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Mortimer Poncz
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Journal Articles

Packaging of supplemented urokinase into alpha granules of in vitro–grown megakaryocytes for targeted nascent clot lysis

Mortimer Poncz, Sergei V. Zaitsev, Hyunsook Ahn, M. Anna Kowalska, Khalil Bdeir, Konstantin V. Dergilev, Lacramioara Ivanciu, Rodney M. Camire, Douglas B. Cines, Victoria Stepanova
Journal: Blood Advances
Blood Adv (2024) 8 (14): 3798–3809.
https://doi.org/10.1182/bloodadvances.2024012835
Published: 2024
Includes: Multimedia, Supplemental data
Journal Articles

Altered platelet-megakaryocyte endocytosis and trafficking of albumin and fibrinogen in RUNX1 haplodeficiency

Fabiola Del Carpio-Cano, Guangfen Mao, Lawrence E. Goldfinger, Jeremy Wurtzel, Liying Guan, Mohammad Afaque Alam, Kiwon Lee, Mortimer Poncz, A. Koneti Rao
Journal: Blood Advances
Blood Adv (2024) 8 (7): 1699–1714.
https://doi.org/10.1182/bloodadvances.2023011098
Published: 2024
Includes: Supplemental data
Journal Articles

Treatment of thrombocytopenia and thrombosis in HIT in mice using deglycosylated KKO: a novel therapeutic?

Amrita Sarkar, Sanjay Khandelwal, Gavin T. Koma, Hyunjun Kim, Yves Gruel, Jerome Rollin, Freda Passam, Geoffrey D. Wool, Gowthami M. Arepally, Douglas B. Cines, Lubica Rauova, Mortimer Poncz
Journal: Blood Advances
Blood Adv (2023) 7 (15): 4112–4123.
https://doi.org/10.1182/bloodadvances.2023009661
Published: 2023
Includes: Supplemental data
Journal Articles

Defective RAB31-mediated megakaryocytic early endosomal trafficking of VWF, EGFR, and M6PR in RUNX1 deficiency

Gauthami Jalagadugula, Guangfen Mao, Lawrence E. Goldfinger, Jeremy Wurtzel, Fabiola Del Carpio-Cano, Michele P. Lambert, Brian Estevez, Deborah L. French, Mortimer Poncz, A. Koneti Rao
Journal: Blood Advances
Blood Adv (2022) 6 (17): 5100–5112.
https://doi.org/10.1182/bloodadvances.2021006945
Published: 2022
Includes: Supplemental data
Journal Articles

Enhancing therapeutic efficacy of in vivo platelet-targeted gene therapy in hemophilia A mice

Xuefeng Wang, Richard Y. Fu, Chong Li, Chun-Yu Chen, Jenni Firrman, Barbara A. Konkle, Junping Zhang, Lei Li, Weidong Xiao, Mortimer Poncz, Carol H. Miao
Journal: Blood Advances
Blood Adv (2020) 4 (22): 5722–5734.
https://doi.org/10.1182/bloodadvances.2020002479
Published: 2020
Includes: Supplemental data
Journal Articles

Human mutational constraint as a tool to understand biology of rare and emerging bone marrow failure syndromes

Joseph H. Oved, Daria V. Babushok, Michele P. Lambert, Nicole Wolfset, M. Anna Kowalska, Mortimer Poncz, Konrad J. Karczewski, Timothy S. Olson
Journal: Blood Advances
Blood Adv (2020) 4 (20): 5232–5245.
https://doi.org/10.1182/bloodadvances.2020002687
Published: 2020
Includes: Supplemental data
Journal Articles

Infused factor VIII–expressing platelets or megakaryocytes as a novel therapeutic strategy for hemophilia A

Randolph B. Lyde, Hyun Sook Ahn, Karen K. Vo, Danuta J. Jarocha, John Tkaczynski, Elsa Treffeisen, Spencer K. Sullivan, Rodney M. Camire, Denise E. Sabatino, Deborah L. French, Mortimer Poncz
Journal: Blood Advances
Blood Adv (2019) 3 (9): 1368–1378.
https://doi.org/10.1182/bloodadvances.2017007914
Published: 2019
Includes: Supplemental data
Journal Articles

2-O, 3-O desulfated heparin mitigates murine chemotherapy- and radiation-induced thrombocytopenia

Elizabeth Tkaczynski, Abinaya Arulselvan, John Tkaczynski, Stephen Avery, Liqing Xiao, Beverly Torok-Storb, Kraig Abrams, Narayanam V. Rao, Gregory Johnson, Thomas P. Kennedy, Mortimer Poncz, Michele P. Lambert
Journal: Blood Advances
Blood Adv (2018) 2 (7): 754–761.
https://doi.org/10.1182/bloodadvances.2017013672
Published: 2018
Includes: Supplemental data
Journal Articles

Enhancing functional platelet release in vivo from in vitro–grown megakaryocytes using small molecule inhibitors

Danuta Jarocha, Karen K. Vo, Randolph B. Lyde, Vincent Hayes, Rodney M. Camire, Mortimer Poncz
Journal: Blood Advances
Blood Adv (2018) 2 (6): 597–606.
https://doi.org/10.1182/bloodadvances.2017010975
Published: 2018
Includes: Supplemental data
Journal Articles

Biocompatible coupling of therapeutic fusion proteins to human erythrocytes

Carlos H. Villa, Daniel C. Pan, Ian H. Johnston, Colin F. Greineder, Landis R. Walsh, Elizabeth D. Hood, Douglas B. Cines, Mortimer Poncz, Don L. Siegel, Vladimir R. Muzykantov
Journal: Blood Advances
Blood Adv (2018) 2 (3): 165–176.
https://doi.org/10.1182/bloodadvances.2017011734
Published: 2018
Includes: Multimedia, Supplemental data
Journal Articles

Platelet dense granules begin to selectively accumulate mepacrine during proplatelet formation

Hayley A. Hanby, Jialing Bao, Ji-Yoon Noh, Danuta Jarocha, Mortimer Poncz, Mitchell J. Weiss, Michael S. Marks
Journal: Blood Advances
Blood Adv (2017) 1 (19): 1478–1490.
https://doi.org/10.1182/bloodadvances.2017006726
Published: 2017
Includes: Supplemental data
Journal Articles

ICAM-1–targeted thrombomodulin mitigates tissue factor–driven inflammatory thrombosis in a human endothelialized microfluidic model

Colin F. Greineder, Ian H. Johnston, Carlos H. Villa, Kandace Gollomp, Charles T. Esmon, Douglas B. Cines, Mortimer Poncz, Vladimir R. Muzykantov
Journal: Blood Advances
Blood Adv (2017) 1 (18): 1452–1465.
https://doi.org/10.1182/bloodadvances.2017007229
Published: 2017
Includes: Multimedia, Supplemental data
Journal Articles

Polyphosphate/platelet factor 4 complexes can mediate heparin-independent platelet activation in heparin-induced thrombocytopenia

Douglas B. Cines, Serge V. Yarovoi, Sergei V. Zaitsev, Tatiana Lebedeva, Lubica Rauova, Mortimer Poncz, Gowthami M. Arepally, Sanjay Khandelwal, Victoria Stepanova, Ann H. Rux, Adam Cuker, Cecilia Guo, Linnette Mae Ocariza, Richard J. Travers, Stephanie A. Smith, Hugh Kim, James H. Morrissey, Edward M. Conway
Journal: Blood Advances
Blood Adv (2016) 1 (1): 62–74.
https://doi.org/10.1182/bloodadvances.2016000877
Published: 2016
Includes: Supplemental data