythropoietin-Induced Hemoglobinization in Erythroleukemic SKT6 Cells

Elizabeth R. Sharlow,Robert Pacifici,Jill Crouse,Jennifer Batac,Kazuo Todokoro,D.M. Wojchowski

View Articletitled, Hematopoietic Cell Phosphatase Negatively Regulates Erythropoietin-Induced Hemoglobinization in Erythroleukemic SKT6 Cells

IDEC-C2B8 (Rituximab) Anti-CD20 Monoclonal Antibody Therapy in Patients With Relapsed Low-Grade Non-Hodgkin's Lymphoma

David G. Maloney,Antonio J. Grillo-López,Christine A. White,David Bodkin,Russell J. Schilder,James A. Neidhart,Nalini Janakiraman,Kenneth A. Foon,Tina-Marie Liles,Brian K. Dallaire,Ken Wey,Ivor Royston,Thomas Davis,Ronald Levy

View Articletitled, IDEC-C2B8 (Rituximab) Anti-CD20 Monoclonal Antibody Therapy in Patients With Relapsed Low-Grade Non-Hodgkin's Lymphoma

CLINICAL INTERVENTION AND THERAPEUTIC TRIALS

Safety of Autologous, Ex Vivo-Expanded Human Immunodeficiency Virus (HIV)-Specific Cytotoxic T-Lymphocyte Infusion in HIV-Infected Patients

Judy Lieberman,Paul R. Skolnik,G. Robert Parkerson, III,Jessica A. Fabry,Bernard Landry,James Bethel,Jonathan Kagan,the DATRI 006 Study Team

View Articletitled, Safety of Autologous, Ex Vivo-Expanded Human Immunodeficiency Virus (HIV)-Specific Cytotoxic T-Lymphocyte Infusion in HIV-Infected Patients

Long-Term Efficacy of α-Interferon in β-Thalassemics With Chronic Hepatitis C

V. Di Marco,O. Lo Iacono,P. Almasio,C. Ciaccio,M. Capra,M. Rizzo,R. Malizia,A. Maggio,C. Fabiano,F. Barbaria,A. Craxı̀

View Articletitled, Long-Term Efficacy of α-Interferon in β-Thalassemics With Chronic Hepatitis C

HEMATOPOIESIS

Skewed X-Inactivation in Carriers of X-Linked Dyskeratosis Congenita

T.J. Vulliamy,S.W. Knight,I. Dokal,P.J. Mason

View Articletitled, Skewed X-Inactivation in Carriers of X-Linked Dyskeratosis Congenita

CD44 Regulates Hematopoietic Progenitor Distribution, Granuloma Formation, and Tumorigenicity

Rudolf Schmits,Jorge Filmus,Nicole Gerwin,Giorgio Senaldi,Friedemann Kiefer,Thomas Kundig,Andrew Wakeham,Arda Shahinian,Charles Catzavelos,Janusz Rak,Caren Furlonger,Arsen Zakarian,John J.L. Simard,Pamela S. Ohashi,Christopher J. Paige,Jose C. Gutierrez-Ramos,Tak W. Mak

View Articletitled, CD44 Regulates Hematopoietic Progenitor Distribution, Granuloma Formation, and Tumorigenicity

In Vitro Senescence and Apoptotic Cell Death of Human Megakaryocytes

Giorgio Zauli,Marco Vitale,Elisabetta Falcieri,Davide Gibellini,Alessandra Bassini,Claudio Celeghini,Marta Columbaro,Silvano Capitani

View Articletitled, In Vitro Senescence and Apoptotic Cell Death of Human Megakaryocytes

Interferon γ Downregulates Stem Cell Factor and Erythropoietin Receptors But Not Insulin-Like Growth Factor-I Receptors in Human Erythroid Colony-Forming Cells

Shuichi Taniguchi,Chun-Hua Dai,James O. Price,Sanford B. Krantz

View Articletitled, Interferon γ Downregulates Stem Cell Factor and Erythropoietin Receptors But Not Insulin-Like Growth Factor-I Receptors in Human Erythroid Colony-Forming Cells

Characterization of Signal Transduction Pathways in Human Bone Marrow Endothelial Cells

Zhong-Ying Liu,Ramesh K. Ganju,Jian-Feng Wang,Karin Schweitzer,Babette Weksler,Shalom Avraham,Jerome E. Groopman

View Articletitled, Characterization of Signal Transduction Pathways in Human Bone Marrow Endothelial Cells

Increased Recruitment of Hematopoietic Progenitor Cells Underlies the Ex Vivo Expansion Potential of FLT3 Ligand

David N. Haylock,Martyn J. Horsfall,Tracey L. Dowse,Hayley S. Ramshaw,Silvana Niutta,Sandra Protopsaltis,Li Peng,Christopher Burrell,Irene Rappold,Hans-Jorg Buhring,Paul J. Simmons

View Articletitled, Increased Recruitment of Hematopoietic Progenitor Cells Underlies the Ex Vivo Expansion Potential of FLT3 Ligand

Clonal Variability in β-Globin mRNA Content in an Interleukin-3–Dependent Bone Marrow Cell Line Transfected With the Erythropoietin Receptor Before and After Stimulation With Erythropoietin

Kimiko Ishiguro,Alan C. Sartorelli

View Articletitled, Clonal Variability in β-Globin mRNA Content in an Interleukin-3–Dependent Bone Marrow Cell Line Transfected With the Erythropoietin Receptor Before and After Stimulation With Erythropoietin

Ability of Early Acting Cytokines to Directly Promote Survival and Suppress Apoptosis of Human Primitive CD34⁺CD38⁻ Bone Marrow Cells With Multilineage Potential at the Single-Cell Level: Key Role of Thrombopoietin

Ole J. Borge,Veslemøy Ramsfjell,Li Cui,Sten E.W. Jacobsen

View Articletitled, Ability of Early Acting Cytokines to Directly Promote Survival and Suppress Apoptosis of Human Primitive CD34+CD38− Bone Marrow Cells With Multilineage Potential at the Single-Cell Level: Key Role of Thrombopoietin

Cell Cycle Analysis and Synchronization of Pluripotent Hematopoietic Progenitor Stem Cells

G. Prem Veer Reddy,Cheryl Y. Tiarks,Lizhen Pang,Joanne Wuu,Chung-Cheng Hsieh,Peter J. Quesenberry

View Articletitled, Cell Cycle Analysis and Synchronization of Pluripotent Hematopoietic Progenitor Stem Cells

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

CD34 Expression Patterns During Early Mouse Development Are Related to Modes of Blood Vessel Formation and Reveal Additional Sites of Hematopoiesis

Heather B. Wood,Gillian May,Lyn Healy,Tariq Enver,Gillian M. Morriss-Kay

View Articletitled, CD34 Expression Patterns During Early Mouse Development Are Related to Modes of Blood Vessel Formation and Reveal Additional Sites of Hematopoiesis

Vascular Smooth Muscle Cells Potentiate Plasmin Generation by Both Urokinase and Tissue Plasminogen Activator-Dependent Mechanisms: Evidence for a Specific Tissue-Type Plasminogen Activator Receptor on These Cells

Vincent Ellis,Simon A. Whawell

View Articletitled, Vascular Smooth Muscle Cells Potentiate Plasmin Generation by Both Urokinase and Tissue Plasminogen Activator-Dependent Mechanisms: Evidence for a Specific Tissue-Type Plasminogen Activator Receptor on These Cells

An In Vitro Model for Toxin-Mediated Vascular Leak Syndrome: Ricin Toxin A Chain Increases the Permeability of Human Endothelial Cell Monolayers

Alan L. Lindstrom,Stanley L. Erlandsen,John H. Kersey,Christopher A. Pennell

View Articletitled, An In Vitro Model for Toxin-Mediated Vascular Leak Syndrome: Ricin Toxin A Chain Increases the Permeability of Human Endothelial Cell Monolayers

Relative Importance of the Glycoprotein Ib-Binding Domain and the RGD Sequence of von Willebrand Factor for Its Interaction With Endothelial Cells

Christelle Perrault,Hanneke Lankhof,Dominique Pidard,Danièle Kerbiriou-Nabias,Jan J. Sixma,Dominique Meyer,Dominique Baruch

View Articletitled, Relative Importance of the Glycoprotein Ib-Binding Domain and the RGD Sequence of von Willebrand Factor for Its Interaction With Endothelial Cells

Dilazep, an Antiplatelet Agent, Inhibits Tissue Factor Expression in Endothelial Cells and Monocytes

Hiroshi Deguchi,Hiroyuki Takeya,Hideo Wada,Esteban C. Gabazza,Nobuyuki Hayashi,Hajime Urano,Koji Suzuki

View Articletitled, Dilazep, an Antiplatelet Agent, Inhibits Tissue Factor Expression in Endothelial Cells and Monocytes

Suppression of Megakaryocyte Colony Growth by Plasma From Foals Infected With Equine Infectious Anemia Virus

Susan J. Tornquist,Timothy B. Crawford

View Articletitled, Suppression of Megakaryocyte Colony Growth by Plasma From Foals Infected With Equine Infectious Anemia Virus

IMMUNOBIOLOGY

Conjugation of Blocked Ricin to an Anti-CD19 Monoclonal Antibody Increases Antibody-Induced Cell Calcium Mobilization and CD19 Internalization

Anne-Christine Goulet,Victor S. Goldmacher,John M. Lambert,Chantal Baron,Denis-Claude Roy,Edouard Kouassi

View Articletitled, Conjugation of Blocked Ricin to an Anti-CD19 Monoclonal Antibody Increases Antibody-Induced Cell Calcium Mobilization and CD19 Internalization

Increased In Vivo Antibody Activity Against Interferon α, Interleukin-1α, and Interleukin-6 After High-Dose Ig Therapy

Christian Ross,Morten Svenson,Henrik Nielsen,Charlotte Lundsgaard,Morten Bagge Hansen,Klaus Bendtzen

View Articletitled, Increased In Vivo Antibody Activity Against Interferon α, Interleukin-1α, and Interleukin-6 After High-Dose Ig Therapy

Soluble Monomeric P-Selectin Containing Only the Lectin and Epidermal Growth Factor Domains Binds to P-Selectin Glycoprotein Ligand-1 on Leukocytes

Padmaja Mehta,Kamala D. Patel,Thomas M. Laue,Harold P. Erickson,Rodger P. McEver

View Articletitled, Soluble Monomeric P-Selectin Containing Only the Lectin and Epidermal Growth Factor Domains Binds to P-Selectin Glycoprotein Ligand-1 on Leukocytes

Downregulation of TAP1 in B Lymphocytes by Cellular and Epstein-Barr Virus–Encoded Interleukin-10

Reinhard Zeidler,Günther Eissner,Petra Meissner,Stephan Uebel,Robert Tampé,Sabine Lazis,Wolfgang Hammerschmidt

View Articletitled, Downregulation of TAP1 in B Lymphocytes by Cellular and Epstein-Barr Virus–Encoded Interleukin-10

CD84 Leukocyte Antigen Is a New Member of the Ig Superfamily

Miguel Angel de la Fuente,Pilar Pizcueta,Marga Nadal,Jaime Bosch,Pablo Engel

View Articletitled, CD84 Leukocyte Antigen Is a New Member of the Ig Superfamily

Replication-Defective Canarypox (ALVAC) Vectors Effectively Activate Anti–Human Immunodeficiency Virus-1 Cytotoxic T Lymphocytes Present in Infected Patients: Implications for Antigen-Specific Immunotherapy

G. Ferrari,C. Berend,J. Ottinger,R. Dodge,J. Bartlett,J. Toso,D. Moody,J. Tartaglia,William I. Cox,E. Paoletti,K.J. Weinhold

View Articletitled, Replication-Defective Canarypox (ALVAC) Vectors Effectively Activate Anti–Human Immunodeficiency Virus-1 Cytotoxic T Lymphocytes Present in Infected Patients: Implications for Antigen-Specific Immunotherapy

NEOPLASIA

CD7⁺ and CD56⁺ Myeloid/Natural Killer Cell Precursor Acute Leukemia: A Distinct Hematolymphoid Disease Entity

Ritsuro Suzuki,Kazuhito Yamamoto,Masao Seto,Yoshitoyo Kagami,Michinori Ogura,Yasushi Yatabe,Taizan Suchi,Yoshihisa Kodera,Yasuo Morishima,Toshitada Takahashi,Hidehiko Saito,Ryuzo Ueda,Shigeo Nakamura

View Articletitled, CD7+ and CD56+ Myeloid/Natural Killer Cell Precursor Acute Leukemia: A Distinct Hematolymphoid Disease Entity

Adverse Clinical Outcome in Hodgkin's Disease Is Associated With Loss of Retinoblastoma Protein Expression, High Ki67 Proliferation Index, and Absence of Epstein-Barr Virus-Latent Membrane Protein 1 Expression

Manuel M. Morente,Miguel A. Piris,Victor Abraira,Agustin Acevedo,Beatriz Aguilera,Carmen Bellas,Máximo Fraga,Raimundo Garcia-Del-Moral,Francisco Gomez-Marcos,Javier Menarguez,Horacio Oliva,Margarita Sanchez-Beato,Carlos Montalban

View Articletitled, Adverse Clinical Outcome in Hodgkin's Disease Is Associated With Loss of Retinoblastoma Protein Expression, High Ki67 Proliferation Index, and Absence of Epstein-Barr Virus-Latent Membrane Protein 1 Expression

New Xenograft Model of Multiple Myeloma and Efficacy of a Humanized Antibody Against Human Interleukin-6 Receptor

Toshiaki Tsunenari,Yasuo Koishihara,Akito Nakamura,Miki Moriya,Hiroyuki Ohkawa,Hideo Goto,Chihiro Shimazaki,Masao Nakagawa,Yoshiyuki Ohsugi,Tadamitsu Kishimoto,Ken-ichi Akamatsu

View Articletitled, New Xenograft Model of Multiple Myeloma and Efficacy of a Humanized Antibody Against Human Interleukin-6 Receptor

BCL-6 Protein Expression in Human Peripheral T-Cell Neoplasms Is Restricted to CD30⁺ Anaplastic Large-Cell Lymphomas

Antonino Carbone,Annunziata Gloghini,Gianluca Gaidano,Riccardo Dalla-Favera,Brunangelo Falini

View Articletitled, BCL-6 Protein Expression in Human Peripheral T-Cell Neoplasms Is Restricted to CD30+ Anaplastic Large-Cell Lymphomas

Immunohistochemical Analysis of Interleukin-1β–Converting Enzyme/Ced-3 Family Protease, CPP32/Yama/Caspase-3, in Hodgkin's Disease

Mukesh Chhanabhai,Stanislaw Krajewski,Maryla Krajewska,Hong-Gang Wang,John C. Reed,Randy D. Gascoyne

View Articletitled, Immunohistochemical Analysis of Interleukin-1β–Converting Enzyme/Ced-3 Family Protease, CPP32/Yama/Caspase-3, in Hodgkin's Disease

Rapid Molecular Cloning of Rearrangements of the IGHJ Locus Using Long-Distance Inverse Polymerase Chain Reaction

T.G. Willis,D.M. Jadayel,L.J.A. Coignet,M. Abdul-Rauf,J.G. Treleaven,D. Catovsky,M.J.S. Dyer

View Articletitled, Rapid Molecular Cloning of Rearrangements of the IGHJ Locus Using Long-Distance Inverse Polymerase Chain Reaction

Immunophenotyping Investigation of Minimal Residual Disease Is a Useful Approach for Predicting Relapse in Acute Myeloid Leukemia Patients

J.F. San Miguel,A. Martı́nez,A. Macedo,M.B. Vidriales,C. López-Berges,M. González,D. Caballero,M.A. Garcı́a-Marcos,F. Ramos,J. Fernández-Calvo,M.J. Calmuntia,J. Diaz-Mediavilla,A. Orfao

View Articletitled, Immunophenotyping Investigation of Minimal Residual Disease Is a Useful Approach for Predicting Relapse in Acute Myeloid Leukemia Patients

RED CELLS

A Markedly Disrupted Skeletal Network With Abnormally Distributed Intramembrane Particles in Complete Protein 4.1-Deficient Red Blood Cells (Allele 4.1 Madrid): Implications Regarding a Critical Role of Protein 4.1 in Maintenance of the Integrity of the Red Blood Cell Membrane

Ayumi Yawata,Akio Kanzaki,Florinda Gilsanz,Jean Delaunay,Yoshihito Yawata

View Articletitled, A Markedly Disrupted Skeletal Network With Abnormally Distributed Intramembrane Particles in Complete Protein 4.1-Deficient Red Blood Cells (Allele 4.1 Madrid): Implications Regarding a Critical Role of Protein 4.1 in Maintenance of the Integrity of the Red Blood Cell Membrane

TRANSFUSION MEDICINE

Spread of Human Cytomegalovirus (HCMV) After Infection of Human Hematopoietic Progenitor Cells: Model of HCMV Latency

T. Zhuravskaya,J.P. Maciejewski,D.M. Netski,E. Bruening,F.R. Mackintosh,S. St Jeor

View Articletitled, Spread of Human Cytomegalovirus (HCMV) After Infection of Human Hematopoietic Progenitor Cells: Model of HCMV Latency

Intrauterine Transfusions Affect Fetal T-Cell Immunity

Henk E. Viëtor,Gail E. Hawes,Claudia van den Oever,Els van Beelen,Humphrey H.H. Kanhai,Anneke Brand,Peter J. Van den Elsen

View Articletitled, Intrauterine Transfusions Affect Fetal T-Cell Immunity

TRANSPLANTATION

Neutropenia in Allogeneic Marrow Transplant Recipients Receiving Ganciclovir for Prevention of Cytomegalovirus Disease: Risk Factors and Outcome

Bernd Salzberger,Raleigh A. Bowden,Robert C. Hackman,Chris Davis,Michael Boeckh

View Articletitled, Neutropenia in Allogeneic Marrow Transplant Recipients Receiving Ganciclovir for Prevention of Cytomegalovirus Disease: Risk Factors and Outcome

ERRATA

ERRATUM

View Articletitled, ERRATUM

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