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Journal Articles

Donor T-Derived Memory Progenitors Differentiated into CD103 +/- CXCR6 + CD4 + Tissue-Resident T Cell Subsets Driven Cutaneous Chronic Graft-Versus-Host Disease

Xiaohui Kong, Bixin Wang, Xiwei Wu, Weijia Fu, Qinjian Li, Moqian Zheng, Raju Pillai, Ryotaro Nakamura, Paul J. Martin, Defu Zeng

Blood (2024) 144 (Supplement 1): 4776.

https://doi.org/10.1182/blood-2024-210519

Published: 2024

Journal Articles

Blockade of PD-L1/CD80 Interactions Augments Function of Activated Donor T Cells Results in Augmenting Gvhd Induced By Donor Naïve CD8 + t Cells and GVL Effect Mediated By Donor Memory CD8 + T Cells

Qingxiao Song, Yuankun Zhang, Kaniel Cassady, Qinjian Li, Paul J. Martin, Defu Zeng

Blood (2023) 142 (Supplement 1): 4793.

https://doi.org/10.1182/blood-2023-190733

Published: 2023

Journal Articles

Clonal Expansion and Differentiation of Stem-like Memory T Cells to Tissue-Resident Memory T Cells Perpetuates Pathogenesis of Chronic Graft-Versus-Host Disease

Xiaohui Kong, Bixin Wang, Xiwei Wu, Hyejin Cho, Moqian Zheng, Yuankun Zhang, Shanshan Tang, Qinjian Li, Ubaydah Nasri, Alyssa Wu, Hanjun Qin, Raju Pillai, Ryotaro Nakamura, Paul J. Martin, Yuanzhong Chen, Defu Zeng

Blood (2023) 142 (Supplement 1): 2044.

https://doi.org/10.1182/blood-2023-174768

Published: 2023

Journal Articles

ST2/ Rorγt-Dependent Th1/Th2-like CD4 + Trm Cells Mediate Cutaneous Chronic Gvhd

Qinjian Li, Xiaoqi Wang, Xiaohui Kong, Bixin Wang, Paul J. Martin, Xi Zhang, Defu Zeng

Blood (2023) 142 (Supplement 1): 6785.

https://doi.org/10.1182/blood-2023-190648

Published: 2023

Journal Articles

Trafficking between clonally related peripheral T-helper cells and tissue-resident T-helper cells in chronic GVHD

Xiaohui Kong, Xiwei Wu, Bixin Wang, Deye Zeng, Kaniel Cassady, Ubaydah Nasri, Moqian Zheng, Alyssa Wu, Hanjun Qin, Weimin Tsai, Amandeep Salhotra, Ryotaro Nakamura, Paul J. Martin, Defu Zeng

Blood (2022) 140 (25): 2740–2753.

https://doi.org/10.1182/blood.2022016581

Published: 2022

Includes: Supplemental data

Journal Articles

Targeting Intestinal Epithelial Ceacam1 Expands Peripheral Tregs and Prevents Steroid-Refractory Acute Gut Graft-Versus-Host Disease

Qingxiao Song, Moqian Zheng, Qinjian Li, Xiwei Wu, Hanjun Qin, Tae Hyuk Kang, Yaqun Hong, Bixin Wang, Maciej Kujawski, Jack Shively, Ryotaro Nakamura, Paul J Martin, Defu Zeng

Blood (2022) 140 (Supplement 1): 10225–10226.

https://doi.org/10.1182/blood-2022-163572

Published: 2022

Journal Articles

Tolerogenic anti–IL-2 mAb prevents graft-versus-host disease while preserving strong graft-versus-leukemia activity

Qingxiao Song, Xiaoning Wang, Xiwei Wu, Hanjun Qin, Yingfei Li, Arthur D. Riggs, Paul J. Martin, Yuan-Zhong Chen, Defu Zeng

Blood (2021) 137 (16): 2243–2255.

https://doi.org/10.1182/blood.2020006345

Published: 2021

Includes: Supplemental data

Journal Articles

Mouse models usher in precision medicine

Defu Zeng

Blood (2020) 135 (26): 2331–2333.

https://doi.org/10.1182/blood.2020005679

Published: 2020

Journal Articles

Expansion of Th/Tc17 T Cells and Loss of CX3CR1 + Macrophages Play a Critical Role in the Pathogenesis of Steroid-Refractory Acute Intestinal Gvhd

Qingxiao Song, MD PhD, Xiaoning Wang, MD, Paul J Martin, MD, Yuanzhong Chen, MD PhD, Defu Zeng, MD PhD

Blood (2019) 134 (Supplement_1): 1925.

https://doi.org/10.1182/blood-2019-126261

Published: 2019

Journal Articles

Role of Donor-Derived CD19.CAR-T Cells in Treating Patients That Relapsed after Allogeneic Hematopoietic Stem Cell Transplantation

Cheng Zhang, MD PhD, Lei Gao, Yao Liu, Li Gao, Pei-Yan Kong, Jun Liu, Ruihao Huang, Ying-Ying Ma, Defu Zeng, MD PhD, Qing-Hui Xiong, Wei-Ling Mei, Jia Liu, Peng-Fei Jiang, Xun Ye, De-Ping Han, Wei Cao, Xi Zhang

Blood (2019) 134 (Supplement_1): 4561.

https://doi.org/10.1182/blood-2019-128262

Published: 2019

Journal Articles

Combination Therapy of Allogeneic HSCT and In Vivo Activated iNKT Cells Prevents Acute Gvhd While Augmenting GVL Effect

Samuel Zeng, Qingxiao Song, MD PhD, Shanshan Tang, Xi Wang, PhD, Yuchen Wang, PhD, Defu Zeng, MD PhD, Lili Yang, PhD

Blood (2019) 134 (Supplement_1): 4439.

https://doi.org/10.1182/blood-2019-130826

Published: 2019

Journal Articles

Tissue-Resident PSGL1 lo CD4 + T Cells Interact with B Cells Via PD-1 and PD-L2 in Gvhd Target Tissues to Augment Autoimmune-like Chronic Gvhd

Xiaohui Kong, PhD, Deye Zeng, MD, Xiwei Wu, PhD, Shijie Yang, PhD, Bixin Wang, Qingxiao Song, MD PhD, Yongping Zhu, Martha Salas, Hanjun Qin, Ubaydah Nasri, Ryotaro Nakamura, MD, Paul J Martin, MD, Aimin Huang, Defu Zeng, MD PhD

Blood (2019) 134 (Supplement_1): 5607.

https://doi.org/10.1182/blood-2019-126315

Published: 2019

Journal Articles

Stat3 -/- Alloreactive Donor T Cells Reduce FAO but Increase Leakage of ROS in Response to PD-1 Signaling Triggered By Host-Tissue PD-L1, Leading to Prevention of Gvhd While Preserving GVL Effect

Xiaoqi Wang, MD, Shijie Yang, PhD, Yating Wang, PhD, Xiwei Wu, PhD, Martha Salas, Qingxiao Song, MD PhD, Hanjun Qin, Ubaydah Nasri, Arthur D. Riggs, PhD, Paul J Martin, MD, Xi Zhang, Defu Zeng, MD PhD

Blood (2019) 134 (Supplement_1): 198.

https://doi.org/10.1182/blood-2019-127228

Published: 2019

Journal Articles

Study on Use of CAR-T Cells in Allogeneic Hematopoietic Stem Cell Transplantation

Jun Liu, Xu Tan, Ma Ying-Ying, Wang Mai-Hong, Yao Liu, Gao Lei, Kong Peiyan, Cheng Zhang, MD PhD, Xi Zhang, Defu Zeng, MD

Blood (2018) 132 (Supplement 1): 5225.

https://doi.org/10.1182/blood-2018-99-114287

Published: 2018

Journal Articles

Neutralizing IL-2 Early after HCT Specifically Prevents Expansion of Donor GM-CSF-Producing CD4 + T Cells That Initiate Acute Gut Gvhd

Qingxiao Song, MD, Xiaoning Wang, MD, Paul J Martin, MD, Yuanzhong Chen, MD PhD, Defu Zeng, MD

Blood (2018) 132 (Supplement 1): 2030.

https://doi.org/10.1182/blood-2018-99-119966

Published: 2018

Journal Articles

10-Day Low Dose Decitabine Regimen for Elderly Acute Myeloid Leukemia Patient Maintenance Treatment

Jia Liu, Kong Peiyan, Li Gao, Cheng Zhang, MD PhD, Yao Liu, Hongju Yan, Lidan Zhu, Shichun Gao, Gao Lei, Defu Zeng, MD, Xi Zhang

Blood (2018) 132 (Supplement 1): 5228.

https://doi.org/10.1182/blood-2018-99-115861

Published: 2018

Journal Articles

Stat3 Regulates Alloreactive T Cell Susceptibility Towards PD-L1-Mediated Tolerance Signaling, Gvhd and GVL Activity

Shijie Yang, PhD, Xiaoqi Wang, MD, Yuankun Zhang, PhD, Deye Zeng, MD, Qingxiao Song, MD, Paul J Martin, MD, Xi Zhang, Defu Zeng, MD

Blood (2018) 132 (Supplement 1): 3323.

https://doi.org/10.1182/blood-2018-99-119474

Published: 2018

Journal Articles

Decitabine Combined with FB3 As Conditional Regimen for Elderly Acute Myeloid Leukemia Patient with Allogeneic Hematopoietic Stem Cell Transplantation

Shichun Gao, Jia Liu, Kong Peiyan, Li Gao, Cheng Zhang, MD PhD, Yao Liu, Hongju Yan, Lidan Zhu, Defu Zeng, MD, Lei Gao, Xi Zhang

Blood (2018) 132 (Supplement 1): 2108.

https://doi.org/10.1182/blood-2018-99-115926

Published: 2018

Journal Articles

Efficacy of Low-Dose Decitabine in the Early Relapse of AML/MDS after Allogeneic Hematopoietic Stem Cell Transplantation

Xu Guo-Fa, Chen Ting, Liu Huanfeng, Lin Shijia, Lei Gao, Cheng Zhang, MD PhD, Yao Liu, Xi Zhang, Defu Zeng, MD, Kong Peiyan

Blood (2018) 132 (Supplement 1): 5739.

https://doi.org/10.1182/blood-2018-99-115659

Published: 2018

Journal Articles

Tandem Autologous Hematopoietic Stem Cell Transplantation Treatment for Adult T-Cell Lymphoblastic Lymphoma: A Multiple Center Prospective Study in Southwestern China

Blood (2018) 132 (Supplement 1): 5747.

https://doi.org/10.1182/blood-2018-99-115705

Published: 2018

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Donor T-Derived Memory Progenitors Differentiated into CD103 +/- CXCR6 + CD4 + Tissue-Resident T Cell Subsets Driven Cutaneous Chronic Graft-Versus-Host Disease

Blockade of PD-L1/CD80 Interactions Augments Function of Activated Donor T Cells Results in Augmenting Gvhd Induced By Donor Naïve CD8 + t Cells and GVL Effect Mediated By Donor Memory CD8 + T Cells

Clonal Expansion and Differentiation of Stem-like Memory T Cells to Tissue-Resident Memory T Cells Perpetuates Pathogenesis of Chronic Graft-Versus-Host Disease

ST2/ Rorγt-Dependent Th1/Th2-like CD4 + Trm Cells Mediate Cutaneous Chronic Gvhd

Trafficking between clonally related peripheral T-helper cells and tissue-resident T-helper cells in chronic GVHD

Targeting Intestinal Epithelial Ceacam1 Expands Peripheral Tregs and Prevents Steroid-Refractory Acute Gut Graft-Versus-Host Disease

Tolerogenic anti–IL-2 mAb prevents graft-versus-host disease while preserving strong graft-versus-leukemia activity

Mouse models usher in precision medicine

Expansion of Th/Tc17 T Cells and Loss of CX3CR1 + Macrophages Play a Critical Role in the Pathogenesis of Steroid-Refractory Acute Intestinal Gvhd

Role of Donor-Derived CD19.CAR-T Cells in Treating Patients That Relapsed after Allogeneic Hematopoietic Stem Cell Transplantation

Combination Therapy of Allogeneic HSCT and In Vivo Activated iNKT Cells Prevents Acute Gvhd While Augmenting GVL Effect

Tissue-Resident PSGL1 lo CD4 + T Cells Interact with B Cells Via PD-1 and PD-L2 in Gvhd Target Tissues to Augment Autoimmune-like Chronic Gvhd

Stat3 -/- Alloreactive Donor T Cells Reduce FAO but Increase Leakage of ROS in Response to PD-1 Signaling Triggered By Host-Tissue PD-L1, Leading to Prevention of Gvhd While Preserving GVL Effect

Study on Use of CAR-T Cells in Allogeneic Hematopoietic Stem Cell Transplantation

Neutralizing IL-2 Early after HCT Specifically Prevents Expansion of Donor GM-CSF-Producing CD4 + T Cells That Initiate Acute Gut Gvhd

10-Day Low Dose Decitabine Regimen for Elderly Acute Myeloid Leukemia Patient Maintenance Treatment

Stat3 Regulates Alloreactive T Cell Susceptibility Towards PD-L1-Mediated Tolerance Signaling, Gvhd and GVL Activity

Decitabine Combined with FB3 As Conditional Regimen for Elderly Acute Myeloid Leukemia Patient with Allogeneic Hematopoietic Stem Cell Transplantation

Efficacy of Low-Dose Decitabine in the Early Relapse of AML/MDS after Allogeneic Hematopoietic Stem Cell Transplantation

Tandem Autologous Hematopoietic Stem Cell Transplantation Treatment for Adult T-Cell Lymphoblastic Lymphoma: A Multiple Center Prospective Study in Southwestern China

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American Society of Hematology

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