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Richard Lock
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Journal Articles

Amx-883, a potent and selective degrader of BRD9 drives differentiation in acute myeloid leukaemia and shows synergistic efficacy in combination with venetoclax In Vivo and prevents the emergence of resistance to venetoclax in vitro.

Free
Martin O'Rourke, Louise Modis, Rebecca Harris, Anna Tasegian, Aleksandra Azevedo, Ivan Del Barco Barrantes Del Barco Barrantes, Liliana Greger, Praful Gokhale, Richard Lock, Patrick Connerty, Colin Davies, Edward Hooper-Greenhill, David McGarry, Giles Brown, Martin Pass
Journal: Blood
Blood (2025) 146 (Supplement 1): 1489.
https://doi.org/10.1182/blood-2025-1489
Published: 2025
Journal Articles

Inhibition of nicotinamide metabolism by the novel NAMPT inhibitor OT-82 potentiates venetoclax in paediatric and adult acute myeloid leukaemia models

Free
Mawar Karsa, Patrick Connerty, Ayu Karsa, Dayna Spurling, Giovanna Pomillio, Veronique Litalien, Laurence Cheung, Rishi Kotecha, Olga Chernova, Andrei Gudkov, Richard Lock, Murray Norris, Michelle Haber, Andrew Wei, Donia Moujalled, Klaartje Somers
Journal: Blood
Blood (2025) 146 (Supplement 1): 3282.
https://doi.org/10.1182/blood-2025-3282
Published: 2025
Journal Articles

ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer

Free
Julie A. I. Thoms, Yehudit Birger, Sam Foster, Kathy Knezevic, Yael Kirschenbaum, Vashe Chandrakanthan, Georg Jonquieres, Dominik Spensberger, Jason W. Wong, S. Helen Oram, Sarah J. Kinston, Yoram Groner, Richard Lock, Karen L. MacKenzie, Berthold Göttgens, Shai Izraeli, John E. Pimanda
Journal: Blood
Blood (2011) 117 (26): 7079–7089.
https://doi.org/10.1182/blood-2010-12-317990
Published: 2011
Includes: Supplemental data
Journal Articles

ENMD-1198 in Combination with Vincristine Shows Synergistic Activity in Leukemia Cells and Prolonged Mouse Survival in Human Leukemia Xenografts.

Free
Tracy T.Y.E. Liaw, BSci(Hons), Patricia P.A. Burke, PhD, X. Chen, PhD, Theresa T.M. LaVallee, PhD, Richard Lock, PhD, Maria Kavallaris, PhD
Journal: Blood
Blood (2007) 110 (11): 859.
https://doi.org/10.1182/blood.V110.11.859.859
Published: 2007
Journal Articles

The Role of Hyaluronic Acid in Normal and Perturbed Hemopoietic Stem Cell Biology.

Free
Sarah E. Shaw, BSc (Hons), David N. Haylock, PhD, Hayley M. Johnston, BSc, Richard Lock, PhD, Susie K. Nilsson, PhD
Journal: Blood
Blood (2006) 108 (11): 708.
https://doi.org/10.1182/blood.V108.11.708.708
Published: 2006