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Issue Archive

Volume 133, Issue 8
February 21 2019
Issue Cover

Table of Contents

BLOOD COMMENTARIES

CLINICAL TRIALS AND OBSERVATIONS
If Trousseau had a stroke
Clinical Trials & Observations
Alok A. Khorana
View Articletitled, If Trousseau had a stroke
Hematopoiesis and Stem Cells
Splicing up hematopoietic development
Jill L. O. de Jong
View Articletitled, Splicing up hematopoietic development
Hematopoiesis and Stem Cells
Directing the conductor: TNF regulation of HSCs
Stephen L. Nutt
View Articletitled, Directing the conductor: TNF regulation of HSCs
IMMUNOBIOLOGY AND IMMUNOTHERAPY
RAGs usurp cellular factors for both breaking and repairing
Katheryn Meek
View Articletitled, RAGs usurp cellular factors for both breaking and repairing
Lymphoid Neoplasia
FBXW7 is a biologically validated cancer driver gene for CLL
Davide Rossi
View Articletitled, <em>FBXW7</em> is a biologically validated cancer driver gene for CLL
THROMBOSIS AND HEMOSTASIS
A silent response to silent thrombosis
Sarah O’Brien
View Articletitled, A silent response to silent thrombosis
TRANSPLANTATION
T’ing off on posttransplant CMV
Jeffery J. Auletta
View Articletitled, T’ing off on posttransplant CMV

PLENARY PAPER

CLINICAL TRIALS AND OBSERVATIONS
Arterial thromboembolic events preceding the diagnosis of cancer in older persons
Clinical Trials & Observations
Babak B. Navi,Anne S. Reiner,Hooman Kamel,Costantino Iadecola,Peter M. Okin,Scott T. Tagawa,Katherine S. Panageas,Lisa M. DeAngelis
View Articletitled, Arterial thromboembolic events preceding the diagnosis of cancer in older persons

BLOOD SPOTLIGHT

Luspatercept for the treatment of anemia in myelodysplastic syndromes and primary myelofibrosis
Pierre Fenaux,Jean Jacques Kiladjian,Uwe Platzbecker
View Articletitled, Luspatercept for the treatment of anemia in myelodysplastic syndromes and primary myelofibrosis

HOW I TREAT

How I treat low von Willebrand factor levels
Michelle Lavin,James S. O’Donnell
View Articletitled, How I treat low von Willebrand factor levels

HEMATOPOIESIS AND STEM CELLS

BCAS2 is essential for hematopoietic stem and progenitor cell maintenance during zebrafish embryogenesis
Shanshan Yu,Tao Jiang,Danna Jia,Yunqiao Han,Fei Liu,Yuwen Huang,Zhen Qu,Yuntong Zhao,Jiayi Tu,Yuexia Lv,Jingzhen Li,Xuebin Hu,Zhaojing Lu,Shanshan Han,Yayun Qin,Xiliang Liu,Shanglun Xie,Qing K. Wang,Zhaohui Tang,Daji Luo,Mugen Liu
View Articletitled, BCAS2 is essential for hematopoietic stem and progenitor cell maintenance during zebrafish embryogenesis
Supplemental data
Inflammatory signals directly instruct PU.1 in HSCs via TNF
Brief Report
Martin Etzrodt,Nouraiz Ahmed,Philipp S. Hoppe,Dirk Loeffler,Stavroula Skylaki,Oliver Hilsenbeck,Konstantinos D. Kokkaliaris,Hans-Michael Kaltenbach,Jörg Stelling,Claus Nerlov,Timm Schroeder
View Articletitled, Inflammatory signals directly instruct PU.1 in HSCs via TNF
Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

A novel RAG1 mutation reveals a critical in vivo role for HMGB1/2 during V(D)J recombination
Daniel T. Thwaites,Clive Carter,Dylan Lawless,Sinisa Savic,Joan M. Boyes
View Articletitled, A novel <em>RAG1</em> mutation reveals a critical in vivo role for HMGB1/2 during V(D)J recombination
Supplemental data

LYMPHOID NEOPLASIA

FBXW7 mutations reduce binding of NOTCH1, leading to cleaved NOTCH1 accumulation and target gene activation in CLL
Viola Close,William Close,Sabrina Julia Kugler,Michaela Reichenzeller,Deyan Yordanov Yosifov,Johannes Bloehdorn,Leiling Pan,Eugen Tausch,Mike-Andrew Westhoff,Hartmut Döhner,Stephan Stilgenbauer,Franz Oswald,Daniel Mertens
View Articletitled, <em>FBXW7</em> mutations reduce binding of NOTCH1, leading to cleaved NOTCH1 accumulation and target gene activation in CLL
Supplemental data

MYELOID NEOPLASIA

Midostaurin added to chemotherapy and continued single-agent maintenance therapy in acute myeloid leukemia with FLT3-ITD
Clinical Trials & Observations
Richard F. Schlenk,Daniela Weber,Walter Fiedler,Helmut R. Salih,Gerald Wulf,Hans Salwender,Thomas Schroeder,Thomas Kindler,Michael Lübbert,Dominik Wolf,Jörg Westermann,Doris Kraemer,Katharina S. Götze,Heinz-August Horst,Jürgen Krauter,Michael Girschikofsky,Mark Ringhoffer,Thomas Südhoff,Gerhard Held,Hans-Günter Derigs,Roland Schroers,Richard Greil,Martin Grießhammer,Elisabeth Lange,Alexander Burchardt,Uwe Martens,Bernd Hertenstein,Lore Marretta,Michael Heuser,Felicitas Thol,Verena I. Gaidzik,Wolfgang Herr,Julia Krzykalla,Axel Benner,Konstanze Döhner,Arnold Ganser,Peter Paschka,Hartmut Döhner,on behalf of the German-Austrian AML Study Group
View Articletitled, Midostaurin added to chemotherapy and continued single-agent maintenance therapy in acute myeloid leukemia with <em>FLT3</em>-ITD
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

A natural regulatory mutation in the proximal promoter elevates fetal globin expression by creating a de novo GATA1 site
Brief Report
Gabriella E. Martyn,Beeke Wienert,Ryo Kurita,Yukio Nakamura,Kate G. R. Quinlan,Merlin Crossley
View Articletitled, A natural regulatory mutation in the proximal promoter elevates fetal <em>globin</em> expression by creating a de novo GATA1 site
Supplemental data

THROMBOSIS AND HEMOSTASIS

The natural history of asymptomatic central venous catheter–related thrombosis in critically ill children
CME Clinical Trials & Observations
Sophie Jones,Warwick Butt,Paul Monagle,Timothy Cain,Fiona Newall
View Articletitled, The natural history of asymptomatic central venous catheter–related thrombosis in critically ill children

TRANSPLANTATION

Deep functional immunophenotyping predicts risk of cytomegalovirus reactivation after hematopoietic cell transplantation
Jose F. Camargo,Eric D. Wieder,Erik Kimble,Cara L. Benjamin,Despina S. Kolonias,Deukwoo Kwon,Xi Steven Chen,Krishna V. Komanduri
View Articletitled, Deep functional immunophenotyping predicts risk of cytomegalovirus reactivation after hematopoietic cell transplantation
Supplemental data

LETTER TO BLOOD

B-cell lymphomas present immunoglobulin neoantigens
Michael S. Khodadoust,Niclas Olsson,Binbin Chen,Brian Sworder,Tanaya Shree,Chih Long Liu,Lichao Zhang,Debra K. Czerwinski,Mark M. Davis,Ronald Levy,Joshua E. Elias,Ash A. Alizadeh
View Articletitled, B-cell lymphomas present immunoglobulin neoantigens
Supplemental data

BLOOD WORK

Fibrin-associated diffuse large B-cell lymphoma confined to a cardiac myxoma
Sofia Garces,Vathany Sriganeshan
View Articletitled, Fibrin-associated diffuse large B-cell lymphoma confined to a cardiac myxoma
“Myelodysplasia” from copper deficiency
Salahuddin Siddiqui,Reshma Ramlal
View Articletitled, “Myelodysplasia” from copper deficiency

CONTINUING MEDICAL EDUCATION (CME) QUESTIONS

CVC-related thrombosis in critically ill children
CME
View Articletitled, CVC-related thrombosis in critically ill children
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