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Jorge J. Castillo
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Journal Articles

Peripheral Neuropathy in the Phase 3 ASPEN Study of Bruton Tyrosine Kinase Inhibitors for Waldenström Macroglobulinemia

Clinical Trials & Observations
Benjamin M. Heyman, Stephen S. Opat, Björn E. Wahlin, Meletios Athanasios A. Dimopoulos, Jorge J. Castillo, Alessandra Tedeschi, Constantine S. Tam, Christian Buske, Roger G. Owen, Véronique Leblond, Judith Trotman, Gisoo Barnes, Wai Y. Chan, Jingjing Schneider, Heather Allewelt, Aileen Cleary Cohen, Jeffrey V. Matous
Journal: Blood Advances
Blood Adv bloodadvances.2024014115.
https://doi.org/10.1182/bloodadvances.2024014115
Published: 2024
Journal Articles

Identification of robust predictors for ibrutinib response by multiomics in MYD88-mutated Waldenström macroglobulinemia

Clinical Trials & Observations
Kris Richardson, Jorge J. Castillo, Shayna R. Sarosiek, Andrew R. Branagan, Catherine A. Flynn, Kirsten Meid, Joshua N. Gustine, Xia Liu, Amanda Kofides, Shirong Liu, Julie L. Wolf, Katherine A. Kacena, Christopher J. Patterson, Maria Luisa Guerrera, Nicholas Tsakmaklis, Steven P. Treon, Zachary R. Hunter
Journal: Blood Advances
Blood Adv (2024) 8 (9): 2133–2137.
https://doi.org/10.1182/bloodadvances.2023012111
Published: 2024
Includes: Supplemental data
Journal Articles

Biomarker analysis of the ASPEN study comparing zanubrutinib with ibrutinib for patients with Waldenström macroglobulinemia

Clinical Trials & Observations
Constantine S. Tam, Stephen Opat, Shirley D'Sa, Wojciech Jurczak, Hui-Peng Lee, Gavin Cull, Roger G. Owen, Paula Marlton, Björn E. Wahlin, Ramón García-Sanz, Helen McCarthy, Stephen Mulligan, Alessandra Tedeschi, Jorge J. Castillo, Jarosław Czyż, Carlos Fernández De Larrea, David Belada, Edward Libby, Jeffrey Matous, Marina Motta, Tanya Siddiqi, Monica Tani, Marek Trněný, Monique C. Minnema, Christian Buske, Véronique Leblond, Steven P. Treon, Judith Trotman, Binghao Wu, Yiling Yu, Zhirong Shen, Wai Y. Chan, Jingjing Schneider, Heather Allewelt, Aileen Cohen, Meletios A. Dimopoulos
Journal: Blood Advances
Blood Adv (2024) 8 (7): 1639–1650.
https://doi.org/10.1182/bloodadvances.2023010906
Published: 2024
Includes: Supplemental data
Journal Articles

High frequency of central nervous system involvement in transformed Waldenström macroglobulinemia

Clinical Trials & Observations
Eric Durot, Lukshe Kanagaratnam, Saurabh Zanwar, Elise Toussaint, Efstathios Kastritis, Shirley D’Sa, Miguel Alcoceba, Cécile Tomowiak, Bénédicte Hivert, Caroline Protin, Jithma P. Abeykoon, Josephine M. I. Vos, Anne-Sophie Michallet, Cyrielle Rodier, Jehan Dupuis, Stéphane Leprêtre, Fatiha Merabet, Xavier Roussel, Jean-Marc Zini, Caroline Regny, Aisha Patel, Pierre Morel, Damien Roos-Weil, Steven P. Treon, Meletios A. Dimopoulos, Ramon Garcia-Sanz, Prashant Kapoor, Jorge J. Castillo, Alain Jacques Delmer
Journal: Blood Advances
Blood Adv (2022) 6 (12): 3655–3658.
https://doi.org/10.1182/bloodadvances.2022007331
Published: 2022
Includes: Supplemental data
Journal Articles

A new role for the SRC family kinase HCK as a driver of SYK activation in MYD88 mutated lymphomas

Manit Munshi, Xia Liu, Amanda Kofides, Nickolas Tsakmaklis, Maria Luisa Guerrera, Zachary R. Hunter, M. Lia Palomba, Kimon V. Argyropoulos, Christopher J. Patterson, Alexa G. Canning, Kirsten Meid, Joshua Gustine, Andrew R. Branagan, Catherine A. Flynn, Shayna Sarosiek, Jorge J. Castillo, Jinhua Wang, Sara J. Buhrlage, Nathanael S. Gray, Nikhil C. Munshi, Kenneth C. Anderson, Steven P. Treon, Guang Yang
Journal: Blood Advances
Blood Adv (2022) 6 (11): 3332–3338.
https://doi.org/10.1182/bloodadvances.2021006147
Published: 2022
Includes: Supplemental data
Journal Articles

Clonal hematopoiesis is associated with increased risk of progression of asymptomatic Waldenström macroglobulinemia

Clinical Trials & Observations
Sabrin Tahri, Tarek H. Mouhieddine, Robert Redd, Luisa Lampe, Katarina I. Nilsson, Habib El-Khoury, Nang Kham Su, Amin H. Nassar, Elio Adib, Govind Bindra, Sarah Abou Alaiwi, Lorenzo Trippa, David P. Steensma, Jorge J. Castillo, Steven P. Treon, Irene M. Ghobrial, Adam S. Sperling
Journal: Blood Advances
Blood Adv (2022) 6 (7): 2230–2235.
https://doi.org/10.1182/bloodadvances.2021004926
Published: 2022
Includes: Supplemental data
Journal Articles

An international analysis evaluating frontline bendamustine with rituximab in extranodal marginal zone lymphoma

Clinical Trials & Observations
Juan Pablo Alderuccio, Luca Arcaini, Marcus P. Watkins, Anne W. Beaven, Geoffrey Shouse, Narendranath Epperla, Michele Spina, Alexandra Stefanovic, Jose Sandoval-Sus, Pallawi Torka, Ash B. Alpert, Adam J. Olszewski, Seo-Hyun Kim, Brian Hess, Sameh Gaballa, Sabarish Ayyappan, Jorge J. Castillo, Lisa Argnani, Timothy J. Voorhees, Raya Saba, Sayan Mullick Chowdhury, Fernando Vargas, Isildinha M. Reis, Deukwoo Kwon, Jonathan S. Alexander, Wei Zhao, Dali Edwards, Peter Martin, Emanuele Cencini, Manali Kamdar, Brian K. Link, Constantine N. Logothetis, Alex F. Herrera, Jonathan W. Friedberg, Brad S. Kahl, Stefano Luminari, Pier Luigi Zinzani, Izidore S. Lossos
Journal: Blood Advances
Blood Adv (2022) 6 (7): 2035–2044.
https://doi.org/10.1182/bloodadvances.2021006844
Published: 2022
Journal Articles

Response and survival predictors in a cohort of 319 patients with Waldenström macroglobulinemia treated with ibrutinib monotherapy

Clinical Trials & Observations
Jorge J. Castillo, Shayna R. Sarosiek, Joshua N. Gustine, Catherine A. Flynn, Carly R. Leventoff, Timothy P. White, Kirsten Meid, Maria L. Guerrera, Amanda Kofides, Xia Liu, Manit Munshi, Nicholas Tsakmaklis, Zachary R. Hunter, Christopher J. Patterson, Andrew R. Branagan, Steven P. Treon
Journal: Blood Advances
Blood Adv (2022) 6 (3): 1015–1024.
https://doi.org/10.1182/bloodadvances.2021006106
Published: 2022
Includes: Supplemental data
Journal Articles

Zanubrutinib for the treatment of MYD88 wild-type Waldenström macroglobulinemia: a substudy of the phase 3 ASPEN trial

Clinical Trials & Observations
Meletios Dimopoulos, Ramon Garcia Sanz, Hui-Peng Lee, Marek Trneny, Marzia Varettoni, Stephen Opat, Shirley D'Sa, Roger G. Owen, Gavin Cull, Stephen Mulligan, Jaroslaw Czyz, Jorge J. Castillo, Marina Motta, Tanya Siddiqi, Mercedes Gironella Mesa, Miquel Granell Gorrochategui, Dipti Talaulikar, Pier Luigi Zinzani, Elham Askari, Sebastian Grosicki, Albert Oriol, Simon Rule, Janusz Kloczko, Alessandra Tedeschi, Christian Buske, Veronique Leblond, Judith Trotman, Wai Y. Chan, Jan Michel, Jingjing Schneider, Ziwen Tan, Aileen Cohen, Jane Huang, Constantine S. Tam
Journal: Blood Advances
Blood Adv (2020) 4 (23): 6009–6018.
https://doi.org/10.1182/bloodadvances.2020003010
Published: 2020
Includes: Supplemental data
Journal Articles

Multicenter phase 2 study of daratumumab monotherapy in patients with previously treated Waldenström macroglobulinemia

Clinical Trials & Observations
Jorge J. Castillo, Edward N. Libby, Stephen M. Ansell, M. Lia Palomba, Kirsten Meid, Catherine A. Flynn, Carly Leventoff, Christopher B. Hergott, Tomasz Sewastianik, Elizabeth A. Morgan, Ruben Carrasco, Jonathan R. Fromm, Guang Yang, Zachary Hunter, Steven P. Treon
Journal: Blood Advances
Blood Adv (2020) 4 (20): 5089–5092.
https://doi.org/10.1182/bloodadvances.2020003087
Published: 2020
Journal Articles

Comparative genomics of CXCR4 MUT and CXCR4 WT single cells in Waldenström’s macroglobulinemia

Cristina Jiménez, Lian Xu, Nickolas Tsakmaklis, Maria G. Demos, Amanda Kofides, Gloria G. Chan, Maria Luisa Guerrera, Jiaji G. Chen, Xia Liu, Manit Munshi, Christopher J. Patterson, Guang Yang, Jorge J. Castillo, Steven P. Treon, Zachary R. Hunter
Journal: Blood Advances
Blood Adv (2020) 4 (18): 4550–4553.
https://doi.org/10.1182/bloodadvances.2020001775
Published: 2020
Includes: Supplemental data
Journal Articles

Ixazomib, dexamethasone, and rituximab in treatment-naive patients with Waldenström macroglobulinemia: long-term follow-up

Clinical Trials & Observations
Jorge J. Castillo, Kirsten Meid, Catherine A. Flynn, Jiaji Chen, Maria G. Demos, Maria L. Guerrera, Amanda Kofides, Xia Liu, Manit Munshi, Nicholas Tsakmaklis, Christopher J. Patterson, Guang Yang, Zachary Hunter, Steven P. Treon
Journal: Blood Advances
Blood Adv (2020) 4 (16): 3952–3959.
https://doi.org/10.1182/bloodadvances.2020001963
Published: 2020
Journal Articles

Expression of the prosurvival kinase HCK requires PAX5 and mutated MYD88 signaling in MYD88-driven B-cell lymphomas

Xia Liu, Jiaji G. Chen, Manit Munshi, Zachary R. Hunter, Lian Xu, Amanda Kofides, Nickolas Tsakmaklis, Maria G. Demos, Maria Luisa Guerrera, Gloria G. Chan, Cristina Jimenez, Christopher J. Patterson, Kirsten Meid, Andrew Keezer, Jorge J. Castillo, Steven P. Treon, Guang Yang
Journal: Blood Advances
Blood Adv (2020) 4 (1): 141–153.
https://doi.org/10.1182/bloodadvances.2019000947
Published: 2020
Journal Articles

CXCR4 S338X clonality is an important determinant of ibrutinib outcomes in patients with Waldenström macroglobulinemia

Joshua N. Gustine, Lian Xu, Nicholas Tsakmaklis, Maria G. Demos, Amanda Kofides, Jiaji G. Chen, Xia Liu, Manit Munshi, Maria Luisa Guerrera, Gloria G. Chan, Christopher J. Patterson, Andrew Keezer, Kirsten Meid, Toni Dubeau, Guang Yang, Zachary R. Hunter, Steven P. Treon, Jorge J. Castillo
Journal: Blood Advances
Blood Adv (2019) 3 (19): 2800–2803.
https://doi.org/10.1182/bloodadvances.2019000635
Published: 2019
Includes: Supplemental data
Journal Articles

Insights into the genomic landscape of MYD88 wild-type Waldenström macroglobulinemia

Clinical Trials & Observations
Zachary R. Hunter, Lian Xu, Nickolas Tsakmaklis, Maria G. Demos, Amanda Kofides, Cristina Jimenez, Gloria G. Chan, Jiaji Chen, Xia Liu, Manit Munshi, Joshua Gustine, Kirsten Meid, Christopher J. Patterson, Guang Yang, Toni Dubeau, Mehmet K. Samur, Jorge J. Castillo, Kenneth C. Anderson, Nikhil C. Munshi, Steven P. Treon
Journal: Blood Advances
Blood Adv (2018) 2 (21): 2937–2946.
https://doi.org/10.1182/bloodadvances.2018022962
Published: 2018
Includes: Supplemental data
Journal Articles

What should be the goal of therapy for Waldenström macroglobulinemia patients? Complete response should be the goal of therapy

Clinical Trials & Observations
Steven P. Treon, Jorge J. Castillo
Journal: Blood Advances
Blood Adv (2017) 1 (25): 2486–2490.
https://doi.org/10.1182/bloodadvances.2017005637
Published: 2017