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Journal Articles

Peripheral Neuropathy in the Phase 3 ASPEN Study of Bruton Tyrosine Kinase Inhibitors for Waldenström Macroglobulinemia

Clinical Trials & Observations
Benjamin M. Heyman, Stephen S. Opat, Björn E. Wahlin, Meletios Athanasios A. Dimopoulos, Jorge J. Castillo, Alessandra Tedeschi, Constantine S. Tam, Christian Buske, Roger G. Owen, Véronique Leblond, Judith Trotman, Gisoo Barnes, Wai Y. Chan, Jingjing Schneider, Heather Allewelt, Aileen Cleary Cohen, Jeffrey V. Matous
Journal: Blood Advances
Blood Adv bloodadvances.2024014115.
https://doi.org/10.1182/bloodadvances.2024014115
Published: 2024
Journal Articles

Cardiovascular events reported in patients with B-cell malignancies treated with zanubrutinib

Clinical Trials & Observations
Javid J. Moslehi, Richard R. Furman, Constantine S. Tam, Joe-Elie Salem, Christopher R. Flowers, Aileen Cohen, Meng Zhang, Jun Zhang, Lipeng Chen, Han Ma, Jennifer R. Brown
Journal: Blood Advances
Blood Adv (2024) 8 (10): 2478–2490.
https://doi.org/10.1182/bloodadvances.2023011641
Published: 2024
Includes: Supplemental data
Journal Articles

Biomarker analysis of the ASPEN study comparing zanubrutinib with ibrutinib for patients with Waldenström macroglobulinemia

Clinical Trials & Observations
Constantine S. Tam, Stephen Opat, Shirley D'Sa, Wojciech Jurczak, Hui-Peng Lee, Gavin Cull, Roger G. Owen, Paula Marlton, Björn E. Wahlin, Ramón García-Sanz, Helen McCarthy, Stephen Mulligan, Alessandra Tedeschi, Jorge J. Castillo, Jarosław Czyż, Carlos Fernández De Larrea, David Belada, Edward Libby, Jeffrey Matous, Marina Motta, Tanya Siddiqi, Monica Tani, Marek Trněný, Monique C. Minnema, Christian Buske, Véronique Leblond, Steven P. Treon, Judith Trotman, Binghao Wu, Yiling Yu, Zhirong Shen, Wai Y. Chan, Jingjing Schneider, Heather Allewelt, Aileen Cohen, Meletios A. Dimopoulos
Journal: Blood Advances
Blood Adv (2024) 8 (7): 1639–1650.
https://doi.org/10.1182/bloodadvances.2023010906
Published: 2024
Includes: Supplemental data
Journal Articles

Venetoclax-rituximab is active in patients with BTKi-exposed CLL, but durable treatment-free remissions are uncommon

Thomas E. Lew, Rory Bennett, Victor S. Lin, Ashley Whitechurch, Sasanka M. Handunnetti, Paula Marlton, Yandong Shen, Stephen P. Mulligan, Joshua Casan, Piers Blombery, Constantine S. Tam, Andrew W. Roberts, John F. Seymour, Philip A. Thompson, Mary A. Anderson
Journal: Blood Advances
Blood Adv (2024) 8 (6): 1439–1443.
https://doi.org/10.1182/bloodadvances.2023011327
Published: 2024
Includes: Supplemental data
Journal Articles

Immune restoration with ibrutinib plus venetoclax in first-line chronic lymphocytic leukemia: the phase 2 CAPTIVATE study

Clinical Trials & Observations
Carol Moreno, Isabelle G. Solman, Constantine S. Tam, Andrew Grigg, Lydia Scarfò, Thomas J. Kipps, Srimathi Srinivasan, Raghuveer Singh Mali, Cathy Zhou, James P. Dean, Edith Szafer-Glusman, Michael Choi
Journal: Blood Advances
Blood Adv (2023) 7 (18): 5294–5303.
https://doi.org/10.1182/bloodadvances.2023010236
Published: 2023
Includes: Supplemental data
Journal Articles

Real-world experience of combined treatment with azacitidine and romidepsin in patients with peripheral T-cell lymphoma

Clinical Trials & Observations
Matko Kalac, Salvia Jain, Constantine S. Tam, Zhengrui Xiao, Francesca Montanari, Jennifer Kanakry, Bryan D. Huber, Mendel Goldfinger, Owen A. O’Connor, Enrica Marchi
Journal: Blood Advances
Blood Adv (2023) 7 (14): 3760–3763.
https://doi.org/10.1182/bloodadvances.2022009445
Published: 2023
Includes: Supplemental data
Journal Articles

Zanubrutinib for the treatment of relapsed/refractory hairy cell leukemia

Clinical Trials & Observations
Constantine S. Tam, Judith Trotman, Stephen Opat, Jennifer C. Stern, Heather Allewelt, Kunthel By, William Novotny, Jane Huang, Alessandra Tedeschi
Journal: Blood Advances
Blood Adv (2023) 7 (12): 2884–2887.
https://doi.org/10.1182/bloodadvances.2022008990
Published: 2023
Includes: Supplemental data
Journal Articles

BTK and PLCG2 remain unmutated in one-third of patients with CLL relapsing on ibrutinib

Silvia Bonfiglio, Lesley-Ann Sutton, Viktor Ljungström, Antonella Capasso, Tatjana Pandzic, Simone Weström, Hassan Foroughi-Asl, Aron Skaftason, Anna Gellerbring, Anna Lyander, Francesca Gandini, Gianluca Gaidano, Livio Trentin, Lisa Bonello, Gianluigi Reda, Csaba Bödör, Niki Stavroyianni, Constantine S. Tam, Roberto Marasca, Francesco Forconi, Panayiotis Panayiotidis, Ingo Ringshausen, Ozren Jaksic, Anna Maria Frustaci, Sunil Iyengar, Marta Coscia, Stephen P. Mulligan, Loïc Ysebaert, Vladimir Strugov, Carolina Pavlovsky, Renata Walewska, Anders Österborg, Diego Cortese, Pamela Ranghetti, Panagiotis Baliakas, Kostas Stamatopoulos, Lydia Scarfò, Richard Rosenquist, Paolo Ghia
Journal: Blood Advances
Blood Adv (2023) 7 (12): 2794–2806.
https://doi.org/10.1182/bloodadvances.2022008821
Published: 2023
Includes: Supplemental data
Journal Articles

Enrichment of BTK Leu528Trp mutations in patients with CLL on zanubrutinib: potential for pirtobrutinib cross-resistance

Piers Blombery, Ella R. Thompson, Thomas E. Lew, Ing Soo Tiong, Rory Bennett, Chan Y. Cheah, Katharine Louise Lewis, Sasanka M. Handunnetti, Chloe Pek Sang Tang, Andrew Roberts, John F. Seymour, Constantine S. Tam
Journal: Blood Advances
Blood Adv (2022) 6 (20): 5589–5592.
https://doi.org/10.1182/bloodadvances.2022008325
Published: 2022
Includes: Supplemental data
Journal Articles

Long-term safety for patients with tisagenlecleucel-treated relapsed/refractory diffuse large B-cell lymphoma

Clinical Trials & Observations
Ulrich Jaeger, Constantine S. Tam, Peter Borchmann, Joseph P. McGuirk, Marianne Johansen, Edmund K. Waller, Samantha Jaglowski, Charalambos Andreadis, Stephen R. Foley, Jason R. Westin, Isabelle Fleury, P. Joy Ho, Stephan Mielke, Takanori Teshima, Gilles Salles, Stephen J. Schuster, Fiona He, Richard T. Maziarz, Sebastian Mayer, Shinichi Makita, Marie J. Kersten, Monalisa Ghosh, Nina Wagner-Johnston, Koji Kato, Paolo Corradini, Hideki Goto, Silvia Colicino, Abhijit Agarwal, Chiara Lobetti-Bodoni, Michael R. Bishop
Journal: Blood Advances
Blood Adv (2022) 6 (16): 4816–4820.
https://doi.org/10.1182/bloodadvances.2021006193
Published: 2022
Includes: Supplemental data
Journal Articles

Zanubrutinib monotherapy in relapsed/refractory indolent non-Hodgkin lymphoma

Clinical Trials & Observations
Tycel Phillips, Henry Chan, Constantine S. Tam, Alessandra Tedeschi, Patrick Johnston, Sung Yong Oh, Stephen Opat, Hyeon-Seok Eom, Heather Allewelt, Jennifer C. Stern, Ziwen Tan, William Novotny, Jane Huang, Judith Trotman
Journal: Blood Advances
Blood Adv (2022) 6 (11): 3472–3479.
https://doi.org/10.1182/bloodadvances.2021006083
Published: 2022
Includes: Supplemental data
Journal Articles

Pooled safety analysis of zanubrutinib monotherapy in patients with B-cell malignancies

Clinical Trials & Observations
Constantine S. Tam, Meletios Dimopoulos, Ramon Garcia-Sanz, Judith Trotman, Stephen Opat, Andrew W. Roberts, Roger Owen, Yuqin Song, Wei Xu, Jun Zhu, Jianyong Li, Lugui Qiu, Shirley D’Sa, Wojciech Jurczak, Gavin Cull, Paula Marlton, David Gottlieb, Javier Munoz, Tycel Phillips, Chenmu Du, Meng Ji, Lei Zhou, Haiyi Guo, Hongjie Zhu, Wai Y. Chan, Aileen Cohen, William Novotny, Jane Huang, Alessandra Tedeschi
Journal: Blood Advances
Blood Adv (2022) 6 (4): 1296–1308.
https://doi.org/10.1182/bloodadvances.2021005621
Published: 2022
Includes: Supplemental data
Journal Articles

Single-cell sequencing demonstrates complex resistance landscape in CLL and MCL treated with BTK and BCL2 inhibitors

Ella R. Thompson, Tamia Nguyen, Yamuna Kankanige, John F. Markham, Mary Ann Anderson, Sasanka M. Handunnetti, Rachel Thijssen, Paul Sung-Hao Yeh, Constantine S. Tam, John F. Seymour, Andrew W. Roberts, David A. Westerman, Piers Blombery
Journal: Blood Advances
Blood Adv (2022) 6 (2): 503–508.
https://doi.org/10.1182/bloodadvances.2021006211
Published: 2022
Includes: Supplemental data
Journal Articles

Tisagenlecleucel immunogenicity in relapsed/refractory acute lymphoblastic leukemia and diffuse large B-cell lymphoma

Clinical Trials & Observations
Karen Thudium Mueller, Stephan A. Grupp, Shannon L. Maude, John E. Levine, Michael A. Pulsipher, Michael W. Boyer, Keith J. August, G. Doug Myers, Constantine S. Tam, Ulrich Jaeger, Stephen Ronan Foley, Peter Borchmann, Stephen J. Schuster, Edmund K. Waller, Rakesh Awasthi, Bernd Potthoff, Andy Warren, Edward R. Waldron, Fraser McBlane, Andrea Chassot-Agostinho, Theodore W. Laetsch
Journal: Blood Advances
Blood Adv (2021) 5 (23): 4980–4991.
https://doi.org/10.1182/bloodadvances.2020003844
Published: 2021
Includes: Supplemental data
Journal Articles

Outcomes of patients with CLL sequentially resistant to both BCL2 and BTK inhibition

Clinical Trials & Observations
Thomas E. Lew, Victor S. Lin, Edward R. Cliff, Piers Blombery, Ella R. Thompson, Sasanka M. Handunnetti, David A. Westerman, Bryone J. Kuss, Constantine S. Tam, David C. S. Huang, John F. Seymour, Andrew W. Roberts, Mary Ann Anderson
Journal: Blood Advances
Blood Adv (2021) 5 (20): 4054–4058.
https://doi.org/10.1182/bloodadvances.2021005083
Published: 2021
Includes: Supplemental data
Journal Articles

Zanubrutinib for the treatment of relapsed or refractory mantle cell lymphoma

Clinical Trials & Observations
Constantine S. Tam, Stephen Opat, David Simpson, Gavin Cull, Javier Munoz, Tycel J. Phillips, Won Seog Kim, Simon Rule, Siminder Kaur Atwal, Rachel Wei, William Novotny, Jane Huang, Michael Wang, Judith Trotman
Journal: Blood Advances
Blood Adv (2021) 5 (12): 2577–2585.
https://doi.org/10.1182/bloodadvances.2020004074
Published: 2021
Includes: Supplemental data
Journal Articles

Zanubrutinib for the treatment of MYD88 wild-type Waldenström macroglobulinemia: a substudy of the phase 3 ASPEN trial

Clinical Trials & Observations
Meletios Dimopoulos, Ramon Garcia Sanz, Hui-Peng Lee, Marek Trneny, Marzia Varettoni, Stephen Opat, Shirley D'Sa, Roger G. Owen, Gavin Cull, Stephen Mulligan, Jaroslaw Czyz, Jorge J. Castillo, Marina Motta, Tanya Siddiqi, Mercedes Gironella Mesa, Miquel Granell Gorrochategui, Dipti Talaulikar, Pier Luigi Zinzani, Elham Askari, Sebastian Grosicki, Albert Oriol, Simon Rule, Janusz Kloczko, Alessandra Tedeschi, Christian Buske, Veronique Leblond, Judith Trotman, Wai Y. Chan, Jan Michel, Jingjing Schneider, Ziwen Tan, Aileen Cohen, Jane Huang, Constantine S. Tam
Journal: Blood Advances
Blood Adv (2020) 4 (23): 6009–6018.
https://doi.org/10.1182/bloodadvances.2020003010
Published: 2020
Includes: Supplemental data
Journal Articles

Immune recovery in patients with mantle cell lymphoma receiving long-term ibrutinib and venetoclax combination therapy

Clinical Trials & Observations
Joanne E. Davis, Sasanka M. Handunnetti, Mandy Ludford-Menting, Chia Sharpe, Piers Blombery, Mary Ann Anderson, Andrew W. Roberts, John F. Seymour, Constantine S. Tam, David S. Ritchie, Rachel M. Koldej
Journal: Blood Advances
Blood Adv (2020) 4 (19): 4849–4859.
https://doi.org/10.1182/bloodadvances.2020002810
Published: 2020
Includes: Supplemental data
Journal Articles

Zanubrutinib (BGB-3111) plus obinutuzumab in patients with chronic lymphocytic leukemia and follicular lymphoma

Clinical Trials & Observations
Constantine S. Tam, Hang Quach, Andrew Nicol, Xavier Badoux, Hannah Rose, H. Miles Prince, Michael F. Leahy, Richard Eek, Nicholas Wickham, Sushrut S. Patil, Jane Huang, Radha Prathikanti, Aileen Cohen, Rebecca Elstrom, William Reed, Jingjing Schneider, Ian W. Flinn
Journal: Blood Advances
Blood Adv (2020) 4 (19): 4802–4811.
https://doi.org/10.1182/bloodadvances.2020002183
Published: 2020
Journal Articles

Patient-reported long-term quality of life after tisagenlecleucel in relapsed/refractory diffuse large B-cell lymphoma

Clinical Trials & Observations
Richard T. Maziarz, Edmund K. Waller, Ulrich Jaeger, Isabelle Fleury, Joseph McGuirk, Harald Holte, Samantha Jaglowski, Stephen J. Schuster, Michael R. Bishop, Jason R. Westin, Stephan Mielke, Takanori Teshima, Veronika Bachanova, Stephen R. Foley, Peter Borchmann, Gilles A. Salles, Jie Zhang, Ranjan Tiwari, Lida B. Pacaud, Qiufei Ma, Constantine S. Tam
Journal: Blood Advances
Blood Adv (2020) 4 (4): 629–637.
https://doi.org/10.1182/bloodadvances.2019001026
Published: 2020
Includes: Supplemental data