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Journal Articles

Long-Term Outcome Of 151 Patients With Relapsed APL Receiving Second-Line With Chemotherapy Or Arsenic Trioxide-Based Regimens

Pau Montesinos, David Martínez-Cuadrón, Concha Rivas, Salut Brunet, MD, PhD, José David González-San Miguel, Vicente Rubio, Cristina Pérez, Félix Manso, Pedro Sánchez-Godoy, Lourdes Escoda, Elena Amutio, Mark Zijlmans, MD, Mar Tormo, MD, Marcos González, MD, Chelo Rayón, María José Sayas, Josep-Maria Ribera, MD, PhD, Guillermo Deben, José Hernández-Martín, Jordi Esteve, MD, PhD, Edo Vellenga, MD, PhD, Miguel Sanz
Journal: Blood
Blood (2013) 122 (21): 3922.
https://doi.org/10.1182/blood.V122.21.3922.3922
Published: 2013
Journal Articles

Arsenic Trioxide-Based Therapy Of Relapsed Acute Promyelocytic Leukemia: Updated Results Of The European Registry Of Relapsed APL (PROMYSE)

Eva Lengfelder, MD, Francesco Lo-Coco, MD, Lionel Ades, Pau Montesinos, David Grimwade, MD, PhD, Bhuvan Kishore, Safaa Ramadan, MD, Maria Pagoni, Massimo Breccia, Concha Rivas, MD, José Gonzáles-Sanmiguel, MD, Anne Schmidt, Jean-Francois Lambert, Wolf-Karsten Hofmann, MD, Maria Cristina Sauerland, Pierre Fenaux, Miguel Sanz
Journal: Blood
Blood (2013) 122 (21): 1406.
https://doi.org/10.1182/blood.V122.21.1406.1406
Published: 2013
Journal Articles

Gene Microdeletions in Adult and Pediatric Acute Lymphoblastic Leukemia,

Inés Gómez-Seguí, MD., Esperanza Such, Jose Cervera, MD, Pascual Fernandez, MD., Lurdes Zamora, PhD, Mara Andres, Irene Luna, Mariam Ibañez, Maria López-Pavia, MD, Beatriz Costan, Eva Barragan, PhD, Oscar Fuster, PhD, Jose Francisco Fernandez, David Martinez-Cuadrón, MD, Leonor Senent, Silvestre Oltra, Pascual Bolufer, Amparo Verdeguer, MD, Concha Rivas, Josep-Maria Ribera, MD, PhD, Miguel A. Sanz, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 3539.
https://doi.org/10.1182/blood.V118.21.3539.3539
Published: 2011
Journal Articles

Clinical significance of CD56 expression in patients with acute promyelocytic leukemia treated with all- trans retinoic acid and anthracycline-based regimens

Clinical Trials & Observations
Pau Montesinos, Chelo Rayón, Edo Vellenga, Salut Brunet, José González, Marcos González, Aleksandra Holowiecka, Jordi Esteve, Juan Bergua, José D. González, Concha Rivas, Mar Tormo, Vicente Rubio, Javier Bueno, Félix Manso, Gustavo Milone, Javier de la Serna, Inmaculada Pérez, Manuel Pérez-Encinas, Isabel Krsnik, Josep M. Ribera, Lourdes Escoda, Bob Lowenberg, Miguel A. Sanz, on behalf of the PETHEMA and HOVON Groups
Journal: Blood
Blood (2011) 117 (6): 1799–1805.
https://doi.org/10.1182/blood-2010-04-277434
Published: 2011
Journal Articles

Does microgranular variant morphology of acute promyelocytic leukemia independently predict a less favorable outcome compared with classical M3 APL? A joint study of the North American Intergroup and the PETHEMA Group

Clinical Trials & Observations
Martin S. Tallman, Haesook T. Kim, Pau Montesinos, Frederick R. Appelbaum, Javier de la Serna, John M. Bennett, Guillermo Deben, Clara D. Bloomfield, Jose Gonzalez, James H. Feusner, Marcos Gonzalez, Robert Gallagher, Jose D. Gonzalez-San Miguel, Richard A. Larson, Gustavo Milone, Elisabeth Paietta, Chelo Rayon, Jacob M. Rowe, Concha Rivas, Charles A. Schiffer, Edo Vellenga, Lois Shepherd, James L. Slack, Peter H. Wiernik, Cheryl L. Willman, Miguel A. Sanz
Journal: Blood
Blood (2010) 116 (25): 5650–5659.
https://doi.org/10.1182/blood-2010-06-288613
Published: 2010
Journal Articles

Risk-adapted treatment of acute promyelocytic leukemia based on all- trans retinoic acid and anthracycline with addition of cytarabine in consolidation therapy for high-risk patients: further improvements in treatment outcome

CME
Miguel A. Sanz, Pau Montesinos, Chelo Rayón, Alexandra Holowiecka, Javier de la Serna, Gustavo Milone, Elena de Lisa, Salut Brunet, Vicente Rubio, José M. Ribera, Concha Rivas, Isabel Krsnik, Juan Bergua, José González, Joaquín Díaz-Mediavilla, Rafael Rojas, Félix Manso, Gert Ossenkoppele, José D. González, Bob Lowenberg
Journal: Blood
Blood (2010) 115 (25): 5137–5146.
https://doi.org/10.1182/blood-2010-01-266007
Published: 2010
Journal Articles

Salvage Therapy with Chemotherapy- or Arsenic Trioxide-Based Regimens for Acute Promyelocytic Leukemia in First Relapse.

Pau Montesinos, Jordi Esteve, Edo Vellenga, Concha Rivas, Salut Brunet, Montserrat Arnan, Jose D. Gonzalez, Pedro Sanchez, Joaquín Díaz-Mediavilla, Amparo Verdeguer, Lourdes Escoda, Elena Amutio, Vicente Rubio, Inmaculada Perez, Ramon Guardia, Javier Bueno, Bob Lowenberg, Miguel A. Sanz
Journal: Blood
Blood (2009) 114 (22): 1062.
https://doi.org/10.1182/blood.V114.22.1062.1062
Published: 2009
Journal Articles

Treatment of Newly Diagnosed Acute Promyelocytic Leukemia (APL) in the Elderly: A Joint Analysis of the French -Belgian-Swiss and PETHEMA Groups.

Lionel Ades, MD, Pau Montesinos, MD, Sylvie Chevret, PhD, Edo Vellenga, MD, Emmanuel Raffoux, MD, Chelo Rayon, MD, Joaquim Díaz-Mediavilla, Xavier Thomas, MD, PhD, Patrice Chevallier, MD, Concha Rivas, Agnes Guerci, MD, PhD, Elena Amutio, MD, Francoise Huguet, MD, Jesus Arias, MD, Norbert Vey, MD, PhD, Guillermo Deben, MD, Sandrine Meyer, MD, PhD, Andres Novo, MD, Augustin Ferrant, MD, PhD, Juan Bergua, MD, Mathieu Resche Rigon, PhD, Javier de la Serna, MD, Herve Dombret, MD, PhD, Sylvie Castaigne, MD, PhD, Pierre Fenaux, MD, PhD, Miguel A. Sanz, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 845.
https://doi.org/10.1182/blood.V114.22.845.845
Published: 2009
Journal Articles

Differentiation syndrome in patients with acute promyelocytic leukemia treated with all- trans retinoic acid and anthracycline chemotherapy: characteristics, outcome, and prognostic factors

Clinical Trials & Observations
Pau Montesinos, Juan M. Bergua, Edo Vellenga, Chelo Rayón, Ricardo Parody, Javier de la Serna, Angel León, Jordi Esteve, Gustavo Milone, Guillermo Debén, Concha Rivas, Marcos González, Mar Tormo, Joaquín Díaz-Mediavilla, Jose D. González, Silvia Negri, Elena Amutio, Salut Brunet, Bob Lowenberg, Miguel A. Sanz
Journal: Blood
Blood (2009) 113 (4): 775–783.
https://doi.org/10.1182/blood-2008-07-168617
Published: 2009
Journal Articles

Incidence, Outcome and Risk Factors of Pseudotumor Cerebri after All- Trans Retinoic Acid and Anthracycline-Based Chemotherapy in Patients with Acute Promyelocytic Leukemia

Pau Montesinos, MD, Edo Vellenga, Aleksandra Holowiecka, Chelo Rayon, Gustavo Milone, Javier de la Serna, Angel Leon, Juan Bergua, Concha Rivas, Jose Gonzalez, Jordi Esteve, Miguel A. Sanz, MD, PhD, On behalf of the PETHEMA, HOVON, PALG, and GATLA cooperative groups
Journal: Blood
Blood (2008) 112 (11): 2992.
https://doi.org/10.1182/blood.V112.11.2992.2992
Published: 2008
Journal Articles

Risk-Adapted Treatment of Acute Promyelocytic Leukemia: Results of the PETHEMA LPA2005 Trial Using All- Trans Retinoic Acid and Anthracycline with Cytarabine for High-Risk Patients

Miguel A. Sanz, MD, PhD, Pau Montesinos, Aleksandra Holowiecka, Gustavo Milone, Chelo Rayon, Elena de Lisa, Javier de la Serna, Salut Brunet, Angel Leon, Isabel Krsnik, Concha Rivas, Jose M. Ribera, Jose Gonzalez, Joaquín Díaz- Mediavilla, Javier Bueno, Jose David Gonzalez, Juan Bergua, Marcos Gonzalez
Journal: Blood
Blood (2008) 112 (11): 138.
https://doi.org/10.1182/blood.V112.11.138.138
Published: 2008
Journal Articles

Risk-adapted treatment of acute promyelocytic leukemia with all- trans retinoic acid and anthracycline monochemotherapy: long-term outcome of the LPA 99 multicenter study by the PETHEMA Group

Brief Report
Miguel A. Sanz, Pau Montesinos, Edo Vellenga, Consuelo Rayón, Javier de la Serna, Ricardo Parody, Juan M. Bergua, Angel León, Silvia Negri, Marcos González, Concha Rivas, Jordi Esteve, Gustavo Milone, José D. González, Elena Amutio, Salut Brunet, J. García-Laraña, Dolors Colomer, María J. Calasanz, Carmen Chillón, Eva Barragán, Pascual Bolufer, Bob Lowenberg
Journal: Blood
Blood (2008) 112 (8): 3130–3134.
https://doi.org/10.1182/blood-2008-05-159632
Published: 2008
Journal Articles

Causes and prognostic factors of remission induction failure in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and idarubicin

Clinical Trials & Observations
Javier de la Serna, Pau Montesinos, Edo Vellenga, Chelo Rayón, Ricardo Parody, Angel León, Jordi Esteve, Juan M. Bergua, Gustavo Milone, Guillermo Debén, Concha Rivas, Marcos González, Mar Tormo, Joaquín Díaz-Mediavilla, Jose D. González, Silvia Negri, Elena Amutio, Salut Brunet, Bob Lowenberg, Miguel A. Sanz
Journal: Blood
Blood (2008) 111 (7): 3395–3402.
https://doi.org/10.1182/blood-2007-07-100669
Published: 2008
Journal Articles

Risk-Adapted Treatment of Acute Promyelocytic Leukemia: Updated Results of the Spanish PETHEMA LPA99 Trial Using ATRA and Anthracycline Monochemotherapy.

Miguel A. Sanz, PhD, Pau Montesinos, MD, Edo Vellenga, PhD, Chelo Rayon, PhD, Ricardo Parody, PhD, Javier de la Serna, PhD, Juan Bergua, PhD, Angel Leon, PhD, Silvia Negri, PhD, Concha Rivas, PhD, Salut Brunet, PhD, Marcos Gonzalez, PhD, Jordi Esteve, PhD, Bob Lowenberg, PhD
Journal: Blood
Blood (2007) 110 (11): 590.
https://doi.org/10.1182/blood.V110.11.590.590
Published: 2007
Journal Articles

All- trans retinoic acid and anthracycline monochemotherapy for the treatment of elderly patients with acute promyelocytic leukemia

Clinical Trials & Observations
Miguel A. Sanz, Edo Vellenga, Chelo Rayón, Joaquín Díaz-Mediavilla, Concha Rivas, Elena Amutio, Jesús Arias, Guillermo Debén, Andrés Novo, Juan Bergua, Javier de la Serna, Javier Bueno, Silvia Negri, José M. Beltrán de Heredia, Guillermo Martín
Journal: Blood
Blood (2004) 104 (12): 3490–3493.
https://doi.org/10.1182/blood-2004-04-1642
Published: 2004
Journal Articles

Additional Chromosome Abnormalities Have No Prognostic Value in Acute Promyelocytic Leukemia Patients Treated with Simultaneous ATRA and Anthracycline-Based Chemotherapy: An Update of the APL96 and APL99 Pethema Protocols.

Jose Cervera, MD, Guillermo Martin, MD, Jesus M. Hernandez, MD, Edo Vellenga, MD, Maria J. Calasanz, MD, Jose A. Martinez-Climent, MD, Elisa Luño, MD, Maria T. Ferro, MD, Consuelo Rayon, MD, Marcos Gonzalez, MD, Mar Tormo, MD, Concha Rivas, MD, Elena Amutio, MD, Javier de la Serna, MD, Jose D. Gonzalez-San Miguel, MD, Juan Bergua, MD, Angel Leon, MD, Joaquin Diaz-Mediavilla, MD, Jose Garcia-Laraña, MD, Jordi Esteve, MD, Miguel A. Sanz, on behalf of the PETHEMA Cooperative Group
Journal: Blood
Blood (2004) 104 (11): 2019.
https://doi.org/10.1182/blood.V104.11.2019.2019
Published: 2004
Journal Articles

Microgranular Variant (M3V) of Acute Promyelocytic Leukemia (APL) Does Not Have a Worse Prognosis than Classical APL in the Atra Era: A Report of 153 Patients Treated on Intergroup 0129 and Pethema LPA96 and LPA99.

Martin S. Tallman, MD, Haesook T. Kim, PhD, Charles A. Schiffer, MD, Frederick R. Appelbaum, MD, James H. Feusner, MD, Angela K. Ogden, MD, Lois Shepherd, MD, Cheryl L. Willman, MD, Clara D. Bloomfield, MD, Jacob M. Rowe, MD, Richard A. Larson, MD, Peter H. Wiernik, MD, Guillermo Martin, MD, Chelo Rayon, MD, Javier de la Serna, MD, Concha Rivas, MD, Jose D. Gonzalez-San Miguel, MD, Guillermo Deben, MD, Miguel A. Sanz, MD
Journal: Blood
Blood (2004) 104 (11): 394.
https://doi.org/10.1182/blood.V104.11.394.394
Published: 2004
Journal Articles

Causes of Induction Failure in Newly Diagnosed Acute Promyelocytic Leukemia Patients Treated with Simultaneous ATRA and Idarubicin (AIDA).

Javier de la Serna, MD, Guillermo Martin, MD, Edo Vellenga, MD, Chelo Rayon, MD, Concha Rivas, MD, Guillermo Deben, MD, Marcos Gonzalez, MD, Mar Tormo, MD, Juan Bergua, MD, Jaoquin Diaz-Mediavilla, MD, Angel Leon, MD, Jordi Esteve, MD, Ricardo Parody, MD, Elena Amutio, MD, Jose D. Gonzalez, MD, Silvia Negri, MD, Francisco J. Capote, MD, Javier Bueno, MD, Manuel Perez-Encina, MD, Andres Novo, MD, Antonia Rodriguez, MD, Miguel A. Sanz, MD
Journal: Blood
Blood (2004) 104 (11): 887.
https://doi.org/10.1182/blood.V104.11.887.887
Published: 2004
Journal Articles

Risk-adapted treatment of acute promyelocytic leukemia with all- trans -retinoic acid and anthracycline monochemotherapy: a multicenter study by the PETHEMA group

Clinical Trials & Observations
Miguel A. Sanz, Guillermo Martín, Marcos González, Angel León, Chelo Rayón, Concha Rivas, Dolors Colomer, Elena Amutio, Francisco J. Capote, Gustavo A. Milone, Javier de la Serna, José Román, Eva Barragán, Juan Bergua, Lourdes Escoda, Ricardo Parody, Silvia Negri, María J. Calasanz, Pascual Bolufer
Journal: Blood
Blood (2004) 103 (4): 1237–1243.
https://doi.org/10.1182/blood-2003-07-2462
Published: 2004
Journal Articles

A Modified AIDA Protocol With Anthracycline-Based Consolidation Results in High Antileukemic Efficacy and Reduced Toxicity in Newly Diagnosed PML/RAR-Positive Acute Promyelocytic Leukemia: Presented in part at the 40th meeting of the American Society of Hematology, Miami Beach, FL, December 4-8, 1998.

Miguel A. Sanz, Guillermo Martı́n, Consuelo Rayón, Jordi Esteve, Marcos González, Joaquı́n Dı́az-Mediavilla, Pascual Bolufer, Eva Barragán, Marı́a J. Terol, José D. González, Dolors Colomer, Carmen Chillón, Concha Rivas, Teresa Gómez, José M. Ribera, Rafael Bornstein, José Román, Marı́a J. Calasanz, Jesus Arias, Carmen Álvarez, Fernando Ramos, Guillermo Debén
Journal: Blood
Blood (1999) 94 (9): 3015–3021.
https://doi.org/10.1182/blood.V94.9.3015
Published: 1999