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Issue Archive

Volume 120, Issue 8
August 23 2012
Issue Cover

Table of Contents

Inside Blood

CLINICAL TRIALS
ATRA plus arsenic gets another “A” in APL
Jae H. Park
View Articletitled, ATRA plus arsenic gets another “A” in APL
CLINICAL TRIALS
When it comes to MRD, AML ≠ ALL
Elisabeth Paietta
View Articletitled, When it comes to MRD, AML ≠ ALL
CLINICAL TRIALS
Second to none
S. Vincent Rajkumar
View Articletitled, Second to none
IMMUNOBIOLOGY
Toward an off-the-shelf vaccine for B-cell malignancies
James L. Gulley
View Articletitled, Toward an off-the-shelf vaccine for B-cell malignancies
IMMUNOBIOLOGY
What T cells see in WT-1
Jeffrey J. Molldrem
View Articletitled, What T cells see in WT-1
TRANSPLANTATION
Allogeneic HSCT for ATL: a good start
Camille Abboud
View Articletitled, Allogeneic HSCT for ATL: a good start

Blood Work

Lymphocytosis: T-cell large granular lymphocyte leukemia
Javier Munoz,Philip Kuriakose
View Articletitled, Lymphocytosis: T-cell large granular lymphocyte leukemia

Perspectives

Economics of hematopoietic cell transplantation
Nandita Khera,Steven B. Zeliadt,Stephanie J. Lee
View Articletitled, Economics of hematopoietic cell transplantation

Review Article

Does size matter in platelet production?
Jonathan N. Thon,Joseph E. Italiano, Jr
View Articletitled, Does size matter in platelet production?

How I Treat

How I manage venous thromboembolism risk in hospitalized medical patients
Mark Dobromirski,Alexander T. Cohen
View Articletitled, How I manage venous thromboembolism risk in hospitalized medical patients

Clinical Trials and Observations

All-trans-retinoic acid, idarubicin, and IV arsenic trioxide as initial therapy in acute promyelocytic leukemia (APML4)
CME
Harry J. Iland,Ken Bradstock,Shane G. Supple,Alberto Catalano,Marnie Collins,Mark Hertzberg,Peter Browett,Andrew Grigg,Frank Firkin,Amanda Hugman,John Reynolds,Juliana Di Iulio,Campbell Tiley,Kerry Taylor,Robin Filshie,Michael Seldon,John Taper,Jeff Szer,John Moore,John Bashford,John F. Seymour,for the Australasian Leukaemia and Lymphoma Group
View Articletitled, All-<em>trans</em>-retinoic acid, idarubicin, and IV arsenic trioxide as initial therapy in acute promyelocytic leukemia (APML4)
Residual disease detected by multidimensional flow cytometry signifies high relapse risk in patients with de novo acute myeloid leukemia: a report from Children's Oncology Group
Clinical Trials & Observations
Michael R. Loken,Todd A. Alonzo,Laura Pardo,Robert B. Gerbing,Susana C. Raimondi,Betsy A. Hirsch,Phoenix A. Ho,Janet Franklin,Todd M. Cooper,Alan S. Gamis,Soheil Meshinchi
View Articletitled, Residual disease detected by multidimensional flow cytometry signifies high relapse risk in patients with de novo acute myeloid leukemia: a report from Children's Oncology Group

Hematopoiesis and Stem Cells

Necdin, a p53 target gene, regulates the quiescence and response to genotoxic stress of hematopoietic stem/progenitor cells
Takashi Asai,Yan Liu,Silvana Di Giandomenico,Narae Bae,Delphine Ndiaye-Lobry,Anthony Deblasio,Silvia Menendez,Yevgeniy Antipin,Boris Reva,Rachel Wevrick,Stephen D. Nimer
View Articletitled, Necdin, a p53 target gene, regulates the quiescence and response to genotoxic stress of hematopoietic stem/progenitor cells
Supplemental data

Immunobiology

TCL1: a shared tumor-associated antigen for immunotherapy against B-cell lymphomas
Jinsheng Weng,Seema Rawal,Fuliang Chu,Hyun Jun Park,Rakesh Sharma,David A. Delgado,Luis Fayad,Michelle Fanale,Jorge Romaguera,Amber Luong,Larry W. Kwak,Sattva S. Neelapu
View Articletitled, TCL1: a shared tumor-associated antigen for immunotherapy against B-cell lymphomas
Supplemental data
Intrinsic impairment of CD4+CD25+ regulatory T cells in acquired aplastic anemia
Jun Shi,Meili Ge,Shihong Lu,Xingxin Li,Yingqi Shao,Jinbo Huang,Zhendong Huang,Jing Zhang,Neng Nie,Yizhou Zheng
View Articletitled, Intrinsic impairment of CD4<sup>+</sup>CD25<sup>+</sup> regulatory T cells in acquired aplastic anemia
Mapping of novel peptides of WT-1 and presenting HLA alleles that induce epitope-specific HLA-restricted T cells with cytotoxic activity against WT-1+ leukemias
Ekaterina Doubrovina,Taissia Carpenter,Dmitry Pankov,Annamalai Selvakumar,Aisha Hasan,Richard J. O'Reilly
View Articletitled, Mapping of novel peptides of WT-1 and presenting HLA alleles that induce epitope-specific HLA-restricted T cells with cytotoxic activity against WT-1<sup>+</sup> leukemias
Deletion of cognate CD8 T cells by immature dendritic cells: a novel role for perforin, granzyme A, TREM-1, and TLR7
Lior Zangi,Yael Zlotnikov Klionsky,Liran Yarimi,Esther Bachar-Lustig,Yaki Eidelstein,Elias Shezen,David Hagin,Yumi Ito,Toshiyuki Takai,Shlomit Reich-Zeliger,Assaf Lask,Oren Milstein,Steffen Jung,Vera Shinder,Yair Reisner
View Articletitled, Deletion of cognate CD8 T cells by immature dendritic cells: a novel role for perforin, granzyme A, TREM-1, and TLR7
Supplemental data
Fbw7γ-mediated degradation of KLF13 prevents RANTES expression in resting human but not murine T lymphocytes
Dong Seok Kim,Wei Zhang,Scott E. Millman,Byung Joon Hwang,Seok Joo Kwon,Carol Clayberger,Michele Pagano,Alan M. Krensky
View Articletitled, Fbw7γ-mediated degradation of KLF13 prevents RANTES expression in resting human but not murine T lymphocytes

Lymphoid Neoplasia

Superiority of bortezomib, thalidomide, and dexamethasone (VTD) as induction pretransplantation therapy in multiple myeloma: a randomized phase 3 PETHEMA/GEM study
Clinical Trials & Observations
Laura Rosiñol,Albert Oriol,Ana Isabel Teruel,Dolores Hernández,Javier López-Jiménez,Javier de la Rubia,Miquel Granell,Joan Besalduch,Luis Palomera,Yolanda González,Mª Asunción Etxebeste,Joaquín Díaz-Mediavilla,Miguel T. Hernández,Felipe de Arriba,Norma C. Gutiérrez,Mª Luisa Martín-Ramos,Mª Teresa Cibeira,Mª Victoria Mateos,Joaquín Martínez,Adrián Alegre,Juan José Lahuerta,Jesús San Miguel,Joan Bladé,on behalf of the Programa para el Estudio y la Terapéutica de las Hemopatías Malignas/Grupo Español de Mieloma (PETHEMA/GEM) group
View Articletitled, Superiority of bortezomib, thalidomide, and dexamethasone (VTD) as induction pretransplantation therapy in multiple myeloma: a randomized phase 3 PETHEMA/GEM study
Supplemental data
Second malignancies in total therapy 2 and 3 for newly diagnosed multiple myeloma: influence of thalidomide and lenalidomide during maintenance
Clinical Trials & Observations
Saad Z. Usmani,Rachel Sexton,Antje Hoering,Christoph J. Heuck,Bijay Nair,Sarah Waheed,Yazan Al Sayed,Nabeel Chauhan,Nisar Ahmad,Shebli Atrash,Nathan Petty,Frits van Rhee,John Crowley,Bart Barlogie
View Articletitled, Second malignancies in total therapy 2 and 3 for newly diagnosed multiple myeloma: influence of thalidomide and lenalidomide during maintenance
Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A
Mary Pulvino,Yue Liang,David Oleksyn,Michael DeRan,Elise Van Pelt,Joel Shapiro,Ignacio Sanz,Luojing Chen,Jiyong Zhao
View Articletitled, Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A
Supplemental data
LNA-mediated anti–miR-155 silencing in low-grade B-cell lymphomas
Yong Zhang,Aldo M. Roccaro,Christopher Rombaoa,Ludmilla Flores,Susanna Obad,Stacey M. Fernandes,Antonio Sacco,Yang Liu,Hai Ngo,Phong Quang,Abdel Kareem Azab,Feda Azab,Patricia Maiso,Michaela Reagan,Jennifer R. Brown,To-Ha Thai,Sakari Kauppinen,Irene M. Ghobrial
View Articletitled, LNA-mediated anti–miR-155 silencing in low-grade B-cell lymphomas
Supplemental data
Single nucleotide polymorphisms and inherited risk of chronic lymphocytic leukemia among African Americans
Brief Report
Catherine C. Coombs,Laura Z. Rassenti,Lorenzo Falchi,Susan L. Slager,Sara S. Strom,Alessandra Ferrajoli,J. Brice Weinberg,Thomas J. Kipps,Mark C. Lanasa
View Articletitled, Single nucleotide polymorphisms and inherited risk of chronic lymphocytic leukemia among African Americans
Supplemental data

Myeloid Neoplasia

SOCS1 cooperates with FLT3-ITD in the development of myeloproliferative disease by promoting the escape from external cytokine control
Pavankumar N. G. Reddy,Bülent Sargin,Chunaram Choudhary,Stefan Stein,Manuel Grez,Carsten Müller-Tidow,Wolfgang E. Berdel,Hubert Serve,Christian H. Brandts,on behalf of the Study Alliance Leukemia (SAL)
View Articletitled, SOCS1 cooperates with FLT3-ITD in the development of myeloproliferative disease by promoting the escape from external cytokine control
Supplemental data
Posttranslational regulation of self-renewal capacity: insights from proteome and phosphoproteome analyses of stem cell leukemia
e-blood
Matthias Trost,Martin Sauvageau,Olivier Hérault,Paul Deleris,Christelle Pomiès,Jalila Chagraoui,Nadine Mayotte,Sylvain Meloche,Guy Sauvageau,Pierre Thibault
View Articletitled, Posttranslational regulation of self-renewal capacity: insights from proteome and phosphoproteome analyses of stem cell leukemia
Supplemental data

Phagocytes, Granulocytes, and Myelopoiesis

Inactivation of heparan sulfate 2-O-sulfotransferase accentuates neutrophil infiltration during acute inflammation in mice
Jakob Axelsson,Ding Xu,Bit Na Kang,Julia K. Nussbacher,Tracy M. Handel,Klaus Ley,P. Sriramarao,Jeffrey D. Esko
View Articletitled, Inactivation of heparan sulfate 2-<em>O</em>-sulfotransferase accentuates neutrophil infiltration during acute inflammation in mice
Supplemental data

Platelets and Thrombopoiesis

Chronic estradiol treatment reduces platelet responses and protects mice from thromboembolism through the hematopoietic estrogen receptor α
Marie-Cécile Valéra,Marie-Pierre Gratacap,Pierre Gourdy,Françoise Lenfant,Cendrine Cabou,Celine E. Toutain,Marlene Marcellin,Nathalie Saint Laurent,Pierre Sié,Michel Sixou,Jean-François Arnal,Bernard Payrastre
View Articletitled, Chronic estradiol treatment reduces platelet responses and protects mice from thromboembolism through the hematopoietic estrogen receptor α
Full reconstitution of human platelets in humanized mice after macrophage depletion
Brief Report
Zheng Hu,Yong-Guang Yang
View Articletitled, Full reconstitution of human platelets in humanized mice after macrophage depletion
Supplemental data

Thrombosis and Hemostasis

Thrombin generates previously unidentified C5 products that support the terminal complement activation pathway
Michael J. Krisinger,Verena Goebeler,Zhen Lu,Scott C. Meixner,Timothy Myles,Edward L. G. Pryzdial,Edward M. Conway
View Articletitled, Thrombin generates previously unidentified C5 products that support the terminal complement activation pathway
Supplemental data
Structural basis for catalytic activation of protein Z–dependent protease inhibitor (ZPI) by protein Z
Xin Huang,Yahui Yan,Yizheng Tu,Jeffrey Gatti,George J. Broze, Jr,Aiwu Zhou,Steven T. Olson
View Articletitled, Structural basis for catalytic activation of protein Z–dependent protease inhibitor (ZPI) by protein Z
Supplemental data

Transplantation

Allogeneic hematopoietic stem cell transplantation for adult T-cell leukemia-lymphoma with special emphasis on preconditioning regimen: a nationwide retrospective study
Clinical Trials & Observations
Takashi Ishida,Masakatsu Hishizawa,Koji Kato,Ryuji Tanosaki,Takahiro Fukuda,Shuichi Taniguchi,Tetsuya Eto,Yoshifusa Takatsuka,Yasushi Miyazaki,Yukiyoshi Moriuchi,Michihiro Hidaka,Koichi Akashi,Naokuni Uike,Hisashi Sakamaki,Yasuo Morishima,Ritsuro Suzuki,Takeshi Nishiyama,Atae Utsunomiya
View Articletitled, Allogeneic hematopoietic stem cell transplantation for adult T-cell leukemia-lymphoma with special emphasis on preconditioning regimen: a nationwide retrospective study
Supplemental data

Other Departments

Continuing Medical Education (CME) questions: all-trans-retinoic acid, idarubicin, and arsenic therapy for APL
CME
View Articletitled, Continuing Medical Education (CME) questions: all-<em>trans</em>-retinoic acid, idarubicin, and arsenic therapy for APL
All Issues

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Cardiac complete response in AL amyloidosis has similar survival to matched general population
Randomized Bendamustine-Rituximab(R) + Bortezomib Induction and R + Lenalidomide Maintenance for Mantle Cell Lymphoma
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NOVEL THERAPEUTIC APPROACHES IN THALASSEMIAS, SICKLE CELL DISEASE AND OTHER RED CELL DISORDERS

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