Issue Archive

Thirty years ago, Kaposi sarcoma (KS) arose as a prominent manifestation of the AIDS epidemic. Seventeen years ago we discovered the virus that causes KS,¹  Kaposi sarcoma–associated herpesvirus (KSHV), and within a year KSHV had been also shown to be the likely cause of AIDS-associated primary effusion lymphoma (PEL)²  and most cases of multicentric Castleman disease (MCD).³ 

In this issue of Blood, Barao and colleagues describe repopulation of Ly49G2 single-positive NK cells after congenic hematopoietic stem cell transplantation (HSCT) that appear fully functional, having tumor cytolytic capacity despite recipients lacking MHC molecules thought necessary to license them.

In this issue of Blood, Pancaldi et al report on the latent presence of large T antigen (LTag) sequences of the Merkel cell polyomavirus (MCPyV) in buffy coats of healthy individuals.¹