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Journal Articles

NOTCH1 Signaling Is Dysregulated in CLL By the Deubiquitinase USP28 That Is Recurrently Affected By Del(11q) and Can be Therapeutically Targeted

Alena Sophie Ehrmann, Miguel Quijada Álamo, Viola Close, Min Guo, Claudia Pérez Carretero, Luis A Corchete, Eugen Tausch, Christof Schneider, Hartmut Döhner, Stephan Stilgenbauer, Franz Oswald, Jesus Maria Hernández-Rivas, Daniel Mertens
Journal: Blood
Blood (2022) 140 (Supplement 1): 4100–4102.
https://doi.org/10.1182/blood-2022-158168
Published: 2022
Journal Articles

FBXW7 mutations reduce binding of NOTCH1, leading to cleaved NOTCH1 accumulation and target gene activation in CLL

Viola Close, William Close, Sabrina Julia Kugler, Michaela Reichenzeller, Deyan Yordanov Yosifov, Johannes Bloehdorn, Leiling Pan, Eugen Tausch, Mike-Andrew Westhoff, Hartmut Döhner, Stephan Stilgenbauer, Franz Oswald, Daniel Mertens
Journal: Blood
Blood (2019) 133 (8): 830–839.
https://doi.org/10.1182/blood-2018-09-874529
Published: 2019
Includes: Supplemental data
Journal Articles

NOTCH1 Signaling Is Activated in CLL By Mutations of FBXW7 and Low Expression of USP28 at 11q23

Viola Close, MSc, William Close, MSc, Sabrina Julia Kugler, PhD, Michaela Reichenzeller, PhD, Deyan Yordanov Yosifov, PhD, Johannes Bloehdorn, MD, Leiling Pan, MSc, Eugen Tausch, MD, Mike-Andrew Westhoff, PhD, Hartmut Döhner, MD, Stephan Stilgenbauer, MD PhD, Franz Oswald, PhD, Daniel Mertens
Journal: Blood
Blood (2018) 132 (Supplement 1): 946.
https://doi.org/10.1182/blood-2018-99-114491
Published: 2018