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Issue Archive

Volume 6, Issue 15
August 9 2022
Issue Cover

Table of Contents

STIMULUS REPORTS

Improvement of hemolytic anemia with GBT1118 is renoprotective in transgenic sickle mice
Guohui Ren,Suman Setty,Xu Zhang,Alexandru Susma,Maria Armila Ruiz,Richard D. Minshall,James P. Lash,Victor R. Gordeuk,Santosh L. Saraf
View Articletitled, Improvement of hemolytic anemia with GBT1118 is renoprotective in transgenic sickle mice
Supplemental data
COVID-19 and venous thromboembolism risk in patients with sickle cell disease
Clinical Trials & Observations
Ashima Singh,Amanda M. Brandow,Ted Wun,Arun S. Shet
View Articletitled, COVID-19 and venous thromboembolism risk in patients with sickle cell disease
Supplemental data
Addition of romiplostim to conditioning prior to HSCT allows chemotherapy reduction while maintaining engraftment levels
C. Matthias Wilk,Larisa V. Kovtonyuk,Markus G. Manz
View Articletitled, Addition of romiplostim to conditioning prior to HSCT allows chemotherapy reduction while maintaining engraftment levels
Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

Iptacopan monotherapy in patients with paroxysmal nocturnal hemoglobinuria: a 2-cohort open-label proof-of-concept study
Clinical Trials & Observations
Jun Ho Jang,Lily Wong,Bor-Sheng Ko,Sung-Soo Yoon,Katie Li,Irina Baltcheva,Prasanna Kumar Nidamarthy,Raghav Chawla,Guido Junge,Eng Soo Yap
View Articletitled, Iptacopan monotherapy in patients with paroxysmal nocturnal hemoglobinuria: a 2-cohort open-label proof-of-concept study
Supplemental data
Longitudinal study of glomerular hyperfiltration in adults with sickle cell anemia: a multicenter pooled analysis
Clinical Trials & Observations
Kenneth I. Ataga,Qingning Zhou,Santosh L. Saraf,Jane S. Hankins,Emily J. Ciccone,Laura R. Loehr,Allison E. Ashley-Koch,Melanie E. Garrett,Jianwen Cai,Marilyn J. Telen,Vimal K. Derebail
View Articletitled, Longitudinal study of glomerular hyperfiltration in adults with sickle cell anemia: a multicenter pooled analysis
Supplemental data
Depth of response and response kinetics of isatuximab plus carfilzomib and dexamethasone in relapsed multiple myeloma
Clinical Trials & Observations
Thomas Martin,Joseph Mikhael,Roman Hajek,Kihyun Kim,Kenshi Suzuki,Cyrille Hulin,Mamta Garg,Hang Quach,Hanlon Sia,Anup George,Tatiana Konstantinova,Marie-Laure Risse,Gaelle Asset,Sandrine Macé,Helgi van de Velde,Philippe Moreau
View Articletitled, Depth of response and response kinetics of isatuximab plus carfilzomib and dexamethasone in relapsed multiple myeloma

GENE THERAPY

In vivo HSC transduction in rhesus macaques with an HDAd5/3+ vector targeting desmoglein 2 and transiently overexpressing cxcr4
Hongjie Wang,Audrey Germond,Chang Li,Sucheol Gil,Jiho Kim,Hans-Peter Kiem,André Lieber
View Articletitled, In vivo HSC transduction in rhesus macaques with an HDAd5/3<strong>+</strong> vector targeting desmoglein 2 and transiently overexpressing cxcr4
Supplemental data

HEALTH SERVICES AND OUTCOMES

Evaluating the impact of eligibility criteria in first-line clinical trials for follicular lymphoma: a MER/LEO cohort analysis
Danny Luan,Tolulope Fatola,Ahmed Toure,Christopher R. Flowers,Brian Link,Jonathan W. Friedberg,Jonathon B. Cohen,Brad Kahl,Izidore S. Lossos,Loretta Nastoupil,Matthew J. Maurer,James R. Cerhan,Peter Martin
View Articletitled, Evaluating the impact of eligibility criteria in first-line clinical trials for follicular lymphoma: a MER/LEO cohort analysis
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Refining the migration and engraftment of short-term and long-term HSCs by enhancing homing-specific adhesion mechanisms
Asma S. Al-Amoodi,Yanyan Li,Arwa Al-Ghuneim,Hanaa Allehaibi,Ioannis Isaioglou,Luke E. Esau,Dina B. AbuSamra,Jasmeen S. Merzaban
View Articletitled, Refining the migration and engraftment of short-term and long-term HSCs by enhancing homing-specific adhesion mechanisms
Supplemental data
Single-cell transcriptomics reveals the identity and regulators of human mast cell progenitors
Chenyan Wu,Daryl Boey,Oscar Bril,Jennine Grootens,M. S. Vijayabaskar,Chiara Sorini,Maria Ekoff,Nicola K. Wilson,Johanna S. Ungerstedt,Gunnar Nilsson,Joakim S. Dahlin
View Articletitled, Single-cell transcriptomics reveals the identity and regulators of human mast cell progenitors
Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

The identification of TCF1+ progenitor exhausted T cells in THRLBCL may predict a better response to PD-1/PD-L1 blockade
Valentina Tabanelli,Federica Melle,Giovanna Motta,Saveria Mazzara,Marco Fabbri,Claudio Agostinelli,Angelica Calleri,Marcello Del Corvo,Stefano Fiori,Daniele Lorenzini,Alessandra Cesano,Annalisa Chiappella,Umberto Vitolo,Enrico Derenzini,Gabriel K. Griffin,Scott J. Rodig,Anna Vanazzi,Elena Sabattini,Corrado Tarella,Maria Rosaria Sapienza,Stefano A. Pileri
View Articletitled, The identification of TCF1<sup>+</sup> progenitor exhausted T cells in THRLBCL may predict a better response to PD-1/PD-L1 blockade
Supplemental data

LYMPHOID NEOPLASIA

Risk of diabetes and the impact on preexisting diabetes in patients with lymphoma treated with steroid-containing immunochemotherapy
Joachim Baech,Marianne Tang Severinsen,Andreas K. Øvlisen,Henrik Frederiksen,Peter Vestergaard,Christian Torp-Pedersen,Judit Jørgensen,Michael Roost Clausen,Christian B. Poulsen,Peter Brown,Anne Ortved Gang,Robert Schou Pedersen,Karin Ekström Smedby,Sandra Eloranta,Lasse Hjort Jakobsen,Tarec Christoffer El-Galaly
View Articletitled, Risk of diabetes and the impact on preexisting diabetes in patients with lymphoma treated with steroid-containing immunochemotherapy
Supplemental data
Enhanced systemic antilymphoma immune response by photothermal therapy with CpG deoxynucleotide–coated nanoparticles
Adam Yuh Lin,Bongseo Choi,Taehoon Sim,Eva Yang,Hyunjun Choi,Amir Behdad,Dong-Hyun Kim,Leo I. Gordon
View Articletitled, Enhanced systemic antilymphoma immune response by photothermal therapy with CpG deoxynucleotide–coated nanoparticles
Supplemental data

PLATELETS AND THROMBOPOIESIS

Anchoring IgG-degrading enzymes to the surface of platelets selectively neutralizes antiplatelet antibodies
Donald R. Lynch, Jr,Emily N. Stringham,Boya Zhang,Ginette Balbin-Cuesta,Brian R. Curtis,Joseph S. Palumbo,Colin F. Greineder,Benjamin E. Tourdot
View Articletitled, Anchoring IgG-degrading enzymes to the surface of platelets selectively neutralizes antiplatelet antibodies
Supplemental data

THROMBOSIS AND HEMOSTASIS

CIC-39Na reverses the thrombocytopenia that characterizes tubular aggregate myopathy
Celia Cordero-Sanchez,Emanuela Pessolano,Beatrice Riva,Mauro Vismara,Silvia Maria Grazia Trivigno,Nausicaa Clemente,Silvio Aprile,Federico Alessandro Ruffinatti,Paola Portararo,Nicoletta Filigheddu,Ivan Zaggia,Irene P. Bhela,Marta Serafini,Tracey Pirali,Mario P. Colombo,Mauro Torti,Sabina Sangaletti,Alessandra Bertoni,Armando A. Genazzani
View Articletitled, CIC-39Na reverses the thrombocytopenia that characterizes tubular aggregate myopathy
Supplemental data
Anticoagulant therapy for splanchnic vein thrombosis: an individual patient data meta-analysis
Matteo Candeloro,Emanuele Valeriani,Manuel Monreal,Walter Ageno,Nicoletta Riva,Raquel Lopez-Reyes,Maria Luisa Peris,Jan Beyer Westendorf,Sam Schulman,Vladimir Rosa,Juan José López-Núñez,Juan-Carlos Garcia-Pagan,Marta Magaz,Marco Senzolo,Andrea De Gottardi,Marcello Di Nisio
View Articletitled, Anticoagulant therapy for splanchnic vein thrombosis: an individual patient data meta-analysis
Supplemental data
GRK2 regulates ADP signaling in platelets via P2Y1 and P2Y12
Xuefei Zhao,Matthew Cooper,James V. Michael,Yanki Yarman,Aiden Baltz,J. Kurt Chuprun,Walter J. Koch,Steven E. McKenzie,Maurizio Tomaiuolo,Timothy J. Stalker,Li Zhu,Peisong Ma
View Articletitled, GRK2 regulates ADP signaling in platelets via P2Y<sub>1</sub> and P2Y<sub>12</sub>
Supplemental data
Predicting major bleeding during extended anticoagulation for unprovoked or weakly provoked venous thromboembolism
Clinical Trials & Observations
Philip S. Wells,Tobias Tritschler,Faizan Khan,David R. Anderson,Susan R. Kahn,Alejandro Lazo-Langner,Marc Carrier,Grégoire Le Gal,Lana A. Castellucci,Vinay Shah,Scott Kaatz,Clive Kearon,Susan Solymoss,Russell Zide,Sam Schulman,Isabelle Chagnon,Ranjeeta Mallick,Marc A. Rodger,Michael J. Kovacs
View Articletitled, Predicting major bleeding during extended anticoagulation for unprovoked or weakly provoked venous thromboembolism
Supplemental data
CD44–fibrinogen binding promotes bleeding in acute promyelocytic leukemia by in situ fibrin(ogen) deposition
Chunxu Wang,Yufeng Wang,Nan Zuo,Shaohong Fang,Jialan Shi
View Articletitled, CD44–fibrinogen binding promotes bleeding in acute promyelocytic leukemia by in situ fibrin(ogen) deposition
Supplemental data

TRANSFUSION MEDICINE

Using whole-genome sequencing to characterize clinically significant blood groups among healthy older Australians
Sudhir Jadhao,Candice Davison,Eileen V. Roulis,Simon Lee,Paul Lacaze,Moeen Riaz,John J. McNeil,David M. Thomas,Natalie M. Pecheniuk,Catherine A. Hyland,Robert L. Flower,Shivashankar H. Nagaraj
View Articletitled, Using whole-genome sequencing to characterize clinically significant blood groups among healthy older Australians
Supplemental data

TRANSPLANTATION

Organ-specific response after low-dose interleukin-2 therapy for steroid-refractory chronic graft-versus-host disease
Haesook T. Kim,John Koreth,Jennifer Whangbo,Sarah Nikiforow,Carol G. Reynolds,Peter Stowe,Vincent T. Ho,Corey Cutler,Joseph H. Antin,Robert J. Soiffer,Jerome Ritz
View Articletitled, Organ-specific response after low-dose interleukin-2 therapy for steroid-refractory chronic graft-versus-host disease
Supplemental data
Improved GRFS after posttransplant cyclophosphamide-based vs ATG-based HLA-mismatched unrelated donor transplant
Antonio Jimenez Jimenez,Krishna Komanduri,Samantha Brown,Trent Wang,Denise Pereira,Mark Goodman,Amer Beitinjaneh,Lazaros Lekakis,Stephanie Chinapen,Sean Devlin,Doris Ponce,Craig Sauter,Miguel-Angel Perales,Brian C. Shaffer
View Articletitled, Improved GRFS after posttransplant cyclophosphamide-based vs ATG-based HLA-mismatched unrelated donor transplant
Supplemental data
Improvements in allogeneic hematopoietic cell transplantation outcomes for adults with ALL over the past 3 decades
Clinical Trials & Observations
Satoshi Nishiwaki,Yu Akahoshi,Mari Morita-Fujita,Hiroaki Shimizu,Naoyuki Uchida,Yukiyasu Ozawa,Takahiro Fukuda,Masatsugu Tanaka,Kazuhiro Ikegame,Shuichi Ota,Yuta Katayama,Satoshi Takahashi,Toshiro Kawakita,Takahide Ara,Makoto Onizuka,Takafumi Kimura,Junji Tanaka,Yoshiko Atsuta,Yasuyuki Arai,for the Adult Acute Lymphoblastic Leukemia Working Group of the Japan Society for Transplantation and Cellular Therapy
View Articletitled, Improvements in allogeneic hematopoietic cell transplantation outcomes for adults with ALL over the past 3 decades
Supplemental data
Impact of MRD status in patients with AML undergoing allogeneic stem cell transplantation in the first vs the second remission
Madlen Jentzsch,Lara Bischof,Donata Backhaus,Dominic Brauer,Julia Schulz,Georg-Nikolaus Franke,Vladan Vucinic,Dietger Niederwieser,Uwe Platzbecker,Sebastian Schwind
View Articletitled, Impact of MRD status in patients with AML undergoing allogeneic stem cell transplantation in the first vs the second remission
Supplemental data

VASCULAR BIOLOGY

Defective VWF secretion due to expression of MYH9-RD E1841K mutant in endothelial cells disrupts hemostasis
Yang Cao,Yanjie Sun,Yanan Deng,Guoqin Wei,Junling Liu,Shengyu Jin,Chao Dong,Xuya Kang,Yingqing Huo,Jingjing Zhang,Jincai Luo
View Articletitled, Defective VWF secretion due to expression of <em>MYH9</em>-RD E1841K mutant in endothelial cells disrupts hemostasis
Supplemental data

RESEARCH LETTERS

Clonal hematopoiesis in patients with ANKRD26 or ETV6 germline mutations
Clinical Trials & Observations
Michael W. Drazer,Claire C. Homan,Kai Yu,Marcela Cavalcante de Andrade Silva,Kelsey E. McNeely,Matthew J. Pozsgai,Maria G. Acevedo-Mendez,Jeremy P. Segal,Peng Wang,Jinghua Feng,Sarah L. King-Smith,Erika Kim,Sophia Korotev,David M. Lawrence,Andreas W. Schreiber,Christopher N. Hahn,Hamish S. Scott,Raman Sood,NISC Comparative Sequencing Program,Elvira D. R. P. Velloso,Anna L. Brown,Paul P. Liu,Lucy A. Godley
View Articletitled, Clonal hematopoiesis in patients with <em>ANKRD26</em> or <em>ETV6</em> germline mutations
Supplemental data
Treatment of an HLH-mimic disease based on HAVCR2 variants with absent TIM-3 expression
Clinical Trials & Observations
Samantha A. M. Tromp,Marijn A. Gillissen,Sophie J. Bernelot Moens,Ester M. M. van Leeuwen,Machiel H. Jansen,Lianne Koens,Caroline E. Rutten,Taco W. Kuijpers
View Articletitled, Treatment of an HLH-mimic disease based on <em>HAVCR2</em> variants with absent TIM-3 expression
Supplemental data
Venetoclax retreatment of patients with chronic lymphocytic leukemia after a previous venetoclax-based regimen
Clinical Trials & Observations
Meghan C. Thompson,Rosemary A. Harrup,Catherine C. Coombs,Lindsey E. Roeker,Jeffrey J. Pu,Michael Y. Choi,Paul M. Barr,John N. Allan,Martin Šimkovič,Lori Leslie,Joanna Rhodes,Elise A. Chong,Manali Kamdar,Alan Skarbnik,Frederick Lansigan,Brittany McCall,Khalid Saja,Martin J. S. Dyer,Harriet S. Walter,Marcus Lefebure,Maria Thadani-Mulero,Michelle Boyer,Juliana Biondo,Kavita Sail,Beenish S. Manzoor,Richard Furman,Kurt S. Bantilan,Andre Goy,Tatyana Feldman,Dominic Labella,Stephen J. Schuster,Jae Park,Lia Palomba,Andrew Zelenetz,Toby A. Eyre,Arnon P. Kater,John F. Seymour,Anthony R. Mato
View Articletitled, Venetoclax retreatment of patients with chronic lymphocytic leukemia after a previous venetoclax-based regimen
Real-world characteristics of T-cell apheresis and clinical response to tisagenlecleucel in B-cell lymphoma
Alexis Cuffel,Vincent Allain,Lionel Faivre,Roberta Di Blasi,Florence Morin,Laetitia Vercellino,Mathieu F. Chevalier,Aude Desnoyer,Romain de Jorna,Isabelle Madelaine,Nathalie Parquet,Anne C. Brignier,Catherine Thieblemont,Jerome Larghero,Sophie Caillat-Zucman,Miryam Mebarki
View Articletitled, Real-world characteristics of T-cell apheresis and clinical response to tisagenlecleucel in B-cell lymphoma
Supplemental data

COMMENTARY

RR6 prognostic model provides information about survival for myelofibrosis treated with ruxolitinib: validation in a real-life cohort
Emilia Scalzulli,Claudia Ielo,Cristina Luise,Paolo Musiu,Maria L. Bisegna,Ida Carmosino,Giovanni M. Assanto,Maurizio Martelli,Massimo Breccia
View Articletitled, RR6 prognostic model provides information about survival for myelofibrosis treated with ruxolitinib: validation in a real-life cohort

ERRATA

Koh MJ, Merrill MH, Koh MJ, et al. Comparative outcomes for mature T-cell and NK/T-cell lymphomas in people with and without HIV and to AIDS-defining lymphomas. Blood Adv. 2022;6(5):1420-1431.
View Articletitled, Koh MJ, Merrill MH, Koh MJ, et al. Comparative outcomes for mature T-cell and NK/T-cell lymphomas in people with and without HIV and to AIDS-defining lymphomas. <em>Blood Adv.</em> 2022;6(5):1420-1431.
Etra A, Gergoudis S, Morales G, et al. Assessment of systemic and gastrointestinal tissue damage biomarkers for GVHD risk stratification. Blood Adv. 2022;6(12):3707-3715.
View Articletitled, Etra A, Gergoudis S, Morales G, et al. Assessment of systemic and gastrointestinal tissue damage biomarkers for GVHD risk stratification. <em>Blood Adv.</em> 2022;6(12):3707-3715.
Akhmetzyanova I, Aaron T, Galbo P, et al. Tissue-resident macrophages promote early dissemination of multiple myeloma via IL-6 and TNFα. Blood Adv. 2021;5(18):3592-3608.
View Articletitled, Akhmetzyanova I, Aaron T, Galbo P, et al. Tissue-resident macrophages promote early dissemination of multiple myeloma via IL-6 and TNFα. <em>Blood Adv.</em> 2021;5(18):3592-3608.
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