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Research Article December 18 2025

Platelet Dysfunction in Chronic Kidney Disease Arises from Bone Marrow Remodeling and Megakaryocyte Reprogramming

Estelle Carminita,Virginia Camacho,Siobhan Branfield,Ethan Walsey,Maria N Barrachina,Dylan Nicholas Tabang,Dong H Lee,Isabelle C Becker,Sergey Brodsky,Samer M Issa,Nicolas Gendron,Sarah Machado,Alisa S. Wolberg,Hanno Steen,Bryce A Kerlin,Kellie R Machlus,Abolfazl Zarjou,Joseph E Italiano

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Research Article December 18 2025

10-year experience of CD22 CAR T-cells for children and young adults with B-cell acute lymphoblastic leukemia

Alexandra Dreyzin,Bonnie Yates,Haneen N Shalabi,Sara K Silbert,Hao-Wei Wang,Constance M. Yuan,Chloe N Hoang,August A Culbert,Flavia Gava,Monica S Nair,Victoria M Giordani,Lauren Little,Toni Foley,Veronique Nussenblatt,Terry J Fry,David F Stroncek,Steven L Highfill,Nirali N Shah

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Research Article December 18 2025

Plasma Cell Leukemia: Genomic Features and Their Potential Relevance for Exploring Clinical Actionability

Meera Mohan,Natalie Danziger,Othman Salim Akhtar,Ravi Narra,Marcelo C. Pasquini,Sabarinath Venniyil Radhakrishnan,Binod Dhakal,Anita D'Souza,Douglas I Lin,Caleb Ho,Razelle Kurzrock

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Research Article December 18 2025

Allele-selective Disruption of Pathogenic VWF Variants in Type 2 Von Willebrand Disease using CRISPR/Cas9

Isabel Bär,Stijn A. Groten,Alastair Barraclough,Petra E. Bürgisser,Calvin van Kwawegen,Peter J Lenting,Iris van Moort,Jeroen C.J. Eikenboom,Frank W.G. Leebeek,Jan Voorberg,Maartje van den Biggelaar,Ruben Bierings

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Letter December 18 2025

Early CAR T-cell therapy in relapsed/refractory large B-cell lymphoma is associated with lower hematotoxicity burden

Vanja Zeremski,Enver Aydilek,Akhil Behringer,Franziska Brunner,Tobias Ronny Haage,Mathias Haenel,Igor Age Kos,William Hermann Krueger,Georg Lenz,Vadim Lesan,Jessica Schneider,Christian R Schultze-Florey,Evgenii Shumilov,Thomas Weber,Gerald Georg Wulf,Vladan Vucinic,Dimitrios Mougiakakos

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Letter December 18 2025

Real world comparison of progression free survival and time to next therapy in 761 newly diagnosed multiple myeloma patients

Hira Mian,Mariano Arribas,Rafael Fonseca,Erin Mutterback,Omar Shahid,Rohan Gouda,Gregory Russell Pond,Alissa Visram

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Letter December 12 2025

Outcomes of Radiation Integrated with T-cell-engaging Bispecific Antibodies in Relapsed/Refractory Multiple Myeloma

Heta Patel,Harper Hubbeling,Kyle L. Yu,Maribel Carpenter,Michael J. LaRiviere,John P. Plastaras,Adam D. Cohen,Shivani Kapur,Dan T Vogl,Adam J Waxman,Edward A Stadtmauer,Alfred L Garfall,Sandra Patricia Susanibar-Adaniya

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Research Article December 12 2025

Impact of Age on Graft-vs-Host Disease and Overall Survival in Pediatric Hematopoietic Cell Transplant Recipients

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Research Article December 12 2025

Genome-wide copy number profiling enhances risk stratification in multiple myeloma by shallow whole-genome sequencing

Baijun Fang,Zunmin Zhu,Yinyin Chang,Xiangxiang He,Shiyong Li,Manqian Li,Susu Yan,Dandan Zhu,Zhenling Li,Mao Mao

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Research Article December 11 2025

Venetoclax and ibrutinib induces durable clinical responses in marginal zone lymphoma

Sasanka M. Handunnetti,Amit Khot,Piers Blombery,Kate Burbury,Philip A Thompson,David Ritchie,Rodney John Hicks,Glenda Burke,Rachel M Koldej,Mathias Bressel,Juliana L Di Iulio,David A Westerman,Stephen Lade,Andrew W. Roberts,John F Seymour,Constantine S. Tam,Mary Ann Anderson

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Research Article December 11 2025

Systematic functional validation of IKAROS variants from patients and laboratory-generated mutations

Hye Sun Kuehn,Agustin Alejandro Gil Silva,Natchanun Klangkalya,Ana Esteve-Sole,Shubham Goel,Julie E Niemela,Jennifer L Stoddard,Hey Chong,Kelli W Williams,Winnie Ip,Mario Framil Seoane,Sathish K Loganathan,Ariharan Anantharachagan,Ana García-Soidán,Serena Beth Shaffren,Constance Bindernagel,Philip Mendez,Rahim Z Miller,Hassan Abolhassani,David P Hoytema van Konijnenburg,Ashley V Geerlinks,Diana Cabanillas,Evelien Zonneveld-Huijssoon,Abraham Rutgers,Stuart G. Tangye,Cindy S Ma,Alice Grey,Patrick O'Young,Juan Carlos Aldave Becerra,Jonathan J Lyons,Andrew White,Michael Claiborne,Ali Doroudchi,Brian D Modena,Joshua D. Milner,Xavier Solanich,João Farela Neves,Craig Platt,Lennart Hammarström,John Routes,James Verbsky,Manish Butte,Harry Lesmana,William JH Griffiths,Dinakantha S Kumararatne,Fabian Hauck,Luis M Allende,Carlos Rodríguez-Gallego,Reem Elfeky,Tamar Sarah Rubin,Kaan Boztug,Thomas A. Fleisher,Sergio D Rosenzweig

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Letter December 11 2025

Prognosis and patterns of progression in smoldering multiple myeloma

Theresia Akhlaghi,Kylee H. Maclachlan,Adriana Wiggins,Saad Z. Usmani,Andriy Derkach,Malin L Hultcrantz

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Letter December 11 2025

Real-world evidence of measurable residual disease assessment in multiple myeloma

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Research Article December 11 2025

Benefit of Rituximab Maintenance After First-line Bendamustine-Rituximab in Patients with Mantle Cell Lymphoma

Yucai Wang,Melissa C Larson,Steven R Hwang,Diego Villa,Laveniya Kugathasan,Anita Kumar,Ashlee Joseph,Taylor R Brooks,Brian T. Hill,David A Bond,Kami J Maddocks,Imran A Nizamuddin,Brad S. Kahl,Alexey V Danilov,Christine Argao,Jia Ruan,Christine E. Ryan,Reid W Merryman,Natalie S. Grover,Nazneen B Khan,Evguenia Ouchveridze,Aung Tun,Sabarish Ram Ayyappan,Eric Mou,Georgios N Pongas,Izidore S Lossos,Zoey Ilana Harris,Javier Munoz,Philip Young,Craig A. Portell,Firas Baidoun,Muhamad Alhaj Moustafa,Patrick M. Reagan,Lauren G Banaszak,Priyanka A. Pophali,Arash Velayati,Irl Brian Greenwell,Drew Gerber,Preetesh Jain,Michael L. Wang,Mayur S. Narkhede,Amitkumar Nitinkumar Mehta,Anthony C Stack,Marcus R. Messmer,Rahul S Bhansali,Stefan K. Barta,Tamara K Moyo,Nilanjan Ghosh,Manali Kamdar,Jacob L Anna,Alexander Stanisic,Reem Karmali,Matthew J Maurer,James R Cerhan,Jonathon B Cohen,Peter Martin

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Research Article December 10 2025

CAR T cells targeting C-C motif chemokine receptor 4 (CCR4) selectively deplete human Tregs ex vivo and in vivo

Caitlin M Tilsed,Karen P Fong,Xinyi Shi,Tatiana Akimova,Liqing Wang,Estela Noguera-Ortega,Ryan Krouse,Andres Bermudez,Sunil Singhal,Regina M. Young,Evgeniy Eruslanov,Keisuke Watanabe,Wayne W. Hancock,Carl H. June,Steven Albelda

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Review Article December 10 2025

Towards New Therapy Endpoints in Polycythemia Vera: Targeting Clonal and Inflammatory Pathways

Tiziano Barbui,Joseph Michael Scandura

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Research Article December 10 2025

Clinical Characteristics, Management, and Hematopoietic Cell Transplantation of Patients with TLR8 Gain-of-Function

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Research Article December 10 2025

Neutrophil cathepsin G potentiates biased signaling through Protease Activated Receptor 4

NaShea C Kendrick,Germaine J Harvey,Sofia Andrea Castro,Carson J Rohan,Xu Han,Marvin T. Nieman

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Research Article December 9 2025

Elevated Lactate in AML Bone Marrow Contributes to Macrophage Polarization via GPR81 Signaling

Celia A Soto,Maggie L Lesch,Jennifer L Becker,Azmeer Sharipol,Amal Khan,Xenia L Schafer,Zhewen Li,Amanda R. Streeter,Michael W Becker,Joshua C Munger,Benjamin J Frisch

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Research Article December 9 2025

Microbiome and metabolite biomarkers of CAR T-cell therapy outcomes in relapsed/refractory diffuse large B cell lymphoma

Sang Eun Yoon,Woorim Kang,Junhun Cho,Hyeon Ji Cho,Mauricio Chalita,Hyun-Seok Oh,Dong-Wook Hyun,Sujeong Han,Hyun Kim,Hojun Sung,Jae-Yun Lee,Bon Park,Kyung Ju Ryu,Hyun-Young Kim,Duck Cho,Won Seog Kim,Seok Jin Kim

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Letter December 9 2025

Belamaf: Is Renal Toxicity an Overlooked Side Effect?

Gisella Vischini,Paola Tacchetti,Laura Pavan,Simona Barbuto,Daniele Vetrano,Anita Campus,Valeria Grandinetti,Luca Massarotti,Ivan Zatta,Katia Mancuso,Maria Teresa Petrucci,Renato Zambello,Gaetano La Manna

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Reply December 9 2025

Clarifying comparative evidence on epcoritamab

Alexey V Danilov

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Research Article December 8 2025

Cutaneous diffuse large B-cell lymphoma induces a macrophage immunosuppressive phenotype through IL-10 secretion.

Jean Galtier,Rémi Peanne,Valérie Le Morvan,Thibaut Blondy,Maïlys Melane,Aurore Bidon,Arnaud Chopin,Martina Prochazkova-Carlotti,Sandrine Poglio,Jean-Philippe Merlio,Edith Chevret,Audrey Gros,Anne Pham-Ledard,Marie Beylot-Barry,Laurence Bresson-Bepoldin

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Letter December 8 2025

Impact of Perforin 1 A91V germline background in patients with aggressive B-NHL treated with R-CHOP

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Research Article December 8 2025

Evaluating the American Society of Hematology Quality Measure on Timeliness of Analgesics for Sickle Cell Disease Pain Crisis

Ibrahim Gwarzo,Harish Chandra Dega,Paula J Tanabe,Robin E Miller,David Brousseau

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Letter December 6 2025

Studying clonal heterogeneity of acute myeloid leukemia under nutrient and chemotherapy stress

Christina Mayerhofer,Eve Crompton,Ernst Mayerhofer,Trine A. Kristiansen,Tsuyoshi Fukushima,Samuel Keyes,Azeem Sharda,Dan Li,Carmen Da Silva,Deumaya Shrestha,Anna Kiem,Tobias Feuchtinger,David T Scadden,Peter Grant Miller

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Letter December 6 2025

Single-cell transcriptomics reveals heterocellular g-globin gene expression in Agdb-thalassemia

Phillip A Doerfler,Yichao Li,Yu Yao,Ruopeng Feng,Thiyagaraj Mayuranathan,Jingjing Zhang,Emilia Kooienga,David Cullins,Rohith Jesudas,Dillon C Williams,Jane S Hankins,Yong Cheng,David K Wood,Mitchell J. Weiss

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Research Article December 6 2025

Outcomes of relapsed or refractory acute myeloid leukemia after menin inhibition failure

Kuo-Kai Chin,Brian J. Ball,Yasmin Abaza,Jessica K Altman,Rahul K Thakur,Moiez Ali,Andriy Derkach,Mark B. Geyer,Aaron D. Goldberg,Tamanna Haque,Meghan C. Thompson,Jae H Park,Martin S. Tallman,Sheng F. Cai,Eunice S. Wang,Ibrahim Aldoss,Eytan M. Stein

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Review Article December 6 2025

Inclusion, characteristics and reporting of older patients in recent registration trials for DLBCL: A systematic review

Nina Rosa Neuendorff,Kelly Pugh,Ronit Juthani,Celine Soudant,Colm Mac Eochagain,Pallawi Torka

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Letter December 5 2025

Identification of a Conformational Epitope on the E Antigen Implicated in Anti-E Alloimmunization

Hideaki Matsuura,Ayuna Yamada,Hiroki Doi,Sumie Fujii,Yasuo Miura

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Review Article December 5 2025

The Interplay of Von Willebrand Disease and Women's Reproductive Health

Arielle L Langer,Sarah H. O'Brien

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Letter December 5 2025

Utilization Patterns of Hematology Consultation in the Intensive Care Unit: An 11-year Single Center Experience

Cecily Allen,Michael B Streiff,Rakhi P. Naik,Nitin Seam,Sameer Kadri,Alfred I Lee,Melissa Knauert,George Goshua

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Research Article December 5 2025

Venetoclax/FluBu2 RIC transplant followed by all-oral venetoclax/decitabine maintenance for poor risk MDS/AML

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Research Article December 5 2025

Foundations of Systems-Based Hematology: Thematic Analysis of Expert Interviews to Guide Curriculums and Promote Growth

Richard C. Godby,Jacob C. Cogan,Adam Cuker,David A Garcia,Ming Y Lim,Camila Masias,Jori Ellen May,Colleen T. Morton,Jordan K Schaefer,Surbhi Shah,Marc Zumberg,Ariela L. Marshall

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Research Article December 4 2025

Vulnerability of SRSF2 mutated chronic myelomonocytic leukemia to perturbation of cGAS-STING pathway

Yanan Chen,Koon Chuen Chan,Chun Fung Sin,Lichuan Zheng,Dandan Wang,Lingge Tu,Fangfang He,Wan Hei Jeffrey Hui,Hoi Ki Leung,Leslie Kar Fai Chan,Sze Pui Tsui,Hoi-yi Chan,Alvin Chun Hang Ma,Anskar YH Leung,Xuan Sun

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Research Article December 4 2025

Impact of fitness categorization according to SIE/SIES/GITMO criteria in therapy-related and AML-MRC receiving CPX-351.

Raffaele Palmieri,Fabio Guolo,Luana Fianchi,Felicetto Ferrara,Paola Minetto,Maria Paola Martelli,Carola Riva,Patrizia Chiusolo,Michela Rondoni,Saveria Capria,Clara Minotti,Federica Pilo,Salvatore Perrone,Andrea Corbingi,Francesco Grimaldi,Giulia De Luca,Carla Fili,Caterina Alati,Francesco Mannelli,Federica Lessi,Francesco Marchesi,Lorenzo Brunetti,Debora Capelli,Anna Lina Piccioni,Calogero Vetro,Fanny Erika Palumbo,Carla Mazzone,Alessandra Sperotto,Giovanni Luzi,Michelina Dargenio,Sabrina Mariani,Marco Cerrano,Antonino Mulè,Ambra Di Veroli,Elisa Meddi,Federico Moretti,Cristina Papayannidis,Alessandro Isidori,Antonella Ferrari,Sara Galimberti,Daniela Cilloni,Massimo Breccia,Francesco Lanza,Michele Gottardi,Roberto Cairoli,Anna Candoni,Livio Pagano,Elisabetta Todisco,Roberto Massimo Lemoli,Adriano Venditti,Francesco Buccisano

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Research Article December 4 2025

Proinflammatory GSDMD activation in live macrophages and DLBCL cells marks cognate interactions and better prognosis

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Research Article December 4 2025

Hematopoietic Cell Transplantation for Wiskott-Aldrich syndrome: A PIDTC Report

Jessie L Alexander,Blachy J. Dávila Saldaña,Ruta Brazauskas,Sravya Gethika Dammalapati,Linda M Griffith,Ami J. Shah,Kristin A Shimano,Hans D Ochs,Jack Bleesing,Christen L Ebens,Malika Kapadia,Andrea Bauchat,Neena Kapoor,Joseph H. Oved,Hesham Eissa,Hannah Lust,Michael D. Keller,Hilary Haines,Shanmuganathan Chandrakasan,Julie-An M. Talano,Ahmad Rayes,Lisa M. Madden,Evan B. Shereck,Holly K Miller,Lisa R Forbes Satter,Caridad A. Martinez,Jacob Rozmus,Jeffrey J Bednarski,Lolie C Yu,Deepakbabu Chellapandian,Victor M. Aquino,Alan P Knutsen,Hey Chong,Ashley Chopek,Alfred P Gillio,Avni Joshi,Hemalatha G. Rangarajan,Theodore B Moore,Jeffrey R. Andolina,Kenneth DeSantes,Mark T Vander Lugt,Susan E Prockop,David Shyr,Kathleen E. Sullivan,Suhag H Parikh,Katja G. Weinacht,Troy R. Torgerson,Rebecca A Marsh,Christopher C Dvorak,Alice Y Chan,Elie Haddad,Jennifer Heimall,Michael A. Pulsipher,Jennifer W Leiding,Donald B. Kohn,Jennifer M Puck,Luigi D Notarangelo,David J Rawlings,Morton J Cowan,Aleksandra Petrovic,Sung-Yun Pai,Lauri M. Burroughs

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Letter December 4 2025

ASH's Commitment to SCD: Building on 10 Years of Progress

Alexander Boucher,Oladipo Bankole Cole,Payal Chandarana Desai,Chancellor Donald,Titilope A Fasipe,Charles T. Quinn,Julie Kennedy Lesch,Alexis A. Thompson

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Research Article December 3 2025

Emapalumab use in malignancy-associated hemophagocytic lymphohistiocytosis in the United States: The REAL-HLH study

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Research Article December 3 2025

Reduced PRC2 function causes asparaginase resistance in T-ALL by decreasing WNT pathway activity

Thomas Lefeivre,Theodora-Ioana Grosu,Cosmin Tudose,Luke Jones,Theresa Elizabeth Leon,Kieran Wynne,Giorgio Oliviero,Owen Smith, Professor,Amélie Trinquand,Marc R. Mansour,Colm J Ryan,Jonathan Bond

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Research Article December 3 2025

Increasing ketamine administration in children's hospitals for youth with sickle cell disease

Ashley Jenkins,Erin Hendry,Alexandra Power-Hays,Marin Valentino,Matthew Hall,Kathryn E. Kyler,James W Antoon,Sonya Tang Girdwood,Jennifer Goldman,Armand Morel,Timothy Savage,Lucas Orth,Natasha M. Archer

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Review Article December 3 2025

Consensus Recommendations from the 2024 International Follicular Lymphoma Scientific Workshop

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Research Article December 1 2025

Regional Brain Age is Decreased in Children with Sickle Cell Anemia

Amy E. Mirro,Landon Christian Power,Jinli Wang,Paula Germino-Watnick,Heather Roberts,Yonca Cam,Kristin Guilliams,Slim Fellah,Yasheng Chen,Hongyu An,Jin-Moo Lee,Andria L. Ford,Melanie E Fields

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Letter December 1 2025

Bioenergetic diversity and nutrient auxotrophy shape the metabolic landscape of Multiple Myeloma

Phyllis SY Chong,SL Julia Lim,Tuan Zea Tan,Li Ren Kong,Sanjay De Mel,Aaron Leow Chung Yong,Ernest Yap Gim Seng,Wee-Joo Chng

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Research Article December 1 2025

Engraftment of gene-edited hematopoietic stem cells after antibody-drug conjugate conditioning in nonhuman primates

Jason David Murray,Teresa K Einhaus,Stefan Radtke,Katharine J Bar,Christopher William Peterson,Hans-Peter Kiem

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Research Article December 1 2025

FLT3-directed BiTE Molecules versus CAR T Cells in AML: Co-stimulatory Signals Mitigate T-Cell Exhaustion

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Research Article November 26 2025

Clonal hematopoiesis may precede the diagnosis of aplastic anemia by several years

Qian Wei Liu,Fang Fang,Huiwen Xue,Tove Wästerlid,Karin E. Smedby,Xinyuan Liu

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Review Article November 26 2025

Hairy Cell Leukemia: a chronic B-lymphoma with unique clinicopathological features and unresolved molecular mechanisms

Ge Zhang,Jiancheng Hu

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Research Article November 26 2025

Humoral and cellular immune response after COVID-19 vaccination in patients with sickle cell disease on hydroxyurea

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First Edition

ASH Publications

American Society of Hematology

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