Ariela Noy,for the AIDS Malignancy Consortium,Jeannette Y. Lee,for the AIDS Malignancy Consortium,Ethel Cesarman,for the AIDS Malignancy Consortium,Richard Ambinder,for the AIDS Malignancy Consortium,Robert Baiocchi,for the AIDS Malignancy Consortium,Erin Reid,for the AIDS Malignancy Consortium,Lee Ratner,for the AIDS Malignancy Consortium,Nina Wagner-Johnston,for the AIDS Malignancy Consortium,Lawrence Kaplan,for the AIDS Malignancy Consortium

View Articletitled, AMC 048: modified CODOX-M/IVAC-rituximab is safe and effective for HIV-associated Burkitt lymphoma

Supplemental data

HEMATOPOIESIS AND STEM CELLS

Polycomb repressive complex 2 component Suz12 is required for hematopoietic stem cell function and lymphopoiesis

Stanley C. W. Lee,Sarah Miller,Craig Hyland,Maria Kauppi,Marion Lebois,Ladina Di Rago,Donald Metcalf,Sarah A. Kinkel,Emma C. Josefsson,Marnie E. Blewitt,Ian J. Majewski,Warren S. Alexander

View Articletitled, Polycomb repressive complex 2 component Suz12 is required for hematopoietic stem cell function and lymphopoiesis

Supplemental data

Triallelic and epigenetic-like inheritance in human disorders of telomerase

Laura C. Collopy,Amanda J. Walne,Shirleny Cardoso,Josu de la Fuente,Mahfuzah Mohamed,Helga Toriello,Hannah Tamary,Adam J. Y. V. Ling,Timothy Lloyd,Rebecca Kassam,Hemanth Tummala,Thomas J. Vulliamy,Inderjeet Dokal

View Articletitled, Triallelic and epigenetic-like inheritance in human disorders of telomerase

Supplemental data

IMMUNOBIOLOGY

High-density preculture of PBMCs restores defective sensitivity of circulating CD8 T cells to virus- and tumor-derived antigens

Julia Wegner,Stephan Hackenberg,Claus-Jürgen Scholz,Sergey Chuvpilo,Dmitry Tyrsin,Alexey A. Matskevich,Götz Ulrich Grigoleit,Stefan Stevanović,Thomas Hünig

View Articletitled, High-density preculture of PBMCs restores defective sensitivity of circulating CD8 T cells to virus- and tumor-derived antigens

Supplemental data

LYMPHOID NEOPLASIA

Mutations in CHD2 cause defective association with active chromatin in chronic lymphocytic leukemia

David Rodríguez,Gabriel Bretones,Víctor Quesada,Neus Villamor,Javier R. Arango,Armando López-Guillermo,Andrew J. Ramsay,Tycho Baumann,Pedro M. Quirós,Alba Navarro,Cristina Royo,José I. Martín-Subero,Elías Campo,Carlos López-Otín

View Articletitled, Mutations in CHD2 cause defective association with active chromatin in chronic lymphocytic leukemia

Supplemental data

PD-L1 checkpoint blockade prevents immune dysfunction and leukemia development in a mouse model of chronic lymphocytic leukemia

Fabienne McClanahan,Bola Hanna,Shaun Miller,Andrew James Clear,Peter Lichter,John G. Gribben,Martina Seiffert

View Articletitled, PD-L1 checkpoint blockade prevents immune dysfunction and leukemia development in a mouse model of chronic lymphocytic leukemia

Supplemental data

Mechanisms of PD-L1/PD-1–mediated CD8 T-cell dysfunction in the context of aging-related immune defects in the Eµ-TCL1 CLL mouse model

Fabienne McClanahan,John C. Riches,Shaun Miller,William P. Day,Eleni Kotsiou,Donna Neuberg,Carlo M. Croce,Melania Capasso,John G. Gribben

View Articletitled, Mechanisms of PD-L1/PD-1–mediated CD8 T-cell dysfunction in the context of aging-related immune defects in the Eµ-TCL1 CLL mouse model

Supplemental data

MYELOID NEOPLASIA

Antileukemia activity of the novel peptidic CXCR4 antagonist LY2510924 as monotherapy and in combination with chemotherapy

Byung-Sik Cho,Zhihong Zeng,Hong Mu,Zhiqiang Wang,Sergej Konoplev,Teresa McQueen,Marina Protopopova,Jorge Cortes,Joseph R. Marszalek,Sheng-Bin Peng,Wencai Ma,R. Eric Davis,Donald E. Thornton,Michael Andreeff,Marina Konopleva

View Articletitled, Antileukemia activity of the novel peptidic CXCR4 antagonist LY2510924 as monotherapy and in combination with chemotherapy

Supplemental data

SF3B1 mutation identifies a distinct subset of myelodysplastic syndrome with ring sideroblasts
Clinical Trials & Observations

Luca Malcovati,Mohsen Karimi,Elli Papaemmanuil,Ilaria Ambaglio,Martin Jädersten,Monika Jansson,Chiara Elena,Anna Gallì,Gunilla Walldin,Matteo G. Della Porta,Klas Raaschou-Jensen,Erica Travaglino,Klaus Kallenbach,Daniela Pietra,Viktor Ljungström,Simona Conte,Emanuela Boveri,Rosangela Invernizzi,Richard Rosenquist,Peter J. Campbell,Mario Cazzola,Eva Hellström Lindberg

View Articletitled, SF3B1 mutation identifies a distinct subset of myelodysplastic syndrome with ring sideroblasts

Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

P-selectin promotes neutrophil extracellular trap formation in mice
Brief Report

Julia Etulain,Kimberly Martinod,Siu Ling Wong,Stephen M. Cifuni,Mirta Schattner,Denisa D. Wagner

View Articletitled, P-selectin promotes neutrophil extracellular trap formation in mice

Supplemental data

PLATELETS AND THROMBOPOIESIS

CD8⁺ T cells are predominantly protective and required for effective steroid therapy in murine models of immune thrombocytopenia

Li Ma,Elisa Simpson,June Li,Min Xuan,Miao Xu,Laura Baker,Yan Shi,Issaka Yougbaré,Xiaozhong Wang,Guangheng Zhu,Pingguo Chen,Gerald J. Prud’homme,Alan H. Lazarus,John Freedman,Heyu Ni

View Articletitled, CD8+ T cells are predominantly protective and required for effective steroid therapy in murine models of immune thrombocytopenia

Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Inducing iron deficiency improves erythropoiesis and photosensitivity in congenital erythropoietic porphyria
Brief Report

Daniel N. Egan,Zhantao Yang,John Phillips,Janis L. Abkowitz

View Articletitled, Inducing iron deficiency improves erythropoiesis and photosensitivity in congenital erythropoietic porphyria

Supplemental data

THROMBOSIS AND HEMOSTASIS

Variable content of von Willebrand factor mutant monomer drives the phenotypic variability in a family with von Willebrand disease

Junmei Chen,Jesse D. Hinckley,Sandra Haberichter,Paula Jacobi,Robert Montgomery,Veronica H. Flood,Randall Wong,Gianluca Interlandi,Dominic W. Chung,José A. López,Jorge Di Paola

View Articletitled, Variable content of von Willebrand factor mutant monomer drives the phenotypic variability in a family with von Willebrand disease

Supplemental data

TRANSPLANTATION

Hematopoietic stem cell transplantation for infantile osteopetrosis

Paul J. Orchard,Anders L. Fasth,Jennifer Le Rademacher,Wensheng He,Jaap Jan Boelens,Edwin M. Horwitz,Amal Al-Seraihy,Mouhab Ayas,Carmem M. Bonfim,Farid Boulad,Troy Lund,David K. Buchbinder,Neena Kapoor,Tracey A. O’Brien,Miguel A. Diaz Perez,Paul A. Veys,Mary Eapen

View Articletitled, Hematopoietic stem cell transplantation for infantile osteopetrosis

BLOOD WORK

Pseudo–Pelger-Huët anomaly in a patient on tacrolimus

Upasana Joneja,Guldeep Uppal

View Articletitled, Pseudo–Pelger-Huët anomaly in a patient on tacrolimus

CORRESPONDENCE

Eculizumab treatment efficiently prevents C5 cleavage without C5a generation in vivo

Elena B. Volokhina,Grethe Bergseth,Nicole C. A. J. van de Kar,Lambertus P. van den Heuvel,Tom Eirik Mollnes

View Articletitled, Eculizumab treatment efficiently prevents C5 cleavage without C5a generation in vivo

Response: Maternal and cord C5a in response to eculizumab

Richard M. Burwick,Nicholas Burwick,Bruce B. Feinberg

View Articletitled, Response: Maternal and cord C5a in response to eculizumab

ERRATA

Airoldi I, Cocco C, Giuliani N, et al. Constitutive expression of IL-12Rβ2 on human multiple myeloma cells delineates a novel therapeutic target. Blood. 2008;112(3):750-759.

View Articletitled, Airoldi I, Cocco C, Giuliani N, et al. Constitutive expression of IL-12Rβ2 on human multiple myeloma cells delineates a novel therapeutic target. Blood. 2008;112(3):750-759.

Cover Image

Cover Image

Confocal microscopy showing the distribution of von Willebrand factor (green) in a mouse megakaryocyte during proplatelet formation. Tubulin was used to stain the cytoskeleton (red). See the article by Bem et al on page 133.
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INSIDE BLOOD COMMENTARIES

To be or not to be HIV+, that is no longer the question Clinical Trials & Observations

PLENARY PAPER

REVIEW ARTICLE

HOW I TREAT

How I use bypassing therapy for prophylaxis in patients with hemophilia A and inhibitors Clinical Trials & Observations

CLINICAL TRIALS AND OBSERVATIONS

AMC 048: modified CODOX-M/IVAC-rituximab is safe and effective for HIV-associated Burkitt lymphoma Clinical Trials & Observations

HEMATOPOIESIS AND STEM CELLS

IMMUNOBIOLOGY

LYMPHOID NEOPLASIA

MYELOID NEOPLASIA

SF3B1 mutation identifies a distinct subset of myelodysplastic syndrome with ring sideroblasts Clinical Trials & Observations

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

P-selectin promotes neutrophil extracellular trap formation in mice Brief Report

PLATELETS AND THROMBOPOIESIS

RED CELLS, IRON, AND ERYTHROPOIESIS

Inducing iron deficiency improves erythropoiesis and photosensitivity in congenital erythropoietic porphyria Brief Report

THROMBOSIS AND HEMOSTASIS

TRANSPLANTATION

BLOOD WORK

CORRESPONDENCE

ERRATA

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To be or not to be HIV+, that is no longer the question
Clinical Trials & Observations

How I use bypassing therapy for prophylaxis in patients with hemophilia A and inhibitors
Clinical Trials & Observations

AMC 048: modified CODOX-M/IVAC-rituximab is safe and effective for HIV-associated Burkitt lymphoma
Clinical Trials & Observations

SF3B1 mutation identifies a distinct subset of myelodysplastic syndrome with ring sideroblasts
Clinical Trials & Observations

P-selectin promotes neutrophil extracellular trap formation in mice
Brief Report

Inducing iron deficiency improves erythropoiesis and photosensitivity in congenital erythropoietic porphyria
Brief Report