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Issue Archive

Volume 4, Issue 22
November 24 2020
Issue Cover

Table of Contents

DRUG ADVANCES

C(h)AR-ting a new course in incurable lymphomas: CAR T cells for mantle cell and follicular lymphomas
Clinical Trials & Observations
Caron A. Jacobson,Marcela V. Maus
View Articletitled, C(h)AR-ting a new course in incurable lymphomas: CAR T cells for mantle cell and follicular lymphomas

EXCEPTIONAL CASE REPORT

Remission of anti-TIF1γ dermatomyositis after allogeneic hematopoietic stem cell transplant for myelodysplastic syndrome
Clinical Trials & Observations
Fatima Bawany,Bushra Tbakhi,Jason H. Mendler,Christopher T. Richardson,John M. Bennett,Omar S. Aljitawi
View Articletitled, Remission of anti-TIF1γ dermatomyositis after allogeneic hematopoietic stem cell transplant for myelodysplastic syndrome

REVIEW ARTICLES

Fundamentals of immunology for understanding immunotherapy for lymphoma
Stephen M. Ansell
View Articletitled, Fundamentals of immunology for understanding immunotherapy for lymphoma
Next-generation cell therapies: the emerging role of CAR-NK cells
Rafet Basar,May Daher,Katayoun Rezvani
View Articletitled, Next-generation cell therapies: the emerging role of CAR-NK cells
Supplemental data
Mesenchymal stromal cells in hematopoietic cell transplantation
Andre J. Burnham,Lisa P. Daley-Bauer,Edwin M. Horwitz
View Articletitled, Mesenchymal stromal cells in hematopoietic cell transplantation

CLINICAL TRIALS AND OBSERVATIONS

Durable ibrutinib responses in relapsed/refractory marginal zone lymphoma: long-term follow-up and biomarker analysis
Clinical Trials & Observations
Ariela Noy,Sven de Vos,Morton Coleman,Peter Martin,Christopher R. Flowers,Catherine Thieblemont,Franck Morschhauser,Graham P. Collins,Shuo Ma,Shachar Peles,Stephen D. Smith,Jacqueline C. Barrientos,Elizabeth Chong,Shiquan Wu,Leo W.-K. Cheung,Kevin Kwei,Bernhard Hauns,Israel Arango-Hisijara,Robert Chen
View Articletitled, Durable ibrutinib responses in relapsed/refractory marginal zone lymphoma: long-term follow-up and biomarker analysis
Supplemental data
Determining the recommended dose of pacritinib: results from the PAC203 dose-finding trial in advanced myelofibrosis
Clinical Trials & Observations
Aaron T. Gerds,Michael R. Savona,Bart L. Scott,Moshe Talpaz,Miklos Egyed,Claire N. Harrison,Abdulraheem Yacoub,Alessandro Vannucchi,Adam J. Mead,Jean-Jacques Kiladjian,Jennifer O’Sullivan,Valentin García-Gutiérrez,Prithviraj Bose,Raajit K. Rampal,Carole B. Miller,Jeanne Palmer,Stephen T. Oh,Sarah A. Buckley,Diane R. Mould,Kaori Ito,Shanthakumar Tyavanagimatt,Jennifer A. Smith,Karisse Roman-Torres,Sri Devineni,Adam R. Craig,John O. Mascarenhas
View Articletitled, Determining the recommended dose of pacritinib: results from the PAC203 dose-finding trial in advanced myelofibrosis
Supplemental data
Renal outcome in patients with newly diagnosed multiple myeloma: results from the UK NCRI Myeloma XI trial
Clinical Trials & Observations
Ritika Rana,Paul Cockwell,Mark Drayson,Mark Cook,Guy Pratt,David A. Cairns,Charlotte Pawlyn,Graham Jackson,Faith Davies,Gareth Morgan,Jennifer Helen Pinney
View Articletitled, Renal outcome in patients with newly diagnosed multiple myeloma: results from the UK NCRI Myeloma XI trial
Supplemental data

GENE THERAPY

Combining T-cell–specific activation and in vivo gene delivery through CD3-targeted lentiviral vectors
Annika M. Frank,Angela H. Braun,Lea Scheib,Shiwani Agarwal,Irene C. Schneider,Floriane Fusil,Séverine Perian,Ugur Sahin,Frederic B. Thalheimer,Els Verhoeyen,Christian J. Buchholz
View Articletitled, Combining T-cell–specific activation and in vivo gene delivery through CD3-targeted lentiviral vectors
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Paroxysmal nocturnal hemoglobinuria caused by CN-LOH of constitutional PIGB mutation and 70-kbp microdeletion on 15q
Saskia Langemeijer,Charlotte Schaap,Frank Preijers,Joop H. Jansen,Nicole Blijlevens,Norimitsu Inoue,Petra Muus,Taroh Kinoshita,Yoshiko Murakami
View Articletitled, Paroxysmal nocturnal hemoglobinuria caused by CN-LOH of constitutional PIGB mutation and 70-kbp microdeletion on 15q
Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Virus-specific T-cell therapy to treat BK polyomavirus infection in bone marrow and solid organ transplant recipients
Adam S. Nelson,Daria Heyenbruch,Jeremy D. Rubinstein,Anthony Sabulski,Sonata Jodele,Shawn Thomas,Carolyn Lutzko,Xiang Zhu,Thomas Leemhuis,Jose A. Cancelas,Michael Keller,Catherine M. Bollard,Patrick J. Hanley,Stella M. Davies,Michael S. Grimley
View Articletitled, Virus-specific T-cell therapy to treat BK polyomavirus infection in bone marrow and solid organ transplant recipients
Supplemental data

LYMPHOID NEOPLASIA

Predictive factors of early progression after CAR T-cell therapy in relapsed/refractory diffuse large B-cell lymphoma
Clinical Trials & Observations
Laetitia Vercellino,Roberta Di Blasi,Salim Kanoun,Benoit Tessoulin,Cedric Rossi,Maud D'Aveni-Piney,Lucie Obéric,Caroline Bodet-Milin,Pierre Bories,Pierre Olivier,Ingrid Lafon,Alina Berriolo-Riedinger,Eugenio Galli,Sophie Bernard,Marie-Thérèse Rubio,Celine Bossard,Veronique Meignin,Pascal Merlet,Pierre Feugier,Steven Le Gouill,Loic Ysebaert,Olivier Casasnovas,Michel Meignan,Sylvie Chevret,Catherine Thieblemont
View Articletitled, Predictive factors of early progression after CAR T-cell therapy in relapsed/refractory diffuse large B-cell lymphoma
Supplemental data
Che-1/AATF-induced transcriptionally active chromatin promotes cell proliferation in multiple myeloma
Tiziana Bruno,Francesca De Nicola,Giacomo Corleone,Valeria Catena,Frauke Goeman,Matteo Pallocca,Cristina Sorino,Gianluca Bossi,Bruno Amadio,Giovanni Cigliana,Maria Rosaria Ricciardi,Maria Teresa Petrucci,Enrico Pierluigi Spugnini,Alfonso Baldi,Mario Cioce,Giancarlo Cortese,Elisabetta Mattei,Roberta Merola,Umberto Gianelli,Luca Baldini,Francesco Pisani,Svitlana Gumenyuk,Andrea Mengarelli,Katja Höpker,Thomas Benzing,Bruno Vincenzi,Aristide Floridi,Claudio Passananti,Giovanni Blandino,Simona Iezzi,Maurizio Fanciulli
View Articletitled, Che-1/AATF-induced transcriptionally active chromatin promotes cell proliferation in multiple myeloma
Supplemental data
Follicular lymphoma t(14;18)-negative is genetically a heterogeneous disease
Dominik Nann,Joan Enric Ramis-Zaldivar,Inga Müller,Blanca Gonzalez-Farre,Janine Schmidt,Caoimhe Egan,Julia Salmeron-Villalobos,Guillem Clot,Sven Mattern,Franziska Otto,Barbara Mankel,Dolors Colomer,Olga Balagué,Vanessa Szablewski,Carmen Lome-Maldonado,Lorenzo Leoncini,Stefan Dojcinov,Andreas Chott,Christiane Copie-Bergman,Irina Bonzheim,Falko Fend,Elaine S. Jaffe,Elias Campo,Itziar Salaverria,Leticia Quintanilla-Martinez
View Articletitled, Follicular lymphoma t(14;18)-negative is genetically a heterogeneous disease
Supplemental data
A risk model for relapsed/refractory aggressive NHL integrating clinical risk factors and pretransplant Deauville score
Clinical Trials & Observations
Ho-Young Yhim,Yael Eshet,Ur Metser,Chae-Hong Lim,Katherine Lajkosz,Keren Isaev,Matthew Cooper,Anca Prica,Vishal Kukreti,Sita Bhella,Noémie Lang,Kyung-Han Lee,Wei Xu,David Hodgson,Richard Tsang,Sang Eun Yoon,Seok Jin Kim,Won Seog Kim,Michael Crump,John Kuruvilla,Robert Kridel
View Articletitled, A risk model for relapsed/refractory aggressive NHL integrating clinical risk factors and pretransplant Deauville score
Supplemental data

MYELOID NEOPLASIA

Prognostic and therapeutic impacts of mutant TP53 variant allelic frequency in newly diagnosed acute myeloid leukemia
Clinical Trials & Observations
Nicholas J. Short,Guillermo Montalban-Bravo,Hyunsoo Hwang,Jing Ning,Miguel J. Franquiz,Rashmi Kanagal-Shamanna,Keyur P. Patel,Courtney D. DiNardo,Farhad Ravandi,Guillermo Garcia-Manero,Koichi Takahashi,Marina Konopleva,Naval Daver,Ghayas C. Issa,Michael Andreeff,Hagop Kantarjian,Tapan M. Kadia
View Articletitled, Prognostic and therapeutic impacts of mutant <em>TP53</em> variant allelic frequency in newly diagnosed acute myeloid leukemia
Supplemental data
Transient expansion of TP53 mutated clones in polycythemia vera patients treated with idasanutlin
Clinical Trials & Observations
Bridget K. Marcellino,Noushin Farnoud,Bruno Cassinat,Min Lu,Emanuelle Verger,Erin McGovern,Minal Patel,Juan Medina-Martinez,Max Fine Levine,Juanes E. Arango Ossa,Yangyu Zhou,Heidi Kosiorek,Meenakshi Mehrotra,Jane Houldsworth,Amylou Dueck,Michael Rossi,John Mascarenhas,Jean-Jacques Kiladjian,Raajit K. Rampal,Ronald Hoffman
View Articletitled, Transient expansion of TP53 mutated clones in polycythemia vera patients treated with idasanutlin
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Late-onset and long-lasting autoimmune neutropenia: an analysis from the Italian Neutropenia Registry
Clinical Trials & Observations
Francesca Fioredda,Gioacchino Andrea Rotulo,Piero Farruggia,Francesca Dagliano,Marta Pillon,Angela Trizzino,Lucia Notarangelo,Laura Luti,Tiziana Lanza,Paola Terranova,Marina Lanciotti,Isabella Ceccherini,Alice Grossi,Laura Porretti,Federico Verzegnassi,Elena Mastrodicasa,Angelica Barone,Giovanna Russo,Sonia Bonanomi,Gianluca Boscarol,Andrea Finocchi,Marinella Veltroni,Ugo Ramenghi,Daniela Onofrillo,Baldassare Martire,Roberta Ghilardi,Paola Giordano,Saverio Ladogana,Nicoletta Marra,Sabrina Zanardi,Fabian Beier,Maurizio Miano,Carlo Dufour
View Articletitled, Late-onset and long-lasting autoimmune neutropenia: an analysis from the Italian Neutropenia Registry
Supplemental data

PLATELETS AND THROMBOPOIESIS

A risk score for predicting hospitalization for community-acquired pneumonia in ITP using nationally representative data
Clinical Trials & Observations
Ye-Jun Wu,Ming Hou,Hui-Xin Liu,Jun Peng,Liang-Ming Ma,Lin-Hua Yang,Ru Feng,Hui Liu,Yi Liu,Jia Feng,Hong-Yu Zhang,Ze-Ping Zhou,Wen-Sheng Wang,Xu-Liang Shen,Peng Zhao,Hai-Xia Fu,Qiao-Zhu Zeng,Xing-Lin Wang,Qiu-Sha Huang,Yun He,Qian Jiang,Hao Jiang,Jin Lu,Xiang-Yu Zhao,Xiao-Su Zhao,Ying-Jun Chang,Lan-Ping Xu,Yue-Ying Li,Qian-Fei Wang,Xiao-Hui Zhang,on behalf of the Cooperative ITP Working Group,on behalf of the Cooperative ITP Working Group,on behalf of the Cooperative ITP Working Group,on behalf of the Cooperative ITP Working Group,on behalf of the Cooperative ITP Working Group,on behalf of the Cooperative ITP Working Group,on behalf of the Cooperative ITP Working Group,on behalf of the Cooperative ITP Working Group,on behalf of the Cooperative ITP Working Group,on behalf of the Cooperative ITP Working Group,on behalf of the Cooperative ITP Working Group,on behalf of the Cooperative ITP Working Group,on behalf of the Cooperative ITP Working Group,on behalf of the Cooperative ITP Working Group,on behalf of the Cooperative ITP Working Group,on behalf of the Cooperative ITP Working Group,on behalf of the Cooperative ITP Working Group,on behalf of the Cooperative ITP Working Group,on behalf of the Cooperative ITP Working Group,on behalf of the Cooperative ITP Working Group,on behalf of the Cooperative ITP Working Group,on behalf of the Cooperative ITP Working Group,on behalf of the Cooperative ITP Working Group,on behalf of the Cooperative ITP Working Group,on behalf of the Cooperative ITP Working Group,on behalf of the Cooperative ITP Working Group,on behalf of the Cooperative ITP Working Group,on behalf of the Cooperative ITP Working Group,on behalf of the Cooperative ITP Working Group,on behalf of the Cooperative ITP Working Group
View Articletitled, A risk score for predicting hospitalization for community-acquired pneumonia in ITP using nationally representative data
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

A new role of glutathione peroxidase 4 during human erythroblast enucleation
Hakim Ouled-Haddou,Kahia Messaoudi,Yohann Demont,Rogiéro Lopes dos Santos,Candice Carola,Alexis Caulier,Pascal Vong,Nicolas Jankovsky,Delphine Lebon,Alexandre Willaume,Julien Demagny,Thomas Boyer,Jean-Pierre Marolleau,Jacques Rochette,Loïc Garçon
View Articletitled, A new role of glutathione peroxidase 4 during human erythroblast enucleation
Supplemental data

THROMBOSIS AND HEMOSTASIS

Altered phenotype in LMAN1-deficient mice with low levels of residual LMAN1 expression
Lesley A. Everett,Rami N. Khoriaty,Bin Zhang,David Ginsburg
View Articletitled, Altered phenotype in LMAN1-deficient mice with low levels of residual LMAN1 expression
Supplemental data
Enhancing therapeutic efficacy of in vivo platelet-targeted gene therapy in hemophilia A mice
Xuefeng Wang,Richard Y. Fu,Chong Li,Chun-Yu Chen,Jenni Firrman,Barbara A. Konkle,Junping Zhang,Lei Li,Weidong Xiao,Mortimer Poncz,Carol H. Miao
View Articletitled, Enhancing therapeutic efficacy of in vivo platelet-targeted gene therapy in hemophilia A mice
Supplemental data
The prospective Hemophilia Inhibitor PUP Study reveals distinct antibody signatures prior to FVIII inhibitor development
B. M. Reipert,B. Gangadharan,C. J. Hofbauer,V. Berg,H. Schweiger,J. Bowen,J. Blatny,K. Fijnvandraat,E. S. Mullins,J. Klintman,C. Male,C. McGuinn,S. L. Meeks,V. C. Radulescu,M. V. Ragni,M. Recht,A. D. Shapiro,J. M. Staber,H. M. Yaish,E. Santagostino,D. L. Brown
View Articletitled, The prospective Hemophilia Inhibitor PUP Study reveals distinct antibody signatures prior to FVIII inhibitor development
Supplemental data
Macrophage protease-activated receptor 2 regulates fetal liver erythropoiesis in mice
Mona Saffarzadeh,Kristin Grunz,T. Son Nguyen,Young K. Lee,Maki Kitano,Sven Danckwardt,Carina D. S. Rodrigues,Hartmut Weiler,Sabine Reyda,Wolfram Ruf
View Articletitled, Macrophage protease-activated receptor 2 regulates fetal liver erythropoiesis in mice

TRANSFUSION MEDICINE

The effect of red blood cell transfusion on fatigability after hospital discharge
Micah T. Prochaska,Hui Zhang,Rilwan Babajide,David O. Meltzer
View Articletitled, The effect of red blood cell transfusion on fatigability after hospital discharge
Supplemental data

TRANSPLANTATION

Associations of the gut microbiome and clinical factors with acute GVHD in allogeneic HSCT recipients
Clinical Trials & Observations
Emma E. Ilett,Mette Jørgensen,Marc Noguera-Julian,Jens Christian Nørgaard,Gedske Daugaard,Marie Helleberg,Roger Paredes,Daniel D. Murray,Jens Lundgren,Cameron MacPherson,Joanne Reekie,Henrik Sengeløv
View Articletitled, Associations of the gut microbiome and clinical factors with acute GVHD in allogeneic HSCT recipients
Supplemental data

COMMENTARIES

Malignant progression of donor-engrafted clonal hematopoiesis in sibling recipients after stem cell transplantation
Louis Nevejan,Friedel Nollet,Helena Devos,Matthijs Vynck,Pieter Van Vlierberghe,Mercedeh Tajdar,Tom Lodewyck,Dominik Selleslag
View Articletitled, Malignant progression of donor-engrafted clonal hematopoiesis in sibling recipients after stem cell transplantation
Supplemental data
SF3B1-mutant CMML defines a predominantly dysplastic CMML subtype with a superior acute leukemia–free survival
Clinical Trials & Observations
Kitsada Wudhikarn,Sanam Loghavi,Abhishek A. Mangaonkar,Aref Al-Kali,Moritz Binder,Ryan Carr,Kaaren Reichard,Christy Finke,Matthew Howard,Naseema Gangat,Ayalew Tefferi,Rami Komrokji,Najla Ali,Terra Lasho,Rhett Ketterling,Eric Padron,Mrinal M. Patnaik
View Articletitled, <em>SF3B1</em>-mutant CMML defines a predominantly dysplastic CMML subtype with a superior acute leukemia–free survival
Supplemental data

ERRATA

Mariotti J, Raiola AM, Evangelista A, et al. Impact of donor age and kinship on clinical outcomes after T-cell–replete haploidentical transplantation with PT-Cy. Blood Adv. 2020;4(16):3900-3912.
View Articletitled, Mariotti J, Raiola AM, Evangelista A, et al. Impact of donor age and kinship on clinical outcomes after T-cell–replete haploidentical transplantation with PT-Cy. <em>Blood Adv.</em> 2020;4(16):3900-3912.
Luque Paz D, Jouanneau-Courville R, Riou J, et al. Leukemic evolution of polycythemia vera and essential thrombocythemia: genomic profiles predict time to transformation. Blood Adv. 2020;4(19):4887-4897.
View Articletitled, Luque Paz D, Jouanneau-Courville R, Riou J, et al. Leukemic evolution of polycythemia vera and essential thrombocythemia: genomic profiles predict time to transformation. <em>Blood Adv.</em> 2020;4(19):4887-4897.
Cho S-F, Lin L, Xing L, et al. The immunomodulatory drugs lenalidomide and pomalidomide enhance the potency of AMG 701 in multiple myeloma preclinical models. Blood Adv. 2020;4(17):4195-4207.
View Articletitled, Cho S-F, Lin L, Xing L, et al. The immunomodulatory drugs lenalidomide and pomalidomide enhance the potency of AMG 701 in multiple myeloma preclinical models. <em>Blood Adv.</em> 2020;4(17):4195-4207.
  • Cover Image

    Cover Image

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    COVER FIGURE
    The image represents an enucleating acidophilic erythroblast with AlexaFluor 647–conjugated GPX4 staining (red), AlexaFluor 488–conjugated cholera toxin B for lipid raft immunolabeling (green), and 4’,6-diamidino-2-phenylindole (DAPI) nuclear staining (blue). See the article by Ouled-Haddou et al.

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