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Issue Archive

Volume 113, Issue 4
January 22 2009
Issue Cover

Table of Contents

INSIDE BLOOD

INSIDE BLOOD
B-CLL kicks it up a Notch
Barbara A. Osborne
View Articletitled, B-CLL kicks it up a Notch
HEMATOPOIESIS & STEM CELLS
CLPs find their inner T-cell potential
Kevin D. Bunting
View Articletitled, CLPs find their inner T-cell potential
VASCULAR BIOLOGY
Fractalkine: one chemokine, many functions
Gemma E. White,David R. Greaves
View Articletitled, Fractalkine: one chemokine, many functions

REVIEW ARTICLES

Life after the thymus: CD31+ and CD31− human naive CD4+ T-cell subsets
Siegfried Kohler,Andreas Thiel
View Articletitled, Life after the thymus: CD31<sup>+</sup> and CD31<sup>−</sup> human naive CD4<sup>+</sup> T-cell subsets

CLINICAL TRIALS AND OBSERVATIONS

Differentiation syndrome in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline chemotherapy: characteristics, outcome, and prognostic factors
Clinical Trials & Observations
Pau Montesinos,Juan M. Bergua,Edo Vellenga,Chelo Rayón,Ricardo Parody,Javier de la Serna,Angel León,Jordi Esteve,Gustavo Milone,Guillermo Debén,Concha Rivas,Marcos González,Mar Tormo,Joaquín Díaz-Mediavilla,Jose D. González,Silvia Negri,Elena Amutio,Salut Brunet,Bob Lowenberg,Miguel A. Sanz
View Articletitled, Differentiation syndrome in patients with acute promyelocytic leukemia treated with all-<em>trans</em> retinoic acid and anthracycline chemotherapy: characteristics, outcome, and prognostic factors
The largest prospective warfarin-treated cohort supports genetic forecasting
Clinical Trials & Observations
Mia Wadelius,Leslie Y. Chen,Jonatan D. Lindh,Niclas Eriksson,Mohammed J. R. Ghori,Suzannah Bumpstead,Lennart Holm,Ralph McGinnis,Anders Rane,Panos Deloukas
View Articletitled, The largest prospective warfarin-treated cohort supports genetic forecasting
Supplemental data
Long-term survival in Waldenstrom macroglobulinemia: 10-year follow-up of Southwest Oncology Group–directed intergroup trial S9003
Brief Report
Madhav V. Dhodapkar,Antje Hoering,Morie A. Gertz,Saul Rivkin,Jackie Szymonifka,John Crowley,Bart Barlogie
View Articletitled, Long-term survival in Waldenstrom macroglobulinemia: 10-year follow-up of Southwest Oncology Group–directed intergroup trial S9003
Supplemental data

GENE THERAPY

Long-term correction of inhibitor-prone hemophilia B dogs treated with liver-directed AAV2-mediated factor IX gene therapy
Glenn P. Niemeyer,Roland W. Herzog,Jane Mount,Valder R. Arruda,D. Michael Tillson,John Hathcock,Frederik W. van Ginkel,Katherine A. High,Clinton D. Lothrop, Jr
View Articletitled, Long-term correction of inhibitor-prone hemophilia B dogs treated with liver-directed AAV2-mediated factor IX gene therapy

HEMATOPOIESIS AND STEM CELLS

Reductive isolation from bone marrow and blood implicates common lymphoid progenitors as the major source of thymopoiesis
Thomas Serwold,Lauren I. Richie Ehrlich,Irving L. Weissman
View Articletitled, Reductive isolation from bone marrow and blood implicates common lymphoid progenitors as the major source of thymopoiesis
Supplemental data
The CD34-like protein PODXL and α6-integrin (CD49f) identify early progenitor MSCs with increased clonogenicity and migration to infarcted heart in mice
Ryang Hwa Lee,Min Jeong Seo,Andrey A. Pulin,Carl A. Gregory,Joni Ylostalo,Darwin J. Prockop
View Articletitled, The CD34-like protein PODXL and α6-integrin (CD49f) identify early progenitor MSCs with increased clonogenicity and migration to infarcted heart in mice
Supplemental data

IMMUNOBIOLOGY

CD49d provides access to “untouched” human Foxp3+ Treg free of contaminating effector cells
Markus Kleinewietfeld,Mireille Starke,Diletta Di Mitri,Giovanna Borsellino,Luca Battistini,Olaf Rötzschke,Kirsten Falk
View Articletitled, CD49d provides access to “untouched” human Foxp3<sup>+</sup> Treg free of contaminating effector cells
Supplemental data
Phosphoantigen-activated Vγ2Vδ2 T cells antagonize IL-2–induced CD4+CD25+Foxp3+ T regulatory cells in mycobacterial infection
Guangming Gong,Lingyun Shao,Yunqi Wang,Crystal Y. Chen,Dan Huang,Shuyu Yao,Ximei Zhan,Helene Sicard,Richard Wang,Zheng W. Chen
View Articletitled, Phosphoantigen-activated Vγ2Vδ2 T cells antagonize IL-2–induced CD4<sup>+</sup>CD25<sup>+</sup>Foxp3<sup>+</sup> T regulatory cells in mycobacterial infection
Supplemental data

LYMPHOID NEOPLASIA

SNX-2112, a selective Hsp90 inhibitor, potently inhibits tumor cell growth, angiogenesis, and osteoclastogenesis in multiple myeloma and other hematologic tumors by abrogating signaling via Akt and ERK
Yutaka Okawa,Teru Hideshima,Paul Steed,Sonia Vallet,Steven Hall,Ken Huang,John Rice,Amy Barabasz,Brianna Foley,Hiroshi Ikeda,Noopur Raje,Tanyel Kiziltepe,Hiroshi Yasui,Sotaro Enatsu,Kenneth C. Anderson
View Articletitled, SNX-2112, a selective Hsp90 inhibitor, potently inhibits tumor cell growth, angiogenesis, and osteoclastogenesis in multiple myeloma and other hematologic tumors by abrogating signaling via Akt and ERK
Supplemental data
Constitutively activated Notch signaling is involved in survival and apoptosis resistance of B-CLL cells
Emanuela Rosati,Rita Sabatini,Giuliana Rampino,Antonio Tabilio,Mauro Di Ianni,Katia Fettucciari,Andrea Bartoli,Stefano Coaccioli,Isabella Screpanti,Pierfrancesco Marconi
View Articletitled, Constitutively activated Notch signaling is involved in survival and apoptosis resistance of B-CLL cells

MYELOID NEOPLASIA

Very late antigen-4 function of myeloblasts correlates with improved overall survival for patients with acute myeloid leukemia
Pamela S. Becker,Kenneth J. Kopecky,Adrianne N. Wilks,Sylvia Chien,John M. Harlan,Cheryl L. Willman,Stephen H. Petersdorf,Derek L. Stirewalt,Thalia Papayannopoulou,Frederick R. Appelbaum
View Articletitled, Very late antigen-4 function of myeloblasts correlates with improved overall survival for patients with acute myeloid leukemia
Supplemental data
Primitive quiescent CD34+ cells in chronic myeloid leukemia are targeted by in vitro expanded natural killer cells, which are functionally enhanced by bortezomib
Agnes S. M. Yong,Keyvan Keyvanfar,Nancy Hensel,Rhoda Eniafe,Bipin N. Savani,Maria Berg,Andreas Lundqvist,Sharon Adams,Elaine M. Sloand,John M. Goldman,Richard Childs,A. John Barrett
View Articletitled, Primitive quiescent CD34<sup>+</sup> cells in chronic myeloid leukemia are targeted by in vitro expanded natural killer cells, which are functionally enhanced by bortezomib
RUNX1/AML1 DNA-binding domain and ETO/MTG8 NHR2-dimerization domain are critical to AML1-ETO9a leukemogenesis
Brief Report
Ming Yan,Eun-Young Ahn,Scott W. Hiebert,Dong-Er Zhang
View Articletitled, RUNX1/AML1 DNA-binding domain and ETO/MTG8 NHR2-dimerization domain are critical to AML1-ETO9a leukemogenesis
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

The macrophage scavenger receptor CD163 functions as an innate immune sensor for bacteria
Babs O. Fabriek,Robin van Bruggen,Dong Mei Deng,Antoon J. M. Ligtenberg,Kamran Nazmi,Karin Schornagel,Rianka P. M. Vloet,Christine D. Dijkstra,Timo K. van den Berg
View Articletitled, The macrophage scavenger receptor CD163 functions as an innate immune sensor for bacteria
Supplemental data

PLATELETS AND THROMBOPOIESIS

Two distinct roles of mitogen-activated protein kinases in platelets and a novel Rac1-MAPK–dependent integrin outside-in retractile signaling pathway
Panagiotis Flevaris,Zhenyu Li,Guoying Zhang,Yi Zheng,Junling Liu,Xiaoping Du
View Articletitled, Two distinct roles of mitogen-activated protein kinases in platelets and a novel Rac1-MAPK–dependent integrin outside-in retractile signaling pathway
Species differences in small molecule binding to αIIbβ3 are the result of sequence differences in 2 loops of the αIIb β propeller
Ramesh B. Basani,Hua Zhu,Michael A. Thornton,Cinque S. Soto,William F. DeGrado,M. Anna Kowalska,Joel S. Bennett,Mortimer Poncz
View Articletitled, Species differences in small molecule binding to αIIbβ3 are the result of sequence differences in 2 loops of the αIIb β propeller

RED CELLS, IRON, AND ERYTHROPOIESIS

Maintenance of the BMP4-dependent stress erythropoiesis pathway in the murine spleen requires hedgehog signaling
John M. Perry,Omid F. Harandi,Prashanth Porayette,Shailaja Hegde,Arun K. Kannan,Robert F. Paulson
View Articletitled, Maintenance of the BMP4-dependent stress erythropoiesis pathway in the murine spleen requires hedgehog signaling
Supplemental data
Functional alteration of red blood cells by a megadalton protein of Plasmodium falciparum
Fiona K. Glenister,Kate M. Fernandez,Lev M. Kats,Eric Hanssen,Narla Mohandas,Ross L. Coppel,Brian M. Cooke
View Articletitled, Functional alteration of red blood cells by a megadalton protein of <em>Plasmodium falciparum</em>
Supplemental data

THROMBOSIS AND HEMOSTASIS

N-Glycans of ADAMTS13 modulate its secretion and von Willebrand factor cleaving activity
Wenhua Zhou,Han-Mou Tsai
View Articletitled, N-Glycans of ADAMTS13 modulate its secretion and von Willebrand factor cleaving activity
Supplemental data
Prevention of vascular graft occlusion and thrombus-associated thrombin generation by inhibition of factor XI
Erik I. Tucker,Ulla M. Marzec,Tara C. White,Sawan Hurst,Sandra Rugonyi,Owen J. T. McCarty,David Gailani,András Gruber,Stephen R. Hanson
View Articletitled, Prevention of vascular graft occlusion and thrombus-associated thrombin generation by inhibition of factor XI

TRANSPLANTATION

IL-17 contributes to CD4-mediated graft-versus-host disease
Lucy W. Kappel,Gabrielle L. Goldberg,Christopher G. King,David Y. Suh,Odette M. Smith,Cassandra Ligh,Amanda M. Holland,Jeremy Grubin,Nicholas M. Mark,Chen Liu,Yoichiro Iwakura,Glenn Heller,Marcel R. M. van den Brink
View Articletitled, IL-17 contributes to CD4-mediated graft-versus-host disease
Anti-CD3 preconditioning separates GVL from GVHD via modulating host dendritic cell and donor T-cell migration in recipients conditioned with TBI
Nainong Li,Ying Chen,Wei He,Tangsheng Yi,Dongchang Zhao,Chunyan Zhang,Chia-Lei Lin,Ivan Todorov,Fouad Kandeel,Stephen Forman,Defu Zeng
View Articletitled, Anti-CD3 preconditioning separates GVL from GVHD via modulating host dendritic cell and donor T-cell migration in recipients conditioned with TBI
Supplemental data

VASCULAR BIOLOGY

CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival
Limor Landsman,Liat Bar-On,Alma Zernecke,Ki-Wook Kim,Rita Krauthgamer,Erdenechimeg Shagdarsuren,Sergio A. Lira,Irving L. Weissman,Christian Weber,Steffen Jung
View Articletitled, CX<sub>3</sub>CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival
Supplemental data
Phospholipase D1 is specifically required for regulated secretion of von Willebrand factor from endothelial cells
Jennifer Disse,Nicolas Vitale,Marie-France Bader,Volker Gerke
View Articletitled, Phospholipase D1 is specifically required for regulated secretion of von Willebrand factor from endothelial cells
  • Cover Image

    Cover Image

    issue cover

    Immunofluorescence analysis of schizont-infected red blood cells containing 8 or more DAPI (blue)–stained nuclei. Maurer clefts were visualized using an antibody against the resident cleft protein skeleton binding protein 1 (green). Red blood cells infected with transgenic parasites lacking Pf332 show fewer, abnormally large, aggregated Maurer clefts (middle and bottom panels) when compared to normal parasite-infected red blood cells (top panel). See the article by Glenister et al on page 919.

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