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Volume 119, Issue 17
April 26 2012
Issue Cover

Table of Contents

Inside Blood

CLINICAL TRIALS
Get out—and stay out
Eyal C. Attar
View Articletitled, Get out—and stay out
CLINICAL TRIALS
To SWiTCH or not to SWiTCH?
Mariane de Montalembert
View Articletitled, To SWiTCH or not to SWiTCH?
GENE THERAPY
CARs and cancers: questions and answers
Renier J. Brentjens
View Articletitled, CARs and cancers: questions and answers
IMMUNOBIOLOGY
Lymphocyte cytotoxicity: tug-of-war on microtubules
Stephanie M. Wood,Yenan T. Bryceson
View Articletitled, Lymphocyte cytotoxicity: tug-of-war on microtubules
PHAGOCYTES & GRANULOCYTES
MicroRNAs function on a new level
Ryan M. O'Connell
View Articletitled, MicroRNAs function on a new level
PLATELETS & THROMBOPOIESIS
Platelets and eltrombopag: a not-so-sticky situation
Michele P. Lambert
View Articletitled, Platelets and eltrombopag: a not-so-sticky situation

Blood Work

Pappenheimer bodies in a splenectomized patient with alcohol abuse
Anthony A. M. Ermens,Renee Otten
View Articletitled, Pappenheimer bodies in a splenectomized patient with alcohol abuse

Plenary Paper

IMMUNOBIOLOGY
Terminal transport of lytic granules to the immune synapse is mediated by the kinesin-1/Slp3/Rab27a complex
Mathieu Kurowska,Nicolas Goudin,Nadine T. Nehme,Magali Court,Jérôme Garin,Alain Fischer,Geneviève de Saint Basile,Gaël Ménasché
View Articletitled, Terminal transport of lytic granules to the immune synapse is mediated by the kinesin-1/Slp3/Rab27a complex
Supplemental data

Perspectives

Acute myeloid leukemia in the real world: why population-based registries are needed
Gunnar Juliusson,Vladimir Lazarevic,Ann-Sofi Hörstedt,Oskar Hagberg,Martin Höglund,for the Swedish Acute Leukemia Registry Group
View Articletitled, Acute myeloid leukemia in the real world: why population-based registries are needed
Supplemental data

Review Article

Stem cell heterogeneity: implications for aging and regenerative medicine
Christa E. Muller-Sieburg,Hans B. Sieburg,Jeff M. Bernitz,Giulio Cattarossi
View Articletitled, Stem cell heterogeneity: implications for aging and regenerative medicine

Clinical Trials and Observations

Outcomes after matched unrelated donor versus identical sibling hematopoietic cell transplantation in adults with acute myelogenous leukemia
CME
Wael Saber,Shaun Opie,J. Douglas Rizzo,Mei-Jie Zhang,Mary M. Horowitz,Jeff Schriber
View Articletitled, Outcomes after matched unrelated donor versus identical sibling hematopoietic cell transplantation in adults with acute myelogenous leukemia
A phase 1/2 study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia
Clinical Trials & Observations
Geoffrey L. Uy,Michael P. Rettig,Ibraheem H. Motabi,Kyle McFarland,Kathryn M. Trinkaus,Lindsay M. Hladnik,Shashikant Kulkarni,Camille N. Abboud,Amanda F. Cashen,Keith E. Stockerl-Goldstein,Ravi Vij,Peter Westervelt,John F. DiPersio
View Articletitled, A phase 1/2 study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia
Supplemental data

Gene Therapy

CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: pilot clinical trial results
Clinical Trials & Observations
Brian G. Till,Michael C. Jensen,Jinjuan Wang,Xiaojun Qian,Ajay K. Gopal,David G. Maloney,Catherine G. Lindgren,Yukang Lin,John M. Pagel,Lihua E. Budde,Andrew Raubitschek,Stephen J. Forman,Philip D. Greenberg,Stanley R. Riddell,Oliver W. Press
View Articletitled, CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: pilot clinical trial results
Supplemental data

Hematopoiesis and Stem Cells

p85β regulatory subunit of class IA PI3 kinase negatively regulates mast cell growth, maturation, and leukemogenesis
Subha Krishnan,Raghuveer Singh Mali,Baskar Ramdas,Emily Sims,Peilin Ma,Joydeep Ghosh,Veerendra Munugalavadla,Philip Hanneman,Joal D. Beane,Reuben Kapur
View Articletitled, p85β regulatory subunit of class I<sub>A</sub> PI3 kinase negatively regulates mast cell growth, maturation, and leukemogenesis
Norepinephrine reuptake inhibition promotes mobilization in mice: potential impact to rescue low stem cell yields
Brief Report
Daniel Lucas,Ingmar Bruns,Michela Battista,Simon Mendez-Ferrer,Claire Magnon,Yuya Kunisaki,Paul S. Frenette
View Articletitled, Norepinephrine reuptake inhibition promotes mobilization in mice: potential impact to rescue low stem cell yields
Supplemental data

Immunobiology

Anti-CD20 (rituximab) therapy for anti–IFN-γ autoantibody–associated nontuberculous mycobacterial infection
Clinical Trials & Observations
Sarah K. Browne,Rifat Zaman,Elizabeth P. Sampaio,Kamonwan Jutivorakool,Lindsey B. Rosen,Li Ding,Minjal J. Pancholi,Lauren M. Yang,Debra Long Priel,Gulbu Uzel,Alexandra F. Freeman,Carlton E. Hayes,Roger Baxter,Stuart H. Cohen,Steven M. Holland
View Articletitled, Anti-CD20 (rituximab) therapy for anti–IFN-γ autoantibody–associated nontuberculous mycobacterial infection
Wiskott-Aldrich syndrome protein (WASP) and N-WASP are critical for peripheral B-cell development and function
Lisa S. Westerberg,Carin Dahlberg,Marisa Baptista,Christopher J. Moran,Cynthia Detre,Marton Keszei,Michelle A. Eston,Frederick W. Alt,Cox Terhorst,Luigi D. Notarangelo,Scott B. Snapper
View Articletitled, Wiskott-Aldrich syndrome protein (WASP) and N-WASP are critical for peripheral B-cell development and function
Supplemental data
Neonatal lymph node stromal cells drive myelodendritic lineage cells into a distinct population of CX3CR1+CD11b+F4/80+ regulatory macrophages in mice
Xiangyue Zhang,Songfeng Yu,Katharina Hoffmann,Kai Yu,Reinhold Förster
View Articletitled, Neonatal lymph node stromal cells drive myelodendritic lineage cells into a distinct population of CX3CR1<sup>+</sup>CD11b<sup>+</sup>F4/80<sup>+</sup> regulatory macrophages in mice
Supplemental data
Human NK cells at early stages of differentiation produce CXCL8 and express CD161 molecule that functions as an activating receptor
Elisa Montaldo,Chiara Vitale,Francesca Cottalasso,Romana Conte,Timor Glatzer,Paolo Ambrosini,Lorenzo Moretta,Maria Cristina Mingari
View Articletitled, Human NK cells at early stages of differentiation produce CXCL8 and express CD161 molecule that functions as an activating receptor
Supplemental data
Functional STAT3 deficiency compromises the generation of human T follicular helper cells
Cindy S. Ma,Danielle T. Avery,Anna Chan,Marcel Batten,Jacinta Bustamante,Stephanie Boisson-Dupuis,Peter D. Arkwright,Alexandra Y. Kreins,Diana Averbuch,Dan Engelhard,Klaus Magdorf,Sara S. Kilic,Yoshiyuki Minegishi,Shigeaki Nonoyama,Martyn A. French,Sharon Choo,Joanne M. Smart,Jane Peake,Melanie Wong,Paul Gray,Matthew C. Cook,David A. Fulcher,Jean-Laurent Casanova,Elissa K. Deenick,Stuart G. Tangye
View Articletitled, Functional STAT3 deficiency compromises the generation of human T follicular helper cells
Supplemental data
Bilateral adrenal EBV-associated smooth muscle tumors in a child with a natural killer cell deficiency
Brief Report
Rachel K. Shaw,Andrew C. Issekutz,Robert Fraser,Pierre Schmit,Barb Morash,Linda Monaco-Shawver,Jordan S. Orange,Conrad V. Fernandez
View Articletitled, Bilateral adrenal EBV-associated smooth muscle tumors in a child with a natural killer cell deficiency
Supplemental data
Engagement of NKp30 on Vδ1 T cells induces the production of CCL3, CCL4, and CCL5 and suppresses HIV-1 replication
Brief Report
Kelly Hudspeth,Manuela Fogli,Daniel V. Correia,Joanna Mikulak,Alessandra Roberto,Silvia Della Bella,Bruno Silva-Santos,Domenico Mavilio
View Articletitled, Engagement of NKp30 on Vδ1 T cells induces the production of CCL3, CCL4, and CCL5 and suppresses HIV-1 replication
Supplemental data

Lymphoid Neoplasia

The pan-deacetylase inhibitor panobinostat induces cell death and synergizes with everolimus in Hodgkin lymphoma cell lines
Manuela Lemoine,Enrico Derenzini,Daniela Buglio,L. Jeffrey Medeiros,R. Eric Davis,Jiexin Zhang,Yuan Ji,Anas Younes
View Articletitled, The pan-deacetylase inhibitor panobinostat induces cell death and synergizes with everolimus in Hodgkin lymphoma cell lines
Supplemental data

Myeloid Neoplasia

SRC is a signaling mediator in FLT3-ITD– but not in FLT3-TKD–positive AML
Hannes Leischner,Corinna Albers,Rebekka Grundler,Elena Razumovskaya,Karsten Spiekermann,Stefan Bohlander,Lars Rönnstrand,Katharina Götze,Christian Peschel,Justus Duyster
View Articletitled, SRC is a signaling mediator in FLT3-ITD– but not in FLT3-TKD–positive AML
Supplemental data

Phagocytes, Granulocytes, and Myelopoiesis

Polycombs and microRNA-223 regulate human granulopoiesis by transcriptional control of target gene expression
Giuseppe Zardo,Alberto Ciolfi,Laura Vian,Linda M. Starnes,Monia Billi,Serena Racanicchi,Carmen Maresca,Francesco Fazi,Lorena Travaglini,Nelida Noguera,Marco Mancini,Mauro Nanni,Giuseppe Cimino,Francesco Lo-Coco,Francesco Grignani,Clara Nervi
View Articletitled, Polycombs and microRNA-223 regulate human granulopoiesis by transcriptional control of target gene expression
Supplemental data
Glucose-6-phosphatase-β, implicated in a congenital neutropenia syndrome, is essential for macrophage energy homeostasis and functionality
Hyun Sik Jun,Yuk Yin Cheung,Young Mok Lee,Brian C. Mansfield,Janice Y. Chou
View Articletitled, Glucose-6-phosphatase-β, implicated in a congenital neutropenia syndrome, is essential for macrophage energy homeostasis and functionality

Platelets and Thrombopoiesis

A novel mechanism of sustained platelet αIIbβ3 activation via PEAR1
Alexandre Kauskot,Michela Di Michele,Serena Loyen,Kathleen Freson,Peter Verhamme,Marc F. Hoylaerts
View Articletitled, A novel mechanism of sustained platelet αIIbβ3 activation via PEAR1
Supplemental data
In vivo effects of eltrombopag on platelet function in immune thrombocytopenia: no evidence of platelet activation
Bethan Psaila,James B. Bussel,Matthew D. Linden,Bracken Babula,Youfu Li,Marc R. Barnard,Chinara Tate,Kanika Mathur,Andrew L. Frelinger,Alan D. Michelson
View Articletitled, In vivo effects of eltrombopag on platelet function in immune thrombocytopenia: no evidence of platelet activation
Supplemental data

Red Cells, Iron, and Erythropoiesis

Stroke With Transfusions Changing to Hydroxyurea (SWiTCH)
Clinical Trials & Observations
Russell E. Ware,Ronald W. Helms,for the SWiTCH Investigators
View Articletitled, Stroke With Transfusions Changing to Hydroxyurea (SWiTCH)
Supplemental data

Thrombosis and Hemostasis

CD4+ T-cell epitopes associated with antibody responses after intravenously and subcutaneously applied human FVIII in humanized hemophilic E17 HLA-DRB1*1501 mice
Katharina N. Steinitz,Pauline M. van Helden,Brigitte Binder,David C. Wraith,Sabine Unterthurner,Corinna Hermann,Maria Schuster,Rafi U. Ahmad,Markus Weiller,Christian Lubich,Maurus de la Rosa,Hans Peter Schwarz,Birgit M. Reipert
View Articletitled, CD4<sup>+</sup> T-cell epitopes associated with antibody responses after intravenously and subcutaneously applied human FVIII in humanized hemophilic E17 HLA-DRB1*1501 mice
Supplemental data

Transplantation

Reduced intensity conditioning is superior to nonmyeloablative conditioning for older chronic myelogenous leukemia patients undergoing hematopoietic cell transplant during the tyrosine kinase inhibitor era
Clinical Trials & Observations
Erica Warlick,Kwang Woo Ahn,Tanya L. Pedersen,Andrew Artz,Marcos de Lima,Michael Pulsipher,Gorgun Akpek,Mahmoud Aljurf,Jean-Yves Cahn,Mitchell Cairo,Yi-Bin Chen,Brenda Cooper,Abhinav Deol,Sergio Giralt,Vikas Gupta,H. Jean Khoury,Holbrook Kohrt,Hillard M. Lazarus,Ian Lewis,Richard Olsson,Joseph Pidala,Bipin N. Savani,Matthew Seftel,Gerard Socié,Martin Tallman,Celaettin Ustun,Ravi Vij,Lars Vindeløv,Daniel Weisdorf
View Articletitled, Reduced intensity conditioning is superior to nonmyeloablative conditioning for older chronic myelogenous leukemia patients undergoing hematopoietic cell transplant during the tyrosine kinase inhibitor era

Errata

Ng C-H, Xu S, Lam K-P. Dok-3 plays a nonredundant role in negative regulation of B-cell activation. Blood. 2007;110(1):259–266.
View Articletitled, Ng C-H, Xu S, Lam K-P. Dok-3 plays a nonredundant role in negative regulation of B-cell activation. <em>Blood</em>. 2007;110(1):<span class="related-article">259–266</span>.
Mumford AD, Dawood BB, Daly ME, et al. A novel thromboxane A2 receptor D304N variant that abrogates ligand binding in a patient with a bleeding diathesis. Blood. 2010;115(2):363–369.
View Articletitled, Mumford AD, Dawood BB, Daly ME, et al. A novel thromboxane A<sub>2</sub> receptor D304N variant that abrogates ligand binding in a patient with a bleeding diathesis. <em>Blood</em>. 2010;115(2):<span class="related-article">363–369</span>.

Other Departments

Continuing Medical Education (CME) questions: donor sources for allogeneic transplant in AML
CME
View Articletitled, Continuing Medical Education (CME) questions: donor sources for allogeneic transplant in AML
  • Cover Image

    Cover Image

    issue cover

    A schematic representation elucidating the cycling pathway for glucose-6-phosphate (G6P) metabolism in macrophages. G6P participates in 4 major pathways: glycolysis, the hexose monophosphate shunt (HMS), glycogen synthesis, or endoplasmic reticulum (ER) cycling. In cycling, G6P enters the ER via glucose-6-phosphate transporter (G6PT) where it can accumulate until it is hydrolyzed to glucose by G6Pase-β and transported back into the cytoplasm. By limiting the cytoplasmic glucose/G6P availability, cycling regulates the other 3 cytoplasmic pathways for G6P metabolism. Disruption of this cycling in G6Pase-β–deficient macrophages results in impaired energy homeostasis and functionality. See the article by Jun et al on page 4047.

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