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Ross L. Levine
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Journal Articles

Beat-AML 2024 ELN–refined risk stratification for older adults with newly diagnosed AML given lower-intensity therapy

Fieke W. Hoff, William G. Blum, Ying Huang, Rina Li Welkie, Ronan T. Swords, Elie Traer, Eytan M. Stein, Tara L. Lin, Kellie J. Archer, Prapti A. Patel, Robert H. Collins, Maria R. Baer, Vu H. Duong, Martha L. Arellano, Wendy Stock, Olatoyosi Odenike, Robert L. Redner, Tibor Kovacsovics, Michael W. Deininger, Joshua F. Zeidner, Rebecca L. Olin, Catherine C. Smith, James M. Foran, Gary J. Schiller, Emily K. Curran, Kristin L. Koenig, Nyla A. Heerema, Timothy Chen, Molly Martycz, Mona Stefanos, Sonja G. Marcus, Leonard Rosenberg, Brian J. Druker, Ross L. Levine, Amy Burd, Ashley O. Yocum, Uma M. Borate, Alice S. Mims, John C. Byrd, Yazan F. Madanat
Journal: Blood Advances
Blood Adv (2024) 8 (20): 5297–5305.
https://doi.org/10.1182/bloodadvances.2024013685
Published: 2024
Includes: Supplemental data
Journal Articles

Acute myeloid leukemia stratifies as 2 clinically relevant sphingolipidomic subtypes

B. Bishal Paudel, Su-Fern Tan, Todd E. Fox, Johnson Ung, Upendarrao Golla, Jeremy J. P. Shaw, Wendy Dunton, Irene Lee, Wisam A. Fares, Satyam Patel, Arati Sharma, Aaron D. Viny, Brian M. Barth, Martin S. Tallman, Myles Cabot, Francine E. Garrett-Bakelman, Ross L. Levine, Mark Kester, David J. Feith, David Claxton, Kevin A. Janes, Thomas P. Loughran, Jr.
Journal: Blood Advances
Blood Adv (2024) 8 (5): 1137–1142.
https://doi.org/10.1182/bloodadvances.2023010535
Published: 2024
Includes: Supplemental data
Journal Articles

High-risk and silent clonal hematopoietic genotypes in patients with nonhematologic cancer

Aaron J. Stonestrom, Kamal N. Menghrajani, Sean M. Devlin, Sebastià Franch-Expósito, Ryan N. Ptashkin, Swara Y. Patel, Barbara Spitzer, Xiaodi Wu, Justin Jee, Pablo Sánchez Vela, Jennifer H. Milbank, Ronak H. Shah, Abhinita S. Mohanty, A. Rose Brannon, Wenbin Xiao, Michael F. Berger, Simon Mantha, Ross L. Levine
Journal: Blood Advances
Blood Adv (2024) 8 (4): 846–856.
https://doi.org/10.1182/bloodadvances.2023011262
Published: 2024
Includes: Supplemental data
Journal Articles

A study to assess the efficacy of enasidenib and risk-adapted addition of azacitidine in newly diagnosed IDH2 -mutant AML

Clinical Trials & Observations
Sheng F. Cai, Ying Huang, Jennie R. Lance, Hsiaoyin Charlene Mao, Andrew J. Dunbar, Samantha N. McNulty, Todd Druley, Yan Li, Maria R. Baer, Wendy Stock, Tibor Kovacsovics, William G. Blum, Gary J. Schiller, Rebecca L. Olin, James M. Foran, Mark Litzow, Tara Lin, Prapti Patel, Matthew C. Foster, Michael Boyiadzis, Robert H. Collins, Jordan Chervin, Abigail Shoben, Jo-Anne Vergilio, Nyla A. Heerema, Leonard Rosenberg, Timothy L. Chen, Ashley O. Yocum, Franchesca Druggan, Sonja Marcus, Mona Stefanos, Brian J. Druker, Alice S. Mims, Uma Borate, Amy Burd, John C. Byrd, Ross L. Levine, Eytan M. Stein
Journal: Blood Advances
Blood Adv (2024) 8 (2): 429–440.
https://doi.org/10.1182/bloodadvances.2023010563
Published: 2024
Includes: Supplemental data
Journal Articles

Samples from patients with AML show high concordance in detection of mutations by NGS at local institutions vs central laboratories

Clinical Trials & Observations
Uma Borate, Fei Yang, Richard Press, Amy S. Ruppert, Dan Jones, Sean Caruthers, Weiqiang Zhao, Jo-Anne Vergilio, Dean C. Pavlick, Luke Juckett, Brianna Norris, Taylor Bucy, Amy Burd, Eytan M. Stein, Prapti Patel, Maria R. Baer, Wendy Stock, Gary Schiller, William Blum, Tibor Kovacsovics, Mark Litzow, James Foran, Nyla A. Heerema, Leonard Rosenberg, Sonja Marcus, Ashley Yocum, Mona Stefanos, Brian Druker, John C. Byrd, Ross L. Levine, Alice Mims
Journal: Blood Advances
Blood Adv (2023) 7 (20): 6048–6054.
https://doi.org/10.1182/bloodadvances.2022009008
Published: 2023
Includes: Supplemental data
Journal Articles

Interaction between myelodysplasia-related gene mutations and ontogeny in acute myeloid leukemia

Clinical Trials & Observations
Joseph G. W. McCarter, David Nemirovsky, Christopher A. Famulare, Noushin Farnoud, Abhinita S. Mohanty, Zoe S. Stone-Molloy, Jordan Chervin, Brian J. Ball, Zachary D. Epstein-Peterson, Maria E. Arcila, Aaron J. Stonestrom, Andrew Dunbar, Sheng F. Cai, Jacob L. Glass, Mark B. Geyer, Raajit K. Rampal, Ellin Berman, Omar I. Abdel-Wahab, Eytan M. Stein, Martin S. Tallman, Ross L. Levine, Aaron D. Goldberg, Elli Papaemmanuil, Yanming Zhang, Mikhail Roshal, Andriy Derkach, Wenbin Xiao
Journal: Blood Advances
Blood Adv (2023) 7 (17): 5000–5013.
https://doi.org/10.1182/bloodadvances.2023009675
Published: 2023
Includes: Supplemental data
Journal Articles

Clonal hematopoiesis in survivors of childhood cancer

Danielle Novetsky Friedman, Irenaeus C. C. Chan, Chaya S. Moskowitz, Shanita Li, Kimberly Turner, Jie Liu, Nancy Bouvier, Michael F. Walsh, Barbara Spitzer, Andrew L. Kung, Michael Berger, Megan A. Cooper, Iskra Pusic, Geoffrey Uy, Daniel Link, Todd E. Druley, Luis A. Diaz, Jr., Ross L. Levine, Neerav Shukla, Kelly L. Bolton
Journal: Blood Advances
Blood Adv (2023) 7 (15): 4102–4106.
https://doi.org/10.1182/bloodadvances.2023009817
Published: 2023
Includes: Supplemental data
Journal Articles

Pevonedistat with azacitidine in older patients with TP53 -mutated AML: a phase 2 study with laboratory correlates

Clinical Trials & Observations
Antoine N. Saliba, Scott H. Kaufmann, Eytan M. Stein, Prapti A. Patel, Maria R. Baer, Wendy Stock, Michael Deininger, William Blum, Gary J. Schiller, Rebecca L. Olin, Mark R. Litzow, Tara L. Lin, Brian J. Ball, Michael M. Boyiadzis, Elie Traer, Olatoyosi Odenike, Martha L. Arellano, Alison Walker, Vu H. Duong, Tibor Kovacsovics, Robert H. Collins, Abigail B. Shoben, Nyla A. Heerema, Matthew C. Foster, Kevin L. Peterson, Paula A. Schneider, Molly Martycz, Theophilus J. Gana, Leonard Rosenberg, Sonja Marcus, Ashley O. Yocum, Timothy Chen, Mona Stefanos, Alice S. Mims, Uma Borate, Amy Burd, Brian J. Druker, Ross L. Levine, John C. Byrd, James M. Foran
Journal: Blood Advances
Blood Adv (2023) 7 (11): 2360–2363.
https://doi.org/10.1182/bloodadvances.2022008625
Published: 2023
Includes: Supplemental data
Journal Articles

Cell origin–dependent cooperativity of mutant Dnmt3a and Npm1 in clonal hematopoiesis and myeloid malignancy

Jennifer M. SanMiguel, Elizabeth Eudy, Matthew A. Loberg, Linde A. Miles, Tim Stearns, Jayna J. Mistry, Michael J. Rauh, Ross L. Levine, Jennifer J. Trowbridge
Journal: Blood Advances
Blood Adv (2022) 6 (12): 3666–3677.
https://doi.org/10.1182/bloodadvances.2022006968
Published: 2022
Includes: Supplemental data
Journal Articles

Clinical and molecular predictors of response and survival following venetoclax therapy in relapsed/refractory AML

Clinical Trials & Observations
Maximilian Stahl, Kamal Menghrajani, Andriy Derkach, Alexander Chan, Wenbin Xiao, Jacob Glass, Amber C. King, Anthony F. Daniyan, Christopher Famulare, Bernadette M. Cuello, Troy Z. Horvat, Omar Abdel-Wahab, Ross L. Levine, Aaron D. Viny, Eytan M. Stein, Sheng F. Cai, Mikhail Roshal, Martin S. Tallman, Aaron D. Goldberg
Journal: Blood Advances
Blood Adv (2021) 5 (5): 1552–1564.
https://doi.org/10.1182/bloodadvances.2020003734
Published: 2021
Includes: Supplemental data
Journal Articles

A JAK2 / IDH1 -mutant MPN clone unmasked by ivosidenib in an AML patient without antecedent MPN

Clinical Trials & Observations
Wenbin Xiao, Linde A. Miles, Robert L. Bowman, Vidushi Durani, Helen S. Tian, Nicole L. DelGaudio, Tanmay Mishra, Menglei Zhu, Yanming Zhang, Sarah E. Stump, Martin S. Tallman, Ross L. Levine, Sheng F. Cai
Journal: Blood Advances
Blood Adv (2020) 4 (23): 6034–6038.
https://doi.org/10.1182/bloodadvances.2020003326
Published: 2020
Journal Articles

Phase 2 study of ruxolitinib and decitabine in patients with myeloproliferative neoplasm in accelerated and blast phase

Clinical Trials & Observations
John O. Mascarenhas, Raajit K. Rampal, Heidi E. Kosiorek, Rupali Bhave, Elizabeth Hexner, Eunice S. Wang, Aaron Gerds, Camille N. Abboud, Marina Kremyanskaya, Dimitry Berenzon, Olatoyosi Odenike, Noushin Farnoud, Aishwarya Krishnan, Rona Singer Weinberg, Erin McGovern, Mohamed E. Salama, Vesna Najfeld, Juan S. Medina-Martinez, Juan E. Arango Ossa, Max F. Levine, Yangyu Zhou, Lonette Sandy, Mark L. Heaney, Ross L. Levine, Ruben A. Mesa, Amylou C. Dueck, Ronald Hoffman
Journal: Blood Advances
Blood Adv (2020) 4 (20): 5246–5256.
https://doi.org/10.1182/bloodadvances.2020002119
Published: 2020
Includes: Supplemental data
Journal Articles

JAK2 S523L, a novel gain-of-function mutation in a critical autoregulatory residue in JAK2 V617F − MPNs

Friederike Pastore, Aishwarya Krishnan, Henrik M. Hammarén, Olli Silvennoinen, Benedict Yan, Ross L. Levine
Journal: Blood Advances
Blood Adv (2020) 4 (18): 4554–4559.
https://doi.org/10.1182/bloodadvances.2019001283
Published: 2020
Includes: Supplemental data
Journal Articles

Clonal hematopoiesis in angioimmunoblastic T-cell lymphoma with divergent evolution to myeloid neoplasms

Natasha E. Lewis, Kseniya Petrova-Drus, Sarah Huet, Zachary D. Epstein-Peterson, Qi Gao, Allison E. Sigler, Jeeyeon Baik, Neval Ozkaya, Alison J. Moskowitz, Anita Kumar, Steven M. Horwitz, Yanming Zhang, Maria E. Arcila, Ross L. Levine, Mikhail Roshal, Ahmet Dogan, Wenbin Xiao
Journal: Blood Advances
Blood Adv (2020) 4 (10): 2261–2271.
https://doi.org/10.1182/bloodadvances.2020001636
Published: 2020
Includes: Supplemental data
Journal Articles

Therapy-related acute lymphoblastic leukemia is a distinct entity with adverse genetic features and clinical outcomes

Clinical Trials & Observations
Caner Saygin, Ashwin Kishtagari, Ryan D. Cassaday, Natalie Reizine, Ilana Yurkiewicz, Michaela Liedtke, Wendy Stock, Richard A. Larson, Ross L. Levine, Martin S. Tallman, Jae H. Park, Cassandra Kerr, Bartlomiej Przychodzen, Mikkael A. Sekeres, Matt E. Kalaycio, Hetty E. Carraway, Betty K. Hamilton, Ronald Sobecks, Aaron Gerds, Sudipto Mukherjee, Aziz Nazha, Jaroslaw P. Maciejewski, Anjali S. Advani
Journal: Blood Advances
Blood Adv (2019) 3 (24): 4228–4237.
https://doi.org/10.1182/bloodadvances.2019000925
Published: 2019
Includes: Supplemental data
Journal Articles

Inhibition of the mutated c-KIT kinase in AML1-ETO–positive leukemia cells restores sensitivity to PARP inhibitor

Margaret Nieborowska-Skorska, Elisabeth M. Paietta, Ross L. Levine, Hugo F. Fernandez, Martin S. Tallman, Mark R. Litzow, Tomasz Skorski
Journal: Blood Advances
Blood Adv (2019) 3 (23): 4050–4054.
https://doi.org/10.1182/bloodadvances.2019000756
Published: 2019
Includes: Supplemental data
Journal Articles

Sphingolipid metabolism determines the therapeutic efficacy of nanoliposomal ceramide in acute myeloid leukemia

Brian M. Barth, Weiyuan Wang, Paul T. Toran, Todd E. Fox, Charyguly Annageldiyev, Regina M. Ondrasik, Nicole R. Keasey, Timothy J. Brown, Viola G. Devine, Emily C. Sullivan, Andrea L. Cote, Vasiliki Papakotsi, Su-Fern Tan, Sriram S. Shanmugavelandy, Tye G. Deering, David B. Needle, Stephan T. Stern, Junjia Zhu, Jason Liao, Aaron D. Viny, David J. Feith, Ross L. Levine, Hong-Gang Wang, Thomas P. Loughran, Jr, Arati Sharma, Mark Kester, David F. Claxton
Journal: Blood Advances
Blood Adv (2019) 3 (17): 2598–2603.
https://doi.org/10.1182/bloodadvances.2018021295
Published: 2019
Includes: Supplemental data
Journal Articles

Challenges and approaches to implementing master/basket trials in oncology

Clinical Trials & Observations
Amy Burd, Richard L. Schilsky, John C. Byrd, Ross L. Levine, Vassiliki A. Papadimitrakopoulou, Roy S. Herbst, Mary W. Redman, Brian J. Druker, David R. Gandara
Journal: Blood Advances
Blood Adv (2019) 3 (14): 2237–2243.
https://doi.org/10.1182/bloodadvances.2019031229
Published: 2019
Journal Articles

Safety and efficacy of combined ruxolitinib and decitabine in accelerated and blast-phase myeloproliferative neoplasms

Clinical Trials & Observations
Raajit K. Rampal, John O. Mascarenhas, Heidi E. Kosiorek, Leah Price, Dmitriy Berenzon, Elizabeth Hexner, Camille N. Abboud, Marina Kremyanskaya, Rona Singer Weinberg, Mohamed E. Salama, Kamal Menghrajani, Vesna Najfeld, Lonette Sandy, Mark L. Heaney, Ross L. Levine, Ruben A. Mesa, Amylou C. Dueck, Judith D. Goldberg, Ronald Hoffman
Journal: Blood Advances
Blood Adv (2018) 2 (24): 3572–3580.
https://doi.org/10.1182/bloodadvances.2018019661
Published: 2018
Includes: Supplemental data
Journal Articles

PHF6 and DNMT3A mutations are enriched in distinct subgroups of mixed phenotype acute leukemia with T-lineage differentiation

Clinical Trials & Observations
Wenbin Xiao, Maheetha Bharadwaj, Max Levine, Noushin Farnoud, Friederike Pastore, Bartlomiej M. Getta, Anne Hultquist, Christopher Famulare, Juan S. Medina, Minal A. Patel, Qi Gao, Natasha Lewis, Janine Pichardo, Jeeyeon Baik, Brian Shaffer, Sergio Giralt, Raajit Rampal, Sean Devlin, Robert Cimera, Yanming Zhang, Maria E. Arcila, Elli Papaemmanuil, Ross L. Levine, Mikhail Roshal
Journal: Blood Advances
Blood Adv (2018) 2 (23): 3526–3539.
https://doi.org/10.1182/bloodadvances.2018023531
Published: 2018
Includes: Supplemental data