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Volume 115, Issue 21

May 27 2010

In this Issue

INSIDE BLOOD
PERSPECTIVES
CLINICAL TRIALS AND OBSERVATIONS
IMMUNOBIOLOGY
LYMPHOID NEOPLASIA
MYELOID NEOPLASIA
PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS
PLATELETS AND THROMBOPOIESIS
RED CELLS, IRON, AND ERYTHROPOIESIS
THROMBOSIS AND HEMOSTASIS
TRANSFUSION MEDICINE
TRANSPLANTATION
VASCULAR BIOLOGY
CORRESPONDENCE
ERRATA
OTHER DEPARTMENTS

INSIDE BLOOD

RED CELLS & IRON

Erythropoietin: back to basics

Wolfgang Jelkmann

In this issue of Blood, Sinclair and colleagues¹ and Swift and colleagues² report that the Epo receptor is barely detectable in nonhematopoietic tissues, casting doubt on the role of Epo as a pleiotropic hormone. The results not only have relevance for off-label clinical trials using recombinant human Epo for tissue-protection, but have important implications regarding Epo's alleged effects on tumor cells.

View Articletitled, Erythropoietin: back to basics

CLINICAL TRIALS

Refining “total therapy” for myeloma

Joan Bladé,Laura Rosiñol

In this issue of Blood, Nair and colleagues report similar results with Total Therapy 3 and their subsequent trial, replacing VTD/TD consolidation/maintenance by VRD despite the higher incidence of adverse prognostic features in the current study.

View Articletitled, Refining “total therapy” for myeloma

INSIDE BLOOD

Time to test CLL p53 function

Clive S. Zent

Chronic lymphocytic leukemia (CLL) patients with p53 pathway dysfunction have poor responses to conventional chemoimmunotherapy and short survival. This small but important cohort of CLL patients would benefit from early identification and appropriate management. The challenge is to develop clinically useful tests of p53 pathway function.

View Articletitled, Time to test CLL p53 function

PLATELETS & THROMBOPOIESIS

Triple play of H pylori in ITP

Yeon S. Ahn

In this issue of Blood, the meticulous study by Yeh and colleagues offers new insight into the mechanism of “immune” TP associated with H pylori infection.

View Articletitled, Triple play of H pylori in ITP

PERSPECTIVES

SNP array analysis in hematologic malignancies: avoiding false discoveries

Stefan Heinrichs,Cheng Li,A. Thomas Look

View Articletitled, SNP array analysis in hematologic malignancies: avoiding false discoveries

CLINICAL TRIALS AND OBSERVATIONS

SPIN (Scottish Pregnancy Intervention) study: a multicenter, randomized controlled trial of low-molecular-weight heparin and low-dose aspirin in women with recurrent miscarriage
CME

Peter Clark,Isobel D. Walker,Peter Langhorne,Lena Crichton,Andrew Thomson,Mike Greaves,Sonia Whyte,Ian A. Greer,on behalf of the Scottish Pregnancy Intervention Study (SPIN) collaborators

View Articletitled, SPIN (Scottish Pregnancy Intervention) study: a multicenter, randomized controlled trial of low-molecular-weight heparin and low-dose aspirin in women with recurrent miscarriage

Superior results of Total Therapy 3 (2003-33) in gene expression profiling–defined low-risk multiple myeloma confirmed in subsequent trial 2006-66 with VRD maintenance
Clinical Trials & Observations

Bijay Nair,Frits van Rhee,John D. Shaughnessy, Jr,Elias Anaissie,Jackie Szymonifka,Antje Hoering,Yazan Alsayed,Sarah Waheed,John Crowley,Bart Barlogie

View Articletitled, Superior results of Total Therapy 3 (2003-33) in gene expression profiling–defined low-risk multiple myeloma confirmed in subsequent trial 2006-66 with VRD maintenance

IMMUNOBIOLOGY

Integrin and CD3/TCR activation are regulated by the scaffold protein AKAP450

Javier Robles-Valero,Noa B. Martín-Cófreces,Amalia Lamana,Stephen Macdonald,Yuri Volkov,Francisco Sánchez-Madrid

View Articletitled, Integrin and CD3/TCR activation are regulated by the scaffold protein AKAP450

Supplemental data

IL-4 enhances IFN-λ1 (IL-29) production by plasmacytoid DCs via monocyte secretion of IL-1Ra

Nicholas J. Megjugorac,Grant E. Gallagher,Grant Gallagher

View Articletitled, IL-4 enhances IFN-λ1 (IL-29) production by plasmacytoid DCs via monocyte secretion of IL-1Ra

LYMPHOID NEOPLASIA

microRNA-34a expression correlates with MDM2 SNP309 polymorphism and treatment-free survival in chronic lymphocytic leukemia

Daniela Asslaber,Josefina D. Piñón,Irina Seyfried,Petra Desch,Markus Stöcher,Inge Tinhofer,Alexander Egle,Olaf Merkel,Richard Greil

View Articletitled, microRNA-34a expression correlates with MDM2 SNP309 polymorphism and treatment-free survival in chronic lymphocytic leukemia

Surface IgM of CLL cells displays unusual glycans indicative of engagement of antigen in vivo

Sergey Krysov,Kathleen N. Potter,C. Ian Mockridge,Vania Coelho,Isla Wheatley,Graham Packham,Freda K. Stevenson

View Articletitled, Surface IgM of CLL cells displays unusual glycans indicative of engagement of antigen in vivo

Supplemental data

MYELOID NEOPLASIA

Discovery of a small-molecule type II inhibitor of wild-type and gatekeeper mutants of BCR-ABL, PDGFRα, Kit, and Src kinases: novel type II inhibitor of gatekeeper mutants

Ellen Weisberg,Hwan Geun Choi,Arghya Ray,Rosemary Barrett,Jianming Zhang,Taebo Sim,Wenjun Zhou,Markus Seeliger,Michael Cameron,Mohammed Azam,Jonathan A. Fletcher,Maria Debiec-Rychter,Mark Mayeda,Daisy Moreno,Andrew L. Kung,Pasi Antero Janne,Roya Khosravi-Far,Junia V. Melo,Paul W. Manley,Sophia Adamia,Catherine Wu,Nathanael Gray,James D. Griffin

View Articletitled, Discovery of a small-molecule type II inhibitor of wild-type and gatekeeper mutants of BCR-ABL, PDGFRα, Kit, and Src kinases: novel type II inhibitor of gatekeeper mutants

Supplemental data

AR-42, a novel HDAC inhibitor, exhibits biologic activity against malignant mast cell lines via down-regulation of constitutively activated Kit

Tzu-Yin Lin,Joelle Fenger,Sridhar Murahari,Misty D. Bear,Samuel K. Kulp,Dasheng Wang,Ching-Shih Chen,William C. Kisseberth,Cheryl A. London

View Articletitled, AR-42, a novel HDAC inhibitor, exhibits biologic activity against malignant mast cell lines via down-regulation of constitutively activated Kit

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Inhibition of phagocytosis in HIV-1–infected macrophages relies on Nef-dependent alteration of focal delivery of recycling compartments

Julie Mazzolini,Floriane Herit,Jérôme Bouchet,Alexandre Benmerah,Serge Benichou,Florence Niedergang

View Articletitled, Inhibition of phagocytosis in HIV-1–infected macrophages relies on Nef-dependent alteration of focal delivery of recycling compartments

Supplemental data

Akt isoforms differentially regulate neutrophil functions

Jia Chen,Haiyang Tang,Nissim Hay,Jingsong Xu,Richard D. Ye

View Articletitled, Akt isoforms differentially regulate neutrophil functions

Supplemental data

PLATELETS AND THROMBOPOIESIS

P-selectin–dependent platelet aggregation and apoptosis may explain the decrease in platelet count during Helicobacter pylori infection

Jeng-Jung Yeh,Sharon Tsai,Deng-Chyang Wu,Jeng-Yih Wu,Ta-Chih Liu,Angela Chen

View Articletitled, P-selectin–dependent platelet aggregation and apoptosis may explain the decrease in platelet count during Helicobacter pylori infection

RED CELLS, IRON, AND ERYTHROPOIESIS

Absence of functional EpoR expression in human tumor cell lines

Susan Swift,Aaron R. Ellison,Paul Kassner,Ian McCaffery,John Rossi,Angus M. Sinclair,C. Glenn Begley,Steven Elliott

View Articletitled, Absence of functional EpoR expression in human tumor cell lines

Supplemental data

Functional erythropoietin receptor is undetectable in endothelial, cardiac, neuronal, and renal cells

Angus M. Sinclair,Angela Coxon,Ian McCaffery,Stephen Kaufman,Katherine Paweletz,Liqin Liu,Leigh Busse,Susan Swift,Steven Elliott,C. Glenn Begley

View Articletitled, Functional erythropoietin receptor is undetectable in endothelial, cardiac, neuronal, and renal cells

Supplemental data

THROMBOSIS AND HEMOSTASIS

Cystine 186–cystine 209 disulfide bond is not essential for the procoagulant activity of tissue factor or for its de-encryption

Hema Kothari,Ramesh C. Nayak,L. Vijaya Mohan Rao,Usha R. Pendurthi

View Articletitled, Cystine 186–cystine 209 disulfide bond is not essential for the procoagulant activity of tissue factor or for its de-encryption

TRANSFUSION MEDICINE

Transfusion of red blood cells after prolonged storage produces harmful effects that are mediated by iron and inflammation

Eldad A. Hod,Ning Zhang,Set A. Sokol,Boguslaw S. Wojczyk,Richard O. Francis,Daniel Ansaldi,Kevin P. Francis,Phyllis Della-Latta,Susan Whittier,Sujit Sheth,Jeanne E. Hendrickson,James C. Zimring,Gary M. Brittenham,Steven L. Spitalnik

View Articletitled, Transfusion of red blood cells after prolonged storage produces harmful effects that are mediated by iron and inflammation

TRANSPLANTATION

NK cells mediate reduction of GVHD by inhibiting activated, alloreactive T cells while retaining GVT effects

Janelle A. Olson,Dennis B. Leveson-Gower,Saar Gill,Jeanette Baker,Andreas Beilhack,Robert S. Negrin

View Articletitled, NK cells mediate reduction of GVHD by inhibiting activated, alloreactive T cells while retaining GVT effects

VASCULAR BIOLOGY

Tissue type plasminogen activator regulates myeloid-cell dependent neoangiogenesis during tissue regeneration

Makiko Ohki,Yuichi Ohki,Makoto Ishihara,Chiemi Nishida,Yoshihiko Tashiro,Haruyo Akiyama,Hiromitsu Komiyama,Leif R. Lund,Atsumi Nitta,Kiyofumi Yamada,Zhenping Zhu,Hideoki Ogawa,Hideo Yagita,Ko Okumura,Hiromitsu Nakauchi,Zena Werb,Beate Heissig,Koichi Hattori

View Articletitled, Tissue type plasminogen activator regulates myeloid-cell dependent neoangiogenesis during tissue regeneration

Supplemental data

Thrombotic microangiopathy after GVHD prophylaxis with tacrolimus/sirolimus: a call for use of consensus definition in reporting

Mohamed A. Kharfan-Dabaja,Joseph Pidala,Claudio Anasetti

View Articletitled, Thrombotic microangiopathy after GVHD prophylaxis with tacrolimus/sirolimus: a call for use of consensus definition in reporting

Response: A phase II pilot study of tacrolimus/sirolimus GVHD prophylaxis for sibling donor hematopoietic stem cell transplantation using 3 different conditioning regimens

Ryotaro Nakamura,Roberto Rodriguez,Sepideh Shayani,Pablo Parker,Stephen J. Forman

View Articletitled, Response: A phase II pilot study of tacrolimus/sirolimus GVHD prophylaxis for sibling donor hematopoietic stem cell transplantation using 3 different conditioning regimens

ERRATA

Rodriguez R, Nakamura R, Palmer JM, et al. A phase II pilot study of tacrolimus/sirolimus GVHD prophylaxis for sibling donor hematopoietic stem cell transplantation using 3 conditioning regimens. Blood. 2010;115(5):1098–1105.

View Articletitled, Rodriguez R, Nakamura R, Palmer JM, et al. A phase II pilot study of tacrolimus/sirolimus GVHD prophylaxis for sibling donor hematopoietic stem cell transplantation using 3 conditioning regimens. Blood. 2010;115(5):1098–1105.

OTHER DEPARTMENTS

Continuing Medical Education (CME) questions: ASA/enoxaparin to prevent pregnancy loss
CME

View Articletitled, Continuing Medical Education (CME) questions: ASA/enoxaparin to prevent pregnancy loss

Cover Image

Cover Image

Bone marrow–derived myeloid cells can facilitate angiogenesis during ischemic tissue regeneration. The cover shows an immunofluorescence microscopy image of murine muscle tissue sections after hind limb ischemia induction. Mice had been transplanted with tissue type plasminogen activator–mobilized peripheral blood mononuclear cells (green) from green fluorescent protein (GFP) donor mice. The confocal image revealed that nearly all incorporated GFP⁺ cells stained for CD11b, also known as Mac-1 (red), and consequently gave a yellow signal. See the article by Ohki et al on page 4302.

Editor's note: This cover is dedicated to the memory of Yuichi Ohki, the author who performed the immunostaining experiments, whose co-authors remember him as a passionate scientist, colleague, and friend.
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