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Issue Archive

Volume 9, Issue 7
April 8 2025
Blood Advances Cover Image for Volume 9, Issue 7

Table of Contents

INSIDE BLOOD ADVANCES

Germ line JAK2 variants and hereditary blood cancers
Clinical Trials & Observations
Joseph Cannova,Michael W. Drazer
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Best but not perfect: indirect measure of low iron stores
Franklin Njoku,Victor R. Gordeuk
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Agents of shield: glycans mask antibody epitopes on ADAMTS13
Colin A. Kretz
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SYSTEMATIC REVIEWS

Solitary plasmacytoma: single-institution experience, and systematic review and meta-analysis of clinical outcomes
Charalampos Charalampous,Jean-Sebastien Claveau,Prashant Kapoor,Moritz Binder,Francis K. Buadi,Joselle Cook,David Dingli,Angela Dispenzieri,Amie L. Fonder,Morie A. Gertz,Wilson Gonsalves,Suzanne R. Hayman,Miriam A. Hobbs,Yi L. Hwa,Taxiarchis Kourelis,Martha Q. Lacy,Nelson Leung,Yi Lin,Rahma Warsame,Robert A. Kyle,S. Vincent Rajkumar,Shaji K. Kumar
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Duration of primary/secondary treatment to prevent recurrent venous thromboembolism: a systematic review and meta-analysis
Anqi Li,Rasha Khatib,Luciane Cruz Lopes,Fazila Aloweni,Liming Lu,Qingyong He,Jiaming Wu,Peiming Zhang,Yuyuan Tang,Sureka Pavalagantharajah,Nigar Sekercioglu,Carlos A. Cuello Garcia,Serge Koujanian,Arnav Agarwal,Sean Alexander Kennedy,Ignacio Neumann,Sam Schulman,Wojtek Wiercioch,Gabriel Rada,Andrew M. Peseski,Thomas L. Ortel,Yu-Qing Zhang
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CLINICAL TRIALS AND OBSERVATIONS

Phase 2 trial of ibrutinib and nivolumab in patients with relapsed CNS lymphomas
Clinical Trials & Observations
Dai Chihara,Raphael E. Steiner,Ranjit Nair,Lei Feng,Sairah Ahmed,Paolo Strati,Luis Malpica,Donna P. Griffith,Shivon A. Mathew,Wirt Montinez,Gita Masand,Felipe Samaniego,Maria A. Rodriguez,Fredrick B. Hagemeister,Luis E. Fayad,Swaminathan P. Iyer,Loretta J. Nastoupil,Sattva S. Neelapu,Christopher R. Flowers,Jason R. Westin
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Changes in gut microbiota predict neutropenia after induction treatment in childhood acute lymphoblastic leukemia
Clinical Trials & Observations
Maria Ebbesen Sørum,Ulrika Boulund,Silvia De Pietri,Sarah Weischendorff,Christian Enevold,Mathias Rathe,Bodil Als-Nielsen,Henrik Hasle,Sünje Pamp,Jakob Stokholm,Klaus Müller
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Supplemental data
Trial eligibility, treatment patterns, and outcome for venetoclax-based therapy in AML: a prospective cohort study
Clinical Trials & Observations
Ofir Wolach,Itai Levi,Boaz Nachmias,Sigal Tavor,Irina Amitai,Yishai Ofran,Chezi Ganzel,Tsila Zuckerman,Doaa Okasha,Ilana Hellmann,Tamar Tadmor,Najib Dally,Jonathan Canaani,Galia Stemer,Moshe Grunspan,Adi Jacob Berger,Neta Frankel,Jenia Berelovich,Alexandra Bleterman,Moran Barak,Raanan Cohen,Yakir Moshe,on behalf of the Israeli Acute Leukemia Working Group
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Allogeneic off-the-shelf CAR T-cell therapy for relapsed or refractory B-cell malignancies
Clinical Trials & Observations
Sanam Shahid,Susan E. Prockop,Georgia C. Flynn,Audrey Mauguen,Charlie O. White,Jennifer Bieler,Devin McAvoy,Kinga Hosszu,Maria I. Cancio,Ann A. Jakubowski,Andromachi Scaradavou,Jaap Jan Boelens,Craig S. Sauter,Miguel-Angel Perales,Sergio A. Giralt,Clare Taylor,Jagrutiben Chaudhari,Xiuyan Wang,Isabelle Rivière,Michel Sadelain,Renier J. Brentjens,Nancy A. Kernan,Richard J. O'Reilly,Kevin J. Curran
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Extended clinical phenotypes and treatment modalities in 32 JAGN1-deficient patients: a multicenter study by ESID and EBMT IEWP
Clinical Trials & Observations
Julia Fekadu-Siebald,Emilia Salzmann-Manrique,Jan Robert Heusel,Andre Willasch,Fabian Hauck,Luis Ignacio Gonzalez-Granado,Zahra Chavoshzadeh,Samin Sharafian,Franziska Cuntz,Safa Baris,Andrea Finocchi,Mattia Algeri,Roya Sherkat,Maja Klaudel-Dreszler,Cornelia Zeidler,Christine Bellanné-Chantelot,Gerhard Kindle,Blandine Beaupain,Catherine Paillard,Markus Seidel,Peter Bader,Michael H. Albert,Bénédicte Neven,Jean Donadieu,Shahrzad Bakhtiar
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Six-month rituximab-lenalidomide regimen in advanced untreated follicular lymphoma: SAKK 35/10 trial 10-year update
Clinical Trials & Observations
Eva Kimby,Sämi Schär,Maria Cristina Pirosa,Anna Vanazzi,Ulrich M. Mey,Daniel Rauch,Björn E. Wahlin,Felicitas Hitz,Micaela Hernberg,Ann-Sofie Johansson,Peter de Nully Brown,Hans Hagberg,Andrés José María Ferreri,Fatime Krasniqi,Michèle Voegeli,Urban Novak,Thilo Zander,Hanne Bersvendsen,Christoph Mamot,Walter Mingrone,Anastasios Stathis,Stefan Dirnhofer,Stefanie Hayoz,Bjørn Østenstad,Emanuele Zucca
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HEALTH SERVICES AND OUTCOMES

Anxiety and depression among patients newly diagnosed with lymphoma and myeloma
Oreofe O. Odejide,Angel M. Cronin,Tamryn F. Gray,Tsotso Ablorh,Anna Ying,Amelia Yang,Cheyenne Ashley,Anna Tidswell,Eleanor Shi,Miryam Yusufov,Gregory A. Abel,Lizabeth Roemer
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IMMUNOBIOLOGY AND IMMUNOTHERAPY

Fc mutagenesis enhances the functionality of anti-RhD monoclonal antibodies
Behnaz Heydarchi,Damian B. D'Silva,Huon Wong,Ethan D. Goddard-Borger,Ian P. Wicks
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Differential antibody response to EBV proteome following EBVST immunotherapy in EBV-associated lymphomas
Clinical Trials & Observations
Yomani D. Sarathkumara,Nathan W. Van Bibber,Zhiwei Liu,Helen E. Heslop,Rayne H. Rouce,Anna E. Coghill,Cliona M. Rooney,Carla Proietti,Denise L. Doolan
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Supplemental data
Pretreatment pulmonary function testing has limited utility in B-cell lymphoma treated with CD19 CAR T cells
Inbal Sdayoor,Roni Shouval,Shalev Fried,Ronit Marcus,Ivetta Danylesko,Ronit Yerushalmi,Noga Shem-Tov,Orit Itzhaki,Elad Jacoby,Meirav Kedmi,Arnon Nagler,Avichai Shimoni,Michael J. Segel,Abraham Avigdor
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LYMPHOID NEOPLASIA

ATP citrate lyase is an essential player in the metabolic rewiring induced by PTEN loss during T-ALL development
Guillaume P. Andrieu,Guillaume Hypolite,Mehdi Latiri,Estelle Balducci,Caroline Costa,Els Verhoeyen,Marianne Courgeon,Omran Allatif,Ivan Nemazanyy,Ganna Panasyuk,Kathryn Wellen,Daniel Herranz,Laurent Genestier,Elizabeth Macintyre,Vahid Asnafi,Melania Tesio
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Molecular clustering on ctDNA improves the prognostic stratification of patients with DLBCL compared with ctDNA levels
Riccardo Moia,Donatella Talotta,Lodovico Terzi Di Bergamo,Mohammad Almasri,Riccardo Dondolin,Matin Salehi,Chiara Cosentino,Roberta Soscia,Irene Della Starza,Alessio Bruscaggin,Annalisa Andorno,Francesca Mercalli,Stefania Cresta,Riccardo Bomben,Tamara Bittolo,Filippo Vit,Pietro Bulian,Antonella Zucchetto,Riccardo Bruna,Giulia Maria Rivolta,Mattia Schipani,Eleonora Secomandi,Sreekar Kogila,Matteo Bellia,Samir Mouhssine,Jana Nabki,Bashar Al Deeban,Joseph Ghanej,Luca Cividini,Nawar Maher,Federica Melle,Giovanna Motta,Monica Leutner,Angela Lorenzi,Abdurraouf Mokhtar Mahmoud,Wael Al Essa,Clara Deambrogi,Silvia Rasi,Luigi Petrucci,Renzo Luciano Boldorini,Alice Di Rocco,Ilaria Del Giudice,Michele Spina,Stefano Palazzolo,Fabio Canal,Vincenzo Canzonieri,Maurizio Martelli,Stefano Pileri,Valter Gattei,Robin Foà,Davide Rossi,Gianluca Gaidano
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MYELOID NEOPLASIA

JAK2 p.R564 germ line variants associated with hereditary thrombocythemia and hematologic neoplasms
Clinical Trials & Observations
Brittany L. Stewart,Hetty E. Carraway,Adriana L. Alvarez,Harry Lesmana,John Molina,Zheng Jin Tu,David S. Bosler,Aaron Gerds,Babal Jha,Emilia Calvaresi,Joy Nakitandwe,Abhay Singh
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Germ line JAK2 variants and hereditary blood cancers
Clinical Trials & Observations
Joseph Cannova,Michael W. Drazer
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Dual ASXL1 and CSF3R mutations drive myeloid-biased stem cell expansion and enhance neutrophil differentiation
Lucie Darmusey,Anna J. Bagley,Thai T. Nguyen,Hanqian L. Carlson,Hunter Blaylock,Shawn B. Shrestha,Amara Pang,Samantha Tauchmann,Sarah C. Taylor,Amy C. Foley,Katia E. Niño,Eric M. Pietras,Theodore P. Braun,Julia E. Maxson
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PLATELETS AND THROMBOPOIESIS

The role of genetic sequencing in the diagnostic workup for chronic immune thrombocytopenia
Nehal Joshi,Hana Lango-Allen,Kate Downes,Ilenia Simeoni,Camelia Vladescu,Deena Paul,Alice Hart,Christine Ademokun,Nichola Cooper
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RED CELLS, IRON, AND ERYTHROPOIESIS

Ferritin outperforms other biomarkers in predicting bone marrow iron stores in patients with hematologic disorders
Tapio Lahtiharju,Paula Savola,Anna Lempiäinen,Tuukka Helin,Lotta Joutsi-Korhonen
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Best but not perfect: indirect measure of low iron stores
Franklin Njoku,Victor R. Gordeuk
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THROMBOSIS AND HEMOSTASIS

N-glycan shielded CUB domains of ADAMTS13 prevent binding of C-terminal antibodies in patients with immune-mediated TTP
Tim Postmus,Nelly Schilder,Juliana Ferreira de Santana,Pieter Langerhorst,Paul Kaijen,Paul Coppo,Bérangère S. Joly,Agnès Veyradier,Karen Vanhoorelbeke,Jan Voorberg
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Agents of shield: glycans mask antibody epitopes on ADAMTS13
Colin A. Kretz
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TRANSPLANTATION

Pretransplant MRD does not seem to affect survival in NPM1-mutated AML undergoing allogeneic stem cell transplantation
Alessia Fraccaroli,Vindi Jurinovic,Klaus Hirschbühl,Elena Stauffer,Katrin Koch,Stephan Breitkopf,Sarah Haebe,Heidrun Drolle,Maja Rothenberg-Thurley,Annika Dufour,Klaus H. Metzeler,Karsten Spiekermann,Marcus Hentrich,Andreas Hausmann,Mareike Verbeek,Christoph Schmid,Tobias Herold,Johanna Tischer
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VASCULAR BIOLOGY

Nbeal2 knockout mice are not protected against hypoxia-induced pulmonary vascular remodeling and pulmonary hypertension
Janelle N. Posey,Mariah Jordan,Caitlin V. Lewis,Christina Sul,Evgenia Dobrinskikh,Delaney Swindle,Frederik Denorme,David Irwin,Jorge Di Paola,Kurt Stenmark,Eva S. Nozik,Cassidy Delaney
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RESEARCH LETTERS

Desensitization to calaspargase pegol appears to be less successful than pegaspargase
Milre Matherne,John C. Panetta,Jaclyn Hopp,Hiroto Inaba,Ching-Hon Pui,Seth E. Karol,Hope D. Swanson
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Psychiatric and substance use disorders predict poor outcomes in older veterans with acute myeloid leukemia
Michelle H. Lee,Jennifer La,Mary T. Brophy,Nhan V. Do,Camille V. Edwards,Clark DuMontier,Gabriela S. Hobbs,Nathanael R. Fillmore
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Outcomes of older adults and frail patients receiving idecabtagene vicleucel: a CIBMTR study
Othman Salim Akhtar,Temitope Oloyede,Ruta Brazauskas,Aimaz Afrough,Hamza Hashmi,Surbhi Sidana,Nausheen Ahmed,Matthew Bye,Doris Hansen,Christopher Ferreri,Binod Dhakal,Devender Dhanda,Melanie Harrison,Amani Kitali,Heather Landau,Abu-Sayeef Mirza,Jinalben Patel,Pallavi Patwardhan,Muzaffar Qazilbash,Krina Patel,Taiga Nishihori,Siddhartha Ganguly,Lohith Gowda,Larry D. Anderson, Jr.,Marcelo C. Pasquini,Saad Usmani,Ciara Louise Freeman
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Thalassemia carriers exhibit reduced expression of the receptor for the malarial parasite Plasmodium vivax on erythrocytes
Renliang Huang,Xinze Li,Zhe Lu,Jing Xu,Dan Lin,Yunxue Fu,Yan Liang,Frank Petersen,Xuexia Li,Qiaomiao Zhou,Xinhua Yu
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  • Cover Image

    Cover Image

    issue cover

    Representative image of peak hypoxia-induced Pf4 mRNA expression at day 14 in Nbeal2-/- mouse lungs stained with anti-CD41, anti-CD45, and DAPI antibodies. Pf4 mRNA was expressed in megakaryocytes, as well as leukocytes and other cells throughout the lung. Whole-slide scans were obtained at ×40 objective, 0.5- μm resolution. See the article by Posey et al.

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