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Clinton D. Lothrop
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Journal Articles

Complete Correction of Severe Canine Hemophilia B By Skeletal Muscle Directed AAV-Based FIX-Padua Gene Therapy in Inhibitor-Prone Dogs

Robert French, Nicholas Martin, Timothy C. Nichols, MD, Glenn P Niemeyer, Clinton D. Lothrop, PhD DVM, Valder R Arruda, MD PhD
Journal: Blood
Blood (2015) 126 (23): 3487.
https://doi.org/10.1182/blood.V126.23.3487.3487
Published: 2015
Journal Articles

AAV liver expression of FIX-Padua prevents and eradicates FIX inhibitor without increasing thrombogenicity in hemophilia B dogs and mice

Julie M. Crudele, Jonathan D. Finn, Joshua I. Siner, Nicholas B. Martin, Glenn P. Niemeyer, Shangzhen Zhou, Federico Mingozzi, Clinton D. Lothrop, Jr, Valder R. Arruda
Journal: Blood
Blood (2015) 125 (10): 1553–1561.
https://doi.org/10.1182/blood-2014-07-588194
Published: 2015
Includes: Supplemental data
Journal Articles

Tolerance Induction To FIX Padua With AAV Liver Gene Transfer In Inhibitor-Prone Hemophilia B Dogs

Julie M Crudele, Jonathan D Finn, PhD, Nicholas B Martin, Joshua I Siner, Yifeng Chen, MD, Shangzhen Zhou, MD, Glenn Niemeyer, PhD, Clinton D. Lothrop, PhD, DVM, Federico Mingozzi, PhD., Katherine A. High, MD, Valder R. Arruda, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 4203.
https://doi.org/10.1182/blood.V122.21.4203.4203
Published: 2013
Journal Articles

Long-term correction of inhibitor-prone hemophilia B dogs treated with liver-directed AAV2-mediated factor IX gene therapy

Glenn P. Niemeyer, Roland W. Herzog, Jane Mount, Valder R. Arruda, D. Michael Tillson, John Hathcock, Frederik W. van Ginkel, Katherine A. High, Clinton D. Lothrop, Jr
Journal: Blood
Blood (2009) 113 (4): 797–806.
https://doi.org/10.1182/blood-2008-10-181479
Published: 2009
Journal Articles

Six-Year Follow-Up of Inhibitor Prone Hemophilia B Dogs Treated with Muscle and Liver-Directed AAV2 Mediated Factor IX Gene Therapy.

Glenn P. Niemeyer, PhD, Roland W. Herzog, PhD, Jane D. Mount, PhD, Valder Arruda, MD, PhD, Michael Tillson, DVM, John Hathcock, DVM, Katherine A. High, MD, PhD, Clinton D. Lothrop, PhD, DVM
Journal: Blood
Blood (2006) 108 (11): 3282.
https://doi.org/10.1182/blood.V108.11.3282.3282
Published: 2006
Journal Articles

Increased Unfolded Protein Response in Hematopoietic Cells from Cyclic Hematopoietic Dogs.

Ronghua Meng, David Upchurch, Glenn P. Niemeyer, PhD, Clinton D. Lothrop, DVM PhD
Journal: Blood
Blood (2006) 108 (11): 4185.
https://doi.org/10.1182/blood.V108.11.4185.4185
Published: 2006
Journal Articles

Sustained phenotypic correction of hemophilia B dogs with a factor IX null mutation by liver-directed gene therapy

Jane D. Mount, Roland W. Herzog, D. Michael Tillson, Susan A. Goodman, Nancy Robinson, Mark L. McCleland, Dwight Bellinger, Timothy C. Nichols, Valder R. Arruda, Clinton D. Lothrop, Jr, Katherine A. High
Journal: Blood
Blood (2002) 99 (8): 2670–2676.
https://doi.org/10.1182/blood.V99.8.2670
Published: 2002