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Hans-Peter Kiem
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Journal Articles

A simplified G-CSF–free procedure allows for in vivo HSC gene therapy of sickle cell disease in a mouse model

Chang Li, Anna K. Anderson, Peter Ruminski, Michael Rettig, Darja Karpova, Hans-Peter Kiem, John F. DiPersio, André Lieber
Journal: Blood Advances
Blood Adv (2024) 8 (15): 4089–4101.
https://doi.org/10.1182/bloodadvances.2024012757
Published: 2024
Includes: Supplemental data
Journal Articles

Choosing the right mouse model: comparison of humanized NSG and NBSGW mice for in vivo HSC gene therapy

Seunga Choo, Carl B. Wolf, Heather M. Mack, Mitchell J. Egan, Hans-Peter Kiem, Stefan Radtke
Journal: Blood Advances
Blood Adv (2024) 8 (4): 916–926.
https://doi.org/10.1182/bloodadvances.2023011371
Published: 2024
Includes: Supplemental data
Journal Articles

Answering the “Doctor, can CAR-T therapy cause cancer?” question in clinic

Clinical Trials & Observations
Rahul Banerjee, Christina Poh, Alexandre V. Hirayama, Jordan Gauthier, Ryan D. Cassaday, Mazyar Shadman, Andrew J. Cowan, Brian G. Till, Damian J. Green, Hans-Peter Kiem, Ajay K. Gopal, David G. Maloney
Journal: Blood Advances
Blood Adv (2024) 8 (4): 895–898.
https://doi.org/10.1182/bloodadvances.2023012336
Published: 2024
Journal Articles

Timing of anti–PD-L1 antibody initiation affects efficacy/toxicity of CD19 CAR T-cell therapy for large B-cell lymphoma

Alexandre V. Hirayama, Erik L. Kimble, Jocelyn H. Wright, Salvatore Fiorenza, Jordan Gauthier, Jenna M. Voutsinas, Qian Wu, Cecilia C. S. Yeung, Nicolas Gazeau, Barbara S. Pender, Delaney R. Kirchmeier, Aiko Torkelson, Abigail N. Chutnik, Ryan D. Cassaday, Aude G. Chapuis, Damian J. Green, Hans-Peter Kiem, Filippo Milano, Mazyar Shadman, Brian G. Till, Stanley R. Riddell, David G. Maloney, Cameron J. Turtle
Journal: Blood Advances
Blood Adv (2024) 8 (2): 453–467.
https://doi.org/10.1182/bloodadvances.2023011287
Published: 2024
Includes: Supplemental data
Journal Articles

Factors associated with long-term outcomes of CD19 CAR T-cell therapy for relapsed/refractory CLL

Clinical Trials & Observations
Emily C. Liang, Aya Albittar, Jennifer J. Huang, Alexandre V. Hirayama, Erik L. Kimble, Andrew J. Portuguese, Aude Chapuis, Mazyar Shadman, Brian G. Till, Ryan D. Cassaday, Filippo Milano, Hans-Peter Kiem, Stanley R. Riddell, Cameron J. Turtle, David G. Maloney, Jordan Gauthier
Journal: Blood Advances
Blood Adv (2023) 7 (22): 6990–7005.
https://doi.org/10.1182/bloodadvances.2023011399
Published: 2023
Includes: Supplemental data
Journal Articles

Safe and efficient lentiviral vector integration with HSC-targeted gene therapy

Stefan Radtke, Dnyanada Pande, Mark Enstrom, Hans-Peter Kiem
Journal: Blood Advances
Blood Adv (2023) 7 (17): 5132–5136.
https://doi.org/10.1182/bloodadvances.2022009087
Published: 2023
Includes: Supplemental data
Journal Articles

Intraosseous delivery of platelet-targeted factor VIII lentiviral vector in humanized NBSGW mice

Julia H. Joo, Xuefeng Wang, Swati Singh, Chun-Yu Chen, Chong Li, Jennifer E. Adair, Hans-Peter Kiem, David J. Rawlings, Carol H. Miao
Journal: Blood Advances
Blood Adv (2022) 6 (19): 5556–5569.
https://doi.org/10.1182/bloodadvances.2022008079
Published: 2022
Includes: Supplemental data
Journal Articles

In vivo HSC transduction in rhesus macaques with an HDAd5/3 + vector targeting desmoglein 2 and transiently overexpressing cxcr4

Hongjie Wang, Audrey Germond, Chang Li, Sucheol Gil, Jiho Kim, Hans-Peter Kiem, André Lieber
Journal: Blood Advances
Blood Adv (2022) 6 (15): 4360–4372.
https://doi.org/10.1182/bloodadvances.2022007975
Published: 2022
Includes: Supplemental data
Journal Articles

Single-dose MGTA-145/plerixafor leads to efficient mobilization and in vivo transduction of HSCs with thalassemia correction in mice

Chang Li, Kevin A. Goncalves, Tamás Raskó, Amit Pande, Sucheol Gil, Zhinan Liu, Zsuzsanna Izsvák, Thalia Papayannopoulou, John C. Davis, Jr, Hans-Peter Kiem, André Lieber
Journal: Blood Advances
Blood Adv (2021) 5 (5): 1239–1249.
https://doi.org/10.1182/bloodadvances.2020003714
Published: 2021
Includes: Supplemental data
Journal Articles

Human hematopoietic stem cell maintenance and myeloid cell development in next-generation humanized mouse models

Trisha R. Sippel, Stefan Radtke, Tayla M. Olsen, Hans-Peter Kiem, Anthony Rongvaux
Journal: Blood Advances
Blood Adv (2019) 3 (3): 268–274.
https://doi.org/10.1182/bloodadvances.2018023887
Published: 2019
Includes: Supplemental data
Journal Articles

Rapid immune reconstitution of SCID-X1 canines after G-CSF/AMD3100 mobilization and in vivo gene therapy

Olivier Humbert, Frieda Chan, Yogendra S. Rajawat, Troy R. Torgerson, Christopher R. Burtner, Nicholas W. Hubbard, Daniel Humphrys, Zachary K. Norgaard, Patricia O’Donnell, Jennifer E. Adair, Grant D. Trobridge, Andrew M. Scharenberg, Peter J. Felsburg, David J. Rawlings, Hans-Peter Kiem
Journal: Blood Advances
Blood Adv (2018) 2 (9): 987–999.
https://doi.org/10.1182/bloodadvances.2018016451
Published: 2018
Includes: Supplemental data