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Ropeginterferon alfa-2b, a novel IFNα-2b, induces high response rates with low toxicity in patients with polycythemia vera
Genetics of glucocorticoid-associated osteonecrosis in children with acute lymphoblastic leukemia
Wnt signaling induces transcription, spatial proximity, and translocation of fusion gene partners in human hematopoietic cells
Issue Archive
October 8 2015
Table of Contents
INSIDE BLOOD COMMENTARIES
PLENARY PAPER
PLENARY PAPER
IDH2R172 mutations define a unique subgroup of patients with angioimmunoblastic T-cell lymphoma
Chao Wang,Timothy W. McKeithan,Qiang Gong,Weiwei Zhang,Alyssa Bouska,Andreas Rosenwald,Randy D. Gascoyne,Xiwei Wu,Jinhui Wang,Zahid Muhammad,Bei Jiang,Joseph Rohr,Andrew Cannon,Christian Steidl,Kai Fu,Yuping Li,Stacy Hung,Dennis D. Weisenburger,Timothy C. Greiner,Lynette Smith,German Ott,Eleanor G. Rogan,Louis M. Staudt,Julie Vose,Javeed Iqbal,Wing C. Chan
PERSPECTIVES
CLINICAL TRIALS AND OBSERVATIONS
Ropeginterferon alfa-2b, a novel IFNα-2b, induces high response rates with low toxicity in patients with polycythemia vera
Clinical Trials & Observations
Heinz Gisslinger,Oleh Zagrijtschuk,Veronika Buxhofer-Ausch,Josef Thaler,Ernst Schloegl,Guenther A. Gastl,Dominik Wolf,Robert Kralovics,Bettina Gisslinger,Karin Strecker,Alexander Egle,Thomas Melchardt,Sonja Burgstaller,Ella Willenbacher,Martin Schalling,Nicole C. Them,Pavla Kadlecova,Christoph Klade,Richard Greil
Genetics of glucocorticoid-associated osteonecrosis in children with acute lymphoblastic leukemia
Clinical Trials & Observations
Seth E. Karol,Wenjian Yang,Sara L. Van Driest,Tamara Y. Chang,Sue Kaste,Erica Bowton,Melissa Basford,Lisa Bastarache,Dan M. Roden,Joshua C. Denny,Eric Larsen,Naomi Winick,William L. Carroll,Cheng Cheng,Deqing Pei,Christian A. Fernandez,Chengcheng Liu,Colton Smith,Mignon L. Loh,Elizabeth A. Raetz,Stephen P. Hunger,Paul Scheet,Sima Jeha,Ching-Hon Pui,William E. Evans,Meenakshi Devidas,Leonard A. Mattano, Jr,Mary V. Relling
GENE THERAPY
In vivo genome editing of the albumin locus as a platform for protein replacement therapy
Rajiv Sharma,Xavier M. Anguela,Yannick Doyon,Thomas Wechsler,Russell C. DeKelver,Scott Sproul,David E. Paschon,Jeffrey C. Miller,Robert J. Davidson,David Shivak,Shangzhen Zhou,Julianne Rieders,Philip D. Gregory,Michael C. Holmes,Edward J. Rebar,Katherine A. High
HEMATOPOIESIS AND STEM CELLS
Wnt signaling induces transcription, spatial proximity, and translocation of fusion gene partners in human hematopoietic cells
Brief Report
Giorgia D. Ugarte,Macarena F. Vargas,Matías A. Medina,Pablo León,David Necuñir,Alvaro A. Elorza,Soraya E. Gutiérrez,Randall T. Moon,Alejandra Loyola,Giancarlo V. De Ferrari
IMMUNOBIOLOGY
LYMPHOID NEOPLASIA
CD9, a key actor in the dissemination of lymphoblastic leukemia, modulating CXCR4-mediated migration via RAC1 signaling
Marie-Pierre Arnaud,Audrey Vallée,Guillaume Robert,Jacinthe Bonneau,Christine Leroy,Nadine Varin-Blank,Anne-Gaëlle Rio,Marie-Bérengère Troadec,Marie-Dominique Galibert,Virginie Gandemer
Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia
Chunhua Song,Chandrika Gowda,Xiaokang Pan,Yali Ding,Yongqing Tong,Bi-Hua Tan,Haijun Wang,Sunil Muthusami,Zheng Ge,Mansi Sachdev,Shantu G. Amin,Dhimant Desai,Krishne Gowda,Raghavendra Gowda,Gavin P. Robertson,Hilde Schjerven,Markus Muschen,Kimberly J. Payne,Sinisa Dovat
PLATELETS AND THROMBOPOIESIS
RED CELLS, IRON, AND ERYTHROPOIESIS
THROMBOSIS AND HEMOSTASIS
BLOOD WORK
CORRESPONDENCE
Clinical outcomes of patients with acute myeloid leukemia: evaluation of genetic and molecular findings in a real-life setting
Aleide S. Lima,Mariana R. de Mello,Eliana Fernandes,Matheus F. Bezerra,Mayara M. Oliveira,Bruno K. Duarte,Reijane A. de Assis,Fernanda R. Souto,Clarisa F. Ramos,Cintia G. Machado,Katia Pagnano,Antonio R. Lucena-Araujo,Irene Lorand-Metze,Marcos A. Bezerra
ERRATA
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Cover Image
Cover Image
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The propeptide of von Willebrand factor (VWFpp) contains the necessary signal or conformation for navigating the regulated secretory pathway. To identify the storage signal within VWFpp, a series of C- or N-terminal VWFpp truncations were expressed in AtT-20 cells and intracellular localization assessed by confocal microscopy. A subset of VWFpp truncations (green) were stored in granules, colocalized (yellow) with endogenous ACTH (red). The VWFpp storage signal appears to be localized within the VWF D2 domain. See the article by Haberichter on page 1753.
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