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Journal Articles

Single-cell analysis reveals selection of TP53 -mutated clones after MDM2 inhibition

Nabih Maslah, Emmanuelle Verger, Stéphane Giraudier, Mathias Chea, Ronald Hoffman, John Mascarenhas, Bruno Cassinat, Jean-Jacques Kiladjian
Journal: Blood Advances
Blood Adv (2022) 6 (9): 2813–2823.
https://doi.org/10.1182/bloodadvances.2021005867
Published: 2022
Includes: Supplemental data
Journal Articles

Transient expansion of TP53 mutated clones in polycythemia vera patients treated with idasanutlin

Clinical Trials & Observations
Bridget K. Marcellino, Noushin Farnoud, Bruno Cassinat, Min Lu, Emanuelle Verger, Erin McGovern, Minal Patel, Juan Medina-Martinez, Max Fine Levine, Juanes E. Arango Ossa, Yangyu Zhou, Heidi Kosiorek, Meenakshi Mehrotra, Jane Houldsworth, Amylou Dueck, Michael Rossi, John Mascarenhas, Jean-Jacques Kiladjian, Raajit K. Rampal, Ronald Hoffman
Journal: Blood Advances
Blood Adv (2020) 4 (22): 5735–5744.
https://doi.org/10.1182/bloodadvances.2020002379
Published: 2020
Includes: Supplemental data
Journal Articles

Phase 2 study of ruxolitinib and decitabine in patients with myeloproliferative neoplasm in accelerated and blast phase

Clinical Trials & Observations
John O. Mascarenhas, Raajit K. Rampal, Heidi E. Kosiorek, Rupali Bhave, Elizabeth Hexner, Eunice S. Wang, Aaron Gerds, Camille N. Abboud, Marina Kremyanskaya, Dimitry Berenzon, Olatoyosi Odenike, Noushin Farnoud, Aishwarya Krishnan, Rona Singer Weinberg, Erin McGovern, Mohamed E. Salama, Vesna Najfeld, Juan S. Medina-Martinez, Juan E. Arango Ossa, Max F. Levine, Yangyu Zhou, Lonette Sandy, Mark L. Heaney, Ross L. Levine, Ruben A. Mesa, Amylou C. Dueck, Ronald Hoffman
Journal: Blood Advances
Blood Adv (2020) 4 (20): 5246–5256.
https://doi.org/10.1182/bloodadvances.2020002119
Published: 2020
Includes: Supplemental data
Journal Articles

Advanced forms of MPNs are accompanied by chromosomal abnormalities that lead to dysregulation of TP53

Clinical Trials & Observations
Bridget K. Marcellino, Ronald Hoffman, Joseph Tripodi, Min Lu, Heidi Kosiorek, John Mascarenhas, Raajit K. Rampal, Amylou Dueck, Vesna Najfeld
Journal: Blood Advances
Blood Adv (2018) 2 (24): 3581–3589.
https://doi.org/10.1182/bloodadvances.2018024018
Published: 2018
Journal Articles

Safety and efficacy of combined ruxolitinib and decitabine in accelerated and blast-phase myeloproliferative neoplasms

Clinical Trials & Observations
Raajit K. Rampal, John O. Mascarenhas, Heidi E. Kosiorek, Leah Price, Dmitriy Berenzon, Elizabeth Hexner, Camille N. Abboud, Marina Kremyanskaya, Rona Singer Weinberg, Mohamed E. Salama, Kamal Menghrajani, Vesna Najfeld, Lonette Sandy, Mark L. Heaney, Ross L. Levine, Ruben A. Mesa, Amylou C. Dueck, Judith D. Goldberg, Ronald Hoffman
Journal: Blood Advances
Blood Adv (2018) 2 (24): 3572–3580.
https://doi.org/10.1182/bloodadvances.2018019661
Published: 2018
Includes: Supplemental data
Journal Articles

Ex vivo human HSC expansion requires coordination of cellular reprogramming with mitochondrial remodeling and p53 activation

Luena Papa, Eran Zimran, Mansour Djedaini, Yongchao Ge, Umut Ozbek, Robert Sebra, Stuart C. Sealfon, Ronald Hoffman
Journal: Blood Advances
Blood Adv (2018) 2 (20): 2766–2779.
https://doi.org/10.1182/bloodadvances.2018024273
Published: 2018
Includes: Supplemental data
Journal Articles

Imetelstat, a telomerase inhibitor, is capable of depleting myelofibrosis stem and progenitor cells

Xiaoli Wang, Cing Siang Hu, Bruce Petersen, Jiajing Qiu, Fei Ye, Jane Houldsworth, Kevin Eng, Fei Huang, Ronald Hoffman
Journal: Blood Advances
Blood Adv (2018) 2 (18): 2378–2388.
https://doi.org/10.1182/bloodadvances.2018022012
Published: 2018
Includes: Supplemental data
Journal Articles

The characteristics of vessel lining cells in normal spleens and their role in the pathobiology of myelofibrosis

Jiajing Qiu, Mohamed E. Salama, Cing Siang Hu, Yan Li, Xiaoli Wang, Ronald Hoffman
Journal: Blood Advances
Blood Adv (2018) 2 (10): 1130–1145.
https://doi.org/10.1182/bloodadvances.2017015073
Published: 2018
Includes: Supplemental data