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Issue Archive

Volume 117, Issue 26
June 30 2011
Blood Cover Image for Volume 117, Issue 26

Table of Contents

Inside Blood

CLINICAL TRIALS
KSHV: forgotten but not gone
Patrick S. Moore,Yuan Chang

Thirty years ago, Kaposi sarcoma (KS) arose as a prominent manifestation of the AIDS epidemic. Seventeen years ago we discovered the virus that causes KS,1  Kaposi sarcoma–associated herpesvirus (KSHV), and within a year KSHV had been also shown to be the likely cause of AIDS-associated primary effusion lymphoma (PEL)2  and most cases of multicentric Castleman disease (MCD).3 

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IMMUNOBIOLOGY
Unlicensed natural born killers
Andreas Lundqvist,Richard Childs

In this issue of Blood, Barao and colleagues describe repopulation of Ly49G2 single-positive NK cells after congenic hematopoietic stem cell transplantation (HSCT) that appear fully functional, having tumor cytolytic capacity despite recipients lacking MHC molecules thought necessary to license them.

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INSIDE BLOOD
Opening new roads for MCPyV
Axel zur Hausen

In this issue of Blood, Pancaldi et al report on the latent presence of large T antigen (LTag) sequences of the Merkel cell polyomavirus (MCPyV) in buffy coats of healthy individuals.1 

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Plenary Paper

PLENARY PAPER
High-dose zidovudine plus valganciclovir for Kaposi sarcoma herpesvirus-associated multicentric Castleman disease: a pilot study of virus-activated cytotoxic therapy
Clinical Trials & Observations
Thomas S. Uldrick,Mark N. Polizzotto,Karen Aleman,Deirdre O'Mahony,Kathleen M. Wyvill,Victoria Wang,Vickie Marshall,Stefania Pittaluga,Seth M. Steinberg,Giovanna Tosato,Denise Whitby,Richard F. Little,Robert Yarchoan
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Supplemental data

Perspectives

FLT3/ITD AML and the law of unintended consequences
Mark Levis
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Review Articles

B-cell receptors and heavy chain diseases: guilty by association?
Daniel Corcos,Michael J. Osborn,Louise S. Matheson
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Clinical Trials and Observations

Individual patient data meta-analysis of randomized trials evaluating IL-2 monotherapy as remission maintenance therapy in acute myeloid leukemia
Clinical Trials & Observations
Marc Buyse,Pierre Squifflet,Beverly J. Lange,Todd A. Alonzo,Richard A. Larson,Jonathan E. Kolitz,Stephen L. George,Clara D. Bloomfield,Sylvie Castaigne,Sylvie Chevret,Didier Blaise,Dominique Maraninchi,Kathryn J. Lucchesi,Tomasz Burzykowski
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Supplemental data
Prognostic significance of immunohistochemical biomarkers in diffuse large B-cell lymphoma: a study from the Lunenburg Lymphoma Biomarker Consortium
Clinical Trials & Observations
Gilles Salles,Daphne de Jong,Wanling Xie,Andreas Rosenwald,Mukesh Chhanabhai,Philippe Gaulard,Wolfram Klapper,Maria Calaminici,Birgitta Sander,Christoph Thorns,Elias Campo,Thierry Molina,Abigail Lee,Michael Pfreundschuh,Sandra Horning,Andrew Lister,Laurie H. Sehn,John Raemaekers,Anton Hagenbeek,Randy D. Gascoyne,Edie Weller
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Incidence of the myelodysplastic syndromes using a novel claims-based algorithm: high number of uncaptured cases by cancer registries
Clinical Trials & Observations
Christopher R. Cogle,Benjamin M. Craig,Dana E. Rollison,Alan F. List
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Hematopoiesis and Stem Cells

Sumoylation of CCAAT/enhancer–binding protein α promotes the biased primitive hematopoiesis of zebrafish
Hao Yuan,Jun Zhou,Min Deng,Yong Zhang,Yi Chen,Yi Jin,Jiang Zhu,Sai Juan Chen,Hugues de The,Zhu Chen,Ting Xi Liu,Jun Zhu
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Immunobiology

Role of HLA-G in tumor escape through expansion of myeloid-derived suppressor cells and cytokinic balance in favor of Th2 versus Th1/Th17
Sophie Agaugué,Edgardo D. Carosella,Nathalie Rouas-Freiss
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Supplemental data
Mouse Ly49G2+ NK cells dominate early responses during both immune reconstitution and activation independently of MHC
Isabel Barao,Maite Alvarez,Erik Ames,Mark T. Orr,Heather E. Stefanski,Bruce R. Blazar,Lewis L. Lanier,Stephen K. Anderson,Doug Redelman,William J. Murphy
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Supplemental data
Kindlin-3 is required for the stabilization of TCR-stimulated LFA-1:ICAM-1 bonds critical for lymphocyte arrest and spreading on dendritic cells
Sara W. Feigelson,Valentin Grabovsky,Eugenia Manevich-Mendelson,Ronit Pasvolsky,Ziv Shulman,Vera Shinder,Eugenia Klein,Amos Etzioni,Memet Aker,Ronen Alon
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Modulation of microRNA expression in human T-cell development: targeting of NOTCH3 by miR-150
Margherita Ghisi,Alberto Corradin,Katia Basso,Chiara Frasson,Valentina Serafin,Subhamoy Mukherjee,Lara Mussolin,Katia Ruggero,Laura Bonanno,Alessandro Guffanti,Gianluca De Bellis,Gino Gerosa,Giovanni Stellin,Donna M. D'Agostino,Giuseppe Basso,Vincenzo Bronte,Stefano Indraccolo,Alberto Amadori,Paola Zanovello
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Langerhans cells regulate cutaneous injury by licensing CD8 effector cells recruited to the skin
Clare L. Bennett,Farnaz Fallah-Arani,Thomas Conlan,Celine Trouillet,Hugh Goold,Laurent Chorro,Barry Flutter,Terry K. Means,Frédéric Geissmann,Ronjon Chakraverty
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Lymphoid Neoplasia

ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer
Julie A. I. Thoms,Yehudit Birger,Sam Foster,Kathy Knezevic,Yael Kirschenbaum,Vashe Chandrakanthan,Georg Jonquieres,Dominik Spensberger,Jason W. Wong,S. Helen Oram,Sarah J. Kinston,Yoram Groner,Richard Lock,Karen L. MacKenzie,Berthold Göttgens,Shai Izraeli,John E. Pimanda
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Supplemental data
PTPN2 negatively regulates oncogenic JAK1 in T-cell acute lymphoblastic leukemia
Maria Kleppe,Jean Soulier,Vahid Asnafi,Nicole Mentens,Tekla Hornakova,Laurent Knoops,Stefan Constantinescu,François Sigaux,Jules P. Meijerink,Peter Vandenberghe,Marco Tartaglia,Robin Foa,Elizabeth Macintyre,Torsten Haferlach,Jan Cools
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Myeloid Neoplasia

Prognostic significance of additional cytogenetic aberrations in 733 de novo pediatric 11q23/MLL-rearranged AML patients: results of an international study
Clinical Trials & Observations
Eva A. Coenen,Susana C. Raimondi,Jochen Harbott,Martin Zimmermann,Todd A. Alonzo,Anne Auvrignon,H. Berna Beverloo,Myron Chang,Ursula Creutzig,Michael N. Dworzak,Erik Forestier,Brenda Gibson,Henrik Hasle,Christine J. Harrison,Nyla A. Heerema,Gertjan J. L. Kaspers,Anna Leszl,Nathalia Litvinko,Luca Lo Nigro,Akira Morimoto,Christine Perot,Dirk Reinhardt,Jeffrey E. Rubnitz,Franklin O. Smith,Jan Stary,Irina Stasevich,Sabine Strehl,Takashi Taga,Daisuke Tomizawa,David Webb,Zuzana Zemanova,Rob Pieters,C. Michel Zwaan,Marry M. van den Heuvel-Eibrink
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Supplemental data
Identification of T-lymphocytic leukemia–initiating stem cells residing in a small subset of patients with acute myeloid leukemic disease
Ruth M. Risueño,Clinton J. V. Campbell,Steve Dingwall,Marilyne Levadoux-Martin,Brian Leber,Anargyros Xenocostas,Mickie Bhatia
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Phagocytes, Granulocytes, and Myelopoiesis

Characterization of the mononuclear phagocyte system in zebrafish
Valerie Wittamer,Julien Y. Bertrand,Patrick W. Gutschow,David Traver
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Platelets and Thrombopoiesis

Heat-shock protein gp96/grp94 is an essential chaperone for the platelet glycoprotein Ib-IX-V complex
Matthew Staron,Shuang Wu,Feng Hong,Aleksandra Stojanovic,Xiaoping Du,Robert Bona,Bei Liu,Zihai Li
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Thrombosis and Hemostasis

BCL2/BCL-XL inhibition induces apoptosis, disrupts cellular calcium homeostasis, and prevents platelet activation
Meike Vogler,Hassan A. Hamali,Xiao-Ming Sun,Edward T. W. Bampton,David Dinsdale,Roger T. Snowden,Martin J. S. Dyer,Alison H. Goodall,Gerald M. Cohen
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The anti-fibrinolytic SERPIN, plasminogen activator inhibitor 1 (PAI-1), is targeted to and released from catecholamine storage vesicles
Qijiao Jiang,Neill A. Gingles,Marc A. Olivier,Lindsey A. Miles,Robert J. Parmer
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Supplemental data
Structural basis of thrombin-mediated factor V activation: the Glu666-Glu672 sequence is critical for processing at the heavy chain–B domain junction
María Ángeles Corral-Rodríguez,Paul E. Bock,Erick Hernández-Carvajal,Ricardo Gutiérrez-Gallego,Pablo Fuentes-Prior
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Transfusion Medicine

Merkel cell polyomavirus DNA sequences in the buffy coats of healthy blood donors
Brief Report
Cecilia Pancaldi,Valentina Corazzari,Stefania Maniero,Elisa Mazzoni,Manola Comar,Fernanda Martini,Mauro Tognon
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Transplantation

Prophylactic transfer of BCR-ABL–, PR1-, and WT1-reactive donor T cells after T cell–depleted allogeneic hematopoietic cell transplantation in patients with chronic myeloid leukemia
Clinical Trials & Observations
Martin Bornhäuser,Christian Thiede,Uwe Platzbecker,Alexander Kiani,Uta Oelschlaegel,Jana Babatz,Doris Lehmann,Kristina Hölig,Jörgen Radke,Sebastian Tuve,Martin Wermke,Rebekka Wehner,Hanka Jähnisch,Michael P. Bachmann,E. Peter Rieber,Johannes Schetelig,Gerhard Ehninger,Marc Schmitz
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Vascular Biology

ALK1 as an emerging target for antiangiogenic therapy of cancer
Sara I. Cunha,Kristian Pietras
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Correspondence

Indications for and current results with allogeneic hematopoietic cell transplantation in patients with myelofibrosis
H. Joachim Deeg,Frederick R. Appelbaum
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Errata

Orinska Z, Föger N, Huber M, et al. I787 provides signals for c-Kit receptor internalization and functionality that control mast cell survival and development. Blood. 2010;116(15):2665–2675.
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Feng W, Madajka M, Kerr BA, Mahabeleshwar GH, Whiteheart SW, Byzova TV. A novel role for platelet secretion in angiogenesis: mediating bone marrow–derived cell mobilization and homing. Blood. 2011;117(14):3893–3902.
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Retractions

Niessen F, Furlan-Freguia C, Fernández JA, Mosnier LO, Castellino FJ, Weiler H, Rosen H, Griffin JH, Ruf W. Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality. Blood. 2009;113(12):2859–2866.
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Gatt ME, Zhao JJ, Ebert MS, Zhang Y, Chu Z, Mani M, Gazit R, Carrasco DE, Dutta-Simmons J, Adamia S, Minvielle S, Tai Y-T, Munshi NC, Avet-Loiseau H, Anderson KC, Carrasco DR. MicroRNAs 15a/16-1 function as tumor suppressor genes in multiple myeloma [published online ahead of print October 20, 2010]. Blood. doi:10.1182/blood-2009-11-253294.
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All Issues

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