Gunnar Juliusson,for the Swedish Acute Leukemia Registry Group,Vladimir Lazarevic,for the Swedish Acute Leukemia Registry Group,Ann-Sofi Hörstedt,for the Swedish Acute Leukemia Registry Group,Oskar Hagberg,for the Swedish Acute Leukemia Registry Group,Martin Höglund,for the Swedish Acute Leukemia Registry Group

View Articletitled, Acute myeloid leukemia in the real world: why population-based registries are needed

Supplemental data

Review Article

Stem cell heterogeneity: implications for aging and regenerative medicine

Christa E. Muller-Sieburg,Hans B. Sieburg,Jeff M. Bernitz,Giulio Cattarossi

View Articletitled, Stem cell heterogeneity: implications for aging and regenerative medicine

Clinical Trials and Observations

Outcomes after matched unrelated donor versus identical sibling hematopoietic cell transplantation in adults with acute myelogenous leukemia
CME

Wael Saber,Shaun Opie,J. Douglas Rizzo,Mei-Jie Zhang,Mary M. Horowitz,Jeff Schriber

View Articletitled, Outcomes after matched unrelated donor versus identical sibling hematopoietic cell transplantation in adults with acute myelogenous leukemia

A phase 1/2 study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia
Clinical Trials & Observations

Geoffrey L. Uy,Michael P. Rettig,Ibraheem H. Motabi,Kyle McFarland,Kathryn M. Trinkaus,Lindsay M. Hladnik,Shashikant Kulkarni,Camille N. Abboud,Amanda F. Cashen,Keith E. Stockerl-Goldstein,Ravi Vij,Peter Westervelt,John F. DiPersio

View Articletitled, A phase 1/2 study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia

Supplemental data

Gene Therapy

CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: pilot clinical trial results
Clinical Trials & Observations

Brian G. Till,Michael C. Jensen,Jinjuan Wang,Xiaojun Qian,Ajay K. Gopal,David G. Maloney,Catherine G. Lindgren,Yukang Lin,John M. Pagel,Lihua E. Budde,Andrew Raubitschek,Stephen J. Forman,Philip D. Greenberg,Stanley R. Riddell,Oliver W. Press

View Articletitled, CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: pilot clinical trial results

Supplemental data

Hematopoiesis and Stem Cells

p85β regulatory subunit of class I_A PI3 kinase negatively regulates mast cell growth, maturation, and leukemogenesis

Subha Krishnan,Raghuveer Singh Mali,Baskar Ramdas,Emily Sims,Peilin Ma,Joydeep Ghosh,Veerendra Munugalavadla,Philip Hanneman,Joal D. Beane,Reuben Kapur

View Articletitled, p85β regulatory subunit of class IA PI3 kinase negatively regulates mast cell growth, maturation, and leukemogenesis

Norepinephrine reuptake inhibition promotes mobilization in mice: potential impact to rescue low stem cell yields
Brief Report

Daniel Lucas,Ingmar Bruns,Michela Battista,Simon Mendez-Ferrer,Claire Magnon,Yuya Kunisaki,Paul S. Frenette

View Articletitled, Norepinephrine reuptake inhibition promotes mobilization in mice: potential impact to rescue low stem cell yields

Supplemental data

Immunobiology

Anti-CD20 (rituximab) therapy for anti–IFN-γ autoantibody–associated nontuberculous mycobacterial infection
Clinical Trials & Observations

Sarah K. Browne,Rifat Zaman,Elizabeth P. Sampaio,Kamonwan Jutivorakool,Lindsey B. Rosen,Li Ding,Minjal J. Pancholi,Lauren M. Yang,Debra Long Priel,Gulbu Uzel,Alexandra F. Freeman,Carlton E. Hayes,Roger Baxter,Stuart H. Cohen,Steven M. Holland

View Articletitled, Anti-CD20 (rituximab) therapy for anti–IFN-γ autoantibody–associated nontuberculous mycobacterial infection

Wiskott-Aldrich syndrome protein (WASP) and N-WASP are critical for peripheral B-cell development and function

Lisa S. Westerberg,Carin Dahlberg,Marisa Baptista,Christopher J. Moran,Cynthia Detre,Marton Keszei,Michelle A. Eston,Frederick W. Alt,Cox Terhorst,Luigi D. Notarangelo,Scott B. Snapper

View Articletitled, Wiskott-Aldrich syndrome protein (WASP) and N-WASP are critical for peripheral B-cell development and function

Supplemental data

Neonatal lymph node stromal cells drive myelodendritic lineage cells into a distinct population of CX3CR1⁺CD11b⁺F4/80⁺ regulatory macrophages in mice

Xiangyue Zhang,Songfeng Yu,Katharina Hoffmann,Kai Yu,Reinhold Förster

View Articletitled, Neonatal lymph node stromal cells drive myelodendritic lineage cells into a distinct population of CX3CR1+CD11b+F4/80+ regulatory macrophages in mice

Supplemental data

Human NK cells at early stages of differentiation produce CXCL8 and express CD161 molecule that functions as an activating receptor

Elisa Montaldo,Chiara Vitale,Francesca Cottalasso,Romana Conte,Timor Glatzer,Paolo Ambrosini,Lorenzo Moretta,Maria Cristina Mingari

View Articletitled, Human NK cells at early stages of differentiation produce CXCL8 and express CD161 molecule that functions as an activating receptor

Supplemental data

Functional STAT3 deficiency compromises the generation of human T follicular helper cells

Cindy S. Ma,Danielle T. Avery,Anna Chan,Marcel Batten,Jacinta Bustamante,Stephanie Boisson-Dupuis,Peter D. Arkwright,Alexandra Y. Kreins,Diana Averbuch,Dan Engelhard,Klaus Magdorf,Sara S. Kilic,Yoshiyuki Minegishi,Shigeaki Nonoyama,Martyn A. French,Sharon Choo,Joanne M. Smart,Jane Peake,Melanie Wong,Paul Gray,Matthew C. Cook,David A. Fulcher,Jean-Laurent Casanova,Elissa K. Deenick,Stuart G. Tangye

View Articletitled, Functional STAT3 deficiency compromises the generation of human T follicular helper cells

Supplemental data

Bilateral adrenal EBV-associated smooth muscle tumors in a child with a natural killer cell deficiency
Brief Report

Rachel K. Shaw,Andrew C. Issekutz,Robert Fraser,Pierre Schmit,Barb Morash,Linda Monaco-Shawver,Jordan S. Orange,Conrad V. Fernandez

View Articletitled, Bilateral adrenal EBV-associated smooth muscle tumors in a child with a natural killer cell deficiency

Supplemental data

Engagement of NKp30 on Vδ1 T cells induces the production of CCL3, CCL4, and CCL5 and suppresses HIV-1 replication
Brief Report

Kelly Hudspeth,Manuela Fogli,Daniel V. Correia,Joanna Mikulak,Alessandra Roberto,Silvia Della Bella,Bruno Silva-Santos,Domenico Mavilio

View Articletitled, Engagement of NKp30 on Vδ1 T cells induces the production of CCL3, CCL4, and CCL5 and suppresses HIV-1 replication

Supplemental data

Lymphoid Neoplasia

The pan-deacetylase inhibitor panobinostat induces cell death and synergizes with everolimus in Hodgkin lymphoma cell lines

Manuela Lemoine,Enrico Derenzini,Daniela Buglio,L. Jeffrey Medeiros,R. Eric Davis,Jiexin Zhang,Yuan Ji,Anas Younes

View Articletitled, The pan-deacetylase inhibitor panobinostat induces cell death and synergizes with everolimus in Hodgkin lymphoma cell lines

Supplemental data

Myeloid Neoplasia

SRC is a signaling mediator in FLT3-ITD– but not in FLT3-TKD–positive AML

Hannes Leischner,Corinna Albers,Rebekka Grundler,Elena Razumovskaya,Karsten Spiekermann,Stefan Bohlander,Lars Rönnstrand,Katharina Götze,Christian Peschel,Justus Duyster

View Articletitled, SRC is a signaling mediator in FLT3-ITD– but not in FLT3-TKD–positive AML

Supplemental data

Phagocytes, Granulocytes, and Myelopoiesis

Polycombs and microRNA-223 regulate human granulopoiesis by transcriptional control of target gene expression

Giuseppe Zardo,Alberto Ciolfi,Laura Vian,Linda M. Starnes,Monia Billi,Serena Racanicchi,Carmen Maresca,Francesco Fazi,Lorena Travaglini,Nelida Noguera,Marco Mancini,Mauro Nanni,Giuseppe Cimino,Francesco Lo-Coco,Francesco Grignani,Clara Nervi

View Articletitled, Polycombs and microRNA-223 regulate human granulopoiesis by transcriptional control of target gene expression

Supplemental data

Glucose-6-phosphatase-β, implicated in a congenital neutropenia syndrome, is essential for macrophage energy homeostasis and functionality

Hyun Sik Jun,Yuk Yin Cheung,Young Mok Lee,Brian C. Mansfield,Janice Y. Chou

View Articletitled, Glucose-6-phosphatase-β, implicated in a congenital neutropenia syndrome, is essential for macrophage energy homeostasis and functionality

Platelets and Thrombopoiesis

A novel mechanism of sustained platelet αIIbβ3 activation via PEAR1

Alexandre Kauskot,Michela Di Michele,Serena Loyen,Kathleen Freson,Peter Verhamme,Marc F. Hoylaerts

View Articletitled, A novel mechanism of sustained platelet αIIbβ3 activation via PEAR1

Supplemental data

In vivo effects of eltrombopag on platelet function in immune thrombocytopenia: no evidence of platelet activation

Bethan Psaila,James B. Bussel,Matthew D. Linden,Bracken Babula,Youfu Li,Marc R. Barnard,Chinara Tate,Kanika Mathur,Andrew L. Frelinger,Alan D. Michelson

View Articletitled, In vivo effects of eltrombopag on platelet function in immune thrombocytopenia: no evidence of platelet activation

Supplemental data

Red Cells, Iron, and Erythropoiesis

Stroke With Transfusions Changing to Hydroxyurea (SWiTCH)
Clinical Trials & Observations

Russell E. Ware,for the SWiTCH Investigators,Ronald W. Helms,for the SWiTCH Investigators

View Articletitled, Stroke With Transfusions Changing to Hydroxyurea (SWiTCH)

Supplemental data

Thrombosis and Hemostasis

CD4⁺ T-cell epitopes associated with antibody responses after intravenously and subcutaneously applied human FVIII in humanized hemophilic E17 HLA-DRB1*1501 mice

Katharina N. Steinitz,Pauline M. van Helden,Brigitte Binder,David C. Wraith,Sabine Unterthurner,Corinna Hermann,Maria Schuster,Rafi U. Ahmad,Markus Weiller,Christian Lubich,Maurus de la Rosa,Hans Peter Schwarz,Birgit M. Reipert

View Articletitled, CD4+ T-cell epitopes associated with antibody responses after intravenously and subcutaneously applied human FVIII in humanized hemophilic E17 HLA-DRB1*1501 mice

Supplemental data

Transplantation

Reduced intensity conditioning is superior to nonmyeloablative conditioning for older chronic myelogenous leukemia patients undergoing hematopoietic cell transplant during the tyrosine kinase inhibitor era
Clinical Trials & Observations

Erica Warlick,Kwang Woo Ahn,Tanya L. Pedersen,Andrew Artz,Marcos de Lima,Michael Pulsipher,Gorgun Akpek,Mahmoud Aljurf,Jean-Yves Cahn,Mitchell Cairo,Yi-Bin Chen,Brenda Cooper,Abhinav Deol,Sergio Giralt,Vikas Gupta,H. Jean Khoury,Holbrook Kohrt,Hillard M. Lazarus,Ian Lewis,Richard Olsson,Joseph Pidala,Bipin N. Savani,Matthew Seftel,Gerard Socié,Martin Tallman,Celaettin Ustun,Ravi Vij,Lars Vindeløv,Daniel Weisdorf

View Articletitled, Reduced intensity conditioning is superior to nonmyeloablative conditioning for older chronic myelogenous leukemia patients undergoing hematopoietic cell transplant during the tyrosine kinase inhibitor era

Errata

Ng C-H, Xu S, Lam K-P. Dok-3 plays a nonredundant role in negative regulation of B-cell activation. Blood. 2007;110(1):259–266.

View Articletitled, Ng C-H, Xu S, Lam K-P. Dok-3 plays a nonredundant role in negative regulation of B-cell activation. Blood. 2007;110(1):259–266.

Mumford AD, Dawood BB, Daly ME, et al. A novel thromboxane A₂ receptor D304N variant that abrogates ligand binding in a patient with a bleeding diathesis. Blood. 2010;115(2):363–369.

View Articletitled, Mumford AD, Dawood BB, Daly ME, et al. A novel thromboxane A2 receptor D304N variant that abrogates ligand binding in a patient with a bleeding diathesis. Blood. 2010;115(2):363–369.

Other Departments

Continuing Medical Education (CME) questions: donor sources for allogeneic transplant in AML
CME

View Articletitled, Continuing Medical Education (CME) questions: donor sources for allogeneic transplant in AML

Cover Image

Cover Image

A schematic representation elucidating the cycling pathway for glucose-6-phosphate (G6P) metabolism in macrophages. G6P participates in 4 major pathways: glycolysis, the hexose monophosphate shunt (HMS), glycogen synthesis, or endoplasmic reticulum (ER) cycling. In cycling, G6P enters the ER via glucose-6-phosphate transporter (G6PT) where it can accumulate until it is hydrolyzed to glucose by G6Pase-β and transported back into the cytoplasm. By limiting the cytoplasmic glucose/G6P availability, cycling regulates the other 3 cytoplasmic pathways for G6P metabolism. Disruption of this cycling in G6Pase-β–deficient macrophages results in impaired energy homeostasis and functionality. See the article by Jun et al on page 4047.
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Table of Contents

Inside Blood

Blood Work

Plenary Paper

Perspectives

Review Article

Clinical Trials and Observations

Outcomes after matched unrelated donor versus identical sibling hematopoietic cell transplantation in adults with acute myelogenous leukemia CME

A phase 1/2 study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia Clinical Trials & Observations

Gene Therapy

CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: pilot clinical trial results Clinical Trials & Observations

Hematopoiesis and Stem Cells

Norepinephrine reuptake inhibition promotes mobilization in mice: potential impact to rescue low stem cell yields Brief Report

Immunobiology

Anti-CD20 (rituximab) therapy for anti–IFN-γ autoantibody–associated nontuberculous mycobacterial infection Clinical Trials & Observations

Bilateral adrenal EBV-associated smooth muscle tumors in a child with a natural killer cell deficiency Brief Report

Engagement of NKp30 on Vδ1 T cells induces the production of CCL3, CCL4, and CCL5 and suppresses HIV-1 replication Brief Report

Lymphoid Neoplasia

Myeloid Neoplasia

Phagocytes, Granulocytes, and Myelopoiesis

Platelets and Thrombopoiesis

Red Cells, Iron, and Erythropoiesis

Stroke With Transfusions Changing to Hydroxyurea (SWiTCH) Clinical Trials & Observations

Thrombosis and Hemostasis

Transplantation

Reduced intensity conditioning is superior to nonmyeloablative conditioning for older chronic myelogenous leukemia patients undergoing hematopoietic cell transplant during the tyrosine kinase inhibitor era Clinical Trials & Observations

Errata

Other Departments

Continuing Medical Education (CME) questions: donor sources for allogeneic transplant in AML CME

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Outcomes after matched unrelated donor versus identical sibling hematopoietic cell transplantation in adults with acute myelogenous leukemia
CME

A phase 1/2 study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia
Clinical Trials & Observations

CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: pilot clinical trial results
Clinical Trials & Observations

Norepinephrine reuptake inhibition promotes mobilization in mice: potential impact to rescue low stem cell yields
Brief Report

Anti-CD20 (rituximab) therapy for anti–IFN-γ autoantibody–associated nontuberculous mycobacterial infection
Clinical Trials & Observations

Bilateral adrenal EBV-associated smooth muscle tumors in a child with a natural killer cell deficiency
Brief Report

Engagement of NKp30 on Vδ1 T cells induces the production of CCL3, CCL4, and CCL5 and suppresses HIV-1 replication
Brief Report

Stroke With Transfusions Changing to Hydroxyurea (SWiTCH)
Clinical Trials & Observations

Reduced intensity conditioning is superior to nonmyeloablative conditioning for older chronic myelogenous leukemia patients undergoing hematopoietic cell transplant during the tyrosine kinase inhibitor era
Clinical Trials & Observations

Continuing Medical Education (CME) questions: donor sources for allogeneic transplant in AML
CME